Franz, Monika

[["dc.bibliographiccitation.firstpage","448"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Viral Immunology"],["dc.bibliographiccitation.lastpage","457"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Stolte-Leeb, Nicole"],["dc.contributor.author","Sauermann, Ulrike"],["dc.contributor.author","Norley, Stephen"],["dc.contributor.author","Fagrouch, Zahra"],["dc.contributor.author","Heeney, Jonathan"],["dc.contributor.author","Franz, Monika"],["dc.contributor.author","Hunsmann, Gerhard"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.date.accessioned","2022-10-06T13:34:50Z"],["dc.date.available","2022-10-06T13:34:50Z"],["dc.date.issued","2006"],["dc.description.abstract","As part of a European multicenter study designed to determine the optimal combination and order of a mixed-modality vaccine against acquired immunodeficiency syndrome, rhesus monkeys received a combination of three different vectors, all expressing the same Simian Immunodeficiency Virus (SIV) genes followed by mucosal challenge with highly pathogenic SIV. In the study reported here, animals were primed with DNA followed by one booster immunization with Semliki Forest Virus (SFV) and two immunizations with modified Vaccinia Ankara (MVA). To address the relevance of mucosal immunization, we compared systemic versus a combination of systemic and mucosal antigen application. Although all vaccinees became infected after intrarectal challenge with SIV, most (six of eight) were protected from profound loss of CD4+ cells. In addition, vaccinees showed lower viral loads than did controls (p < 0.05). Overall, these protective effects were more pronounced in those animals whose schedule included immunization via the mucosa. In summary, the vaccine regimen used here achieved one important criterion of efficacy: the suppression of disease development as indicated by conservation of CD4+ cells."],["dc.identifier.doi","10.1089/vim.2006.19.448"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115988"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1557-8976"],["dc.relation.issn","0882-8245"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Sustained Conservation of CD4 + T Cells in Multiprotein Triple Modality-Immunized Rhesus Macaques after Intrarectal Challenge with Simian Immunodeficiency Virus"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4469"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Journal of Virology"],["dc.bibliographiccitation.lastpage","4481"],["dc.bibliographiccitation.volume","80"],["dc.contributor.author","Brenner, Matthias"],["dc.contributor.author","Münch, Jan"],["dc.contributor.author","Schindler, Michael"],["dc.contributor.author","Wildum, Steffen"],["dc.contributor.author","Stolte, Nicole"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.contributor.author","Fuchs, Dietmar"],["dc.contributor.author","Mätz-Rensing, Kerstin"],["dc.contributor.author","Franz, Monika"],["dc.contributor.author","Heeney, Jonathan"],["dc.contributor.author","Kirchhoff, Frank"],["dc.date.accessioned","2022-10-06T13:25:46Z"],["dc.date.available","2022-10-06T13:25:46Z"],["dc.date.issued","2006"],["dc.description.abstract","ABSTRACT\n \n Point mutations in SIVmac239 Nef disrupting CD4 downmodulation and enhancement of virion infectivity attenuate viral replication in acutely infected rhesus macaques, but changes selected later in infection fully restore Nef function (A. J. Iafrate et al., J. Virol. 74:9836-9844, 2000). To further evaluate the relevance of these Nef functions for viral persistence and disease progression, we analyzed an SIVmac239 Nef mutant containing a deletion of amino acids Q64 to N67 (Δ64-67Nef). This mutation inactivates the N-distal AP-2 clathrin adaptor binding element and disrupts the abilities of Nef to downregulate CD4, CD28 and CXCR4 and to stimulate viral replication in vitro. However, it does not impair the downmodulation of CD3 and class I major histocompatibility complex (MHC-I) or MHC-II and the upregulation of the MHC-II-associated invariant chain, and it has only a moderate effect on the enhancement of virion infectivity. Replication of the Δ64-67Nef variant in acutely infected macaques was intermediate between grossly\n nef\n -deleted and wild-type SIVmac239. Subsequently, three of six macaques developed moderate to high viral loads and developed disease, whereas the remaining animals efficiently controlled SIV replication and showed a more attenuated clinical course of infection. Sequence analysis revealed that the deletion in\n nef\n was not repaired in any of these animals. However, some changes that slightly enhanced the ability of Nef to downmodulate CD4 and moderately increased Nef-mediated enhancement of viral replication and infectivity in vitro were observed in macaques developing high viral loads. Our results imply that both the Nef functions that were disrupted by the Δ64-67 mutation and the activities that remained intact contribute to viral pathogenicity."],["dc.identifier.doi","10.1128/JVI.80.9.4469-4481.2006"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114910"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1098-5514"],["dc.relation.issn","0022-538X"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","https://journals.asm.org/non-commercial-tdm-license"],["dc.title","Importance