Keric, Naureen

[["dc.bibliographiccitation.firstpage","317"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Neurosurgical Anesthesiology"],["dc.bibliographiccitation.lastpage","323"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Keric, Naureen"],["dc.contributor.author","Kantelhardt, Sven Rainer"],["dc.contributor.author","Neulen, Axel"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Henning, Antonia"],["dc.contributor.author","Vollmer, Fritz C."],["dc.contributor.author","Thiemann, Ingmar"],["dc.contributor.author","Giese, Alf"],["dc.date.accessioned","2018-11-07T09:22:51Z"],["dc.date.available","2018-11-07T09:22:51Z"],["dc.date.issued","2013"],["dc.description.abstract","Background: Although the skull limits applicability of sonography, bedside intracranial endosonography might be an alternative to computed tomography scans to detect adverse events in sedated patients. However, the usefulness of intracranial endosonography for potential clinical application has not been evaluated. The present study was designed to investigate the suitability of an image-guided intracranial endosonography (IGIE) catheter for intracranial ultrasound imaging in an ex vivo phantom model and in a large animal model.Materials and Methods: IGIE was evaluated in a cranial phantom and a porcine intracranial hemorrhage (ICH) model. Two anesthetized animals underwent an initial magnetic resonance imaging (MRI) scan, followed by placement of an endosonography catheter in the frontal lobe. After anatomic imaging, an experimental ICH was placed in the contralateral hemisphere. B-scan imaging, duplex, Doppler sonography, and a second MRI were performed. A standard image-guiding device tracked the ultrasound catheter.Results: Endosonography provided high-definition imaging of intracranial structures. Image guidance allowed direction of the catheter to and intuitive identification of anatomic structures. Doppler imaging allowed analysis of blood flow in intracranial vessels. Ultrasound imaging was used to monitor evolution of ICH and the resulting brain edema in real time. Coregistration of ultrasound and MRI images acquired after ICH placement demonstrated the high accuracy of the spatial resolution of IGIE (largest mismatch <5 mm).Conclusions: IGIE provides high-definition images of intracranial structures, Doppler analysis of blood flow, and real-time monitoring of intracranial structural lesions. We suggest that IGIE might prove a valuable tool for intracranial monitoring of sedated patients over extended time periods."],["dc.identifier.doi","10.1097/ANA.0b013e31828cb27e"],["dc.identifier.isi","000323217100015"],["dc.identifier.pmid","23552276"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29441"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0898-4921"],["dc.title","Image-guided Intracranial Endosonography"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1055"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Nature Medicine"],["dc.bibliographiccitation.lastpage","1061"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Fledrich, Robert"],["dc.contributor.author","Stassart, Ruth Martha"],["dc.contributor.author","Klink, Axel"],["dc.contributor.author","Rasch, Lennart M."],["dc.contributor.author","Prukop, Thomas"],["dc.contributor.author","Haag, Lauren"],["dc.contributor.author","Czesnik, Dirk"],["dc.contributor.author","Kungl, Theresa"],["dc.contributor.author","Abdelaal, Tamer A. M."],["dc.contributor.author","Keric, Naureen"],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Nave, Klaus-Armin"],["dc.contributor.author","Sereda, Michael W."],["dc.date.accessioned","2018-11-07T09:36:01Z"],["dc.date.available","2018-11-07T09:36:01Z"],["dc.date.issued","2014"],["dc.description.abstract","Duplication of the gene encoding the peripheral myelin protein of 22 kDa (PMP22) underlies the most common inherited neuropathy, Charcot-Marie-Tooth 1A (CMT1A)(1-3), a disease without a known cure(4-6). Although demyelination represents a characteristic feature, the clinical phenotype of CMT1A is determined by the degree of axonal loss, and patients suffer from progressive muscle weakness and impaired sensation(4,7). CMT1A disease manifests within the first two decades of life(8,9), and walking disabilities, foot deformities and electrophysiological abnormalities are already present in childhood(7-11). Here, we show in Pmp22-transgenic rodent models of CMT1A that Schwann cells acquire a persistent differentiation defect during early postnatal development, caused by