Großmann, Marius

[["dc.bibliographiccitation.artnumber","14"],["dc.bibliographiccitation.journal","Journal of Cardiothoracic Surgery"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Bireta, Christian"],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Unsoeld, Bernhard W."],["dc.contributor.author","Wachter, R. Rolf"],["dc.contributor.author","Perl, Thorsten"],["dc.contributor.author","Jebran, Ahmad Fawad"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Popov, Aron Frederik"],["dc.date.accessioned","2018-11-07T10:01:53Z"],["dc.date.available","2018-11-07T10:01:53Z"],["dc.date.issued","2015"],["dc.description.abstract","Giant-cell myocarditis (GCM) is known as a rare, rapidly progressive, and frequently fatal myocardial disease in young and middle-aged adults. We report about a 76 year old male patient who underwent implantation with a biventricular Berlin Heart Excor system at the age of 74 due to acute biventricular heart failure caused by giant-cell myocarditis. The implantation was without any surgical problems; however, a difficulty was the immunosuppressive therapy after implantation. Meanwhile the patient is 76 years old and lives with circulatory support for about 3 years without major adverse events. Also, in terms of mobility in old age there are no major limitations. It seems that in even selected elderly patients an implantation of a long term support with the biventricular Berlin Heart Excor is a useful therapeutic option with an acceptable outcome."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2015"],["dc.identifier.doi","10.1186/s13019-015-0218-9"],["dc.identifier.isi","000350433300001"],["dc.identifier.pmid","25637129"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13464"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38121"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1749-8090"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Long term biventricular support with Berlin Heart Excor in a Septuagenarian with giant-cell myocarditis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","482"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Interactive Cardiovascular and Thoracic Surgery"],["dc.bibliographiccitation.lastpage","488"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Andrasi, Terezia B."],["dc.contributor.author","Kekesi, Violetta"],["dc.contributor.author","Merkely, Bela"],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Danner, Bernhard Christoph"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T10:25:09Z"],["dc.date.available","2018-11-07T10:25:09Z"],["dc.date.issued","2017"],["dc.description.abstract","OBJECTIVES: We aimed to develop a simple, reliable, and timesaving technique for the therapy of thoracoabdominal aortic (TAA) aneurysms that are not suitable for endovascular repair. METHODS: In this pilot study, we sought to combine the advantages of classic open vascular procedure with the use of endoscopic surgical tools and small skin incisions to develop a minimally invasive approach for TAA replacement. The following procedures were used: endoscopic exposure and closure of the lower intercostal arteries; small posterolateral thoracotomy and left retroperitoneal incisions to expose the anastomotic regions of the aorta; partial anticoagulation; passive bypass and sequential aortic clamping; tunnelling of the graft through the native aortic lumen (endoaneurysmorrhaphy) and open performance of vascular anastomosis. RESULTS: Five mixed-breed dogs (25-35 kg) underwent minimally invasive TAA replacement. All animals survived the operation without blood transfusion (lowest Hb = 5.5 mg/dl). Total operation time was 364 +/- 46.3 min. Clamping times were 17.6 +/- 3.2 min for proximal anastomosis, 33.2 +/- 2.48 min for visceral patch and 11 +/- 2.3 min for distal anastomosis. The pull-through procedure of graft through the native aorta was performed during the visceral clamp time. CONCLUSIONS: Surgical replacement of the TAA through small transverse incisions of the thoracic and abdominal wall is feasible and allows open performance of all vascular anastomosis with no leakage at any anastomotic site. Further experimental studies and clinical implementation are needed to establish the safety and long-term outcome of minimally invasive TAA replacement as a possible primary therapeutic tool for complex aneurysms that are not suitable for endovascular treatment and require open surgical repair."],["dc.description.sponsorship","European Society of Vascular Surgery"],["dc.identifier.doi","10.1093/icvts/ivw379"],["dc.identifier.isi","000404043800002"],["dc.identifier.pmid","28040750"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42797"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","1569-9285"],["dc.relation.issn","1569-9293"],["dc.title","A minimally invasive approach for open surgical thoracoabdominal aortic replacement: experimental concept for a novel surgical