Pilavakis, Yiannis

[["dc.bibliographiccitation.firstpage","3384"],["dc.bibliographiccitation.issue","14"],["dc.bibliographiccitation.journal","Cancers"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Leu, Martin"],["dc.contributor.author","Patzer, Christoph"],["dc.contributor.author","Guhlich, Manuel"],["dc.contributor.author","Possiel, Jacqueline"],["dc.contributor.author","Pilavakis, Yiannis"],["dc.contributor.author","Schirmer, Markus Anton"],["dc.contributor.author","Rieken, Stefan"],["dc.contributor.author","Dröge, Leif Hendrik"],["dc.date.accessioned","2021-09-01T06:43:07Z"],["dc.date.available","2021-09-01T06:43:07Z"],["dc.date.issued","2021"],["dc.description.abstract","Locally advanced head and neck squamous cell carcinomas (HNSCC) are often managed with surgery followed by postoperative radiochemotherapy (RCT). With the general increase in life expectancy, the proportion of elderly patients with HNSCC is expected to grow rapidly. Until now, a deeper understanding of specific management strategies for these patients in clinical routine was lacking. In the present study, we compared elderly patients (≥70 years, n = 52) and younger patients (n = 245) treated with postoperative RCT for HNSCC at our tertiary cancer center. All patients were irradiated with modern radiotherapy techniques (IMRT/VMAT). Patients ≥70 years of age had more comorbidities. Additionally, elderly patients less frequently received concomitant systemic treatment. The rates of mucositis and dermatitis were lower in patients ≥70 years. Elderly patients had significantly worse overall and progression-free survival. Locoregional and distant control were comparable in elderly and younger patients. In conclusion, postoperative RCT is a safe and effective treatment option in patients ≥70 years. In light of comorbidities and poor overall survival rates, benefits and harms of radiotherapy and concomitant systemic treatment should be weighed carefully. When exclusively applying up-to-date radiotherapy techniques with, at the same time, careful use of concomitant systemic therapy, favorable acute toxicity profiles are achieved."],["dc.description.abstract","Locally advanced head and neck squamous cell carcinomas (HNSCC) are often managed with surgery followed by postoperative radiochemotherapy (RCT). With the general increase in life expectancy, the proportion of elderly patients with HNSCC is expected to grow rapidly. Until now, a deeper understanding of specific management strategies for these patients in clinical routine was lacking. In the present study, we compared elderly patients (≥70 years, n = 52) and younger patients (n = 245) treated with postoperative RCT for HNSCC at our tertiary cancer center. All patients were irradiated with modern radiotherapy techniques (IMRT/VMAT). Patients ≥70 years of age had more comorbidities. Additionally, elderly patients less frequently received concomitant systemic treatment. The rates of mucositis and dermatitis were lower in patients ≥70 years. Elderly patients had significantly worse overall and progression-free survival. Locoregional and distant control were comparable in elderly and younger patients. In conclusion, postoperative RCT is a safe and effective treatment option in patients ≥70 years. In light of comorbidities and poor overall survival rates, benefits and harms of radiotherapy and concomitant systemic treatment should be weighed carefully. When exclusively applying up-to-date radiotherapy techniques with, at the same time, careful use of concomitant systemic therapy, favorable acute toxicity profiles are achieved."],["dc.identifier.doi","10.3390/cancers13143384"],["dc.identifier.pii","cancers13143384"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89222"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-455"],["dc.publisher","MDPI"],["dc.relation.eissn","2072-6694"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Postoperative Radiochemotherapy Using Modern Radiotherapy Techniques in Elderly Patients with Head and Neck Squamous Cell Carcinoma: The Challenge of Weighing Up Benefits and Harms of Treatment Modalities in Clinical Practice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e1711"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Plastic & Reconstructive Surgery"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Spiegel, Jennifer L."],["dc.contributor.author","Pilavakis, Yiannis"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Welz, Christian"],["dc.date.accessioned","2020-12-10T18:19:54Z"],["dc.date.available","2020-12-10T18:19:54Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1097/GOX.0000000000001711"],["dc.identifier.issn","2169-7574"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75416"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Shoulder