Carstens, Per-Ole

[["dc.bibliographiccitation.artnumber","e327"],["dc.bibliographiccitation.firstpage","e327"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Neurology Genetics"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Carstens, Per-Ole"],["dc.contributor.author","Schwaibold, Eva Maria Christina"],["dc.contributor.author","Schregel, Katharina"],["dc.contributor.author","Obermaier, Carolin D."],["dc.contributor.author","Wrede, Arne"],["dc.contributor.author","Zechel, Sabrina"],["dc.contributor.author","Pauli, Silke"],["dc.contributor.author","Schmidt, Jens"],["dc.date.accessioned","2020-12-10T18:41:40Z"],["dc.date.available","2020-12-10T18:41:40Z"],["dc.date.issued","2019"],["dc.description.abstract","X-linked myotubular myopathy (XLMTM) is a rare hereditary disorder of the skeletal muscle. Symptoms include impaired respiration and muscular hypotonia, usually present at birth and leading to death during infancy or early childhood.1 Pneumothorax, defined as trapping of air in the pleural cavity, can be caused by surgery or can occur spontaneously.2 Pneumothorax has been reported only in a small number of cases with hereditary myopathies, but usually not spontaneously and never in XLMTM."],["dc.identifier.doi","10.1212/NXG.0000000000000327"],["dc.identifier.eissn","2376-7839"],["dc.identifier.pmid","31192301"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16079"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77643"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2376-7839"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","X-linked myotubular myopathy and recurrent spontaneous pneumothorax: A new phenotype?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2739"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Cancer Research"],["dc.bibliographiccitation.lastpage","2748"],["dc.bibliographiccitation.volume","70"],["dc.contributor.author","Nitzki, Frauke"],["dc.contributor.author","Zibat, Arne"],["dc.contributor.author","Koenig, Simone"],["dc.contributor.author","Wijgerde, Mark"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Brembeck, Felix H."],["dc.contributor.author","Carstens, Per-Ole"],["dc.contributor.author","Frommhold, Anke"],["dc.contributor.author","Uhmann, Anja"],["dc.contributor.author","Klingler, Stefan"],["dc.contributor.author","Reifenberger, Julia"],["dc.contributor.author","Pukrop, Tobias"],["dc.contributor.author","Aberger, Fritz"],["dc.contributor.author","Schulz-Schaeffer, Walter J."],["dc.contributor.author","Hahn, Heidi"],["dc.date.accessioned","2018-11-07T08:44:23Z"],["dc.date.available","2018-11-07T08:44:23Z"],["dc.date.issued","2010"],["dc.description.abstract","Basal cell carcinoma (BCC) is the most common skin tumor in humans. Although BCCs rarely metastasize, they can cause significant morbidity due to local aggressiveness. Approximately 20% of BCCs show signs of spontaneous regression. The understanding of molecular events mediating spontaneous regression has the potential to reduce morbidity of BCC and, potentially, other tumors, if translated into tumor therapies. We show that BCCs induced in conditional Ptch(flox/flox)ERT(2+/-) knockout mice regress with time and show a more differentiated phenotype. Differentiation is accompanied by Wnt5a expression in the tumor stroma, which is first detectable at the fully developed tumor stage. Coculture experiments revealed that Wnt5a is upregulated in tumor-adjacent macrophages by soluble signals derived from BCC cells. In turn, Wnt5a induces the expression of the differentiation marker K10 in tumor cells, which is mediated by Wnt/Ca(2+) signaling in a CaMKII-dependent manner. These data support a role of stromal Wnt5a in BCC differentiation and regression, which may have important implications for development of new treatment strategies for this tumor. Taken together, our results establish BCC as an easily accessible model of tumor regression. The regression of BCC despite sustained Hedgehog signaling activity seems to be mediated by tumor-stromal interactions via Wnt5a signaling. Cancer Res; 70(7); 2739-48. (C) 2010 AACR."],["dc.identifier.doi","10.1158/0008-5472.CAN-09-3743"],["dc.identifier.isi","000278486000019"],["dc.identifier.pmid","20233865"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20187"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Assoc Cancer Research"],["dc.relation.issn","0008-5472"],["dc.title","Tumor Stroma-Derived Wnt5a Induces Differentiation of Basal Cell Carcinoma of Ptch-Mutant Mice via