imbalanced activity of the PI3K-Akt and the Mek-Erk signaling pathways. We demonstrate that enhanced PI3K-Akt signaling by axonally overexpressed neuregulin-1 (NRG1) type I drives diseased Schwann cells toward differentiation and preserves peripheral nerve axons. Notably, in a preclinical experimental therapy using a CMT1A rat model, when treatment is restricted to early postnatal development, soluble NRG1 effectively overcomes impaired peripheral nerve development and restores axon survival into adulthood. Our findings suggest a model in which Schwann cell differentiation within a limited time window is crucial for the long-term maintenance of axonal support."],["dc.identifier.doi","10.1038/nm.3664"],["dc.identifier.isi","000341404000019"],["dc.identifier.pmid","25150498"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32517"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1546-170X"],["dc.relation.issn","1078-8956"],["dc.title","Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Glia"],["dc.bibliographiccitation.volume","63"],["dc.contributor.author","Brinkmann, Bastian G."],["dc.contributor.author","Quintes, Susanne"],["dc.contributor.author","Ebert, Matthias"],["dc.contributor.author","Keric, Naureen"],["dc.contributor.author","Matz, A."],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.contributor.author","Nave, K.-A."],["dc.contributor.author","Sereda, Michael W."],["dc.date.accessioned","2018-11-07T09:54:17Z"],["dc.date.available","2018-11-07T09:54:17Z"],["dc.date.issued","2015"],["dc.format.extent","E286"],["dc.identifier.isi","000356386700487"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36504"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","12th European Meeting on Glial Cell Function in Health and Disease"],["dc.relation.eventlocation","Bilbao, SPAIN"],["dc.relation.issn","1098-1136"],["dc.relation.issn","0894-1491"],["dc.title","A novel role for Endothelin receptor B signalling in the peripheral nervous system"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","ons257"],["dc.bibliographiccitation.firstpage","257"],["dc.bibliographiccitation.journal","Neurosurgery"],["dc.bibliographiccitation.lastpage","265"],["dc.bibliographiccitation.volume","68"],["dc.contributor.author","Kantelhardt, Sven Rainer"],["dc.contributor.author","Greke, Christian"],["dc.contributor.author","Keric, Naureen"],["dc.contributor.author","Vollmer, Fritz C."],["dc.contributor.author","Thiemann, Ingmar"],["dc.contributor.author","Giese, Alf"],["dc.date.accessioned","2018-11-07T08:55:36Z"],["dc.date.available","2018-11-07T08:55:36Z"],["dc.date.issued","2011"],["dc.description.abstract","BACKGROUND: Transcranial Doppler (TCD) ultrasonography is an important tool for noninvasive detection and monitoring of vasospasm and other pathological conditions of the intracranial vessels. OBJECTIVE: To demonstrate that image-guided TCD allows rapid identification and blood-flow analysis of specific sections of the vascular anatomy and provides excellent orientation, also allowing diagnostic procedures on pathological vascular structures. METHODS: Three patients who underwent computed tomographic angiography scanning for reasons not related to this study were examined by neuronavigated image-guided TCD. The Doppler probe was fitted with reflective markers and tracked by a commercially available Kolibri image guidance system. RESULTS: Image-guided TCD allowed identification of all major intracranial vessels. Unilateral acquisition of reliable Doppler signals for the internal carotid artery, carotid T, middle cerebral artery, middle cerebral artery bifurcation, and anterior cerebral artery required 14 +/- 6 minutes. Preregistration of these targets and detection by neuronavigation alone shortened examination times significantly to 8 +/- 2 minutes. Registering the optimal examination trajectories on the neuronavigational device and applying navigational pilot software shortened times for repetitive examination further to 4 +/- 1 minutes and ensured that the examination was done at the exact same spot under the same angle as in previous examinations. CONCLUSION: Image guidance can be applied easily and efficiently to TCD. It provides anatomic orientation and may help to standardize investigation protocols, define pathological vascular territories for repeat investigations, and thus reduce inter-investigator variations. Image guidance may also extend the use of TCD to situations of a pathological or variant vascular