Natt, Oliver

[["dc.bibliographiccitation.firstpage","596"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","NeuroImage"],["dc.bibliographiccitation.lastpage","602"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Michaelis, Thomas"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Natt, Oliver"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Utz, Sandra"],["dc.contributor.author","Schachtner, Joachim"],["dc.date.accessioned","2017-09-07T11:45:31Z"],["dc.date.available","2017-09-07T11:45:31Z"],["dc.date.issued","2005"],["dc.description.abstract","High-resolution 3D MRI of male pupae of Manduca sexta was performed at 2.35 T in order to evaluate its potential for an in vivo characterization of insect brain during metamorphosis. T1-weighted 3D FLASH (TR/TE = 20/7.8 ms, 25° flip angle) and T2-weighted 3D fast SE MRI data sets (TR/TEeff = 3000/100 ms) were acquired at different developmental stages with an isotropic resolution of 100 μm. Both T1- and T2-weighted 3D MRI allowed for the identification of cerebral structures such as the antennal nerve, antennal and optical lobe, and central brain. Pronounced developmental alterations of the morphology were observed during metamorphosis. The results demonstrate the feasibility of 3D MRI at nanoliter resolution to identify major brain systems of M. sexta and respective changes during pupal development from caterpillar to sphinx moth. Together with the use of suitable contrast agents, this approach may provide new ways for studying the axonal connectivity and neural function of the developing insect brain."],["dc.identifier.doi","10.1016/j.neuroimage.2004.08.048"],["dc.identifier.gro","3150381"],["dc.identifier.pmid","15627604"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7139"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","1053-8119"],["dc.subject","Magnetic resonance imaging; Metamorphosis; Brain development; Manduca sexta; Entomology"],["dc.title","In vivo 3D MRI of insect brain: cerebral development during metamorphosis of Manduca sexta"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","480"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Brain"],["dc.bibliographiccitation.lastpage","489"],["dc.bibliographiccitation.volume","129"],["dc.contributor.author","Sirén, Anna-Leena"],["dc.contributor.author","Radyushkin, Konstantin"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Kämmer, Daniel"],["dc.contributor.author","Riechers, Claas-Christian"],["dc.contributor.author","Natt, Oliver"],["dc.contributor.author","Sargin, Derya"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Sperling, Swetlana"],["dc.contributor.author","Michaelis, Thomas"],["dc.contributor.author","Price, Jack"],["dc.contributor.author","Meyer, Barbara"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.date.accessioned","2017-09-07T11:45:33Z"],["dc.date.available","2017-09-07T11:45:33Z"],["dc.date.issued","2006"],["dc.description.abstract","In humans, neurotrauma is suspected to cause brain atrophy and accelerate slowly progressive neurodegenerative disorders, such as Alzheimer's disease or schizophrenia. However, a direct link between brain injury and subsequent delayed global neurodegeneration has remained elusive. Here we show that juvenile (4-week-old) mice that are given a discrete unilateral lesion of the parietal cortex, develop to adulthood without obvious clinical symptoms. However, when monitored 3 and 9 months after lesioning, using high-resolution three-dimensional MRI and behavioural testing, the same mice display global neurodegenerative changes. Surprisingly, erythropoietin, a haematopoietic growth factor with potent neuroprotective activity, prevents behavioural abnormalities, cognitive dysfunction and brain atrophy when given for 2 weeks after acute brain injury. This demonstrates that a localized brain lesion is a primary cause of delayed global neurodegeneration that can be efficiently counteracted by neuroprotection."],["dc.identifier.doi","10.1093/brain/awh703"],["dc.identifier.doi","10.1093/brain/awh703"],["dc.identifier.gro","3150392"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7151"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","0006-8950"],["dc.subject","EPO; MRI; neuroprotection; neurodegeneration; neurotrauma; schizophrenia"],["dc.title","Global brain atrophy after unilateral parietal lesion and its prevention by erythropoietin"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","860"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","NeuroImage"],["dc.bibliographiccitation.lastpage","867"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Radulovic, Jelena"],["dc.contributor.author","Spiess, Joachim"],["dc.contributor.author","Natt, Oliver"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Michaelis, Thomas"],["dc.date.accessioned","2017-09-07T11:45:29Z"],["dc.date.available","2017-09-07T11:45:29Z"],["dc.date.issued","2004"],["dc.description.abstract","The