procedure"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","373"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","European Journal of Anaesthesiology"],["dc.bibliographiccitation.lastpage","379"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Kazmaier, Stefan"],["dc.contributor.author","Hanekop, Gerd-Gunnar"],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Dorge, H."],["dc.contributor.author","Gotze, Katharina"],["dc.contributor.author","Schondube, F."],["dc.contributor.author","Quintel, M."],["dc.contributor.author","Weyland, A."],["dc.date.accessioned","2018-11-07T09:51:53Z"],["dc.date.available","2018-11-07T09:51:53Z"],["dc.date.issued","2006"],["dc.description.abstract","Objective: The objective of this study was to describe the diastolic pressure-flow relationship and to assess critical occlusion pressure in arterial coronary bypass grafts in human beings. Methods and results: Fifteen patients were studied following elective surgical coronary artery bypass grafting. Flow in the left internal mammary artery bypass to the left anterior descending artery was measured and simultaneously, aortic pressure, coronary sinus pressure and left ventricular end-diastolic pressure were recorded. The zero-flow pressure intercept as a measure of critical occlusion pressure was extrapolated from the linear regression analysis of the instantaneous diastolic pressure-flow relationship. Mean diastolic flow was 46 +/- 17 mL min(-1), mean diastolic aortic pressure was 60.5 +/- 10.0 mmHg. Diastolic blood flow was linearly related to the respective aortic pressure in all patients (R-values 0.7-0.99). The regression lines had a mean slope of 2.1 +/- 1.2 mL min(-1) mmHg(-1). Mean critical occlusion pressure was 32.3 +/- 9.9 mmHg and exceeded mean coronary sinus pressure and mean left ventricular end-diastolic pressure by factors of 3.1 and 2.6, respectively. Conclusions: Our data demonstrate the presence of a vascular waterfall phenomenon in the coronary circulation after internal mammary artery bypass grafting. Critical occlusion pressure in arterial grafts considerably exceeds coronary sinus pressure as well as left ventricular end-diastolic pressure and should thus be used as the effective downstream pressure when calculating coronary perfusion pressure. Our data further suggest that the slope of diastolic pressure-flow relationships provides a more rational approach to assess regional coronary vascular resistance than conventional calculations of coronary vascular resistance."],["dc.identifier.doi","10.1017/S0265021505001985"],["dc.identifier.isi","000237408100002"],["dc.identifier.pmid","16438765"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36001"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cambridge Univ Press"],["dc.relation.issn","0265-0215"],["dc.title","Instantaneous diastolic pressure-flow relationship in arterial coronary bypass grafts"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1433"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","The Annals of Thoracic Surgery"],["dc.bibliographiccitation.lastpage","1439"],["dc.bibliographiccitation.volume","88"],["dc.contributor.author","Danner, Bernhard Christoph"],["dc.contributor.author","Didilis, Vassilios N."],["dc.contributor.author","Stojanovic, Tomislav"],["dc.contributor.author","Popov, Aron"],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Seipelt, Ralf G."],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T11:22:21Z"],["dc.date.available","2018-11-07T11:22:21Z"],["dc.date.issued","2009"],["dc.description.abstract","Background. Emergent coronary artery bypass graft surgery (CABG) for acute myocardial infarction is associated with an increased operative risk. For estimation of mortality risk, the European System for Cardiac Operative Risk Evaluation (EuroSCORE) is appropriate up to a medium risk score (<6 points). To predict mortality risk more accurately in cases of higher EuroSCORE, additional cardiac data can be helpful. Methods. Over a 3-year period, patient data including acute myocardial infarction and emergent CABG were retrospectively reviewed. Univariate and multivariate analysis for in-hospital mortality was performed. The EuroSCORE analysis and follow-up was investigated. Results. Overall in-hospital mortality was 18.3%. Preoperative cardiac related predictors for in-hospital mortality were cardiogenic shock (p < 0.001), very poor left ventricular function (p = 0.001), and ST-segment elevation (p = 0.012). In multivariate regression analysis, age, cardiogenic shock, and pulmonary hypertension were independent preoperative risk factors. According to the EuroSCORE, we could define three statistically different groups: intermediate-risk, high-risk, and very high risk, with an observed mortality of 3.3%, 20.0%, and 63.2%, respectively. The EuroSCORE correlates with but overestimates the mortality risk. In subgroup analysis, the creatine kinase-myocardial band/hour ratio for the intermediate-risk group and ST-segment elevation for