Dango, Sebastian

[["dc.bibliographiccitation.firstpage","538"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","DMW - Deutsche Medizinische Wochenschrift"],["dc.bibliographiccitation.lastpage","542"],["dc.bibliographiccitation.volume","139"],["dc.contributor.author","Ploenes, T."],["dc.contributor.author","Dango, Sebastian"],["dc.contributor.author","Brugger, Wolfram"],["dc.contributor.author","Ludwig, C."],["dc.contributor.author","Stoelben, Erich"],["dc.date.accessioned","2018-11-07T09:42:46Z"],["dc.date.available","2018-11-07T09:42:46Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.1055/s-0033-1360099"],["dc.identifier.isi","000337291000009"],["dc.identifier.pmid","24595711"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34030"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","1439-4413"],["dc.relation.issn","0012-0472"],["dc.title","Potentially curative surgical therapy in oligometastatic non-small cell lung cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","509"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Langenbeck s Archives of Surgery"],["dc.bibliographiccitation.lastpage","519"],["dc.bibliographiccitation.volume","402"],["dc.contributor.author","Dango, Sebastian"],["dc.contributor.author","Beißbarth, Tim"],["dc.contributor.author","Weiss, Elisabeth"],["dc.contributor.author","Hosseini, Ali Seif Amir"],["dc.contributor.author","Raddatz, Dirk"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Ghadimi, Michael B."],["dc.contributor.author","Beham, Alexander Wilhelm"],["dc.date.accessioned","2018-11-07T10:24:29Z"],["dc.date.available","2018-11-07T10:24:29Z"],["dc.date.issued","2017"],["dc.description.abstract","Upper GI bleeding remains one of the most common emergencies with a substantial overall mortality rate of up to 30%. In severe ill patients, death does not occur due to failure of hemostasis, either medical or surgical, but mainly from comorbidities, treatment complications, and decreased tolerated blood loss. Management strategies have changed dramatically over the last two decades and include primarily endoscopic intervention in combination with acid-suppressive therapy and decrease in surgical intervention. Herein, we present one of the largest patient-based analysis assessing clinical parameters and outcome in patients undergoing endoscopy with an upper GI bleeding. Data were further analyzed to identify potential new risk factors and to investigate the role of surgery. In this retrospective study, we aimed to analyze outcome of patients with an UGIB and data were analyzed to identify potential new risk factors and the role of surgery. Data collection included demographic data, laboratory results, endoscopy reports, and details of management including blood administration, and surgery was carried out. Patient events were grouped and defined as \"overall\" events and \"operated,\" \"non-operated,\" and \"operated and death\" as well as \"non-operated and death\" where appropriate. Blatchford, clinical as well as complete Rockall-score analysis, risk stratification, and disease-related mortality rate were calculated for each group for comparison. Overall, 253 patients were eligible for analysis: endoscopy was carried out in 96% of all patients, 17% needed surgical intervention after endoscopic failure of bleeding control due to persistent bleeding, and the remaining 4% of patients were subjected directly to surgery. The median length of stay to discharge was 26 days. Overall mortality was 22%; out of them, almost 5% were operated and died. Anticoagulation was associated with a high in-hospital mortality risk (23%) and was increased once patients were taken to surgery (43%). Patients taking steroids presented with a risk of death of 26%, once taken to surgery the risk increased to 80%. Patients with liver cirrhosis had a risk of death of 42%; we observed a better outcome for these patients once taken to theater. Clinically, once scored with Blatchford score, statistical correlation was found for initial need for blood transfusion and surgical intervention. Clinical as well as complete Rockall score revealed a correlation between need for blood transfusion as well as surgical intervention in addition with a decreased outcome with increasing Rockall scores. Risk factor analysis including comorbidity, drug administration, and anticoagulation therapy introduced the combination of tumor and non-steroidal antirheumatic medication as independent risk factors for increased disease-related mortality. UGIB remains challenging and endoscopy is the first choice of intervention. Care must be taken once a patient is taking antirheumatic non-steroidal pain medication and suffers from cancer. In patients with presence of liver cirrhosis, an earlier surgical intervention may be considered, in particular for patients with recurrent bleeding. Embolization is not widely available and carries the risk of necrosis of the affected organ and should be restricted to a subgroup of patients not primarily eligible for surgery once endoscopy has failed. Taken together, an interdisciplinary approach including gastroenterologists as well as surgeons should be used once the patient is admitted to the hospital to define the best