Schminke, Boris

[["dc.bibliographiccitation.artnumber","189"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Molecular and Clinical Oncology"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Hoene, Georg"],["dc.contributor.author","Gruber, Rudolf"],["dc.contributor.author","Leonhard, Johanna"],["dc.contributor.author","Wiechens, Bernhard"],["dc.contributor.author","Schminke, Boris"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Schliephake, Henning"],["dc.contributor.author","Brockmeyer, Phillipp"],["dc.date.accessioned","2021-08-12T07:46:07Z"],["dc.date.available","2021-08-12T07:46:07Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.3892/mco.2021.2351"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/88623"],["dc.notes.intern","DOI Import GROB-448"],["dc.relation.eissn","2049-9469"],["dc.relation.issn","2049-9450"],["dc.title","Combined quality of life and posttraumatic growth evaluation during follow‑up care of patients suffering from oral squamous cell carcinoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","194760352096706"],["dc.bibliographiccitation.journal","CARTILAGE"],["dc.contributor.author","Schminke, Boris"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Schubert, Andrea"],["dc.contributor.author","Altherr, Manuel"],["dc.contributor.author","Gelis, Thomas"],["dc.contributor.author","Miosge, Nicolai"],["dc.date.accessioned","2021-04-14T08:31:21Z"],["dc.date.available","2021-04-14T08:31:21Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1177/1947603520967069"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83568"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1947-6043"],["dc.relation.issn","1947-6035"],["dc.title","SMURF1 and SMURF2 in Progenitor Cells from Articular Cartilage and Meniscus during Late-Stage Osteoarthritis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1081"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Cellular and Molecular Life Sciences"],["dc.bibliographiccitation.lastpage","1096"],["dc.bibliographiccitation.volume","71"],["dc.contributor.author","Schminke, Boris"],["dc.contributor.author","Muhammad, Hayat"],["dc.contributor.author","Bode, Christa"],["dc.contributor.author","Sadowski, Boguslawa"],["dc.contributor.author","Gerter, Regina"],["dc.contributor.author","Gersdorff, Nikolaus"],["dc.contributor.author","Buergers, Ralf"],["dc.contributor.author","Monsonego-Ornan, Efrat"],["dc.contributor.author","Rosen, Vicki"],["dc.contributor.author","Miosge, Nicolai"],["dc.date.accessioned","2018-11-07T09:43:22Z"],["dc.date.available","2018-11-07T09:43:22Z"],["dc.date.issued","2014"],["dc.description.abstract","Discoidin domain receptor 1 (DDR-1)-deficient mice exhibited a high incidence of osteoarthritis (OA) in the temporomandibular joint (TMJ) as early as 9 weeks of age. They showed typical histological signs of OA, including surface fissures, loss of proteoglycans, chondrocyte cluster formation, collagen type I upregulation, and atypical collagen fibril arrangements. Chondrocytes isolated from the TMJs of DDR-1-deficient mice maintained their osteoarthritic characteristics when placed in culture. They expressed high levels of runx-2 and collagen type I, as well as low levels of sox-9 and aggrecan. The expression of DDR-2, a key factor in OA, was increased. DDR-1-deficient chondrocytes from the TMJ were positively influenced towards chondrogenesis by a three-dimensional matrix combined with a runx-2 knockdown or stimulation with extracellular matrix components, such as nidogen-2. Therefore, the DDR-1 knock-out mouse can serve as a novel model for temporomandibular disorders, such as OA of the TMJ, and will help to develop new treatment options, particularly those involving tissue regeneration."],["dc.identifier.doi","10.1007/s00018-013-1436-8"],["dc.identifier.isi","000331653900010"],["dc.identifier.pmid","23912900"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34171"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Basel"],["dc.relation.issn","1420-9071"],["dc.relation.issn","1420-682X"],["dc.title","A discoidin domain receptor 1 knock-out mouse as a novel model for osteoarthritis of the temporomandibular joint"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","410"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","The American Journal of Pathology"],["dc.bibliographiccitation.lastpage","418"],["dc.bibliographiccitation.volume","186"],["dc.contributor.author","Schminke, Boris"],["dc.contributor.author","Frese, Jenny"],["dc.contributor.author","Bode, Christa"],["dc.contributor.author","Goldring, Mary