the high-risk group were additional cardiac risk factors. Conclusions. Patients with an acute myocardial infarction and emergency aortocoronary CABG have an elevated operative risk. Logistic EuroSCORE overestimates the mortality rate. Three different risk groups can be defined, in which creatine kinase-MB/h-ratio and ST-segment elevation can more accurately predict operative risk. (Ann Thorac Surg 2009;88:1433-9) (C) 2009 by The Society of Thoracic Surgeons"],["dc.identifier.doi","10.1016/j.athoracsur.2009.06.059"],["dc.identifier.isi","000271215700007"],["dc.identifier.pmid","19853087"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55978"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","0003-4975"],["dc.title","A Three-Group Model to Predict Mortality in Emergent Coronary Artery Bypass Graft Surgery"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","076402"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Physical Review Letters"],["dc.bibliographiccitation.volume","115"],["dc.contributor.author","Schubert, M."],["dc.contributor.author","Schaefer, H."],["dc.contributor.author","Mayer, J."],["dc.contributor.author","Laptev, Aleksej"],["dc.contributor.author","Hettich, M."],["dc.contributor.author","Merklein, M."],["dc.contributor.author","He, C."],["dc.contributor.author","Rummel, C."],["dc.contributor.author","Ristow, O."],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Luo, Y."],["dc.contributor.author","Gusev, V."],["dc.contributor.author","Samwer, Konrad H."],["dc.contributor.author","Fonin, M."],["dc.contributor.author","Dekorsy, T."],["dc.contributor.author","Demsar, J."],["dc.date.accessioned","2018-11-07T09:53:17Z"],["dc.date.available","2018-11-07T09:53:17Z"],["dc.date.issued","2015"],["dc.description.abstract","The origin of the martensitic transition in the magnetic shape memory alloy Ni-Mn-Ga has been widely discussed. While several studies suggest it is electronically driven, the adaptive martensite model reproduced the peculiar nonharmonic lattice modulation. We used femtosecond spectroscopy to probe the temperature and doping dependence of collective modes, and scanning tunneling microscopy revealed the corresponding static modulations. We show that the martensitic phase can be described by a complex charge-density wave tuned by magnetic ordering and strong electron-lattice coupling."],["dc.description.sponsorship","DFG [SFB 767]; BMBF [13N10061, 13N10062]; Carl Zeiss Foundation"],["dc.identifier.doi","10.1103/PhysRevLett.115.076402"],["dc.identifier.isi","000359437000014"],["dc.identifier.pmid","26317735"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36301"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Physical Soc"],["dc.relation.issn","1079-7114"],["dc.relation.issn","0031-9007"],["dc.title","Collective Modes and Structural Modulation in Ni-Mn-Ga(Co) Martensite Thin Films Probed by Femtosecond Spectroscopy and Scanning Tunneling Microscopy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","533"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","JOURNAL OF CARDIOVASCULAR SURGERY"],["dc.bibliographiccitation.lastpage","537"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Ortomann, P."],["dc.contributor.author","Vorkamp, Tobias"],["dc.contributor.author","Heidrich, Florian"],["dc.contributor.author","Kolat, Philipp"],["dc.contributor.author","Popov, A. F."],["dc.contributor.author","Doerge, Hilmar"],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Seipelt, Ralf G."],["dc.contributor.author","Ramadori, Giuliano"],["dc.contributor.author","Schoendube, A."],["dc.date.accessioned","2018-11-07T11:12:30Z"],["dc.date.available","2018-11-07T11:12:30Z"],["dc.date.issued","2008"],["dc.description.abstract","Aim. Valuable models of chronic heart failure to perform histological studies are scarce. The authors aimed at investigating histological changes of the heart, lung, liver and kidneys in a stable and reproducible animal model of chronic heart failure in sheep. Methods. In 8 sheep (N.=8, 77 +/- 2 kg) chronic heart failure was induced by multiple sequential microembolization through bolus injection of polysterol microspheres (90 mu m, N=25 000) into the left main coronary artery. Microembolization (ME) was repeated up to three times in two to three week intervals until animals started to develop stable signs of heart failure. Therefore, clinical and hemodynamic parameters were measured (Troponin T, heart and respiratory rate, cardiac output) after each embolization. Clinical examination was carried out by a veterinarian. All animals were followed for 3 months after first microembolization and then euthanized for histological examination. Histological data of the heart, lung, liver and the kidneys were analyzed in hematoxylin-eosin (HE) stains (10x, 25x, 100x) at baseline (control group) and at 3 months after first ME. Additionally preperations of heart tissue were stained with Picro-Sirius-Red (PSR) for planimetric quantification. A