of the N-Distal AP-2 Binding Element in Nef for Simian Immunodeficiency Virus Replication and Pathogenicity in Rhesus Macaques"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1811"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Vaccine"],["dc.bibliographiccitation.lastpage","1820"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Suh, You S."],["dc.contributor.author","Park, Ki S."],["dc.contributor.author","Sauermann, Ulrike"],["dc.contributor.author","Franz, Monika"],["dc.contributor.author","Norley, Stephen"],["dc.contributor.author","Wilfingseder, Doris"],["dc.contributor.author","Stoiber, Heribert"],["dc.contributor.author","Fagrouch, Zahra"],["dc.contributor.author","Heeney, Jonathan"],["dc.contributor.author","Hunsmann, Gerhard"],["dc.contributor.author","Sung, Young C."],["dc.date.accessioned","2022-10-06T13:33:26Z"],["dc.date.available","2022-10-06T13:33:26Z"],["dc.date.issued","2006"],["dc.identifier.doi","10.1016/j.vaccine.2005.10.026"],["dc.identifier.pii","S0264410X05010637"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115631"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0264-410X"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Reduction of viral loads by multigenic DNA priming and adenovirus boosting in the SIVmac-macaque model"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","13180"],["dc.bibliographiccitation.issue","23"],["dc.bibliographiccitation.journal","Journal of Virology"],["dc.bibliographiccitation.lastpage","13190"],["dc.bibliographiccitation.volume","81"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.contributor.author","Kuate, Seraphin"],["dc.contributor.author","Franz, Monika"],["dc.contributor.author","Suh, You S."],["dc.contributor.author","Stoiber, Heribert"],["dc.contributor.author","Sauermann, Ulrike"],["dc.contributor.author","Tenner-Racz, Klara"],["dc.contributor.author","Norley, Stephen"],["dc.contributor.author","Park, Ki S."],["dc.contributor.author","Sung, Young C."],["dc.contributor.author","Überla, Klaus"],["dc.date.accessioned","2022-10-06T13:25:35Z"],["dc.date.available","2022-10-06T13:25:35Z"],["dc.date.issued","2007"],["dc.description.abstract","ABSTRACT\n The development of needle-free vaccines is one of the recently defined “grand challenges in global health” (H. Varmus, R. Klausner, R. Klausner, R. Zerhouni, T. Acharya, A. S. Daar, and P. A. Singer, Science 302:398-399, 2003). To explore whether a natural pathway to the inductive site of the mucosa-associated lymphatic tissue could be exploited for atraumatic immunization purposes, replication-deficient viral vector vaccines were sprayed directly onto the tonsils of rhesus macaques. Tonsillar immunization with viral vector vaccines encoding simian immunodeficiency virus (SIV) antigens induced cellular and humoral immune responses. Viral RNA levels after a stringent SIV challenge were reduced, providing a level of protection similar to that observed after systemic immunization with the same vaccines. Thus, atraumatic oral spray immunization with replication-deficient vectors can overcome the epithelial barrier, deliver the vaccine antigen to the mucosa-associated lymphatic tissue, and avoid induction of tolerance, providing a novel approach to circumvent acceptability problems of syringe and needle vaccines for children and in developing countries."],["dc.identifier.doi","10.1128/JVI.01400-07"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114872"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1098-5514"],["dc.relation.issn","0022-538X"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","https://journals.asm.org/non-commercial-tdm-license"],["dc.title","Atraumatic Oral Spray Immunization with Replication-Deficient Viral Vector Vaccines"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","933"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","AIDS Research and Human Retroviruses"],["dc.bibliographiccitation.lastpage","943"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Stolte-Leeb, Nicole"],["dc.contributor.author","Loddo, Roberta"],["dc.contributor.author","Antimisiaris, Sophia"],["dc.contributor.author","Schultheiss, Tina"],["dc.contributor.author","Sauermann, Ulrike"],["dc.contributor.author","Franz, Monika"],["dc.contributor.author","Mourtas, Spyridon"],["dc.contributor.author","Parsy, Christophe"],["dc.contributor.author","Storer, Richard"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.contributor.author","La Colla, Paolo"],["dc.date.accessioned","2021-06-01T10:51:15Z"],["dc.date.available","2021-06-01T10:51:15Z"],["dc.date.issued","2011"],["dc.description.abstract","The availability of an effective vaginal microbicide would be a major step toward containment of HIV transmission as well as allowing women self-protection against HIV infection. Here we evaluated the efficacy of vaginal application of the potent nonnucleoside reverse transcriptase inhibitor (NNRTI) MC 1220 against vaginal challenge of macaques with RT-SHIV, a chimeric simian immunodeficiency virus (SIV) containing the reverse transcriptase (RT) gene of HIV-1. Challenge infection of monkeys with RT-SHIV