Demiroglu, Sara Yasemin

[["dc.bibliographiccitation.firstpage","601"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Methods of Information in Medicine"],["dc.bibliographiccitation.lastpage","607"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Helbing, Krister"],["dc.contributor.author","Demiroglu, Sara Yasemin"],["dc.contributor.author","Rakebrandt, Fabian"],["dc.contributor.author","Pommerening, K."],["dc.contributor.author","Rienhoff, Otto"],["dc.contributor.author","Sax, Ulrich"],["dc.date.accessioned","2018-11-07T08:48:08Z"],["dc.date.available","2018-11-07T08:48:08Z"],["dc.date.issued","2010"],["dc.description.abstract","Background The data protection requirements matured in parallel to new clinical tests generating more personal data since the 1960s About ten years ago it was recognized that a generic data protection scheme for medical research networks is required which reinforces patient rights but also allows economically feasible medical research compared to hand carved individual solutions Objectives To give recommendations for more efficient IT infrastructures for medical research networks in compliance with data protection requirements Methods The IT intrastructures of three medical research networks were reviewed with respect to the relevant data manage ment modules Recommendations are derived to increase cost efficiency in research net works assessing the consequences of a service provider approach without lowering the data protection level Results The existing data protection schemes are very complex Smaller research networks cannot afford the implementation of such schemes Larger networks struggle to keep them sustainable Due to a modular redesign in the medical research network community a new approach offers opportunities for an efficent sustainable IT infrastructure involving a service provider concept For standard components 70-80% of the costs could be cut down for open source components about 37% over a three year period Conclusions Future research networks should switch to a service oriented approach to achieve a sustainable, cost efficient IT infrastructure"],["dc.identifier.doi","10.3414/ME09-02-0058"],["dc.identifier.isi","000285774900007"],["dc.identifier.pmid","20644898"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6191"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21133"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Schattauer Gmbh-verlag Medizin Naturwissenschaften"],["dc.relation.issn","0026-1270"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","A Data Protection Scheme for Medical Research Networks Review after Five Years of Operation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","366"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Biopreservation and Biobanking"],["dc.bibliographiccitation.lastpage","374"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Lehmann, Sabine"],["dc.contributor.author","Guadagni, Fiorella"],["dc.contributor.author","Moore, Helen"],["dc.contributor.author","Ashton, Garry"],["dc.contributor.author","Barnes, Michael"],["dc.contributor.author","Benson, Erica E."],["dc.contributor.author","Clements, Judith"],["dc.contributor.author","Koppandi, Iren"],["dc.contributor.author","Coppola, Domenico"],["dc.contributor.author","Demiroglu, Sara Yasemin"],["dc.contributor.author","DeSouza, Yvonne"],["dc.contributor.author","De Wilde, Annemieke"],["dc.contributor.author","Duker, Jacko"],["dc.contributor.author","Eliason, James"],["dc.contributor.author","Glazer, Barbara"],["dc.contributor.author","Harding, Keith"],["dc.contributor.author","Jeon, Jae Pil"],["dc.contributor.author","Kessler, Joseph"],["dc.contributor.author","Kokkat, Theresa"],["dc.contributor.author","Nanni, Umberto"],["dc.contributor.author","Shea, Kathi"],["dc.contributor.author","Skubitz, Amy"],["dc.contributor.author","Somiari, Stella"],["dc.contributor.author","Tybring, Gunnel"],["dc.contributor.author","Gunter, Elaine"],["dc.contributor.author","Betsou, Fotini"],["dc.date.accessioned","2018-11-07T09:07:25Z"],["dc.date.available","2018-11-07T09:07:25Z"],["dc.date.issued","2012"],["dc.description.abstract","The first version of the Standard PREanalytical Code (SPREC) was developed in 2009 by the International Society for Biological and Environmental Repositories (ISBER) Biospecimen Science Working Group to facilitate documentation