Hillemann, Annette

[["dc.bibliographiccitation.firstpage","365"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Leukocyte Biology"],["dc.bibliographiccitation.lastpage","375"],["dc.bibliographiccitation.volume","96"],["dc.contributor.author","Swain, Lija"],["dc.contributor.author","Wottawa, Marieke"],["dc.contributor.author","Hillemann, Annette"],["dc.contributor.author","Beneke, Angelika"],["dc.contributor.author","Odagiri, Haruki"],["dc.contributor.author","Terada, Kazutoyo"],["dc.contributor.author","Endo, Motoyoshi"],["dc.contributor.author","Oike, Yuichi"],["dc.contributor.author","Farhat, Katja"],["dc.contributor.author","Katschinski, Doerthe Magdalena"],["dc.date.accessioned","2018-11-07T09:36:09Z"],["dc.date.available","2018-11-07T09:36:09Z"],["dc.date.issued","2014"],["dc.description.abstract","On a molecular level, cells sense changes in oxygen availability through the PHDs, which regulate the protein stability of the alpha-subunit of the transcription factor HIF. Especially, PHD3 has been additionally associated with apoptotic cell death. We hypothesized that PHD3 plays a role in cell-fate decisions in macrophages. Therefore, myeloid-specific PHD3(-/-) mice were created and analyzed. PHD3(-/-) BMDM showed no altered HIF-1 alpha or HIF-2 alpha stabilization or increased HIF target gene expression in normoxia or hypoxia. Macrophage M1 and M2 polarization was unchanged likewise. Compared with macrophages from WT littermates, PHD3(-/-) BMDM exhibited a significant reduction in TUNEL-positive cells after serum withdrawal or treatment with stauro and SNAP. Under the same conditions, PHD3(-/-) BMDM also showed less Annexin V staining, which is representative for membrane disruption, and indicated a reduced early apoptosis. In an unbiased transcriptome screen, we found that Angptl2 expression was reduced in PHD3(-/-) BMDM under stress conditions. Addition of rAngptl2 rescued the antiapoptotic phenotype, demonstrating that it is involved in the PHD3-mediated response toward apoptotic stimuli in macrophages."],["dc.identifier.doi","10.1189/jlb.2HI1013-533R"],["dc.identifier.isi","000340829400003"],["dc.identifier.pmid","24626957"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32548"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Federation Amer Soc Exp Biol"],["dc.relation.issn","1938-3673"],["dc.relation.issn","0741-5400"],["dc.title","Prolyl-4-hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The FASEB Journal"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Bahn, A."],["dc.contributor.author","Graber-Neufeld, D. S."],["dc.contributor.author","Godehardt, S."],["dc.contributor.author","Knabe, M."],["dc.contributor.author","Hillemann, Annette"],["dc.contributor.author","Burckhardt, Gerhard"],["dc.contributor.author","Wright, Stephen H."],["dc.date.accessioned","2018-11-07T09:17:08Z"],["dc.date.available","2018-11-07T09:17:08Z"],["dc.date.issued","2001"],["dc.format.extent","A434"],["dc.identifier.isi","000167438102483"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28093"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Federation Amer Soc Exp Biol"],["dc.publisher.place","Bethesda"],["dc.relation.issn","0892-6638"],["dc.title","Role of the organic anion transporter 1 (OAT1) in renal heavy metal detoxification."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e2976"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Cell Death & Disease"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Beneke, Angelika"],["dc.contributor.author","Guentsch, Annemarie"],["dc.contributor.author","Hillemann, Annette"],["dc.contributor.author","Zieseniss, Anke"],["dc.contributor.author","Swain, Lija"],["dc.contributor.author","Katschinski, Dörthe M."],["dc.date.accessioned","2019-02-14T11:48:34Z"],["dc.date.available","2019-02-14T11:48:34Z"],["dc.date.issued","2017"],["dc.description.abstract","Macrophages are essential for the inflammatory response after an ischemic insult and thereby influence tissue recovery. For the oxygen sensing prolyl-4-hydroxylase domain enzyme (PHD) 2 a clear impact on the macrophage-mediated arteriogenic response after hind-limb ischemia has been demonstrated previously, which involves fine tuning a M2-like macrophage population. To analyze the role of PHD3 in macrophages, we performed hind-limb ischemia (ligation and excision of the femoral artery) in myeloid-specific PHD3 knockout mice (PHD3-/-) and analyzed the inflammatory cell invasion, reperfusion recovery and fibrosis in the ischemic muscle post-surgery. In contrast to PHD2, reperfusion recovery and angiogenesis was unaltered in PHD3-/- compared to WT mice. Macrophages from PHD3-/- mice showed, however, a dampened inflammatory reaction in the affected skeletal muscle tissues compared to WT controls. This was associated with a decrease in fibrosis and an anti-inflammatory phenotype of the PHD3-/- macrophages, as well as decreased expression of Cyp2s1 and increased PGE2-secretion, which could be mimicked by PHD3-/- bone marrow-derived macrophages in serum starvation."],["dc.identifier.doi","10.1038/cddis.2017.375"],["dc.identifier.pmid","28796258"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16494"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57561"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.eissn","2041-4889"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Loss of PHD3 in myeloid cells dampens the inflammatory response and fibrosis after hind-limb ischemia"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Acta Physiologica"],["dc.bibliographiccitation.volume","216"],["dc.contributor.author","Guentsch, Annemarie"],["dc.contributor.author","Beneke, Angelika"],["dc.contributor.author","Farhat, Katja"],["dc.contributor.author","Swain, Lija"],["dc.contributor.author","Hillemann, Annette"],["dc.contributor.author","Nagarajan, S."],["dc.contributor.author","Dudek, Jan"],["dc.contributor.author","Shah, Ajay M."],["dc.contributor.author","Katschinski, Doerthe Magdalena"],["dc.date.accessioned","2018-11-07T10:17:27Z"],["dc.date.available","2018-11-07T10:17:27Z"],["dc.date.issued","2016"],["dc.identifier.isi","000372285400087"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41228"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","1748-1716"],["dc.relation.issn","1748-1708"],["dc.title","The oxygen sensor PHD2 affects cell migration, energy metabolism and mitochondrial function in macrophages"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","623"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Biochemical and Biophysical Research Communications"],["dc.bibliographiccitation.lastpage","630"],["dc.bibliographiccitation.volume","275"],["dc.contributor.author","Bahn, Andrew"],["dc.contributor.author","Prawitt, Dirk"],["dc.contributor.author","Buttler, Diana"],["dc.contributor.author","Reid, Glen"],["dc.contributor.author","Enklaar, Thorsten"],["dc.contributor.author","Wolff, Natascha A."],["dc.contributor.author","Ebbinghaus, Christian"],["dc.contributor.author","Hillemann, Annette"],["dc.contributor.author","Schulten, Hans-Jürgen"],["dc.contributor.author","Burckhardt, Gerhard"],["dc.date.accessioned","2021-06-01T10:47:29Z"],["dc.date.available","2021-06-01T10:47:29Z"],["dc.date.issued","2000"],["dc.identifier.doi","10.1006/bbrc.2000.3230"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85619"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","0006-291X"],["dc.title","Genomic Structure and in Vivo Expression of the Human Organic Anion Transporter 1 (hOAT1) Gene"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]