currently represents the only nonhuman primate model available to test the anti-HIV-1 effects of NNRTIs. Two different gel formulations containing different MC 1220 concentrations were evaluated for efficacy in female rhesus macaques exposed to RT-SHIV. Five groups of five animals each were treated with two different gel compositions containing no drug, 0.1% or 0.5% MC 1220, followed by vaginal RT-SHIV challenge 30 min later. One animal in each group treated with the low concentration of MC 1220 as well as one control animal remained uninfected after vaginal challenge. By contrast, three of the animals receiving 0.5% MC 1220 remained uninfected, suggesting a threshold of the drug. Despite being negative for plasma viral RNA and absence of seroconversion, almost all uninfected animals exhibited SIV-specific T cells, either in the periphery or in lymph nodes draining the portal of virus entry. Our results make MC 1220 a promising compound for further development as a topical microbicide and warrant additional testing with improved formulation, long-lasting vaginal delivery systems, or even combinations with other inhibitors."],["dc.identifier.doi","10.1089/aid.2010.0339"],["dc.identifier.pmid","21332419"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86945"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","zu prüfen"],["dc.relation.eissn","1931-8405"],["dc.relation.issn","0889-2229"],["dc.title","Topical Nonnucleoside Reverse Transcriptase Inhibitor MC 1220 Partially Prevents Vaginal RT-SHIV Infection of Macaques"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","133"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Virology"],["dc.bibliographiccitation.lastpage","144"],["dc.bibliographiccitation.volume","351"],["dc.contributor.author","Kuate, Seraphin"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.contributor.author","Stoiber, Heribert"],["dc.contributor.author","Nchinda, Godwin"],["dc.contributor.author","Floto, Anja"],["dc.contributor.author","Franz, Monika"],["dc.contributor.author","Sauermann, Ulrike"],["dc.contributor.author","Bredl, Simon"],["dc.contributor.author","Deml, Ludwig"],["dc.contributor.author","Ignatius, Ralf"],["dc.contributor.author","Überla, Klaus"],["dc.date.accessioned","2022-10-06T13:33:27Z"],["dc.date.available","2022-10-06T13:33:27Z"],["dc.date.issued","2006"],["dc.identifier.doi","10.1016/j.virol.2006.03.009"],["dc.identifier.pii","S0042682206001759"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115634"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0042-6822"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Immunogenicity and efficacy of immunodeficiency virus-like particles pseudotyped with the G protein of vesicular stomatitis virus"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","6690"],["dc.bibliographiccitation.issue","51"],["dc.bibliographiccitation.journal","Vaccine"],["dc.bibliographiccitation.lastpage","6698"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Suh, You S."],["dc.contributor.author","Park, Ki S."],["dc.contributor.author","Sauermann, Ulrike"],["dc.contributor.author","Kim, Kwang S."],["dc.contributor.author","Ahn, So S."],["dc.contributor.author","Franz, Monika"],["dc.contributor.author","Schulte, Reiner"],["dc.contributor.author","Wilfingseder, Doris"],["dc.contributor.author","Stoiber, Heribert"],["dc.contributor.author","Überla, Klaus"],["dc.contributor.author","Sung, Young C."],["dc.date.accessioned","2022-10-06T13:33:27Z"],["dc.date.available","2022-10-06T13:33:27Z"],["dc.date.issued","2008"],["dc.identifier.doi","10.1016/j.vaccine.2008.07.055"],["dc.identifier.pii","S0264410X08010098"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115633"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0264-410X"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Prolonged survival of vaccinated macaques after oral SIVmac239 challenge regardless of viremia control in the chronic phase"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","195"],["dc.bibliographiccitation.issue","4-5"],["dc.bibliographiccitation.journal","Journal of Medical Primatology"],["dc.bibliographiccitation.lastpage","205"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.contributor.author","Suh, You Suk"],["dc.contributor.author","Park, Ki Seok"],["dc.contributor.author","Sauermann, Ulrike"],["dc.contributor.author","Kim, Kwang Soon"],["dc.contributor.author","Ahn, Soshin"],["dc.contributor.author","Franz, Monika"],["dc.contributor.author","Schulte, Reiner"],["dc.contributor.author","Stolte-Leeb, Nicole"],["dc.contributor.author","Hunsmann, Gerhard"],["dc.contributor.author","Sung, Young Chul"],["dc.date.accessioned","2022-10-06T13:25:15Z"],["dc.date.available","2022-10-06T13:25:15Z"],["dc.date.issued","2007"],["dc.identifier.doi","10.1111/j.1600-0684.2007.00237.x"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114799"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1600-0684"],["dc.relation.issn","0047-2565"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Immunogenicity of a DNA prime and recombinant adenovirus boost regime significantly varies between rhesus macaques of Chinese and Indian origins"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]