score from 0 to 4 according to Rassler et al. (2005) was used to assess the degree of lung injury. Results. All animals developed histological signs of heart failure as indicated by island-like, patchy fibrosis of the heart Planimetric quantification (PSR stain) of the heart revealed a significant increase of the total amount of fibrosis from 8 +/- 2% (base) to 21 +/- 4% (3 months) (P<0.05), which was distributed homogenously throughout the left ventricle (20 +/- 3% left ventricular [LV] anterior wall, 21 +/- 4% LV posterior wall, 20 +/- 4% septum). Histologic analysis of the lung demonstrated a moderate degree of interstitial edema and pronounced peribronchial processes of inflammation with beginning proliferation of fibrotic tissue. Liver tissue showed histological changes in terms of pericentral adiposis as sign of hypoxia in course of lacking perfusion. Signs of liver congestion could be detected histological in form of central-venous accumulation of erythrocytes and dissolution of liver tissue in proximity of the central veins. Kidney preparations illustrated loss of endothelial function and vascular occlusions, caused by microspheres, with decline of renal parenchyma particularly of the tubules. Conclusion Multiple sequential intracoronary microembolization can effectively induce myocardial dysfunction with histological signs of chronic ischemic cardiomyopathy and pathological changes of lung, liver and kidney, which can directly be coursed by chronic heart failure. Thus, the present model may be suitable in experimental work on heart failure and LV assist devices, e.g. for studying the impact of mechanical unloading, mechanisms of recovery and reverse remodeling."],["dc.identifier.isi","000260851100015"],["dc.identifier.pmid","18665118"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53681"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Edizioni Minerva Medica"],["dc.relation.issn","0021-9509"],["dc.title","Histological changes in a model of chronic heart failure induced by multiple sequential coronary microembolization in sheep"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","642"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Cardiovascular Research"],["dc.bibliographiccitation.lastpage","651"],["dc.bibliographiccitation.volume","79"],["dc.contributor.author","Kockskaemper, Jens"],["dc.contributor.author","Khafaga, Mounir"],["dc.contributor.author","Grimm, Michael"],["dc.contributor.author","Elgner, Andreas"],["dc.contributor.author","Walther, Stefanie"],["dc.contributor.author","Kockskaemper, Anke"],["dc.contributor.author","von Lewinski, Dirk"],["dc.contributor.author","Post, Heiner"],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Doerge, Hilmar"],["dc.contributor.author","Gottlieb, Philip A."],["dc.contributor.author","Sachs, Frederick"],["dc.contributor.author","Eschenhagen, Thomas"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Pieske, Burkert M."],["dc.date.accessioned","2018-11-07T11:11:08Z"],["dc.date.available","2018-11-07T11:11:08Z"],["dc.date.issued","2008"],["dc.description.abstract","Aims Stretch is an important regulator of atrial function. The functional effects of stretch on human atrium, however, are poorly understood. Thus, we characterized the stretch-induced force response in human atrium and evaluated the underlying cellular mechanisms. Methods and results Isometric twitch force of human atrial trabeculae (n = 252) was recorded (37 C, 1 Hz stimulation) following stretch from 88 (L88) to 98% (L98) of optimal length. [Na(+)](i) and pH(i) were measured using SBFI and BCECF epifluorescence, respectively. Stretch induced a biphasic force increase: an immediate increase [first-phase, Frank-Starting mechanism (FSM)] to similar to 190% of force at L88 followed by an additional slower increase [5-10 min; stow force response (SFR)] to similar to 120% of the FSM. FSM and SFR were unaffected by gender, age, ejection fraction, and pre-medication with major cardiovascular drugs. There was a positive correlation between the amplitude of the FSM and the SFR. [Na(+)](i) rose by similar to 1 mmol/L and pH(i) remained unchanged during the SFR. Inhibition of Na(+)/H(+)-exchange (3 mu M HOE642), Na(+)/Ca(2+)-exchange (5 mu M KB-R7943), or stretch-activated channels (0.5 mu M, GsMtx-4 and 80 mu M streptomycin) did not reduce the SFR. Inhibition of angiotensin-II (AngII) receptors (5 mu M saralasin and 0.5 mu M PD123319) or pre-application of 0.5 mu M AngII, however, reduced the SFR by similar to 40-60%. Moreover, stretch increased phosphorylation of myosin tight chain 2 (MLC2a) and inhibition of MLC kinase (10 mu M ML-7 and 5 mu M wortmannin) decreased the SFR by similar to 40-85%. Conclusion Stretch elicits a SFR in human atrium. The atrial SFR is mediated by stretch-induced release and autocrine/paracrine actions of AngII and increased myofilament Ca(2+) responsiveness via phosphorylation of MLC2a by MLC