Riemensperger, Thomas Dieter

[["dc.bibliographiccitation.journal","eLife"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Lavista-Llanos, Sofía"],["dc.contributor.author","Svatoš, Aleš"],["dc.contributor.author","Kai, Marco"],["dc.contributor.author","Riemensperger, Thomas"],["dc.contributor.author","Birman, Serge"],["dc.contributor.author","Stensmyr, Marcus C"],["dc.contributor.author","Hansson, Bill S"],["dc.date.accessioned","2017-05-05T06:44:08Z"],["dc.date.accessioned","2021-10-27T13:11:24Z"],["dc.date.available","2017-05-05T06:44:08Z"],["dc.date.available","2021-10-27T13:11:24Z"],["dc.date.issued","2014"],["dc.description.abstract","Many insect species are host-obligate specialists. The evolutionary mechanism driving the adaptation of a species to a toxic host is, however, intriguing. We analyzed the tight association of Drosophila sechellia to its sole host, the fruit of Morinda citrifolia, which is toxic to other members of the melanogaster species group. Molecular polymorphisms in the dopamine regulatory protein Catsup cause infertility in D. sechellia due to maternal arrest of oogenesis. In its natural host, the fruit compensates for the impaired maternal dopamine metabolism with the precursor l-DOPA, resuming oogenesis and stimulating egg production. l-DOPA present in morinda additionally increases the size of D. sechellia eggs, what in turn enhances early fitness. We argue that the need of l-DOPA for successful reproduction has driven D. sechellia to become an M. citrifolia obligate specialist. This study illustrates how an insect's dopaminergic system can sustain ecological adaptations by modulating ontogenesis and development."],["dc.identifier.doi","10.7554/eLife.03785"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14444"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91593"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.issn","2050-084X"],["dc.relation.orgunit","Fakultät für Biologie und Psychologie"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","570"],["dc.title","Dopamine drives Drosophila sechellia adaptation to its toxic host"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e47518"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Huser, Annina"],["dc.contributor.author","Rohwedder, Astrid"],["dc.contributor.author","Apostolopoulou, Anthi A."],["dc.contributor.author","Widmann, Annekathrin"],["dc.contributor.author","Pfitzenmaier, Johanna E."],["dc.contributor.author","Maiolo, Elena M."],["dc.contributor.author","Selcho, Mareike"],["dc.contributor.author","Pauls, Dennis"],["dc.contributor.author","von Essen, Alina"],["dc.contributor.author","Gupta, Tripti"],["dc.contributor.author","Sprecher, Simon G."],["dc.contributor.author","Birman, Serge"],["dc.contributor.author","Riemensperger, Thomas"],["dc.contributor.author","Stocker, Reinhard F."],["dc.contributor.author","Thum, Andreas S."],["dc.date.accessioned","2018-11-07T09:04:33Z"],["dc.date.available","2018-11-07T09:04:33Z"],["dc.date.issued","2012"],["dc.description.abstract","The Drosophila larva has turned into a particularly simple model system for studying the neuronal basis of innate behaviors and higher brain functions. Neuronal networks involved in olfaction, gustation, vision and learning and memory have been described during the last decade, often up to the single-cell level. Thus, most of these sensory networks are substantially defined, from the sensory level up to third-order neurons. This is especially true for the olfactory system of the larva. Given the wealth of genetic tools in Drosophila it is now possible to address the question how modulatory systems interfere with sensory systems and affect learning and memory. Here we focus on the serotonergic system that was shown to be involved in mammalian and insect sensory perception as well as learning and memory. Larval studies suggested that the serotonergic system is involved in the modulation of olfaction, feeding, vision and heart rate regulation. In a dual anatomical and behavioral approach we describe the basic anatomy of the larval serotonergic system, down to the single-cell level. In parallel, by expressing apoptosis-inducing genes during embryonic and larval development, we ablate most of the serotonergic neurons within the larval central nervous system. When testing these animals for naive odor, sugar, salt and light perception, no profound phenotype was detectable; even appetitive and aversive learning was normal. Our results provide the first comprehensive description of the neuronal network of the larval serotonergic system. Moreover, they suggest that serotonin per se is not necessary for any of the behaviors tested. However, our data do not exclude that this system may modulate or fine-tune a wide set of behaviors, similar to its reported function in other insect species or in mammals. Based on our