Cordes, Andrea

[["dc.bibliographiccitation.firstpage","2710"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Biophysical Journal"],["dc.bibliographiccitation.lastpage","2719"],["dc.bibliographiccitation.volume","110"],["dc.contributor.author","Shabardina, Victoria"],["dc.contributor.author","Kramer, Corinna"],["dc.contributor.author","Gerdes, Benjamin"],["dc.contributor.author","Braunger, Julia A."],["dc.contributor.author","Cordes, Andrea"],["dc.contributor.author","Schäfer, Jonas"],["dc.contributor.author","Mey, Ingo"],["dc.contributor.author","Grill, David"],["dc.contributor.author","Gerke, Volker"],["dc.contributor.author","Steinem, Claudia"],["dc.date.accessioned","2017-09-07T11:44:51Z"],["dc.date.available","2017-09-07T11:44:51Z"],["dc.date.issued","2016"],["dc.description.abstract","Ezrin, a protein of the ezrin, radixin, moesin (ERM) family, provides a regulated linkage between the plasma membrane and the cytoskeleton. The hallmark of this linkage is the activation of ezrin by phosphatidylinositol-4,5-bisphosphate (PIP2) binding and a threonine phosphorylation at position 567. To analyze the influence of these activating factors on the organization of ezrin on lipid membranes and the proposed concomitant oligomer-monomer transition, we made use of supported lipid bilayers in conjunction with atomic force microscopy and fluorescence microscopy. Bilayers doped with either PIP2 as the natural receptor lipid of ezrin or a Ni-nitrilotriacetic acid-equipped lipid to bind the proteins via their His6-tags to the lipid membrane were used to bind two different ezrin variants: ezrin wild-type and ezrin T567D mimicking the phosphorylated state. Using a combination of reflectometric interference spectroscopy, atomic force microscopy, and Forster resonance energy transfer experiments, we show that only the ezrin T567D mutant, upon binding to PIP2-containing bilayers, undergoes a remarkable conformational change, which we attribute to an opening of the conformation resulting in monomeric protein on the lipid bilayer."],["dc.identifier.doi","10.1016/j.bpj.2016.05.009"],["dc.identifier.gro","3141663"],["dc.identifier.isi","000378383300018"],["dc.identifier.pmid","27332129"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/6786"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1542-0086"],["dc.relation.issn","0006-3495"],["dc.title","Mode of Ezrin-Membrane Interaction as a Function of PIP2 Binding and Pseudophosphorylation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","248"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Psychosomatics"],["dc.bibliographiccitation.lastpage","256"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Meyer, Thomas"],["dc.contributor.author","Stanske, Beate"],["dc.contributor.author","Kochen, Michael M."],["dc.contributor.author","Cordes, Andreas"],["dc.contributor.author","Yüksel, Iraz"],["dc.contributor.author","Wachter, Rolf"],["dc.contributor.author","Lüers, Claus"],["dc.contributor.author","Scherer, Martin"],["dc.contributor.author","Binder, Lutz"],["dc.contributor.author","Pieske, Burkert"],["dc.contributor.author","Herrmann-Lingen, Christoph"],["dc.date.accessioned","2019-07-09T11:52:56Z"],["dc.date.available","2019-07-09T11:52:56Z"],["dc.date.issued","2010"],["dc.description.abstract","BACKGROUND: Vital exhaustion, a psychological state characterized by unusual fatigue, irritability, and feelings of demoralization, has been identified as a risk factor for cardiovascular diseases and linked to elevated levels of pro-inflammatory cytokines. OBJECTIVE: The purpose of this study was to investigate the relationship between vital exhaustion and cytokine levels in patients with cardiovascular risk factors. METHOD: The entire cohort consisted of 356 primary-care patients with cardiovascular risk factors who participated in a study of early recognition of heart failure. All participants completed the Maastricht questionnaire (MQ) for assessing vital exhaustion. Cytokine serum levels were measured in all those subjects (N=178) who were assigned to the highest and lowest quartiles of the MQ, respectively. RESULTS: We found that elevated serum concentrations of IL-6, TNFα, and IL-10, but not IL-1β or natriuretic peptides were associated