kinase."],["dc.identifier.doi","10.1093/cvr/cvn126"],["dc.identifier.isi","000259301600014"],["dc.identifier.pmid","18503051"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6310"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53362"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","0008-6363"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Angiotensin II and myosin light-chain phosphorylation contribute to the stretch-induced slow force response in human atrial myocardium"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","900"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Artificial Organs"],["dc.bibliographiccitation.lastpage","U132"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Bireta, Christian"],["dc.contributor.author","Danner, Bernhard Christoph"],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Zenker, Dieter"],["dc.contributor.author","Seidler, Tim"],["dc.contributor.author","Unsoeld, Bernhard W."],["dc.contributor.author","Sabashnikov, Anton"],["dc.contributor.author","Muehlhaeuser, Ulrike"],["dc.contributor.author","Braeuer, Anselm"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Popov, Aron Frederik"],["dc.date.accessioned","2018-11-07T09:33:56Z"],["dc.date.available","2018-11-07T09:33:56Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.1111/aor.12273"],["dc.identifier.isi","000344360700012"],["dc.identifier.pmid","25345363"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32070"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1525-1594"],["dc.relation.issn","0160-564X"],["dc.title","Challenging Treatment of an Infected CircuLite Synergy Micropump After Pump Thrombosis Due to Subtherapeutic Anticoagulation Therapy: Pushing the Limits?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","281"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Vascular Surgery"],["dc.bibliographiccitation.lastpage","297.e2"],["dc.bibliographiccitation.volume","66"],["dc.contributor.author","Andrási, Terézia B."],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Zenker, Dieter"],["dc.contributor.author","Danner, Bernhard C."],["dc.contributor.author","Schöndube, Friedrich A."],["dc.date.accessioned","2020-12-10T15:20:10Z"],["dc.date.available","2020-12-10T15:20:10Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1016/j.jvs.2017.04.024"],["dc.identifier.issn","0741-5214"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72576"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Supra-aortic interventions for endovascular exclusion of the entire aortic arch"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","180"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","The Thoracic and Cardiovascular Surgeon"],["dc.bibliographiccitation.lastpage","184"],["dc.bibliographiccitation.volume","61"],["dc.contributor.author","Doerge, Hilmar"],["dc.contributor.author","Sellin, Christian"],["dc.contributor.author","Bury, Maike-Corinna"],["dc.contributor.author","Drescher, Andreas"],["dc.contributor.author","Seipelt, Ralf G."],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Danner, Bernhard Christoph"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T09:26:35Z"],["dc.date.available","2018-11-07T09:26:35Z"],["dc.date.issued","2013"],["dc.description.abstract","Background Deep sternal wound infections (DSWI) remain a devastating complication in cardiac surgery applying full sternotomy. As the risk profile in cardiac surgery changed toward an older and sicker population, the incidence of DSWI increases. Platelet rich plasma (PRP) holds promise in tissue regeneration with respect to bone regeneration, reduction of bleeding, and accelerated wound healing. The effect of PRP on DSWI was investigated in high-risk patients undergoing cardiac surgery with full sternotomy. Methods 196 consecutive patients at risk of DSWI were randomized to application of autologous PRP before sternal wiring (n = 97) or control (n = 99). All patients underwent cardiac surgery on cardiopulmonary bypass with cardioplegic cardiac arrest. Endpoint was occurrence of DSWI requiring revision surgery. Results Demographic, intraoperative, and perioperative variables as well as risk factors were comparable between groups. Incidence of DSWI was not different between the PRP-group and the control-group (6/97 (6.2%) vs. 3/99 (3.0%); n.s.). Conclusions Local application of autologous PRP in cardiac surgery patients with full sternotomy at high risk for sternal complications did not reduce the incidence of DSWI."],["dc.description.sponsorship","Biomet Deutschland GmbH, Berlin, Germany"],["dc.identifier.doi","10.1055/s-0032-1304537"],["dc.identifier.isi","000317175800002"],["dc.identifier.pmid","22547304"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30332"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0171-6425"],["dc.title","Incidence of Deep Sternal Wound Infection Is Not Reduced with Autologous Platelet Rich Plasma in High-Risk Cardiac Surgery Patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]