observations and the availability of a wide variety of genetic tools, this issue can now be addressed."],["dc.identifier.doi","10.1371/journal.pone.0047518"],["dc.identifier.isi","000311146900071"],["dc.identifier.pmid","23082175"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8324"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25130"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 2.5"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.5"],["dc.title","The Serotonergic Central Nervous System of the Drosophila Larva: Anatomy and Behavioral Function"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Neurogenetics"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Gaffuri, A. L."],["dc.contributor.author","Riemensperger, Thomas"],["dc.contributor.author","Roland, A."],["dc.contributor.author","Gervasi, N."],["dc.contributor.author","Li, L."],["dc.contributor.author","Ladarre, D."],["dc.contributor.author","Placais, P. Y."],["dc.contributor.author","Willaime, H."],["dc.contributor.author","Tabeling, P."],["dc.contributor.author","Tchenio, P."],["dc.contributor.author","Birman, Serge"],["dc.contributor.author","Preat, T."],["dc.contributor.author","Lenkei, Z."],["dc.date.accessioned","2018-11-07T09:02:26Z"],["dc.date.available","2018-11-07T09:02:26Z"],["dc.date.issued","2012"],["dc.format.extent","7"],["dc.identifier.isi","000314975100015"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24682"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Informa Healthcare"],["dc.publisher.place","London"],["dc.relation.issn","0167-7063"],["dc.title","Subcellular dynamics of CAMP/PKA signaling in single Drosophila mushroom body neurons matured in low-density cultures"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1169"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Biochimica et Biophysica Acta (BBA) - General Subjects"],["dc.bibliographiccitation.lastpage","1178"],["dc.bibliographiccitation.volume","1820"],["dc.contributor.author","Riemensperger, Thomas"],["dc.contributor.author","Pech, Ulrike"],["dc.contributor.author","Dipt, Shubham"],["dc.contributor.author","Fiala, Andre"],["dc.date.accessioned","2018-11-07T09:08:06Z"],["dc.date.available","2018-11-07T09:08:06Z"],["dc.date.issued","2012"],["dc.description.abstract","Background: Drosophila melanogaster is one of the best-studied model organisms in biology, mainly because of the versatility of methods by which heredity and specific expression of genes can be traced and manipulated. Sophisticated genetic tools have been developed to express transgenes in selected cell types, and these techniques can be utilized to target DNA-encoded fluorescence probes to genetically defined subsets of neurons. Neuroscientists make use of this approach to monitor the activity of restricted types or subsets of neurons in the brain and the peripheral nervous system. Since membrane depolarization is typically accompanied by an increase in intracellular calcium ions, calcium-sensitive fluorescence proteins provide favorable tools to monitor the spatio-temporal activity across groups of neurons. Scope of review: Here we describe approaches to perform optical calcium imaging in Drosophila in consideration of various calcium sensors and expression systems. In addition, we outline by way of examples for which particular neuronal systems in Drosophila optical calcium imaging have been used. Finally, we exemplify briefly how optical calcium imaging in the brain of Drosophila can be carried out in practice. Major conclusions and general significance: Drosophila provides an excellent model organism to combine genetic expression systems with optical calcium imaging in order to investigate principles of sensory coding, neuronal plasticity, and processing of neuronal information underlying behavior. This article is part of a Special Issue entitled Biochemical, Biophysical and Genetic Approaches to Intracellular Calcium Signaling. (C) 2012 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.bbagen.2012.02.013"],["dc.identifier.isi","000305595300003"],["dc.identifier.pmid","22402253"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25948"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0304-4165"],["dc.title","Optical calcium imaging in the nervous system of Drosophila melanogaster"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1819"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","1837"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Barth, Jonas"],["dc.contributor.author","Dipt, Shubham"],["dc.contributor.author","Pech, Ulrike"],["dc.contributor.author","Hermann, Moritz"],["dc.contributor.author","Riemensperger, Thomas"],["dc.contributor.author","Fiala, Andre"],["dc.date.accessioned","2018-11-07T09:44:54Z"],["dc.date.available","2018-11-07T09:44:54Z"],["dc.date.issued","2014"],["dc.description.abstract","Training