treatment option."],["dc.identifier.doi","10.1007/s00423-017-1552-2"],["dc.identifier.isi","000400365500012"],["dc.identifier.pmid","28091770"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42673"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Springer"],["dc.relation.issn","1435-2451"],["dc.relation.issn","1435-2443"],["dc.title","Relevance of surgery in patients with non-variceal upper gastrointestinal bleeding"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Coloproctology"],["dc.bibliographiccitation.lastpage","7"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Radzikhovskiy, A."],["dc.contributor.author","Dango, S."],["dc.contributor.author","Schrader, D."],["dc.contributor.author","Hesterberg, R."],["dc.date.accessioned","2020-12-10T14:07:54Z"],["dc.date.available","2020-12-10T14:07:54Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1007/s00053-016-0126-z"],["dc.identifier.eissn","1615-6730"],["dc.identifier.issn","0174-2442"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70328"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Langzeitergebnisse der transanalen Hämorrhoidendearterialisation"],["dc.title.alternative","Long-term results of transanal hemorrhoidal dearterialization"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","227"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Minimally Invasive Therapy & Allied Technologies"],["dc.bibliographiccitation.lastpage","231"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Dango, Sebastian"],["dc.contributor.author","Antonakis, Fillimon"],["dc.contributor.author","Schrader, Dirk"],["dc.contributor.author","Radzikhovskiy, Arkadiy"],["dc.contributor.author","Ghadimi, Michael B."],["dc.contributor.author","Hesterberg, Rudolf"],["dc.date.accessioned","2018-11-07T10:28:31Z"],["dc.date.available","2018-11-07T10:28:31Z"],["dc.date.issued","2017"],["dc.description.abstract","Introduction: Treatment failure of anal fistula results in high re-occurrence rate. Material and methods: Efficacy and safety of a nitinol closure clip system (bear-claw clip) were evaluated for anal fistulae treatment in a 36-month long-term follow-up study. Results: Twenty-two patients were included. No patient had been treated with a bear-claw clip system before. All patients were fully continent before treatment. Follow-up time was 36 months (range 19-48 months). We observed a re-occurrence rate of 41% (nine patients) with presence of an active fistula. Time to recurrence was on average 6.9 months (range 3-11 months). Thirteen patients (59%) showed a complete healing of the fistula. Placed clip was removed in all patients on average after almost 5.8 months (3-12 months), in three cases the clip was left in situ. We did not observe any incontinence; one patient reported recurrent burning after defecation once the clip system was removed. Discussions: Clip placement is a minimally invasive sphincter-preserving procedure with minimal complications and with an acceptable recurrence rate in the long term. However, bear-claw clip placement should probably be offered patients as a treatment option before more invasive procedures with higher perioperative morbidity are taken into consideration."],["dc.identifier.doi","10.1080/13645706.2017.1282521"],["dc.identifier.isi","000404934300006"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43438"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Taylor & Francis Ltd"],["dc.relation.issn","1365-2931"],["dc.relation.issn","1364-5706"],["dc.title","Long-term efficacy and safety of a nitinol closure clip system for anal fistula treatment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","66"],["dc.bibliographiccitation.journal","Genome Medicine"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Liefke, Robert"],["dc.contributor.author","Windhof-Jaidhauser, Indra M."],["dc.contributor.author","Gaedcke, Jochen"],["dc.contributor.author","Salinas-Riester, Gabriela"],["dc.contributor.author","Wu, Feizhen"],["dc.contributor.author","Ghadimi, Michael B."],["dc.contributor.author","Dango, Sebastian"],["dc.date.accessioned","2018-11-07T09:55:38Z"],["dc.date.available","2018-11-07T09:55:38Z"],["dc.date.issued","2015"],["dc.description.abstract","Background: The oxidative DNA demethylase ALKBH3 targets single-stranded DNA (ssDNA) in order to perform DNA alkylation damage repair. ALKBH3 becomes upregulated during tumorigenesis and is necessary for proliferation. However, the underlying molecular mechanism remains to be understood. Methods: To further elucidate the function of ALKBH3 in cancer, we performed ChIP-seq to investigate the genomic binding pattern of endogenous ALKBH3 in PC3 prostate cancer cells coupled with microarray experiments to examine the expression effects of ALKBH3 depletion. Results: We demonstrate that ALKBH3 binds to transcription associated locations, such as places of promoter-proximal paused RNA polymerase II and enhancers. Strikingly, ALKBH3 strongly binds to the transcription initiation sites of a small number of highly active gene promoters. These promoters are characterized by high levels of transcriptional regulators, including transcription factors, the Mediator complex, cohesin, histone modifiers, and active histone