and communication of the most important preanalytical quality parameters of different types of biospecimens used for research. This same Working Group has now updated the SPREC to version 2.0, presented here, so that it contains more options to allow for recent technological developments. Existing elements have been fine tuned. An interface to the Biospecimen Reporting for Improved Study Quality (BRISQ) has been defined, and informatics solutions for SPREC implementation have been developed. A glossary with SPREC-related definitions has also been added."],["dc.description.sponsorship","NIAID NIH HHS [P30 AI027763]"],["dc.identifier.doi","10.1089/bio.2012.0012"],["dc.identifier.isi","000308304100008"],["dc.identifier.pmid","24849886"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25793"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mary Ann Liebert, Inc"],["dc.relation.issn","1947-5543"],["dc.relation.issn","1947-5535"],["dc.title","Standard Preanalytical Coding for Biospecimens: Review and Implementation of the Sample PREanalytical Code (SPREC)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1180"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Molecular Psychiatry"],["dc.bibliographiccitation.lastpage","1185"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Demiroglu, Sara Yasemin"],["dc.contributor.author","Skrowny, Daniela"],["dc.contributor.author","Quade, Matthias"],["dc.contributor.author","Schwanke, J."],["dc.contributor.author","Budde, Monika"],["dc.contributor.author","Gullatz, V."],["dc.contributor.author","Reich-Erkelenz, Daniela"],["dc.contributor.author","Jakob, J. J."],["dc.contributor.author","Falkai, Peter Gaston"],["dc.contributor.author","Rienhoff, Otto"],["dc.contributor.author","Helbing, Krister"],["dc.contributor.author","Heilbronner, Urs"],["dc.contributor.author","Schulze, Thomas G."],["dc.date.accessioned","2018-11-07T09:02:58Z"],["dc.date.available","2018-11-07T09:02:58Z"],["dc.date.issued","2012"],["dc.description.abstract","Large-scale collaborative research will be a hallmark of future psychiatric genetic research. Ideally, both academic and non-academic institutions should be able to participate in such collaborations to allow for the establishment of very large samples in a straightforward manner. Any such endeavor requires an easy-to-implement information technology (IT) framework. Here we present the requirements for a centralized framework and describe how they can be met through a modular IT toolbox. Molecular Psychiatry (2012) 17, 1180-1185; doi: 10.1038/mp.2012.11; published online 6 March 2012"],["dc.identifier.doi","10.1038/mp.2012.11"],["dc.identifier.isi","000311425600011"],["dc.identifier.pmid","22392033"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24798"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1359-4184"],["dc.title","Managing sensitive phenotypic data and biomaterial in large-scale collaborative psychiatric genetic research projects: practical considerations"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1108"],["dc.bibliographiccitation.lastpage","1108"],["dc.contributor.author","Menzel, Julia"],["dc.contributor.author","Weil, Philipp"],["dc.contributor.author","Bittihn, Philip"],["dc.contributor.author","Hornung, Daniel"],["dc.contributor.author","Mathieu, Nadine"],["dc.contributor.author","Demiroglu, Sara Y."],["dc.date.accessioned","2019-01-14T14:59:13Z"],["dc.date.available","2019-01-14T14:59:13Z"],["dc.date.issued","2013"],["dc.description.abstract","Sustainable data management in biomedical research requires documentation of metadata for all experiments and results. Scientists usually document research data and metadata in laboratory paper notebooks. An electronic laboratory notebook (ELN) can keep metadata linked to research data resulting in a better understanding of the research results, meaning a scientific benefit [1]. Besides other challenges [2], the biggest hurdles for introducing an ELN seem to be usability, file formats, and data entry mechanisms [3] and that many ELNs are assigned to specific research fields such as biology, chemistry, or physics [4]. We aimed to identify requirements for the introduction of ELN software in a biomedical collaborative research center [5] consisting of different scientific fields and to find software fulfilling most of these