with high MQ scores indicative of vital exhaustion. Using logistic regression analyses controlling for clinical variables and Type D personality, both TNFα (multivariate odds ratio [OR] =1.86; 95%-confidence interval [CI] =1.30-2.68; p=0.001) and IL-10(OR=1.62; 95%-CI=1.15-2.28; p=0.006), but not other cytokines significantly predicted vital exhaustion independently of other clinical and laboratory parameters examined [corrected]. CONCLUSION: The subjective state of vital exhaustion is linked to a substantial alteration in the pattern of secreted cytokines. Data suggest that a disturbance in the levels of both pro-inflammatory and anti-inflammatory mediators, rather than isolated stimulation by pro-inflammatory cytokines, is associated with the mental and physical changes of vital exhaustion."],["dc.identifier.doi","10.1176/appi.psy.51.3.248"],["dc.identifier.fs","573439"],["dc.identifier.pmid","20484723"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6169"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60303"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1545-7206"],["dc.relation.orgunit","Institut für Allgemeinmedizin"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.subject.mesh","Aged"],["dc.subject.mesh","Austria"],["dc.subject.mesh","Cardiovascular Diseases"],["dc.subject.mesh","Cohort Studies"],["dc.subject.mesh","Coronary Disease"],["dc.subject.mesh","Fatigue"],["dc.subject.mesh","Female"],["dc.subject.mesh","Heart Failure"],["dc.subject.mesh","Humans"],["dc.subject.mesh","Interleukin-10"],["dc.subject.mesh","Interleukin-6"],["dc.subject.mesh","Irritable Mood"],["dc.subject.mesh","Male"],["dc.subject.mesh","Middle Aged"],["dc.subject.mesh","Morale"],["dc.subject.mesh","Personality Inventory"],["dc.subject.mesh","Primary Health Care"],["dc.subject.mesh","Psychometrics"],["dc.subject.mesh","Risk Factors"],["dc.subject.mesh","Tumor Necrosis Factor-alpha"],["dc.title","Elevated serum levels of interleukin-10 and tumor necrosis factor α [corrected] are both associated with vital exhaustion in patients with cardiovascular risk factors."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","105"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Behavioral Medicine"],["dc.bibliographiccitation.lastpage","112"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Meyer, Thomas"],["dc.contributor.author","Stanske, Beate"],["dc.contributor.author","Kochen, Michael M."],["dc.contributor.author","Cordes, Andreas"],["dc.contributor.author","Yueksel, Iraz"],["dc.contributor.author","Wachter, R. Rolf"],["dc.contributor.author","Lueers, Claus"],["dc.contributor.author","Scherer, Martin"],["dc.contributor.author","Binder, Lutz"],["dc.contributor.author","Pieske, Burkert M."],["dc.contributor.author","Herrmann-Lingen, Christoph"],["dc.date.accessioned","2018-11-07T09:00:16Z"],["dc.date.available","2018-11-07T09:00:16Z"],["dc.date.issued","2011"],["dc.description.abstract","It is currently unknown whether elevated cytokine levels in depression are confined to any specific subgroup of depressive patients. In this study, medical out-patients presenting with cardiovascular risk factors (N = 356) were assessed for both cognitive-affective and physical symptoms of depression using the Hospital Anxiety and Depression Scale (HADS) and the Maastricht questionnaire (MQ), respectively. In study participants assigned to the highest (>= 21) and lowest (<= 5) quartile for the MQ score, serum levels of cytokines were measured. We found highly significant associations between cognitive-affective symptoms of depression and elevated serum levels of interleukin-6 (IL-6; rho = .231; p = .002) and interleukin-10 (IL-10; rho = .370; p < .001), respectively. In multiple regression models elevated IL-10 serum concentration was independently related to cognitive-affective symptoms of depression (rho = .165; p = .002). When all cytokines were included in one model, elevated IL-10 serum concentrations remained a significant predictor for depressive mood (rho = .157; p = .009). In patients with cardiovascular risk factors and extreme scores for vital exhaustion, elevated serum IL-6 and even more IL-10 concentrations are linked to the presence of depressive mood. Future studies will have to