B."],["dc.contributor.author","Miosge, Nicolai"],["dc.date.accessioned","2018-08-20T09:58:00Z"],["dc.date.available","2018-08-20T09:58:00Z"],["dc.date.issued","2016"],["dc.description.abstract","The aim of this study was to investigate the role of laminins and nidogen-2 in osteoarthritis (OA) and their potential to support chondrogenic differentiation. We applied immunohistochemistry, electron microscopy, siRNA, quantitative RT-PCR, Western blot, and proteome analysis for the investigation of cartilage tissue and isolated chondrocytes in three-dimensional culture obtained from patients with late-stage knee OA and nidogen-2 knockout mice. We demonstrate that subunits of laminins appear in OA cartilage and that nidogen-2-null mice exhibit typical osteoarthritic features. Chondrogenic progenitor cells (CPCs) produced high levels of laminin-α1, laminin-α5, and nidogen-2 in their pericellular matrix, and laminin-α1 enhanced collagen type II and reduced collagen type I expression by cultured CPCs. Nidogen-2 increased SOX9 gene expression. Knockdown of nidogen-2 reduced SOX9 expression, whereas it up-regulated RUNX2 expression. This study reveals that the influence of the pericellular matrix on CPCs is important for the expression of the major regulator transcription factors, SOX9 and RUNX2. Our novel findings that laminins and nidogen-2 drive CPCs toward chondrogenesis may help in the elucidation of new treatment strategies for cartilage tissue regeneration."],["dc.identifier.doi","10.1016/j.ajpath.2015.10.014"],["dc.identifier.pmid","26683663"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15413"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1525-2191"],["dc.title","Laminins and Nidogens in the Pericellular Matrix of Chondrocytes: Their Role in Osteoarthritis and Chondrogenic Differentiation"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","216"],["dc.bibliographiccitation.journal","Archives of Oral Biology"],["dc.bibliographiccitation.lastpage","222"],["dc.bibliographiccitation.volume","82"],["dc.contributor.author","Schubert, Andrea"],["dc.contributor.author","Schminke, Boris"],["dc.contributor.author","Miosge, Nicolai"],["dc.date.accessioned","2018-08-20T09:31:36Z"],["dc.date.available","2018-08-20T09:31:36Z"],["dc.date.issued","2017"],["dc.description.abstract","Periodontitis refers to inflammatory disease of the periodontal structures (the gingiva, dental cementum, periodontal ligament (PDL) and alveolar bone) that ultimately leads to their destruction. Whereas collagens are well-examined main components of the periodontium, little is known about the other structural proteins that make up this tissue. The aim of this study was to identify new extracellular matrix (ECM) components, including fibulins and matrilins, in the periodontium of mice. After sacrificing 14 mice (Sv/129 strain), jaws were prepared. Each tissue sample contained a molar and its surrounding alveolar bone. Immunohistochemistry was carried out on paraffin-embedded sections. Our results show that mice exhibit fibulin-3, -4 and -5 and matrilin-1, -2, -3 and -4 in PDL and in blood vessels of alveolar bone and PDL as well as in the pericellular matrix of osteocytes and cementocytes. In dental cementum, only fibulin-4 is expressed. For the first time, we show that fibulin-3, -4 and -5 and matrilin-1, -2, -3 and -4 are essential components of the periodontal tissues. Our findings indicate an association of these proteins with collagens and oxytalan fibers that might be of future interest in regenerative periodontitis therapy."],["dc.identifier.doi","10.1016/j.archoralbio.2017.06.008"],["dc.identifier.pmid","28654783"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16485"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15410"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.eissn","1879-1506"],["dc.relation.eissn","0003-9969"],["dc.rights","CC BY-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nd/4.0"],["dc.title","Fibulins and matrilins are novel structural components of the periodontium in the mouse"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","111"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Archives of Orthopaedic and Trauma Surgery"],["dc.bibliographiccitation.lastpage","118"],["dc.bibliographiccitation.volume","135"],["dc.contributor.author","Baums, M. H."],["dc.contributor.author","Schminke, B."],["dc.contributor.author","Posmyk, A."],["dc.contributor.author","Miosge, N."],["dc.contributor.author","Klinger, H.