Walter, Lutz

[["dc.bibliographiccitation.firstpage","3957"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","The Journal of Immunology"],["dc.bibliographiccitation.lastpage","3965"],["dc.bibliographiccitation.volume","166"],["dc.contributor.author","Ioannidu, S."],["dc.contributor.author","Walter, L."],["dc.contributor.author","Dressel, Ralf"],["dc.contributor.author","Gunther, E."],["dc.date.accessioned","2018-11-07T09:16:35Z"],["dc.date.available","2018-11-07T09:16:35Z"],["dc.date.issued","2001"],["dc.description.abstract","The rat is an important model for studying organ graft rejection and susceptibility to certain complex diseases. The MHC, the RT1 complex, plays a decisive role in controlling these traits. We have cloned the telomeric class I region of the RT1 complex, RT1-C/E/M, of the BN inbred rat strain in a contig of overlapping pi-derived artificial chromosome clones encompassing similar to2 Mb, and present a physical map of this MHC region, Forty-five class I exon ii-hybridizing BamHI fragments were detected, including the previously known rat class I genes RT1-E, RT-BM1, RT1-N, RT1-M2, RT1-M3 and RT1-M4, Twenty-six non-class I genes known to map to the corresponding part of the human and mouse MHC were tested and could be fine mapped in the RT1-C/E/M region at orthologous position. Four previously known microsatellite markers were fine mapped in the RT1-C/E/M region and found to occur in multiple copies. In addition, a new, single-copy polymorphic microsatellite has been defined. The expression profiles of several class I genes and the 26 non-class I genes were determined in 13 different tissues and exhibited restricted patterns in most cases. The data provide further molecular information on the MHC for analyzing disease susceptibility and underline the usefulness of the rat model."],["dc.identifier.isi","000167437700044"],["dc.identifier.pmid","11238641"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27965"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Assoc Immunologists"],["dc.relation.issn","0022-1767"],["dc.title","Physical map and expression profile of genes of the telomeric class I gene region of the rat MHC"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","631"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Genome Research"],["dc.bibliographiccitation.lastpage","639"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Hurt, P."],["dc.contributor.author","Walter, L."],["dc.contributor.author","Sudbrak, R."],["dc.contributor.author","Klages, S."],["dc.contributor.author","Mueller, I."],["dc.contributor.author","Shiina, T."],["dc.contributor.author","Inoko, H."],["dc.contributor.author","Lehrach, H."],["dc.contributor.author","Gunther, E."],["dc.contributor.author","Reinhardt, R."],["dc.contributor.author","Himmelbauer, H."],["dc.date.accessioned","2018-11-07T10:49:53Z"],["dc.date.available","2018-11-07T10:49:53Z"],["dc.date.issued","2004"],["dc.description.abstract","We have determined the sequence of a 4-Mb interval on rat chromosome 20p12 that encompasses the rat major histocompatibility complex (MHC). This is the first report of a finished sequence for a segment of the rat genome and constitutes one of the largest contiguous sequences thus far for rodent genomes in general. The rat MHC is, next to the human MHC, the second mammalian MHC sequenced to completion. Our analysis has resulted in the identification of at least 220 genes located within the sequenced interval. Although gene content and order are well conserved in the class II and class III gene intervals as well as the framework gene regions, profound rat-specific features were encountered within the class I gene regions, in comparison to human and mouse. Class I region-associated differences were found both at the structural level, the number, and organization of class I genes and gene families, and, in a more global context, in the way that evolution worked to shape the present-day rat MHC."],["dc.identifier.doi","10.1101/gr.1987704"],["dc.identifier.isi","000220629900015"],["dc.identifier.pmid","15060004"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48533"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cold Spring Harbor Lab Press, Publications Dept"],["dc.relation.issn","1088-9051"],["dc.title","The genomic sequence and comparative analysis of the rat major histocompatibility complex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","970"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","The Journal of Immunology"],["dc.bibliographiccitation.lastpage","975"],["dc.bibliographiccitation.volume","174"],["dc.contributor.author","Roos, Christian"],["dc.contributor.author","Dressel, Ralf"],["dc.contributor.author","Schmidt, Bernhard"],["dc.contributor.author","Günther, Eberhard"],["dc.contributor.author","Walter, Lutz"],["dc.date.accessioned","2022-10-06T13:26:53Z"],["dc.date.available","2022-10-06T13:26:53Z"],["dc.date.issued","2005"],["dc.identifier.doi","10.4049/jimmunol.174.2.970"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115191"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1550-6606"],["dc.relation.issn","0022-1767"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","The Rat Expresses Two Complement Factor C4 Proteins, but Only One Isotype Is Expressed in the Liver"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Wiener klinische Wochenschrift"],["dc.bibliographiccitation.volume","120"],["dc.contributor.author","Novota, P."],["dc.contributor.author","Sviland, Lisbet"],["dc.contributor.author","Opitz, Lennart"],["dc.contributor.author","Hitt, Reiner"],["dc.contributor.author","Dickinson, Anne