test whether the so far unreported association of IL-10 with depressive mood represents a causal pathway involved in the pathogenesis or in the prognostic effect of depressive mood in cardiac patients."],["dc.identifier.doi","10.1080/08964289.2011.609192"],["dc.identifier.isi","000299995600006"],["dc.identifier.pmid","21895428"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24115"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0896-4289"],["dc.relation.orgunit","Institut für Allgemeinmedizin"],["dc.title","Serum Levels of Interleukin-6 and Interleukin-10 in Relation to Depression Scores in Patients with Cardiovascular Risk Factors"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Anticancer Research"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Salehin, D."],["dc.contributor.author","Hemmerlein, Bernhard"],["dc.contributor.author","Thill, M."],["dc.contributor.author","Cordes, T."],["dc.contributor.author","Friedrich, M."],["dc.date.accessioned","2018-11-07T08:57:13Z"],["dc.date.available","2018-11-07T08:57:13Z"],["dc.date.issued","2011"],["dc.format.extent","1494"],["dc.identifier.isi","000290292000067"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23341"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Int Inst Anticancer Research"],["dc.publisher.place","Athens"],["dc.relation.issn","0250-7005"],["dc.title","EXPRESSION OF VITAMIN D RECEPTOR IN SQUAMOUS EPITHELIAL VULVAR CANCER AND VULVAR INTRAEPITHELIAL NEOPLASIA"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","6277"],["dc.bibliographiccitation.journal","Science"],["dc.bibliographiccitation.volume","351"],["dc.contributor.author","Anderson, Christopher J."],["dc.contributor.author","Bahnik, Stepan"],["dc.contributor.author","Barnett-Cowan, Michael"],["dc.contributor.author","Bosco, Frank A."],["dc.contributor.author","Chandler, Jesse"],["dc.contributor.author","Chartier, Christopher R."],["dc.contributor.author","Cheung, Felix"],["dc.contributor.author","Christopherson, Cody D."],["dc.contributor.author","Cordes, Andreas"],["dc.contributor.author","Cremata, Edward J."],["dc.contributor.author","Della Penna, Nicolas"],["dc.contributor.author","Estel, Vivien"],["dc.contributor.author","Fedor, Anna"],["dc.contributor.author","Fitneva, Stanka A."],["dc.contributor.author","Frank, Michael C."],["dc.contributor.author","Grange, James A."],["dc.contributor.author","Hartshorne, Joshua K."],["dc.contributor.author","Hasselman, Fred"],["dc.contributor.author","Henninger, Felix"],["dc.contributor.author","van der Hulst, Marije"],["dc.contributor.author","Jonas, Kai J."],["dc.contributor.author","Lai, Calvin K."],["dc.contributor.author","Levitan, Carmel A."],["dc.contributor.author","Miller, Jeremy K."],["dc.contributor.author","Moore, Katherine S."],["dc.contributor.author","Meixner, Johannes M."],["dc.contributor.author","Munafo, Marcus R."],["dc.contributor.author","Neijenhuijs, Koen I."],["dc.contributor.author","Nilsonne, Gustav"],["dc.contributor.author","Nosek, Brian A."],["dc.contributor.author","Plessow, Franziska"],["dc.contributor.author","Prenoveau, Jason M."],["dc.contributor.author","Ricker, Ashley A."],["dc.contributor.author","Schmidt, Kathleen"],["dc.contributor.author","Spies, Jeffrey R."],["dc.contributor.author","Stieger, Stefan"],["dc.contributor.author","Strohminger, Nina"],["dc.contributor.author","Sullivan, Gavin B."],["dc.contributor.author","van Aert, Robbie C. M."],["dc.contributor.author","van Assen, Marcel A. L. M."],["dc.contributor.author","Vanpaemel, Wolf"],["dc.contributor.author","Vianello, Michelangelo"],["dc.contributor.author","Voracek, Martin"],["dc.contributor.author","Zuni, Kellylynn"],["dc.date.accessioned","2018-11-07T10:16:58Z"],["dc.date.available","2018-11-07T10:16:58Z"],["dc.date.issued","2016"],["dc.description.abstract","Gilbert et al. conclude that evidence from the Open Science Collaboration's Reproducibility Project: Psychology indicates high reproducibility, given the study methodology. Their very optimistic assessment is limited by statistical misconceptions and by causal inferences from selectively interpreted, correlational data. Using the Reproducibility Project: Psychology data, both optimistic and pessimistic conclusions about reproducibility