Morbidity in Patients after Head and Neck Reconstruction with the Pedicled Supraclavicular Island Flap"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e0233811"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","PLoS One"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Mavropoulou, Eirini"],["dc.contributor.author","Mechie, Nicolae-Catalin"],["dc.contributor.author","Knoop, Richard"],["dc.contributor.author","Petzold, Golo"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Kunsch, Steffen"],["dc.contributor.author","Pilavakis, Yiannis"],["dc.contributor.author","Amanzada, Ahmad"],["dc.contributor.editor","Bonaz, Bruno"],["dc.date.accessioned","2021-04-14T08:25:13Z"],["dc.date.available","2021-04-14T08:25:13Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1371/journal.pone.0233811"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17632"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81557"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","1932-6203"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Association of serum interleukin-6 and soluble interleukin-2-receptor levels with disease activity status in patients with inflammatory bowel disease: A prospective observational study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e25111"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Medicine"],["dc.bibliographiccitation.volume","100"],["dc.contributor.author","Mechie, Nicolae-Catalin"],["dc.contributor.author","Burmester, Merle"],["dc.contributor.author","Mavropoulou, Eirini"],["dc.contributor.author","Pilavakis, Yiannis"],["dc.contributor.author","Kunsch, Steffen"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Amanzada, Ahmad"],["dc.date.accessioned","2021-06-01T10:47:00Z"],["dc.date.available","2021-06-01T10:47:00Z"],["dc.date.issued","2021"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.1097/MD.0000000000025111"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17849"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85446"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","1536-5964"],["dc.relation.issn","0025-7974"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Evaluation of ustekinumab trough levels during induction and maintenance therapy with regard to disease activity status in difficult to treat Crohn disease patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2311"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","European Archives of Oto-Rhino-Laryngology"],["dc.bibliographiccitation.lastpage","2318"],["dc.bibliographiccitation.volume","276"],["dc.contributor.author","Spiegel, Jennifer L."],["dc.contributor.author","Pilavakis, Yiannis"],["dc.contributor.author","Weiss, Bernhard G."],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Welz, Christian"],["dc.date.accessioned","2020-12-10T14:10:30Z"],["dc.date.available","2020-12-10T14:10:30Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00405-019-05478-6"],["dc.identifier.eissn","1434-4726"],["dc.identifier.issn","0937-4477"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70779"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Quality of life in patients after reconstruction with the supraclavicular artery island flap (SCAIF) versus the radial free forearm flap (RFFF)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Leu, Martin"],["dc.contributor.author","Kitz, J."],["dc.contributor.author","Pilavakis, Y."],["dc.contributor.author","Hakroush, S."],["dc.contributor.author","Wolff, H. A."],["dc.contributor.author","Canis, M."],["dc.contributor.author","Rieken, S."],["dc.contributor.author","Schirmer, M. A."],["dc.date.accessioned","2021-06-01T09:41:42Z"],["dc.date.available","2021-06-01T09:41:42Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract Treatment of locally advanced, unresectable head and neck squamous cell carcinoma (HNSCC) often yields only modest results with radiochemotherapy (RCT) as standard of care. Prognostic features related to outcome upon RCT might be highly valuable to improve treatment. Monocarboxylate transporters-1 and -4 (MCT1/MCT4) were evaluated as potential biomarkers. A cohort of HNSCC patients without signs for distant metastases was assessed eliciting 82 individuals eligible whereof 90% were diagnosed with locally advanced stage IV. Tumor specimens were stained for MCT1 and MCT4 in the cell membrane by immunohistochemistry. Obtained data were evaluated with respect to overall (OS) and progression-free survival (PFS). Protein expression of MCT1 and MCT4 in cell membrane was detected in 16% and 85% of the tumors, respectively. Expression of both transporters was not statistically different according to the human papilloma virus (HPV) status. Positive staining for MCT1 (n = 13, negative in n = 69) strongly worsened PFS with a hazard ratio (HR) of 3.1 (95%-confidence interval 1.6–5.7, p < 0.001). OS was likewise affected with a HR of 3.8 (2.0–7.3, p < 0.001). Multivariable Cox regression confirmed these findings. We propose MCT1 as a promising biomarker in HNSCC treated by primary RCT."