morphology and function of the hippocampal system of C57BL/6J mice (n = 8) was studied in vivo using T1-weighted 3D magnetic resonance imaging (MRI) (117 μm isotropic resolution) after bilateral injection of MnCl2 (0.25 μl, 5 or 200 mM) into the posterior hippocampal formation. The neuronal uptake of the T1-shortening Mn2+ ions resulted in a pronounced MRI signal enhancement within the CA3 subfield and dentate gyrus with milder increases in CA1 and subiculum. This finding is in line with differences in the excitability of hippocampal neurons previously reported using electrophysiologic recordings. The subsequent axonal transport of Mn2+ highlighted the principal extrinsic projections from the posterior hippocampal formation via the fimbria and the precommissural fornix to the dorsal part of the lateral septal nucleus. A strong MRI signal enhancement was also observed in the ventral hippocampal commissure. A time-course analysis revealed unsaturated conditions of Mn2+ accumulation at about 2 h after injection and optimal contrast-to-noise ratios at about 6 h after injection. The present results using Mn2+-enhanced 3D MRI open new ways for studying the role of the hippocampal system in specific aspects of learning and memory in normal and mutant mice."],["dc.identifier.doi","10.1016/j.neuroimage.2004.01.028"],["dc.identifier.gro","3150384"],["dc.identifier.pmid","15193616"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7143"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","1053-8119"],["dc.subject","Hippocampus; Efferent pathways; Fornix; Manganese-enhanced MRI; Neuroanatomic tracing"],["dc.title","In vivo 3D MRI staining of the mouse hippocampal system using intracerebral injection of MnCl2"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","933"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Molecular Psychiatry"],["dc.bibliographiccitation.lastpage","941"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","van der Hart, M G C"],["dc.contributor.author","Czéh, B"],["dc.contributor.author","de Biurrun, G"],["dc.contributor.author","Michaelis, T"],["dc.contributor.author","Watanabe, T"],["dc.contributor.author","Natt, O"],["dc.contributor.author","Frahm, J"],["dc.contributor.author","Fuchs, E"],["dc.date.accessioned","2022-10-06T13:34:20Z"],["dc.date.available","2022-10-06T13:34:20Z"],["dc.date.issued","2002"],["dc.identifier.doi","10.1038/sj.mp.4001130"],["dc.identifier.pii","BF4001130"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115886"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1476-5578"],["dc.relation.issn","1359-4184"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","https://www.springer.com/tdm"],["dc.title","Substance P receptor antagonist and clomipramine prevent stress-induced alterations in cerebral metabolites, cytogenesis in the dentate gyrus and hippocampal volume"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","203"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Neuroscience Methods"],["dc.bibliographiccitation.lastpage","209"],["dc.bibliographiccitation.volume","120"],["dc.contributor.author","Natt, Oliver"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Radulovic, Jelena"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Michaelis, Thomas"],["dc.date.accessioned","2017-09-07T11:45:33Z"],["dc.date.available","2017-09-07T11:45:33Z"],["dc.date.issued","2002"],["dc.description.abstract","This work demonstrates technical approaches to high-quality magnetic resonance imaging (MRI) of small structures of the mouse brain in vivo. It turns out that excellent soft-tissue contrast requires the reduction of partial volume effects by using 3D MRI at high (isotropic) resolution with linear voxel dimensions of about 100–150 μm. The long T2 relaxation times at relatively low magnetic fields (2.35 T) offer the benefit of a small receiver bandwidth (increased signal-to-noise) at a moderate echo time which together with the small voxel size avoids visual susceptibility artifacts. For measuring times of 1–1.5 h both T1-weighted (FLASH) and T2-weighted (Fast Spin-Echo) 3D MRI acquisitions exhibit detailed anatomical insights in accordance with histological sections from a mouse brain atlas. Preliminary applications address the identification of neuroanatomical variations in different mouse strains and the use of Mn2+ as a T1 contrast agent for neuroaxonal tracing of fiber tracts within the mouse visual