-M."],["dc.contributor.author","Lakemeier, S."],["dc.date.accessioned","2018-08-20T12:33:19Z"],["dc.date.available","2018-08-20T12:33:19Z"],["dc.date.issued","2015"],["dc.description.abstract","The clinical superiority of the double-row technique is still a subject of controversial debate in rotator cuff repair. We hypothesised that the expression of different collagen types will differ between double-row and single-row rotator cuff repair indicating a faster healing response by the double-row technique."],["dc.identifier.doi","10.1007/s00402-014-2118-1"],["dc.identifier.pmid","25416099"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15438"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1434-3916"],["dc.relation.eissn","0936-8051"],["dc.title","Effect of single- and double-row rotator cuff repair at the tendon-to-bone interface"],["dc.title.subtitle","Preliminary results using an in vivo sheep model"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","461"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Current Rheumatology Reports"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Schminke, Boris"],["dc.contributor.author","Miosge, Nicolai"],["dc.date.accessioned","2018-08-20T10:23:54Z"],["dc.date.available","2018-08-20T10:23:54Z"],["dc.date.issued","2014"],["dc.description.abstract","The most common diseases of the joints and its tissues are osteoarthritis and rheumatoid arthritis, with osteoarthritis being anticipated to be the fourth leading cause of disability by the year 2020. To date, no truly causal therapies are available, and this has promoted tissue engineering attempts mainly involving mesenchymal stem cells. The goal of all tissue repairs would be to restore a fully functional tissue, here a hyaline articular cartilage. The hyaline cartilage is the most affected in osteoarthritis, where altered cell-matrix interactions gradually destroy tissue integrity. In rheumatoid arthritis, the inflammatory aspect is more important, and the cartilage tissue is destroyed by the invasion of tumor-like pannus tissue arising from the inflamed synovia. Furthermore, the fibrocartilage of the meniscus is clearly involved in the initiation of osteoarthritis, especially after trauma. Recent investigations have highlighted the role of migratory progenitor cells found in diseased tissues in situ. In osteoarthritis and rheumatoid arthritis, these chondrogenic progenitor cells are involved in regeneration efforts that are largely unsuccessful in diseased cartilage tissue. However, these progenitor cells are interesting targets for a cell-based regenerative therapy for joint diseases."],["dc.identifier.doi","10.1007/s11926-014-0461-4"],["dc.identifier.pmid","25240685"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15415"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1534-6307"],["dc.relation.eissn","1523-3774"],["dc.relation.eissn","1534-6307"],["dc.title","Cartilage Repair In Vivo"],["dc.title.subtitle","The Role of Migratory Progenitor Cells"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","18"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Maxillofacial Plastic and Reconstructive Surgery"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Cordesmeyer, Robert"],["dc.contributor.author","Fouellefack, Giséle Awondzeko"],["dc.contributor.author","Schminke, Boris"],["dc.contributor.author","Wiese, Karl-Günther"],["dc.date.accessioned","2019-07-09T11:45:43Z"],["dc.date.available","2019-07-09T11:45:43Z"],["dc.date.issued","2018"],["dc.description.abstract","Background: Clefts in newborns are associated with severe morphological and functional impairment. Especially the lip is of importance as if the treatment result is unsatisfactory, it can lead to psychological changes in the patient. Different operative procedures have been developed over the last decades. The aim of the presented study was the comparison of the surgical techniques according to Millard and Pfeifer regarding the temporal development of the postoperative symmetry of the lip height and mouth width. Methods: Digitized photographs of patients from the department of oral and maxillofacial surgery at the University of Göttingen were evaluated from 1979 to 1996. With a video analysis program, the lip height and mouth width were analyzed regarding the symmetry. We demonstrated the symmetry values over a period of 8 years in order to show the influence of growth on postoperative results. Results: The development of the vertical symmetry of the Philtrum and the lip vermillion on the cleft side in comparison to the healthy side