marks. Gene expression analysis showed that ALKBH3 does not directly influence the transcription of its target genes, but its depletion induces an upregulation of ALKBH3 non-bound inflammatory genes. Conclusions: The genomic binding pattern of ALKBH3 revealed a putative novel hyperactive promoter type. Further, we propose that ALKBH3 is an intrinsic DNA repair protein that suppresses transcription associated DNA damage at highly expressed genes and thereby plays a role to maintain genomic integrity in ALKBH3-overexpressing cancer cells. These results raise the possibility that ALKBH3 may be a potential target for inhibiting cancer progression."],["dc.identifier.doi","10.1186/s13073-015-0180-0"],["dc.identifier.isi","000358641600001"],["dc.identifier.pmid","26221185"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12502"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36798"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1756-994X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1009"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Zeitschrift für Gastroenterologie"],["dc.bibliographiccitation.lastpage","1013"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","Neesse, Albrecht"],["dc.contributor.author","Grade, Marian"],["dc.contributor.author","Dango, Sebastian"],["dc.contributor.author","Ghadimi, Michael"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Kunsch, Steffen"],["dc.contributor.author","Amanzada, Ahmad"],["dc.date.accessioned","2020-12-10T18:12:24Z"],["dc.date.available","2020-12-10T18:12:24Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1055/s-0043-108125"],["dc.identifier.eissn","1439-7803"],["dc.identifier.issn","0044-2771"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74358"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","A case report of delayed intra-abdominal and intra-luminal haemorrhage after polypectomy"],["dc.title.alternative","Rare complication after colonoscopy and polypectomy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","36"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Clinical Pathology"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Lokka, Suvi"],["dc.contributor.author","Scheel, Andreas H."],["dc.contributor.author","Dango, Sebastian"],["dc.contributor.author","Schmitz, Katja"],["dc.contributor.author","Hesterberg, Rudolf"],["dc.contributor.author","Rüschoff, Josef"],["dc.contributor.author","Schildhaus, Hans-Ulrich"],["dc.date.accessioned","2019-07-09T11:40:00Z"],["dc.date.available","2019-07-09T11:40:00Z"],["dc.date.issued","2014"],["dc.description.abstract","Background Liposarcoma is the most frequent soft tissue sarcoma. Well differentiated liposarcoma may progress into dedifferentiated liposarcoma with pleomorphic histology. A minority additionally features myogenic, osteo- or chondrosarcomatous heterologous differentiation. Genomic amplification of the Mouse double minute 2 homolog (MDM2) locus is characteristic for well differentiated and dedifferentiated liposarcomas. Detection of MDM2 amplification may supplement histopathology and aid to distinguish liposarcoma from other soft tissue neoplasia. Case presentation Here we present two cases of dedifferentiated liposarcoma with challenging presentation. Case 1 features a myogenic component. As the tumour infiltrated the abdominal muscles and showed immunohistochemical expression of myogenic proteins, rhabdomyosarcoma had to be ruled out. Case 2 has an osteosarcomatous component resembling extraosseous osteosarcoma. The MDM2 status was determined in both cases and helped making the correct diagnosis. Overexpression of MDM2 and co-overexpression of Cyclin-dependent kinase 4 is demonstrated by immunohistochemistry. The underlying MDM2 amplification is shown by fluorescence in situ hybridisation. Since low grade osteosarcoma may also harbour MDM2 amplification it is emphasised that the amplification has to be present in the lipomatous parts of the tumour to distinguish liposarcoma from extraosseous osteosarcoma. Conclusions The two cases exemplify challenges in the diagnoses of dedifferentiated liposarcoma. Liposarcoma often has pleomorphic histology and additionally may feature heterologous components that mimic other soft tissue neoplasms. Amplification of MDM2 is characteristic for well differentiated and dedifferentiated liposarcomas. Determination of the MDM2 status by in situ hybridisation may assist histopathology and help to rule out differential diagnoses."],["dc.identifier.doi","10.1186/1472-6890-14-36"],["dc.identifier.fs","611818"],["dc.identifier.pmid","25126005"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10586"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58073"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Challenging dedifferentiated liposarcoma identified by MDM2-amplification, a report of two cases"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1687"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","The EMBO Journal"],["dc.bibliographiccitation.lastpage","1703"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Zhao, Y. U."],["dc.contributor.author","Majid, Mona C."],["dc.contributor.author","Soll, Jennifer M."],["dc.contributor.author","Brickner, Joshua