Eimer, Christine

[["dc.bibliographiccitation.journal","Cancer Research"],["dc.bibliographiccitation.volume","72"],["dc.contributor.author","Grade, Marian"],["dc.contributor.author","Eimer, Christine"],["dc.contributor.author","Emons, Georg"],["dc.contributor.author","Kendziorra, Emil"],["dc.contributor.author","Spitzner, Melanie"],["dc.contributor.author","Gaedcke, Jochen"],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Beißbarth, Tim"],["dc.contributor.author","Ried, Thomas"],["dc.contributor.author","Pukrop, Tobias"],["dc.contributor.author","Ghadimi, Michael B."],["dc.date.accessioned","2018-11-07T09:11:10Z"],["dc.date.available","2018-11-07T09:11:10Z"],["dc.date.issued","2012"],["dc.identifier.doi","10.1158/1538-7445.AM2012-5729"],["dc.identifier.isi","209701500032"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26661"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Assoc Cancer Research"],["dc.publisher.place","Philadelphia"],["dc.title","The Wnt transcription factor TCF4 mediates resistance of colorectal cancer cells to (chemo-) radiotherapy in a beta-catenin independent manner"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","31"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Bone and Mineral Metabolism"],["dc.bibliographiccitation.lastpage","39"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Hoffmann, D. B."],["dc.contributor.author","Sehmisch, S."],["dc.contributor.author","Hofmann, A. M."],["dc.contributor.author","Eimer, C."],["dc.contributor.author","Komrakova, M."],["dc.contributor.author","Saul, D."],["dc.contributor.author","Wassmann, M."],["dc.contributor.author","Stürmer, K. M."],["dc.contributor.author","Tezval, M."],["dc.date.accessioned","2018-10-08T06:30:06Z"],["dc.date.accessioned","2020-06-15T06:44:32Z"],["dc.date.available","2018-10-08T06:30:06Z"],["dc.date.available","2020-06-15T06:44:32Z"],["dc.date.issued","2016"],["dc.description.abstract","We investigated the combinatorial effects of whole-body vertical vibration (WBVV) with the primarily osteoanabolic parathyroid hormone (PTH) and the mainly antiresorptive strontium ranelate (SR) in a rat model of osteoporosis. Ovariectomies were performed on 76 three-month-old Sprague-Dawley rats (OVX, n = 76; NON-OVX, n = 12). After 8 weeks, the ovariectomized rats were divided into 6 groups. One group (OVX + PTH) received daily injections of PTH (40 µg/kg body weight/day) for 6 weeks. Another group (OVX + SR) was fed SR-supplemented chow (600 mg/kg body weight/day). Three groups (OVX + VIB, OVX + PTH + VIB, and OVX + SR + VIB) were treated with WBVV twice a day at 70 Hz for 15 min. Two groups (OVX + PTH + VIB, OVX + SR + VIB) were treated additionally with PTH and SR, respectively. The rats were killed at 14 weeks post-ovariectomy. The lumbar vertebrae and femora were removed for biomechanical and morphological assessment. PTH produced statistically significant improvements in biomechanical and structural properties, including bone mineral density (BMD) and trabecular bone quality. In contrast, SR treatment exerted mild effects, with significant effects in cortical thickness only. SR produced no significant improvement in biomechanical properties. WBVV as a single or an adjunctive therapy produced no significant improvements. In conclusion, vibration therapy administered as a single or dual treatment had no significant impact on bones affected by osteoporosis. PTH considerably improved bone quality in osteoporosis cases and is superior to treatment with SR."],["dc.identifier.doi","10.1007/s00774-016-0736-0"],["dc.identifier.pmid","26825660"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66239"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1435-5604"],["dc.title","Comparison of parathyroid hormone and strontium ranelate in combination with whole-body vibration in a rat model of osteoporosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2564"],["dc.bibliographiccitation.issue","14"],["dc.bibliographiccitation.journal","Molecular biology of the cell"],["dc.bibliographiccitation.lastpage","2578"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Luo, L."],["dc.contributor.author","Hannemann, M."],["dc.contributor.author","Koenig, S."],["dc.contributor.author","Hegermann, J."],["dc.contributor.author","Ailion, M."],["dc.contributor.author","Cho, M.