Beisiegel, Ulrike

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[["dc.contributor.author","Beisiegel, Ulrike"],["dc.contributor.author","Klein, Joachim"],["dc.contributor.author","Krull, Wilhelm"],["dc.contributor.author","Litfin, Gerd"],["dc.date.accessioned","2021-07-08T13:49:54Z"],["dc.date.available","2021-07-08T13:49:54Z"],["dc.date.issued","2011-02-01"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/88037"],["dc.relation.conference","Vom Nutzen des Nutzlosen: Vom Spiel zum Produkt"],["dc.relation.date","2011-02-01"],["dc.relation.eventlocation","Göttingen"],["dc.relation.multimedia","https://goedoc.uni-goettingen.de/docs/audio/ring2011-02-01.mp3"],["dc.title","Wissenschaftlicher Fortschritt: Kreativität braucht Raum und Zeit (mit anschließender Podiumsdiskussion)"],["dc.type","lecture"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

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[["dc.bibliographiccitation.firstpage","150"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Neurobiology of Disease"],["dc.bibliographiccitation.lastpage","156"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Arlt, Soenke"],["dc.contributor.author","Kontush, A."],["dc.contributor.author","Zerr, I."],["dc.contributor.author","Buhmann, Carsten"],["dc.contributor.author","Jacobi, C."],["dc.contributor.author","Schroter, A."],["dc.contributor.author","Poser, Sigrid"],["dc.contributor.author","Beisiegel, U."],["dc.date.accessioned","2018-11-07T10:23:28Z"],["dc.date.available","2018-11-07T10:23:28Z"],["dc.date.issued","2002"],["dc.description.abstract","Oxidative pathomechanisms play an important role in neurodegenerative diseases like Alzheimer's disease (AD). It has been shown that lipid peroxidation in cerebrospinal fluid (CSF) and plasma is increased in AD. To assess the role of oxidative stress in Creutzfeldt-Jakob disease (CJD), we investigated the oxidizability of lipids, the lipid composition and the levels of the antioxidants ascorbate and alpha-tocopherol in CSF and plasma of 15 CJD patients and 12 neurologically healthy controls. CSF and plasma lipid peroxidation was increased in CJD patients and polyunsaturated fatty acids were reduced in CSF of these patients. Ascorbate levels were lower in CSF and plasma of CJD patients, while alpha-tocopherol was found to be decreased in CSF but not in plasma. These results support the hypothesis that oxidative mechanisms are involved in the pathogenesis of CJD and provide a rationale for the use of antioxidants in the therapy of this disease. (C) 2002 Elsevier Science (USA)."],["dc.identifier.doi","10.1006/nbdi.2002.0496"],["dc.identifier.isi","000177049700008"],["dc.identifier.pmid","12127153"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42460"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","0969-9961"],["dc.title","Increased lipid peroxidation in cerebrospinal fluid and plasma from patients with Creutzfeldt-Jakob disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","187"],["dc.bibliographiccitation.lastpage","218"],["dc.bibliographiccitation.seriesnr","83"],["dc.contributor.author","Niendorf, A."],["dc.contributor.author","Beisiegel, Ulrike"],["dc.contributor.editor","Seifert, G."],["dc.date.accessioned","2019-07-19T07:59:16Z"],["dc.date.available","2019-07-19T07:59:16Z"],["dc.date.issued","1991"],["dc.description.abstract","The origins of the receptor theory are based on the work of Paul Ehrlich (1854–1915) and John Newport Langley (1852–1925) (Parascandola 1981), who were the first to postulate that specific cellular reactions to drugs must be based on so-called receptive substances. Receptors are proteins that specifically bind and take up hormones, growth factors, transport proteins, viruses, and toxins. The understanding of the physiological effects that are caused by certain ligands depends to a considerable extent on knowledge of where the target cells are located and how they interact with their ligands. In Chap. 4 of this book, M. Dietel reviews the different locations of cell receptors with special reference to morphological and biochemical aspects. This chapter focuses on specific receptors for low-density lipoproteins (LDL)."],["dc.identifier.doi","10.1007/978-3-642-75515-6_8"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61753"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.publisher","Springer"],["dc.publisher.place","Berlin"],["dc.relation.crisseries","Current Topics in Pathology"],["dc.relation.doi","10.1007/978-3-642-75515-6"],["dc.relation.eisbn","978-3-642-75515-6"],["dc.relation.isbn","978-3-642-75517-0"],["dc.relation.ispartof","Cell Receptors: Morphological Characterization and Pathological Aspects"],["dc.relation.ispartofseries","Current Topics in Pathology;83"],["dc.relation.issn","0070-2188"],["dc.title","Low-Density Lipoprotein Receptors"],["dc.type","book_chapter"],["dc.type.internalPublication","no"],["dspace.entity.type","Publication"]]