R."],["dc.contributor.author","Dango, Sebastian"],["dc.contributor.author","Mosammaparast, Nima"],["dc.date.accessioned","2018-11-07T09:55:54Z"],["dc.date.available","2018-11-07T09:55:54Z"],["dc.date.issued","2015"],["dc.description.abstract","Repair of DNA alkylation damage is critical for genomic stability and involves multiple conserved enzymatic pathways. Alkylation damage resistance, which is critical in cancer chemotherapy, depends on the overexpression of alkylation repair proteins. However, the mechanisms responsible for this upregulation are unknown. Here, we show that an OTU domain deubiquitinase, OTUD4, is a positive regulator of ALKBH2 and ALKBH3, two DNA demethylases critical for alkylation repair. Remarkably, we find that OTUD4 catalytic activity is completely dispensable for this function. Rather, OTUD4 is a scaffold for USP7 and USP9X, two deubiquitinases that act directly on the AlkB proteins. Moreover, we show that loss of OTUD4, USP7, or USP9X in tumor cells makes them significantly more sensitive to alkylating agents. Taken together, this work reveals a novel, noncanonical mechanism by which an OTU family deubiquitinase regulates its substrates, and provides multiple new targets for alkylation chemotherapy sensitization of tumors."],["dc.identifier.doi","10.15252/embj.201490497"],["dc.identifier.isi","000356171300010"],["dc.identifier.pmid","25944111"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36853"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1460-2075"],["dc.relation.issn","0261-4189"],["dc.title","Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","826"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Biochimica et Biophysica Acta. Gene Regulatory Mechanisms"],["dc.bibliographiccitation.lastpage","840"],["dc.bibliographiccitation.volume","1861"],["dc.contributor.author","Liefke, Robert"],["dc.contributor.author","Bokelmann, Kristin"],["dc.contributor.author","Ghadimi, B. Michael"],["dc.contributor.author","Dango, Sebastian"],["dc.date.accessioned","2020-12-10T14:22:33Z"],["dc.date.available","2020-12-10T14:22:33Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.bbagrm.2018.06.007"],["dc.identifier.issn","1874-9399"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71651"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Enhancer-driven transcriptional regulation is a potential key determinant for human visceral and subcutaneous adipocytes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","443"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","BJA British Journal of Anaesthesia"],["dc.bibliographiccitation.lastpage","449"],["dc.bibliographiccitation.volume","110"],["dc.contributor.author","Dango, Sebastian"],["dc.contributor.author","Harris, Sarah E."],["dc.contributor.author","Offner, Kristin"],["dc.contributor.author","Hennings, E."],["dc.contributor.author","Priebe, H.-J."],["dc.contributor.author","Buerkle, H."],["dc.contributor.author","Passlick, Bernward"],["dc.contributor.author","Loop, T."],["dc.date.accessioned","2018-11-07T09:27:50Z"],["dc.date.available","2018-11-07T09:27:50Z"],["dc.date.issued","2013"],["dc.description.abstract","Although thoracic epidural analgesia (TEA) is considered the gold standard for post-thoracotomy pain relief, thoracic paravertebral block (PVB) and intrathecal opioid (ITO) administration have also been shown to be efficacious. We hypothesized that the combination of PVB and ITO provides analgesia comparable with that of TEA. After local ethics committee approval, 84 consecutive patients undergoing open thoracic procedures were randomized to the TEA (ropivacaine 0.2sufentanil) or the PVB (ropivacaine 0.5)ITO (sufentanilmorphine) group. The primary endpoints were pain intensities at rest and during coughing/movement at 1, 2, 4, 8, 12, 24, 48, and 72 h after operation assessed by visual analogue scale (VAS) score. Data were analysed by multivariate analysis (anova; P0.05). Patient and surgical characteristics were comparable between the groups. The mean and maximal VAS scores were lower in the TEA (n43) than in the PVBITO group (n37) at several time points at rest (P0.026) and during coughing/movement (P0.021). However, in the PVBITO group, the mean VAS scores never exceeded 1.9 and 3.5 at rest and during coughing/movement, respectively; and the maximal differences between the groups (TEA vs PVBITO) in the maximal VAS scores were only 1.2 (3.4 vs 4.6) at rest, and 1.3 (4.4 vs 5.7) during coughing/movement. Although VAS scores were statistically lower in the TEA compared with the PVBITO group at some observation points, the differences were small and of questionable clinical relevance. Thus, combined PVB and ITO can be considered a satisfactory alternative to TEA for post-thoracotomy pain relief. ClinicalTrials.gov number. NCT00493909."],["dc.identifier.doi","10.1093/bja/aes394"],["dc.identifier.isi","000315123800017"],["dc.identifier.pmid","23151421"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30633"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","0007-0912"],["dc.title","Combined paravertebral and intrathecal vs thoracic epidural analgesia for post-thoracotomy pain relief"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]