-K."],["dc.contributor.author","Sasidharan, N."],["dc.contributor.author","Zweckstetter, M."],["dc.contributor.author","Rensing, S. A."],["dc.contributor.author","Eimer, S."],["dc.date.accessioned","2012-10-22T14:47:20Z"],["dc.date.accessioned","2021-10-27T13:11:00Z"],["dc.date.available","2012-10-22T14:47:20Z"],["dc.date.available","2021-10-27T13:11:00Z"],["dc.date.issued","2011-07-15"],["dc.description.abstract","In yeast the Golgi-associated retrograde protein (GARP) complex is required for tethering of endosome-derived transport vesicles to the late Golgi. It consists of four subunits--Vps51p, Vps52p, Vps53p, and Vps54p--and shares similarities with other multimeric tethering complexes, such as the conserved oligomeric Golgi (COG) and the exocyst complex. Here we report the functional characterization of the GARP complex in the nematode Caenorhabditis elegans. Furthermore, we identified the C. elegans Vps51 subunit, which is conserved in all eukaryotes. GARP mutants are viable but show lysosomal defects. We show that GARP subunits bind specific sets of Golgi SNAREs within the yeast two-hybrid system. This suggests that the C. elegans GARP complex also facilitates tethering as well as SNARE complex assembly at the Golgi. The GARP and COG tethering complexes may have overlapping functions for retrograde endosome-to-Golgi retrieval, since loss of both complexes leads to a synthetic lethal phenotype."],["dc.identifier.doi","10.1091/mbc.E10-06-0493"],["dc.identifier.fs","580298"],["dc.identifier.pmid","21613545"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8148"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91551"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.issn","1939-4586"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.mesh","Amino Acid Sequence"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Caenorhabditis elegans"],["dc.subject.mesh","Caenorhabditis elegans Proteins"],["dc.subject.mesh","Conserved Sequence"],["dc.subject.mesh","Endosomes"],["dc.subject.mesh","Golgi Apparatus"],["dc.subject.mesh","Lysosomes"],["dc.subject.mesh","Molecular Sequence Data"],["dc.subject.mesh","Multiprotein Complexes"],["dc.subject.mesh","Phylogeny"],["dc.subject.mesh","SNARE Proteins"],["dc.subject.mesh","Transport Vesicles"],["dc.subject.mesh","Two-Hybrid System Techniques"],["dc.subject.mesh","Vesicular Transport Proteins"],["dc.title","The Caenorhabditis elegans GARP complex contains the conserved Vps51 subunit and is required to maintain lysosomal morphology."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Annals of Oncology"],["dc.contributor.author","Hernández-Verdin, I."],["dc.contributor.author","Kirasic, E."],["dc.contributor.author","Wienand, K."],["dc.contributor.author","Mokhtari, K."],["dc.contributor.author","Eimer, S."],["dc.contributor.author","Loiseau, H."],["dc.contributor.author","Rousseau, A."],["dc.contributor.author","Paillassa, J."],["dc.contributor.author","Ahle, G."],["dc.contributor.author","Lerintiu, F."],["dc.contributor.author","Alentorn, A."],["dc.date.accessioned","2022-12-01T08:31:58Z"],["dc.date.available","2022-12-01T08:31:58Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1016/j.annonc.2022.11.002"],["dc.identifier.pii","S0923753422047329"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/118321"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-621"],["dc.relation.issn","0923-7534"],["dc.rights.uri","https://www.elsevier.com/tdm/userlicense/1.0/"],["dc.title","Molecular and clinical diversity in primary central nervous system lymphoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]