can improve the ability to discriminate between similar, confusable stimuli, including odors. One possibility of enhancing behaviorally expressed discrimination (i.e., sensory acuity) relies on differential associative learning, during which animals are forced to detect the differences between similar stimuli. Drosophila represents a key model organism for analyzing neuronal mechanisms underlying both odor processing and olfactory learning. However, the ability of flies to enhance fine discrimination between similar odors through differential associative learning has not been analyzed in detail. We performed associative conditioning experiments using chemically similar odorants that we show to evoke overlapping neuronal activity in the fly's antennal lobes and highly correlated activity in mushroom body lobes. We compared the animals' performance in discriminating between these odors after subjecting them to one of two types of training: either absolute conditioning, in which only one odor is reinforced, or differential conditioning, in which one odor is reinforced and a second odor is explicitly not reinforced. First, we show that differential conditioning decreases behavioral generalization of similar odorants in a choice situation. Second, we demonstrate that this learned enhancement in olfactory acuity relies on both conditioned excitation and conditioned inhibition. Third, inhibitory local interneurons in the antennal lobes are shown to be required for behavioral fine discrimination between the two similar odors. Fourth, differential, but not absolute, training causes decorrelation of odor representations in the mushroom body. In conclusion, differential training with similar odors ultimately induces a behaviorally expressed contrast enhancement between the two similar stimuli that facilitates fine discrimination."],["dc.identifier.doi","10.1523/JNEUROSCI.2598-13.2014"],["dc.identifier.isi","000331455000024"],["dc.identifier.pmid","24478363"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34499"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc Neuroscience"],["dc.relation.issn","0270-6474"],["dc.title","Differential Associative Training Enhances Olfactory Acuity in Drosophila melanogaster"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","76"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Frontiers in Systems Neuroscience"],["dc.bibliographiccitation.lastpage","13"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Niens, Janna"],["dc.contributor.author","Reh, Fabienne"],["dc.contributor.author","Çoban, Büşra"],["dc.contributor.author","Cichewicz, Karol"],["dc.contributor.author","Eckardt, Julia"],["dc.contributor.author","Liu, Yi-Ting"],["dc.contributor.author","Hirsh, Jay"],["dc.contributor.author","Riemensperger, Thomas D."],["dc.date.accessioned","2019-07-09T11:44:30Z"],["dc.date.available","2019-07-09T11:44:30Z"],["dc.date.issued","2017"],["dc.description.abstract","Parkinson’s disease (PD) results from a progressive degeneration of the dopaminergic nigrostriatal system leading to a decline in movement control, with resting tremor, rigidity and postural instability. Several aspects of PD can be modeled in the fruit fly, Drosophila melanogaster, including a-synuclein-induced degeneration of dopaminergic neurons, or dopamine (DA) loss by genetic elimination of neural DA synthesis. Defective behaviors in this latter model can be ameliorated by feeding the DA precursor L-DOPA, analogous to the treatment paradigm for PD. Secondary complication from L-DOPA treatment in PD patients are associated with ectopic synthesis of DA in serotonin (5-HT)-releasing neurons, leading to DA/5-HT imbalance. Here we examined the neuroanatomical adaptations resulting from imbalanced DA/5-HT signaling in Drosophila mutants lacking neural DA. We find that, similar to rodent models of PD, lack of DA leads to increased 5-HT levels and arborizations in specific brain regions. Conversely, increased DA levels by L-DOPA feeding leads to reduced connectivity of 5-HT neurons to their target neurons in the mushroom body (MB). The observed alterations of 5-HT neuron plasticity indicate that loss of DA signaling is not solely responsible for the behavioral disorders observed in Drosophila models of PD, but rather a combination of the latter with alterations of 5-HT circuitry."],["dc.identifier.doi","10.3389/fnsys.2017.00076"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14799"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59024"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1662-5137"],["dc.relation.issn","1663-4365"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","570"],["dc.title","Dopamine Modulates Serotonin Innervation in the Drosophila Brain"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","952"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Cell