pathway."],["dc.identifier.doi","10.1016/s0165-0270(02)00211-x"],["dc.identifier.gro","3150389"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7148"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.issn","0165-0270"],["dc.title","High-resolution 3D MRI of mouse brain reveals small cerebral structures in vivo"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","969"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Nature Genetics"],["dc.bibliographiccitation.lastpage","976"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Kassmann, Celia M."],["dc.contributor.author","Lappe-Siefke, Corinna"],["dc.contributor.author","Baes, Myriam"],["dc.contributor.author","Bruegger, Britta"],["dc.contributor.author","Mildner, Alexander"],["dc.contributor.author","Werner, Hauke B."],["dc.contributor.author","Natt, Oliver"],["dc.contributor.author","Michaelis, Thomas"],["dc.contributor.author","Prinz, Marco R."],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Nave, Klaus-Armin"],["dc.date.accessioned","2018-11-07T11:00:20Z"],["dc.date.available","2018-11-07T11:00:20Z"],["dc.date.issued","2007"],["dc.description.abstract","Oligodendrocytes myelinate axons for rapid impulse conduction and contribute to normal axonal functions in the central nervous system. In multiple sclerosis, demyelination is caused by autoimmune attacks, but the role of oligodendroglial cells in disease progression and axon degeneration is unclear. Here we show that oligodendrocytes harbor peroxisomes whose function is essential for maintaining white matter tracts throughout adult life. By selectively inactivating the import factor PEX5 in myelinating glia, we generated mutant mice that developed normally, but within several months showed ataxia, tremor and premature death. Absence of functional peroxisomes from oligodendrocytes caused widespread axonal degeneration and progressive subcortical demyelination, but did not interfere with glial survival. Moreover, it caused a strong proinflammatory milieu and, unexpectedly, the infiltration of B and activated CD8(+) T cells into brain lesions. We conclude that peroxisomes provide oligodendrocytes with an essential neuroprotective function against axon degeneration and neuroinflammation, which is relevant for human demyelinating diseases."],["dc.identifier.doi","10.1038/ng2070"],["dc.identifier.isi","000248446900013"],["dc.identifier.pmid","17643102"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50899"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1061-4036"],["dc.title","Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","NEURON GLIA BIOLOGY"],["dc.bibliographiccitation.volume","2"],["dc.contributor.author","Kassmann, Celia M."],["dc.contributor.author","Lappe-Siefke, Corinna"],["dc.contributor.author","Baes, Myriam"],["dc.contributor.author","Mildner, Alexander"],["dc.contributor.author","Natt, Oliver"],["dc.contributor.author","Werner, Hauke B."],["dc.contributor.author","Prinz, Marco R."],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Nave, Klaus-Armin"],["dc.date.accessioned","2018-11-07T11:07:12Z"],["dc.date.available","2018-11-07T11:07:12Z"],["dc.date.issued","2007"],["dc.format.extent","S57"],["dc.identifier.isi","000251708800173"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52500"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cambridge Univ Press"],["dc.publisher.place","New york"],["dc.relation.issn","1740-925X"],["dc.title","Inactivation of peroxisome function in oligodendrocytes - a mouse phenocopy of human adrenoleukodystrophy"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1113"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Magnetic Resonance Imaging"],["dc.bibliographiccitation.lastpage","1120"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Natt, Oliver"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Michaelis, Thomas"],["dc.date.accessioned","2017-09-07T11:45:29Z"],["dc.date.available","2017-09-07T11:45:29Z"],["dc.date.issued","2004"],["dc.description.abstract","Extending applications of magnetization transfer contrast (MTC) in magnetic resonance imaging (MRI) of the human central nervous system, this work quantitatively describes MTC of the murine brain. As a novel finding, complementing T1- and T2-weighted MRI, MTC allows for the distinction of densely packed gray matter from normal gray and white matter. Examples include the Purkinje cell layer and the granular cell layer in the mouse cerebellum as well as the delineation of the CA3 subfield of the hippocampus relative to surrounding hippocampal gray matter and white matter tracts such as the hippocampal fimbria. Using a kainate lesion model, the CA3 hyperintensities in MTC and T1-weighted MRI are assigned to the densely packed somata of pyramidal