M."],["dc.contributor.author","Walter, L."],["dc.contributor.author","Dressel, Ralf"],["dc.date.accessioned","2018-11-07T11:12:51Z"],["dc.date.available","2018-11-07T11:12:51Z"],["dc.date.issued","2008"],["dc.format.extent","124"],["dc.identifier.isi","000259367100404"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53754"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Wien"],["dc.relation.issn","0043-5325"],["dc.title","Major histocompatibility complex (MHC) gene expression profiling of the graft versus host reaction in skin explant assays"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","409"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Immunogenetics"],["dc.bibliographiccitation.lastpage","418"],["dc.bibliographiccitation.volume","62"],["dc.contributor.author","Rosner, Cornelia"],["dc.contributor.author","Kruse, Philip H."],["dc.contributor.author","Luebke, Torben"],["dc.contributor.author","Walter, Lutz"],["dc.date.accessioned","2018-11-07T08:42:46Z"],["dc.date.available","2018-11-07T08:42:46Z"],["dc.date.issued","2010"],["dc.description.abstract","The MHC class I gene family of rhesus macaques is characterised by considerable gene duplications. While a HLA-C-orthologous gene is absent, the Mamu-A and in particular the Mamu-B genes have expanded, giving rise to plastic haplotypes with differential gene content. Although some of the rhesus macaque MHC class I genes are known to be associated with susceptibility/resistance to infectious diseases, the functional significance of duplicated Mamu-A and Mamu-B genes and the expression pattern of their encoded proteins are largely unknown. Here, we present data of the subcellular localization of AcGFP-tagged Mamu-A and Mamu-B molecules. We found strong cell surface and low intracellular expression for Mamu-A1, Mamu-A2 and Mamu-A3-encoded molecules as well as for Mamu-B 01704, Mamu-B 02101, Mamu-B 04801, Mamu-B 06002 and Mamu-B 13401. In contrast, weak cell surface and strong intracellular expression was seen for Mamu-A4 1403, Mamu-B 01202, Mamu-B 02804, Mamu-B 03002, Mamu-B 05704, Mamu-I 010201 and Mamu-I 0121. The different expression patterns were assigned to the antigen-binding alpha 1 and alpha 2 domains, suggesting failure of peptide binding is responsible for retaining 'intracellular' Mamu class I molecules in the endoplasmic reticulum. These findings indicate a diverse functional role of the duplicated rhesus macaque MHC class I genes."],["dc.identifier.doi","10.1007/s00251-010-0447-y"],["dc.identifier.isi","000278026700006"],["dc.identifier.pmid","20445972"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6705"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19777"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0093-7711"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Rhesus macaque MHC class I molecules show differential subcellular localizations (vol 62, pg 149, 2010)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","85"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Immunogenetics"],["dc.bibliographiccitation.lastpage","93"],["dc.bibliographiccitation.volume","63"],["dc.contributor.author","Averdam, Anne"],["dc.contributor.author","Kuschal, Christiane"],["dc.contributor.author","Otto, Nicole"],["dc.contributor.author","Westphal, Nico"],["dc.contributor.author","Roos, Christian"],["dc.contributor.author","Reinhardt, Richard"],["dc.contributor.author","Walter, Lutz"],["dc.date.accessioned","2022-10-06T13:31:02Z"],["dc.date.available","2022-10-06T13:31:02Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1007/s00251-010-0487-3"],["dc.identifier.pii","487"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115286"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1432-1211"],["dc.relation.issn","0093-7711"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Sequence analysis of the grey mouse lemur (Microcebus murinus) MHC class II DQ and DR region"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","561"],["dc.bibliographiccitation.journal","Frontiers in Immunology"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Walter, Lutz"],["dc.contributor.author","Bontrop, Ronald"],["dc.date.accessioned","2022-10-06T13:26:43Z"],["dc.date.available","2022-10-06T13:26:43Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.3389/fimmu.2020.00561"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115149"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1664-3224"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Editorial: Comparative Genetics of NK Cell Receptor Families in Relation to MHC Class I Ligands and Their Function"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","149"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Immunogenetics"],["dc.bibliographiccitation.lastpage","158"],["dc.bibliographiccitation.volume","62"],["dc.contributor.author","Rosner, Cornelia"],["dc.contributor.author","Kruse, Philip H."],["dc.contributor.author","Luebke, Torben"],["dc.contributor.author","Walter, Lutz"],["dc.date.accessioned","2018-11-07T08:45:28Z"],["dc.date.available","2018-11-07T08:45:28Z"],["dc.date.issued","2010"],["dc.description.abstract","The MHC class I gene family of rhesus macaques is characterised by considerable gene duplications. While a HLA-C-orthologous gene is absent, the Mamu-A and in particular the Mamu-B genes have expanded, giving rise to plastic haplotypes with differential gene content. Although some of the rhesus macaque MHC class I genes are known to be associated with susceptibility/resistance to infectious diseases, the functional significance of duplicated Mamu-A and Mamu-B genes and the expression pattern of their encoded proteins are largely