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.1038/s41598-021-84019-w"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85012"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","2045-2322"],["dc.relation.orgunit","Klinik für Strahlentherapie und Radioonkologie"],["dc.rights","CC BY 4.0"],["dc.title","Monocarboxylate transporter-1 (MCT1) protein expression in head and neck cancer affects clinical outcome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1997"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","European Archives of Oto-Rhino-Laryngology"],["dc.bibliographiccitation.lastpage","2004"],["dc.bibliographiccitation.volume","274"],["dc.contributor.author","Weiss, Bernhard G."],["dc.contributor.author","Ihler, Friedrich"],["dc.contributor.author","Pilavakis, Yiannis"],["dc.contributor.author","Wolff', Hendrik A."],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Welz, Christian"],["dc.contributor.author","Steiner, Wolfgang"],["dc.date.accessioned","2018-11-07T10:25:34Z"],["dc.date.available","2018-11-07T10:25:34Z"],["dc.date.issued","2017"],["dc.description.abstract","For the treatment of T1b glottic carcinoma, different treatment options, such as transoral laser microsurgery, open surgical techniques, and primary radiotherapy, are under discussion. In this context, the aim of the present study was to describe oncologic results and complication rates of transoral laser microsurgery in treatment of T1b glottic carcinoma. This is a retrospective unicenter chart review of patients treated at an academic tertiary referral center between 1986 and 2006. Fifty-one previously untreated T1b cases were exclusively treated by transoral laser microsurgery and included into this study, 47 were male, and 4 were female. The main outcome measures included local control rate and complications, overall, disease specific, and recurrence-free survival. The median follow-up period was 98 months. The 5-year local control rate was 90.2%; larynx preservation rate was 92.2%. No intra- or postoperative complications, such as wound infections, postoperative bleeding, hematoma, edema, and fistula development, were observed. A single patient required revision surgery due to synechia. Five-year survival rates were: overall 84.7%, disease specific 97.7%, and recurrence free 72.4%. Our data support the conclusion that transoral laser microsurgery is a considerable treatment option in T1b glottic carcinoma. The oncologic outcome was at least comparable to other treatment options, while the perioperative morbidity and complication rate were lower."],["dc.identifier.doi","10.1007/s00405-016-4432-4"],["dc.identifier.isi","000399177000028"],["dc.identifier.pmid","28028607"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42879"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Springer"],["dc.relation.issn","1434-4726"],["dc.relation.issn","0937-4477"],["dc.title","Transoral laser microsurgery for T1b glottic cancer: review of 51 cases"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2261"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Journal of Oral and Maxillofacial Surgery"],["dc.bibliographiccitation.lastpage","2269"],["dc.bibliographiccitation.volume","75"],["dc.contributor.author","Welz, Christian"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Schwenk-Zieger, Sabina"],["dc.contributor.author","Spiegel, Jennifer L."],["dc.contributor.author","Weiss, Bernhard G."],["dc.contributor.author","Pilavakis, Yiannis"],["dc.date.accessioned","2020-12-10T14:25:17Z"],["dc.date.available","2020-12-10T14:25:17Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1016/j.joms.2017.02.017"],["dc.identifier.issn","0278-2391"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72511"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Oral Cancer Reconstruction Using the Supraclavicular Artery Island Flap: Comparison to Free Radial Forearm Flap"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]