cells."],["dc.identifier.doi","10.1016/j.mri.2003.08.012"],["dc.identifier.gro","3150385"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7144"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.issn","0730-725X"],["dc.title","Magnetization transfer MRI of mouse brain reveals areas of high neural density"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","852"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Magnetic Resonance in Medicine"],["dc.bibliographiccitation.lastpage","859"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Natt, Oliver"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Michaelis, Thomas"],["dc.date.accessioned","2017-09-07T11:45:29Z"],["dc.date.available","2017-09-07T11:45:29Z"],["dc.date.issued","2002"],["dc.description.abstract","Follow-up T1-weighted 3D gradient-echo MRI (2.35 T) of murine brain in vivo (N = 5) at 120 μm isotropic resolution revealed spatially distinct signal increases 6–48 hr after subcutaneous application of MnCl2 (20 mg/kg). The effects result from a shortening of the water proton T1 relaxation time due to the presence of unchelated paramagnetic Mn2+ ions, which access the brain by systemic circulation and crossing of the blood–brain barrier (BBB). A pronounced Mn2+-induced signal enhancement was first seen in structures without a BBB, such as the choroid plexus, pituitary gland, and pineal gland. Within 24 hr after administration, Mn2+ contrast highlighted the olfactory bulb, inferior colliculi, cerebellum, and the CA3 subfield of the hippocampus. The affinity of Mn2+ to various brain systems suggests the neuronal uptake of Mn2+ ions from the extracellular space and subsequent axonal transport. Thus, at least part of the Mn2+ contrast reflects a functional brain response of behaving animals, for example, in the olfactory system. In vivo MRI staining of the brain by systemic administration of MnCl2 may contribute to phenotyping mutant mice with morphologic and functional alterations of the central nervous system. Magn Reson Med 48:852–859, 2002. © 2002 Wiley-Liss, Inc."],["dc.identifier.doi","10.1002/mrm.10276"],["dc.identifier.gro","3150388"],["dc.identifier.pmid","12418000"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7147"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","0740-3194"],["dc.title","In Vivo 3D MRI Staining of Mouse Brain After Subcutaneous Application of MnCl2"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","339"],["dc.bibliographiccitation.issue","3-6"],["dc.bibliographiccitation.journal","Magnetic Resonance Materials in Physics, Biology and Medicine"],["dc.bibliographiccitation.lastpage","347"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Boretius, S."],["dc.contributor.author","Natt, O."],["dc.contributor.author","Watanabe, T."],["dc.contributor.author","Tammer, R."],["dc.contributor.author","Ehrenreich, L."],["dc.contributor.author","Frahm, J."],["dc.contributor.author","Michaelis, T."],["dc.date.accessioned","2017-09-07T11:45:31Z"],["dc.date.available","2017-09-07T11:45:31Z"],["dc.date.issued","2004"],["dc.description.abstract","The purpose was to assess the potential of half Fourier diffusion-weighted single-shot STEAM MRI for diffusion tensor mapping of animal brain in vivo. A STEAM sequence with image acquisition times of about 500 ms was implemented at 2.35 T using six gradient orientations and b values of 200, 700, and 1200 s mm(-2). The use of half Fourier phase-encoding increased the signal-to-noise ratio by 45% relative to full Fourier acquisitions. Moreover, STEAM-derived maps of the relative anisotropy and main diffusion direction were completely free of susceptibility-induced signal losses and geometric distortions. Within measuring times of 3 h, the achieved resolution varied from 600x700x1000 microm3 for squirrel monkeys to 140x280x720 microm3 for mice. While in monkeys the accessible white matter fiber connections were comparable to those reported for humans, detectable fiber structures in mice focused on the corpus callosum, anterior commissure, and hippocampal fimbria. In conclusion diffusion-weighted single-shot STEAM MRI allows for in vivo diffusion tensor mapping of the brain of squirrel monkeys, rats, and mice without motion artifacts and susceptibility distortions."],["dc.identifier.doi","10.1007/s10334-004-0069-1"],["dc.identifier.gro","3150383"],["dc.identifier.pmid","15580374"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7141"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","0968-5243"],["dc.subject","Magnetic resonance imaging; Diffusion-weighted imaging; Anisotropy; White matter; Animal brain"],["dc.title","In vivo diffusion tensor mapping of the brain of squirrel monkey, rat, and mouse using single-shot STEAM MRI"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]