anatomy."],["dc.identifier.doi","10.1227/NEU.0b013e31821553b2"],["dc.identifier.isi","000291219500004"],["dc.identifier.pmid","21389880"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22945"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1524-4040"],["dc.relation.issn","0148-396X"],["dc.title","Image Guidance for Transcranial Doppler Ultrasonography"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","E111"],["dc.bibliographiccitation.journal","Journal of Neurological Surgery Part A Central European Neurosurgery"],["dc.bibliographiccitation.lastpage","E115"],["dc.bibliographiccitation.volume","74"],["dc.contributor.author","Keric, Naureen"],["dc.contributor.author","Burger, Ralf"],["dc.contributor.author","Elolf, Erck"],["dc.contributor.author","Wrede, Arne"],["dc.contributor.author","Rohde, Veit"],["dc.date.accessioned","2018-11-07T09:16:54Z"],["dc.date.available","2018-11-07T09:16:54Z"],["dc.date.issued","2013"],["dc.description.abstract","BackgroundWe report the rare case of an adult transsphenoidal meningoencephalocele and outline the microneurosurgical strategy. Clinical history, the findings of computerized tomography (CT) scans and magnetic resonance imaging (MRI), the microsurgical procedure, and histopathology are reported. Case ReportA 54-year-old female patient complained about cerebrospinal fluid (CSF) rhinorrhea; a transnasal biopsy of a mass in the maxillar sinus prior to diagnostic work-up was performed elsewhere. Persisting CSF leakage prompted CT and MRI, which showed brain tissue extending from the left middle cranial fossa into the left sphenoid sinus through several bony defects. The diagnosis of a transsphenoidal meningoencephalocele was made, and the lesion was targeted via a subtemporal intradural approach with resection of the herniated brain tissue and closure of the bony as well as of dural defects. The postoperative course was uneventful without recurrence of the CSF fistula. ConclusionThe transsphenoidal subtype of basal meningoencephaloceles is exceedingly rare. Nonetheless, it has to be considered as a differential diagnosis if a nasal or intrasphenoidal mass is diagnosed. Otherwise, unjustified biopsy or unsuccessful management of CSF leakage could not be avoided. The intradural subtemporal approach is effective to treat the transsphenoidal type of basal meningoencephaloceles."],["dc.identifier.doi","10.1055/s-0032-1327444"],["dc.identifier.isi","000328582200026"],["dc.identifier.pmid","23044912"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28042"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Thieme Medical Publ Inc"],["dc.relation.issn","2193-6323"],["dc.relation.issn","2193-6315"],["dc.title","Temporobasal, Transsphenoidal Meningoencephalocele Becoming Symptomatic with Spontaneous Cerebrospinal Fluid Rhinorrhea: Diagnostic Work-up and Microsurgical Strategy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S88"],["dc.bibliographiccitation.journal","Translational Stroke Research"],["dc.bibliographiccitation.lastpage","S93"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Keric, Naureen"],["dc.contributor.author","Maier, Gerrit Steffen"],["dc.contributor.author","Samadani, Uzma"],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Heuer, J. F."],["dc.contributor.author","Rohde, Veit"],["dc.date.accessioned","2018-11-07T09:08:53Z"],["dc.date.available","2018-11-07T09:08:53Z"],["dc.date.issued","2012"],["dc.description.abstract","Hematoma puncture and subsequent clot lysis with recombinant tissue plasminogen activator (rtPA) emerged as an alternative therapy for spontaneous intracerebral hemorrhage (ICH) and is associated with delayed edema possibly counteracting the beneficial effects of hematoma volume reduction. We hypothesized that immediate reversal of rtPA activity after clot lysis and hematoma drainage diminishes edema formation. To test this hypothesis, we administered plasminogen activator inhibitor (PAI)-1 after rtPA lysis of experimentally induced ICH. A right frontal ICH was placed through a twist drill burr hole and autologous blood injection. Following creation of the frontal ICH, pigs received no further treatment (n=5), lysis with rtPA (n=7), or lysis with rtPA followed by administration of PAI-1 (n=6). Hematoma and edema volumes were assessed with magnetic resonance imaging on days 0, 4, and 10. The rtPA significantly reduced hematoma volume and contributed to edema on day 10 after experimentally induced ICH. Administration of PAI-1 attenuated the rtPA-induced edema volume on day 10, but the hematoma volume reduction was less