unknown. Here, we present data of the subcellular localization of AcGFP-tagged Mamu-A and Mamu-B molecules. We found strong cell surface and low intracellular expression for Mamu-A1, Mamu-A2 and Mamu-A3-encoded molecules as well as for Mamu-B 01704, Mamu-B 02101, Mamu-B 04801, Mamu-B 06002 and Mamu-B 13401. In contrast, weak cell surface and strong intracellular expression was seen for Mamu-A4 1403, Mamu-B 01202, Mamu-B 02804, Mamu-B 03002, Mamu-B 05704, Mamu-I 010201 and Mamu-I 0121. The different expression patterns were assigned to the antigen-binding alpha 1 and alpha 2 domains, suggesting failure of peptide binding is responsible for retaining 'intracellular' Mamu class I molecules in the endoplasmic reticulum. These findings indicate a diverse functional role of the duplicated rhesus macaque MHC class I genes."],["dc.identifier.doi","10.1007/s00251-010-0424-5"],["dc.identifier.isi","000274903800003"],["dc.identifier.pmid","20151120"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/4144"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20447"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0093-7711"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Rhesus macaque MHC class I molecules show differential subcellular localizations"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","37"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Immunogenetics"],["dc.bibliographiccitation.lastpage","47"],["dc.bibliographiccitation.volume","72"],["dc.contributor.author","Bruijnesteijn, Jesse"],["dc.contributor.author","de Groot, Natasja G."],["dc.contributor.author","Otting, Nel"],["dc.contributor.author","Maccari, Giuseppe"],["dc.contributor.author","Guethlein, Lisbeth A."],["dc.contributor.author","Robinson, James"],["dc.contributor.author","Marsh, Steven G. E."],["dc.contributor.author","Walter, Lutz"],["dc.contributor.author","O’Connor, David H."],["dc.contributor.author","Hammond, John A."],["dc.contributor.author","Bontrop, Ronald E."],["dc.date.accessioned","2022-10-06T13:31:46Z"],["dc.date.available","2022-10-06T13:31:46Z"],["dc.date.issued","2019"],["dc.description.sponsorship"," National Institutes of Health http://dx.doi.org/10.13039/100000002"],["dc.description.sponsorship","UKRI-BBSCR"],["dc.identifier.doi","10.1007/s00251-019-01135-8"],["dc.identifier.pii","1135"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115297"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1432-1211"],["dc.relation.issn","0093-7711"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","http://www.springer.com/tdm"],["dc.title","Nomenclature report for killer-cell immunoglobulin-like receptors (KIR) in macaque species: new genes/alleles, renaming recombinant entities and IPD-NHKIR updates"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","5523"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","The Journal of Immunology"],["dc.bibliographiccitation.lastpage","5533"],["dc.bibliographiccitation.volume","179"],["dc.contributor.author","Elsner, Leslie"],["dc.contributor.author","Muppala, Vijayakumar"],["dc.contributor.author","Gehrmann, Mathias"],["dc.contributor.author","Lozano, Jingky"],["dc.contributor.author","Malzahn, Dörthe"],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.author","Brunner, Edgar"],["dc.contributor.author","Zientkowska, Marta"],["dc.contributor.author","Herrmann, Thomas"],["dc.contributor.author","Walter, Lutz"],["dc.contributor.author","Dressel, Ralf"],["dc.date.accessioned","2022-06-08T07:57:36Z"],["dc.date.available","2022-06-08T07:57:36Z"],["dc.date.issued","2007"],["dc.description.abstract","The stress-inducible heat shock protein (HSP) 70 is known to function as an endogenous danger signal that can increase the immunogenicity of tumors and induce CTL responses. We show in this study that HSP70 also activates mouse NK cells that recognize stress-inducible NKG2D ligands on tumor cells. Tumor size and the rate of metastases derived from HSP70-overexpressing human melanoma cells were found to be reduced in T and B cell-deficient SCID mice, but not in SCID/beige mice that lack additionally functional NK cells. In the SCID mice with HSP70-overexpressing tumors, NK cells were activated so that they killed ex vivo tumor cells that expressed NKG2D ligands. In the tumors, the MHC class I chain-related (MIC) A and B molecules were found to be expressed. Interestingly, a counter selection was observed against the expression of MICA/B in HSP70-overexpressing tumors compared with control tumors in SCID, but not in SCID/beige mice, suggesting a functional relevance of MICA/B expression. The melanoma cells were found to release exosomes. HSP70-positive exosomes from the HSP70-overexpressing cells, in contrast to HSP70-negative exosomes from the control cells, were able to activate mouse NK cells in vitro to kill YAC-1 cells, which express NKG2D ligands constitutively, or the human melanoma cells, in which MICA/B expression was induced. Thus, HSP70 and inducible NKG2D ligands synergistically promote the activation of mouse NK cells resulting in a reduced tumor growth and suppression of metastatic disease."],["dc.identifier.doi","10.4049/jimmunol.179.8.5523"],["dc.identifier.isi","000250099400061"],["dc.identifier.pmid","17911639"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/110150"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-575"],["dc.notes.status","final"],["dc.notes.submitter","Najko"],["dc.relation.eissn","1550-6606"],["dc.relation.issn","0022-1767"],["dc.title","The Heat Shock Protein HSP70 Promotes Mouse NK Cell Activity against Tumors That Express Inducible NKG2D Ligands"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]