Krüger, Juliane M.

[["dc.bibliographiccitation.firstpage","15504"],["dc.bibliographiccitation.issue","39"],["dc.bibliographiccitation.journal","Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","15517"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Krueger, Juliane M."],["dc.contributor.author","Favaro, Plinio D."],["dc.contributor.author","Liu, Mingna"],["dc.contributor.author","Kitlinska, Agata"],["dc.contributor.author","Huang, Xiaojie"],["dc.contributor.author","Raabe, Monika"],["dc.contributor.author","Akad, Derya S."],["dc.contributor.author","Liu, Yanling"],["dc.contributor.author","Urlaub, Henning"],["dc.contributor.author","Dong, Yan"],["dc.contributor.author","Xu, Weifeng"],["dc.contributor.author","Schlueter, Oliver M."],["dc.date.accessioned","2018-11-07T09:19:47Z"],["dc.date.available","2018-11-07T09:19:47Z"],["dc.date.issued","2013"],["dc.description.abstract","In the postsynaptic density of glutamatergic synapses, the discs large (DLG)-membrane-associated guanylate kinase (MAGUK) family of scaffolding proteins coordinates a multiplicity of signaling pathways to maintain and regulate synaptic transmission. Postsynaptic density-93 (PSD-93) is the most variable paralog in this family; it exists in six different N-terminal isoforms. Probably because of the structural and functional variability of these isoforms, the synaptic role of PSD-93 remains controversial. To accurately characterize the synaptic role of PSD-93, we quantified the expression of all six isoforms in the mouse hippocampus and examined them individually in hippocampal synapses. Using molecular manipulations, including overexpression, gene knockdown, PSD-93 knock-out mice combined with biochemical assays, and slice electrophysiology both in rat and mice, we demonstrate that PSD-93 is required at different developmental synaptic states to maintain the strength of excitatory synaptic transmission. This strength is differentially regulated by the six isoforms of PSD-93, including regulations of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor-active and inactive synapses, and activity-dependent modulations. Collectively, these results demonstrate that alternative combinations of N-terminal PSD-93 isoforms and DLG-MAGUK paralogs can fine-tune signaling scaffolds to adjust synaptic needs to regulate synaptic transmission."],["dc.identifier.doi","10.1523/JNEUROSCI.0019-12.2013"],["dc.identifier.isi","000324912500021"],["dc.identifier.pmid","24068818"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28724"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc Neuroscience"],["dc.relation.issn","0270-6474"],["dc.title","Differential Roles of Postsynaptic Density-93 Isoforms in Regulating Synaptic Transmission"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Biology and Fertility of Soils"],["dc.contributor.author","Clausing, S."],["dc.contributor.author","Likulunga, L. E."],["dc.contributor.author","Janz, D."],["dc.contributor.author","Feng, H. Y."],["dc.contributor.author","Schneider, D."],["dc.contributor.author","Daniel, R."],["dc.contributor.author","Krüger, J."],["dc.contributor.author","Lang, F."],["dc.contributor.author","Polle, A."],["dc.date.accessioned","2021-10-01T09:58:52Z"],["dc.date.available","2021-10-01T09:58:52Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract N and P are essential macronutrients for all organisms. How shifts in the availability of N or P affect fungal communities in temperate forests is not well understood. Here, we conducted a factorial P × N fertilization experiment to disentangle the effects of nutrient availability on soil-residing, root-associated, and ectomycorrhizal fungi in beech ( Fagus sylvatica ) forests differing in P availability. We tested the hypotheses that in P-poor forests, P fertilization leads to enhanced fungal diversity in soil and roots, resulting in enhanced P nutrition of beech, and that N fertilization aggravates P shortages, shifting the fungal communities toward nitrophilic species. In response to fertilizer treatments (1 × 50 kg ha −1 P and 5 × 30 kg ha −1  N within 2 years), the labile P fractions increased in soil and roots, regardless of plant-available P in soil. Root total P decreased in response to N fertilization and root total P increased in response to P addition at the low P site. Ectomycorrhizal species richness was unaffected by fertilizer treatments, but the relative abundances of ectomycorrhizal fungi increased in response to P or N addition. At the taxon level, fungal assemblages were unaffected by fertilizer treatments, but at the order level, different response patterns for saprotrophic fungi among soil and ectomycorrhizal fungi on roots were found. Boletales increased in response to P, and Russulales decreased under N + P addition. Our results suggest that trait conservatism in related species afforded resistance of the resident mycobiome composition to nutritional imbalances."],["dc.description.abstract","Abstract N and P are essential macronutrients for all organisms. How shifts in the availability of N or P affect fungal communities in temperate forests is not well understood. Here, we conducted a factorial P × N fertilization experiment to disentangle the effects of nutrient availability on soil-residing, root-associated, and ectomycorrhizal fungi in beech ( Fagus sylvatica ) forests differing in P availability. We tested the hypotheses that in P-poor forests, P fertilization leads to enhanced fungal diversity in soil and roots, resulting in enhanced P nutrition of beech, and that N fertilization aggravates P shortages, shifting the fungal communities toward nitrophilic species. In response to fertilizer treatments (1 × 50 kg ha −1 P and 5 × 30 kg ha −1  N within 2 years), the labile P fractions increased in soil and roots, regardless of plant-available P in soil. Root total P decreased in response to N fertilization and root total P increased in response to P addition at the low P site. Ectomycorrhizal species richness was unaffected by fertilizer treatments, but the relative abundances of ectomycorrhizal fungi increased in response to P or N addition. At the taxon level, fungal assemblages were unaffected by fertilizer treatments, but at the order level, different response patterns for saprotrophic fungi among soil and ectomycorrhizal fungi on roots were found. Boletales increased in response to P, and Russulales decreased under N + P addition. Our results suggest that trait conservatism in related species afforded resistance of the resident mycobiome composition to nutritional imbalances."],["dc.identifier.doi","10.1007/s00374-021-01593-x"],["dc.identifier.pii","1593"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/90165"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-469"],["dc.relation.eissn","1432-0789"],["dc.relation.issn","0178-2762"],["dc.title","Impact of nitrogen and phosphorus addition on resident soil and root mycobiomes in beech forests"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]