are possible, and neither are yet warranted."],["dc.identifier.doi","10.1126/science.aad9163"],["dc.identifier.isi","000371597500031"],["dc.identifier.pmid","26941312"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41141"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Assoc Advancement Science"],["dc.relation.issn","1095-9203"],["dc.relation.issn","0036-8075"],["dc.title","Response to Comment on \"Estimating the reproducibility of psychological science\""],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","6424"],["dc.bibliographiccitation.issue","27"],["dc.bibliographiccitation.journal","Soft Matter"],["dc.bibliographiccitation.lastpage","6433"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Witt, Hannes"],["dc.contributor.author","Vache, Marian"],["dc.contributor.author","Cordes, Andrea"],["dc.contributor.author","Janshoff, Andreas"],["dc.date.accessioned","2022-03-01T11:46:13Z"],["dc.date.available","2022-03-01T11:46:13Z"],["dc.date.issued","2020"],["dc.description.abstract","We combine detachment experiments of giant unilamellar vesicles (GUVs) and membrane coated glass beads with theoretical considerations to study the impact of receptor mobility of adhesive glycolipids."],["dc.description.abstract","Cellular adhesion is an intricate physical process controlled by ligand–receptor affinity, density, mobility, and external forces transmitted through the elastic properties of the cell. As a model for cellular adhesion we study the detachment of cell-sized liposomes and membrane-coated silica beads from supported bilayers using atomic force microscopy. Adhesion between the two surfaces is mediated by the interaction between the adhesive lipid anchored saccharides lactosylceramide and the ganglioside G M3 . We found that force–distance curves of liposome detachment have a very peculiar, partially concave shape, reminiscent of the nonlinear extension of polymers. By contrast, detachment of membrane coated beads led to force–distance curves similar to the detachment of living cells. Theoretical modelling of the enforced detachment suggests that the non-convex force curve shape arises from the mobility of ligands provoking a switch of shapes from spherical to unduloidal during detachment."],["dc.description.abstract","We combine detachment experiments of giant unilamellar vesicles (GUVs) and membrane coated glass beads with theoretical considerations to study the impact of receptor mobility of adhesive glycolipids."],["dc.description.abstract","Cellular adhesion is an intricate physical process controlled by ligand–receptor affinity, density, mobility, and external forces transmitted through the elastic properties of the cell. As a model for cellular adhesion we study the detachment of cell-sized liposomes and membrane-coated silica beads from supported bilayers using atomic force microscopy. Adhesion between the two surfaces is mediated by the interaction between the adhesive lipid anchored saccharides lactosylceramide and the ganglioside G M3 . We found that force–distance curves of liposome detachment have a very peculiar, partially concave shape, reminiscent of the nonlinear extension of polymers. By contrast, detachment of membrane coated beads led to force–distance curves similar to the detachment of living cells. Theoretical modelling of the enforced detachment suggests that the non-convex force curve shape arises from the mobility of ligands provoking a switch of shapes from spherical to unduloidal during detachment."],["dc.identifier.doi","10.1039/D0SM00863J"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103598"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1744-6848"],["dc.relation.issn","1744-683X"],["dc.rights.uri","http://creativecommons.org/licenses/by-nc/3.0/"],["dc.title","Detachment of giant liposomes – coupling of receptor mobility and membrane shape"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Cordes, Andrea"],["dc.contributor.author","Witt, Hannes"],["dc.contributor.author","Gallemí-Pérez, Aina"],["dc.contributor.author","Brückner, Bastian"],["dc.contributor.author","Grimm, Florian"],["dc.contributor.author","Vache, Marian"],["dc.contributor.author","Oswald, Tabea"],["dc.contributor.author","Flormann, Daniel"],["dc.contributor.author","Lautenschläger, Franziska"],["dc.contributor.author","Tarantola, Marco"],["dc.contributor.author","Janshoff, Andreas"],["dc.date.accessioned","2020-11-05T15:08:11Z"],["dc.date.available","2020-11-05T15:08:11Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1101/783613"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/68483"],["dc.notes.intern","DOI