requirements."],["dc.identifier.doi","10.3233/978-1-61499-289-9-1108"],["dc.identifier.pmid","23920882"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57309"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/38"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | INF: Unterstützung der SFB 1002 Forschungsdatenintegration, -visualisierung und -nachnutzung"],["dc.relation.eisbn","978-1-61499-289-9"],["dc.relation.isbn","978-1-61499-288-2"],["dc.relation.ispartof","MEDINFO 2013"],["dc.relation.ispartofseries","Studies in Health Technology and Informatics; 192"],["dc.relation.workinggroup","RG Nußbeck"],["dc.title","Requirement Analysis for an Electronic Laboratory Notebook for Sustainable Data Management in Biomedical Research"],["dc.type","book_chapter"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Wiener klinische Wochenschrift"],["dc.bibliographiccitation.volume","120"],["dc.contributor.author","Elsner, Leslie"],["dc.contributor.author","Fluegge, Perris F."],["dc.contributor.author","Lozano, Jingky P."],["dc.contributor.author","Muppala, Vijayakumar"],["dc.contributor.author","Demiroglu, Sara Yasemin"],["dc.contributor.author","Malzahn, D."],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Multhoff, Gabriele"],["dc.contributor.author","Walter, L."],["dc.contributor.author","Dressel, Ralf"],["dc.date.accessioned","2018-11-07T11:12:50Z"],["dc.date.available","2018-11-07T11:12:50Z"],["dc.date.issued","2008"],["dc.identifier.isi","000259367100065"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53750"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Wien"],["dc.title","The stress-inducible endogenous danger signals HSP70 and MICA synergistically activate the cytotoxic effector functions of human NK cells"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","992"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Cellular and Molecular Medicine"],["dc.bibliographiccitation.lastpage","1002"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Elsner, Leslie"],["dc.contributor.author","Lozano, Jingky P."],["dc.contributor.author","Muppala, Vijayakumar"],["dc.contributor.author","Eiz-Vesper, Britta"],["dc.contributor.author","Demiroglu, Sara Y."],["dc.contributor.author","Malzahn, Doerthe"],["dc.contributor.author","Herrmann, Thomas R."],["dc.contributor.author","Brunner, Edgar"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Multhoff, Gabriele"],["dc.contributor.author","Walter, Lutz"],["dc.contributor.author","Dressel, Ralf"],["dc.contributor.author","Flügge, Perris F."],["dc.date.accessioned","2018-11-07T08:44:34Z"],["dc.date.available","2018-11-07T08:44:34Z"],["dc.date.issued","2010"],["dc.description.abstract","Although natural killer (NK) cells are often described as first line defence against infected or malignant cells which act without the need of prior activation, it is known now that the NK cell activity is tightly regulated by other cells and soluble factors. We show here that the stress-inducible heat shock protein (HSP) 70 activates human NK cells to kill target cells expressing major histocompatibility complex class I chain-related molecule A (MICA) in a natural killer group 2 member D (NKG2D-) dependent manner. The HSP70-derived peptide TKD (TKDNNLLGRFELSG) was able to replace the full-length HSP70 and to exert the same function. Interestingly, the expression of the cytotoxic effector protease granzyme B in NK cells was increased after TKD stimulation. When MICA and MICB expression was induced in human tumour cells by a histone deacetylase inhibitor and NK cells were activated by HSP70 or TKD, both treatments jointly improved the killing of the tumour cells. Thus, the synergistic activity of two stress-inducible immunological danger signals, HSP70 and MICA/B, leads to activation and enhanced cytotoxicity of human NK cells against tumour cells."],["dc.identifier.doi","10.1111/j.1582-4934.2008.00677.x"],["dc.identifier.isi","000277526400023"],["dc.identifier.pmid","20569278"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20231"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/111096"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-575"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1582-1838"],["dc.title","The endogenous danger signals HSP70 and MICA cooperate in the activation of cytotoxic effector functions of NK cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]