behaves differently depending on Pfeifer and Millard. The lip height of the cleft lip was shorter in both techniques than on the healthy side, but Pfeifer's difference was significantly more pronounced. The lip vermillion height on the cleft side was slightly shorter in the Millard group and markedly larger in the Pfeifer group. Both techniques can achieve good symmetry results for the vertical dimension of the lip. According to Pfeifer, the development of the horizontal dimension on the cleft side is bigger within the first 4 years than on the healthy side; according to the Millard technique, the horizontal development is smaller. These differences are greater within the first 6 years and approach between the 6th and 8th year. Conclusions: The Millard technique demonstrates better results concerning the philtrum and vermillion symmetry during growth within the first 6 years. Over the whole study period, growth corrects the philtrum and vermillion symmetry within the Pfeifer group."],["dc.identifier.doi","10.1186/s40902-018-0157-1"],["dc.identifier.pmid","30105221"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15255"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59294"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","In goescholar not merged with http://resolver.sub.uni-goettingen.de/purl?gs-1/15294 but duplicate"],["dc.relation.issn","2288-8101"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)."],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Postoperative long-term results for the comparison of the symmetry of the upper lip during lip closure according to Millard and Pfeifer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","541"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Expert Opinion on Biological Therapy"],["dc.bibliographiccitation.lastpage","548"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Muhammad, Hayat"],["dc.contributor.author","Schminke, Boris"],["dc.contributor.author","Miosge, Nicolai"],["dc.date.accessioned","2018-11-07T09:26:49Z"],["dc.date.available","2018-11-07T09:26:49Z"],["dc.date.issued","2013"],["dc.description.abstract","Introduction: Hyaline articular cartilage is the connective tissue responsible for frictionless joint movement. Its degeneration ultimately results in complete loss of joint function in the late stages of osteoarthritis. Intrinsic repair is compromised, and cartilage tissue regeneration is difficult. However, new options are available to repair cartilage tissue by applying ESCs, MSCs and CPCs. Areas covered: In this review, the authors shed light on the different concepts currently under investigation for cartilage repair. Expert opinion: So far, there is no way to derive a chondrogenic lineage from stem cells that forms functional hyaline cartilage tissue in vivo. One alternative might be to enhance the chondrogenic potential of repair cells, which are already present in diseased cartilage tissue. CPCs found in diseased cartilage tissue in situ are biologically driven toward the osteochondrogenic lineage and can be directed toward chondrogenesis at least in vitro."],["dc.description.sponsorship","DFG"],["dc.identifier.doi","10.1517/14712598.2013.758707"],["dc.identifier.isi","000316069200008"],["dc.identifier.pmid","23320740"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30387"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Informa Healthcare"],["dc.relation.issn","1471-2598"],["dc.title","Current concepts in stem cell therapy for articular cartilage repair"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","238"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Cranio-Maxillofacial Surgery"],["dc.bibliographiccitation.lastpage","245"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Böhrnsen, Florian"],["dc.contributor.author","Melsheimer, Petra"],["dc.contributor.author","Natorp, Mareike"],["dc.contributor.author","Rolf, Hans"],["dc.contributor.author","Schminke, Boris"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Wolfer, Susanne"],["dc.contributor.author","Schliephake, Henning"],["dc.date.accessioned","2021-04-14T08:28:56Z"],["dc.date.available","2021-04-14T08:28:56Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1016/j.jcms.2020.03.001"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82745"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.issn","1010-5182"],["dc.title","Cotransplantation of mesenchymal stromal cells and endothelial cells on calcium carbonate and hydroxylapatite scaffolds in vivo"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]