CaMKII"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2996"],["dc.bibliographiccitation.issue","22"],["dc.bibliographiccitation.journal","Bioinformatics"],["dc.bibliographiccitation.lastpage","2997"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Kalev, I."],["dc.contributor.author","Mechelke, M."],["dc.contributor.author","Kopec, K. O."],["dc.contributor.author","Holder, T."],["dc.contributor.author","Carstens, S."],["dc.contributor.author","Habeck, M."],["dc.date.accessioned","2022-03-01T11:46:40Z"],["dc.date.available","2022-03-01T11:46:40Z"],["dc.date.issued","2012"],["dc.identifier.doi","10.1093/bioinformatics/bts538"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103753"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1460-2059"],["dc.relation.issn","1367-4803"],["dc.title","CSB: a Python framework for structural bioinformatics"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2132"],["dc.bibliographiccitation.issue","20"],["dc.bibliographiccitation.journal","Neurology"],["dc.bibliographiccitation.lastpage","2138"],["dc.bibliographiccitation.volume","87"],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Carstens, Per-Ole"],["dc.contributor.author","Zhang, Shuo"],["dc.contributor.author","von Fintel, Eva"],["dc.contributor.author","Friede, Tim"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Schmidt, Jens"],["dc.date.accessioned","2020-12-10T18:41:43Z"],["dc.date.available","2020-12-10T18:41:43Z"],["dc.date.issued","2016"],["dc.description.abstract","Objective: To assess safety and feasibility of real-time (RT) MRI for evaluation of dysphagia and to compare this technique to standard assessment by flexible endoscopic evaluation of swallowing (FEES) and videofluoroscopy (VF) in a cohort of patients with inclusion body myositis (IBM). Methods: Using RT-MRI, FEES, and VF, an unselected cohort of 20 patients with IBM was studied as index disease with a uniform dysphagia. Symptoms of IBM and dysphagia were explored by standardized tools including Swallowing-Related Quality of Life Questionnaire (SWAL-QoL), IBM Functional Rating Scale, Patient-Reported Functional Assessment, and Medical Research Council Scale. Results: Dysphagia was noted in 80% of the patients and SWAL-QoL was impaired in patients with IBM compared to published reference values of healthy elderly. Swallowing in a supine position during RT-MRI was well-tolerated by all patients. RT-MRI equally revealed dysphagia compared to VF and FEES and correlated well with the SWAL-QoL. Only RT-MRI allowed precise time measurements and identification of the respective tissue morphology. The pharyngeal transit times were 2-fold longer compared to published reference values and significantly correlated with morphologic abnormalities. Conclusions: RT-MRI is safe and equally capable as VF to identify the cause of dysphagia in IBM. Advantages of RT-MRI include visualization of soft tissue, more reliable timing analysis, and lack of X-ray exposure. RT-MRI may become a routine diagnostic tool for detailed assessment of the esophagus and other moving parts of the body, facilitating longitudinal evaluations in daily practice and clinical trials."],["dc.identifier.doi","10.1212/WNL.0000000000003337"],["dc.identifier.eissn","1526-632X"],["dc.identifier.isi","000392236100014"],["dc.identifier.issn","0028-3878"],["dc.identifier.pmid","27770070"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77659"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1526-632X"],["dc.relation.issn","0028-3878"],["dc.title","Evaluation of dysphagia by novel real-time MRI"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e86"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Neurology® neuroimmunology & neuroinflammation"],["dc.bibliographiccitation.volume","2"],["dc.contributor.author","Stoeck, Katharina"],["dc.contributor.author","Carstens, Per-Ole"],["dc.contributor.author","Jarius, Sven"],["dc.contributor.author","Raddatz, Dirk"],["dc.contributor.author","Stöcker, Winfried"],["dc.contributor.author","Wildemann, Brigitte"],["dc.contributor.author","Schmidt, Jens"],["dc.date.accessioned","2016-08-23T08:33:42Z"],["dc.date.accessioned","2021-10-27T13:20:42Z"],["dc.date.available","2016-08-23T08:33:42Z"],["dc.date.available","2021-10-27T13:20:42Z"],["dc.date.issued","2015-06-01"],["dc.description.abstract","not available"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2017"],["dc.identifier.doi","10.1212/NXI.0000000000000086"],["dc.identifier.fs","618857"],["dc.identifier.pmid","25798450"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13595"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91977"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.issn","2332-7812"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","CC BY-NC-ND 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/3.0"],["dc.title","Prednisolone and azathioprine are effective in DPPX antibody-positive autoimmune encephalitis."