pronounced. In conclusion, PAI-1 attenuated delayed cerebral edema after rtPA lysis of experimental ICH but also reduced the lytic activity of rtPA. The combination of rtPA clot lysis with PAI-1 might have the potential to further improve the effect of the lytic therapy of ICH, but additional studies to define the optimum time point for PAI-1 administration are required."],["dc.identifier.doi","10.1007/s12975-012-0188-3"],["dc.identifier.isi","000305436500011"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8890"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26132"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1868-4483"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Tissue Plasminogen Activator Induced Delayed Edema in Experimental Porcine Intracranial Hemorrhage: Reduction with Plasminogen Activator Inhibitor-1 Administration"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e0234956"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","PLoS One"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Krenzlin, Harald"],["dc.contributor.author","Bettag, Christoph"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Ringel, Florian"],["dc.contributor.author","Keric, Naureen"],["dc.contributor.editor","Ashkenazi, Itamar"],["dc.date.accessioned","2021-04-14T08:25:13Z"],["dc.date.available","2021-04-14T08:25:13Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1371/journal.pone.0234956"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81555"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1932-6203"],["dc.title","Involuntary ambulatory triage during the COVID-19 pandemic – A neurosurgical perspective"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","533"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Acta Neurochirurgica"],["dc.bibliographiccitation.lastpage","539"],["dc.bibliographiccitation.volume","153"],["dc.contributor.author","Bock, Hans Christoph"],["dc.contributor.author","Cohnen, Joseph"],["dc.contributor.author","Keric, Naureen"],["dc.contributor.author","Kantelhardt, Sven Rainer"],["dc.contributor.author","Giese, Alf"],["dc.date.accessioned","2018-11-07T08:58:58Z"],["dc.date.available","2018-11-07T08:58:58Z"],["dc.date.issued","2011"],["dc.description.abstract","Implantation of 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) wafer for malignant glioma is not recommended in the case of surgical opening of the ventricular system during microsurgical tumor resection because the wafer material may dislocate from the resection cavity into the ventricular system and cause obstructive hydrocephalus. TachoSil is an adhesive collagen fleece used in different surgical disciplines that provides an air- and liquid-tight seal closing communications between the ventricular system and the resection cavity after tumor removal. Occlusion of ventricular defects with TachoSil after microsurgical glioma resection was performed in two patients with newly diagnosed and seven patients with recurrent malignant glioma prior to BCNU wafer implantation into the resection cavity. Early postoperative cranial computed tomography (CCT)/MRI and follow-up MRI at 3 months' intervals were performed with a median follow-up of 10.4 months. The collagen fleece was identified as a linear structure hypodense/hypointense to white matter on postoperative CT/MRI separating the resection cavity from the ventricular lumen in all cases. In no case did early CCT/MRI or follow-up MRI reveal wafer material within the ventricular system. In no case did signs of obstructive hydrocephalus occur. Sealing of the ventricular system using a fibrinogen-coated collagen fleece effectively separates the resection cavity from the ventricular system and allows implantation of BCNU wafers into the resection cavity. No morphological evidence for wafer material dislocation into the ventricular system or obstruction of CSF pathways was found in nine patients who received 41 follow-up MRI over 10.4 months of follow-up."],["dc.identifier.doi","10.1007/s00701-010-0923-z"],["dc.identifier.isi","000287497500012"],["dc.identifier.pmid","21210161"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6645"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23777"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Wien"],["dc.relation.issn","0001-6268"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Occlusion of surgical opening of the ventricular system with fibrinogen-coated collagen fleece: a case collection study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]