Import GROB-352.7"],["dc.title","Pre-stress of actin cortices is important for the viscoelastic response of living cells"],["dc.type","preprint"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Physical Review Letters"],["dc.bibliographiccitation.volume","125"],["dc.contributor.author","Cordes, Andrea"],["dc.contributor.author","Witt, Hannes"],["dc.contributor.author","Gallemí-Pérez, Aina"],["dc.contributor.author","Brückner, Bastian"],["dc.contributor.author","Grimm, Florian"],["dc.contributor.author","Vache, Marian"],["dc.contributor.author","Oswald, Tabea"],["dc.contributor.author","Bodenschatz, Jonathan"],["dc.contributor.author","Flormann, Daniel"],["dc.contributor.author","Lautenschläger, Franziska"],["dc.contributor.author","Tarantola, Marco"],["dc.contributor.author","Janshoff, Andreas"],["dc.date.accessioned","2020-11-05T15:08:09Z"],["dc.date.available","2020-11-05T15:08:09Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1103/PhysRevLett.125.068101"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/68476"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-352.7"],["dc.relation.eissn","1079-7114"],["dc.relation.issn","0031-9007"],["dc.title","Prestress and Area Compressibility of Actin Cortices Determine the Viscoelastic Response of Living Cells"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","The Thoracic and Cardiovascular Surgeon"],["dc.contributor.author","Lehrke, Jan"],["dc.contributor.author","Boos, Margarete"],["dc.contributor.author","Cordes, Andreas"],["dc.contributor.author","Leitsmann, Conrad"],["dc.contributor.author","Friedrich, Martin"],["dc.date.accessioned","2022-04-01T10:02:45Z"],["dc.date.available","2022-04-01T10:02:45Z"],["dc.date.issued","2022"],["dc.description.abstract","Abstract Background Noise in operating theaters (OT) exceeds safety standards with detrimental effects on the health and performance of OT crews as well as patient safety. One of the reasons for these effects is the stress response to noise, which could be minimized by the Silent Operating Theater Optimisation System (SOTOS), a noise-reductive headset solution. Methods This study evaluates the effects of the SOTOS on the stress perceived by OT crew members, operationalized through stress level and exhaustion. Twenty-one heart surgeries and 32 robot-assisted prostatectomies at the University Medical Center Goettingen, Germany were examined. Twenty-six surgeries were conducted with and 27 without the SOTOS. The SOTOS-effect is defined as a more beneficial stress course from before to after surgery, when comparing the experimental group with and control group without SOTOS. Findings Eighty-one OT workers were investigated. The linear multilevel models revealed significant interactions between treatment and time of measurement on stress level (F[1, 406.66] = 3.62, p = 0.029) and exhaustion (F[1, 397.62] = 13.12, p = 0.00017). Nevertheless, there was no a significant main effect of surgery type on stress level (F[1, 82.69] = 1.00, p = 0.32) or on exhaustion (F[1, 80.61] = 0.58, p = 0.45). Additionally, no significant three-way interaction including surgery type, for stress level (F[1, 406.66] = 0.32, p = 0.29) or exhaustion (F[1, 397.62] = 0.03, p = 0.43), was found. Interpretation An SOTOS-effect was confirmed: the development of stress over the course of an operation was beneficially modified by the SOTOS. Both surgery types are perceived as similarly stressful, and the staff benefits equally strongly from the intervention in both settings."],["dc.identifier.doi","10.1055/s-0041-1741059"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/105998"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","1439-1902"],["dc.relation.issn","0171-6425"],["dc.title","Effects of a Technical Solution on Stress of Surgical Staff in Operating Theatres"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]