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of the Neurological Sciences"],["dc.bibliographiccitation.volume","357"],["dc.contributor.author","Stoeck, Katharina"],["dc.contributor.author","Carstens, Per-Ole"],["dc.contributor.author","Jarius, Sven"],["dc.contributor.author","Raddatz, Dirk"],["dc.contributor.author","Stoecker, Winfried"],["dc.contributor.author","Wildemann, Brigitte"],["dc.contributor.author","Schmidt, J."],["dc.date.accessioned","2018-11-07T09:50:11Z"],["dc.date.available","2018-11-07T09:50:11Z"],["dc.date.issued","2015"],["dc.format.extent","E436"],["dc.identifier.doi","10.1016/j.jns.2015.09.066"],["dc.identifier.isi","000384634802340"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35658"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.publisher.place","Amsterdam"],["dc.relation.conference","22nd World Congress of Neurology (WCN)"],["dc.relation.eventlocation","Santiago, CHILE"],["dc.relation.issn","1878-5883"],["dc.relation.issn","0022-510X"],["dc.title","Prednisolone and azathioprine are effective in dppx-autoantibody-positive autoimmune encephalitis"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Journal of Neurology"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Carstens, P.-O."],["dc.contributor.author","Zhang, S."],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Bremen, E."],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Schmidt, J."],["dc.date.accessioned","2018-11-07T09:56:03Z"],["dc.date.available","2018-11-07T09:56:03Z"],["dc.date.issued","2015"],["dc.format.extent","110"],["dc.identifier.isi","000357033500175"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36885"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","1st Congress of the European-Academy-of-Neurology"],["dc.relation.eventlocation","Berlin, GERMANY"],["dc.relation.issn","1468-1331"],["dc.relation.issn","1351-5101"],["dc.title","Evaluation of dysphagia in inclusion body myositis by novel real-time MRI"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","9-10"],["dc.bibliographiccitation.journal","Neuromuscular Disorders"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Carstens, Per-Ole"],["dc.contributor.author","Zhang, S."],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Bremen, E."],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Schmidt, J."],["dc.date.accessioned","2018-11-07T09:34:35Z"],["dc.date.available","2018-11-07T09:34:35Z"],["dc.date.issued","2014"],["dc.format.extent","814"],["dc.identifier.doi","10.1016/j.nmd.2014.06.080"],["dc.identifier.isi","000342870200077"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32200"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.publisher.place","Oxford"],["dc.relation.conference","19th International Congress of the World-Muscle-Society"],["dc.relation.eventlocation","Berlin, GERMANY"],["dc.relation.issn","1873-2364"],["dc.relation.issn","0960-8966"],["dc.title","Real-time MRI for the evaluation of dysphagia in inclusion body myositis (IBM)"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","349"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Clinical & Experimental Immunology"],["dc.bibliographiccitation.lastpage","358"],["dc.bibliographiccitation.volume","175"],["dc.contributor.author","Carstens, P.-O."],["dc.contributor.author","Schmidt, J."],["dc.date.accessioned","2018-11-07T09:43:18Z"],["dc.date.available","2018-11-07T09:43:18Z"],["dc.date.issued","2014"],["dc.description.abstract","Dermatomyositis (DM), polymyositis (PM), necrotizing myopathy (NM) and inclusion body myositis (IBM) are four distinct subtypes of idiopathic inflammatory myopathies - in short myositis. Recent studies have shed some light on the unique pathogenesis of each entity. Some of the clinical features are distinct, but muscle biopsy is indispensable for making a reliable diagnosis. The use of magnetic resonance imaging of skeletal muscles and detection of myositis-specific autoantibodies have become useful additions to our diagnostic repertoire. Only few controlled trials are available to substantiate current treatment approaches for myositis and hopes are high that novel modalities will become available within the next few years. In this review we provide an up-to-date overview of the pathogenesis and diagnostic approach of myositis. We aim to present a guide towards therapeutic and general management."],["dc.description.sponsorship","Bayer; Biotest; CSL Behring; Novartis; Octapharma"],["dc.identifier.doi","10.1111/cei.12194"],["dc.identifier.isi","000331249100003"],["dc.identifier.pmid","23981102"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34154"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1365-2249"],["dc.relation.issn","0009-9104"],["dc.title","Diagnosis, pathogenesis and treatment of myositis: recent advances"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]