Reports"],["dc.bibliographiccitation.lastpage","960"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Riemensperger, Thomas"],["dc.contributor.author","Issa, Abdul-Raouf"],["dc.contributor.author","Pech, Ulrike"],["dc.contributor.author","Coulom, Helene"],["dc.contributor.author","My-Van Nguyen, My-Van Nguyen"],["dc.contributor.author","Cassar, Marlene"],["dc.contributor.author","Jacquet, Melanie"],["dc.contributor.author","Fiala, Andre"],["dc.contributor.author","Birman, Serge"],["dc.date.accessioned","2018-11-07T09:17:49Z"],["dc.date.available","2018-11-07T09:17:49Z"],["dc.date.issued","2013"],["dc.description.abstract","Expression of the human Parkinson-disease-associated protein alpha-synuclein in all Drosophila neurons induces progressive locomotor deficits. Here, we identify a group of 15 dopaminergic neurons per hemisphere in the anterior medial region of the brain whose disruption correlates with climbing impairments in this model. These neurons selectively innervate the horizontal beta and beta' lobes of the mushroom bodies, and their connections to the Kenyon cells are markedly reduced when they express alpha-synuclein. Using selective mushroom body drivers, we show that blocking or overstimulating neuronal activity in the beta' lobe, but not the beta or gamma lobes, significantly inhibits negative geotaxis behavior. This suggests that modulation of the mushroom body beta' lobes by this dopaminergic pathway is specifically required for an efficient control of startle-induced locomotion in flies."],["dc.identifier.doi","10.1016/j.celrep.2013.10.032"],["dc.identifier.isi","000328266000011"],["dc.identifier.pmid","24239353"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10671"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28258"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cell Press"],["dc.relation.issn","2211-1247"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","A Single Dopamine Pathway Underlies Progressive Locomotor Deficits in a Drosophila Model of Parkinson Disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Systems Neuroscience"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Sun, Jun"],["dc.contributor.author","Xu, An Qi"],["dc.contributor.author","Giraud, Julia"],["dc.contributor.author","Poppinga, Haiko"],["dc.contributor.author","Riemensperger, Thomas"],["dc.contributor.author","Fiala, André"],["dc.contributor.author","Birman, Serge"],["dc.date.accessioned","2020-12-10T18:44:35Z"],["dc.date.available","2020-12-10T18:44:35Z"],["dc.date.issued","2018"],["dc.description.abstract","Startle-induced locomotion is commonly used in Drosophila research to monitor locomotor reactivity and its progressive decline with age or under various neuropathological conditions. A widely used paradigm is startle-induced negative geotaxis (SING), in which flies entrapped in a narrow column react to a gentle mechanical shock by climbing rapidly upwards. Here we combined in vivo manipulation of neuronal activity and splitGFP reconstitution across cells to search for brain neurons and putative circuits that regulate this behavior. We show that the activity of specific clusters of dopaminergic neurons (DANs) afferent to the mushroom bodies (MBs) modulates SING, and that DAN-mediated SING regulation requires expression of the DA receptor Dop1R1/Dumb, but not Dop1R2/Damb, in intrinsic MB Kenyon cells (KCs). We confirmed our previous observation that activating the MB α'β', but not αβ, KCs decreased the SING response, and we identified further MB neurons implicated in SING control, including KCs of the γ lobe and two subtypes of MB output neurons (MBONs). We also observed that co-activating the αβ KCs antagonizes α'β' and γ KC-mediated SING modulation, suggesting the existence of subtle regulation mechanisms between the different MB lobes in locomotion control. Overall, this study contributes to an emerging picture of the brain circuits modulating locomotor reactivity in Drosophila that appear both to overlap and differ from those underlying associative learning and memory, sleep/wake state and stress-induced hyperactivity."],["dc.identifier.doi","10.3389/fnsys.2018.00006"],["dc.identifier.eissn","1662-5137"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78518"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1662-5137"],["dc.rights","http://creativecommons.org/licenses/by/4.0/"],["dc.title","Neural Control of Startle-Induced Locomotion by the Mushroom Bodies and Associated Neurons in Drosophila"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","147"],["dc.bibliographiccitation.journal","Frontiers in Neural Circuits"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Pech, Ulrike"],["dc.contributor.author","Dipt, Shubham"],["dc.contributor.author","Barth, Jonas"],["dc.contributor.author","Singh, Priyanka"],["dc.contributor.author","Jauch, Mandy"],["dc.contributor.author","Thum, Andreas S."],["dc.contributor.author","Fiala, Andre"],["dc.contributor.author","Riemensperger, Thomas"],["dc.date.accessioned","2018-11-07T09:19:49Z"],["dc.date.available","2018-11-07T09:19:49Z"],["dc.date.issued","2013"],["dc.description.abstract","The fruit fly Drosophila melanogaster represents a key model organism for analyzing how neuronal circuits regulate behavior. The mushroom body in the central brain is a particularly prominent brain region that has been intensely studied in several insect species and been implicated in a variety of behaviors, e.g., associative learning, locomotor activity, and sleep. Drosophila melanogaster offers the advantage that transgenes can be easily expressed in neuronal subpopulations, e.g., in intrinsic mushroom body neurons (Kenyon cells). A number of transgenes has been described and engineered to visualize the anatomy of neurons, to monitor physiological parameters of neuronal activity, and to manipulate neuronal function artificially. To target the expression of these transgenes selectively to specific neurons several sophisticated bi- or even multipartite transcription systems have been invented. However, the number of transgenes that can be combined in the genome of an individual fly is limited in practice. To facilitate the analysis of the mushroom body we provide a compilation of transgenic fruit flies that express transgenes under direct control of the Kenyon-cell specific promoter, mb247. The transgenes expressed are fluorescence reporters to analyze neuroanatomical aspects of the mushroom body, proteins to restrict ectopic gene expression to mushroom bodies, or fluorescent sensors to monitor physiological parameters of neuronal activity of Kenyon cells. Some of the transgenic animals compiled here have been published already, whereas others are novel and characterized here for the first time. Overall, the collection of transgenic flies expressing sensor and reporter genes in Kenyon cells facilitates combinations with binary transcription systems and might, ultimately, advance the physiological analysis of mushroom body function."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2013"],["dc.identifier.doi","10.3389/fncir.2013.00147"],["dc.identifier.isi","000324807300001"],["dc.identifier.pmid","24065891"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9305"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28729"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Frontiers Research Foundation"],["dc.relation.issn","1662-5110"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","Mushroom body miscellanea: transgenic Drosophila strains expressing anatomical and physiological sensor proteins in Kenyon cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","174"],["dc.bibliographiccitation.journal","Frontiers in Behavioral Neuroscience"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Vasmer, David"],["dc.contributor.author","Pooryasin, Atefeh"],["dc.contributor.author","Riemensperger, Thomas"],["dc.contributor.author","Fiala, Andre"],["dc.date.accessioned","2018-11-07T09:40:14Z"],["dc.date.available","2018-11-07T09:40:14Z"],["dc.date.issued","2014"],["dc.description.abstract","Drosophila represents a model organism to analyze neuronal mechanisms underlying learning and memory. Kenyon cells of the Drosophila mushroom body are required for associative odor learning and memory retrieval. But is the mushroom body sufficient to acquire and retrieve an associative memory? To answer this question we have conceived an experimental approach to bypass olfactory sensory input and to thermogenetically activate sparse and random ensembles of Kenyon cells directly. We found that if the artifical activation of Kenyon cell ensembles coincides with a salient, aversive stimulus learning was induced. The animals adjusted their behavior in a subsequent test situation and actively avoided reactivation of these Kenyon cells. Our results show that Kenyon cell activity in coincidence with a salient aversive stimulus can suffice to form an associative memory. Memory retrieval is characterized by a closed feedback loop between a behavioral action and the reactivation of sparse ensembles of Kenyon cells."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2014"],["dc.identifier.doi","10.3389/fnbeh.2014.00174"],["dc.identifier.isi","000335956300001"],["dc.identifier.pmid","24860455"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10184"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33463"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Frontiers Research Foundation"],["dc.relation.issn","1662-5153"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","Induction of aversive learning through thermogenetic activation of Kenyon cell ensembles in Drosophila"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]