Batsikadze, Giorgi

[["dc.bibliographiccitation.firstpage","1987"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","The Journal of Physiology"],["dc.bibliographiccitation.lastpage","2000"],["dc.bibliographiccitation.volume","591"],["dc.contributor.author","Batsikadze, Giorgi"],["dc.contributor.author","Moliadze, Vera"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Kuo, M.-F."],["dc.contributor.author","Nitsche, M. A."],["dc.date.accessioned","2018-11-07T09:26:43Z"],["dc.date.available","2018-11-07T09:26:43Z"],["dc.date.issued","2013"],["dc.description.abstract","Transcranial direct current stimulation (tDCS) of the human motor cortex at an intensity of 1mA with an electrode size of 35cm2 has been shown to induce shifts of cortical excitability during and after stimulation. These shifts are polarity-specific with cathodal tDCS resulting in a decrease and anodal stimulation in an increase of cortical excitability. In clinical and cognitive studies, stronger stimulation intensities are used frequently, but their physiological effects on cortical excitability have not yet been explored. Therefore, here we aimed to explore the effects of 2mA tDCS on cortical excitability. We applied 2mA anodal or cathodal tDCS for 20min on the left primary motor cortex of 14 healthy subjects. Cathodal tDCS at 1mA and sham tDCS for 20min was administered as control session in nine and eight healthy subjects, respectively. Motor cortical excitability was monitored by transcranial magnetic stimulation (TMS)-elicited motor-evoked potentials (MEPs) from the right first dorsal interosseous muscle. Global corticospinal excitability was explored via single TMS pulse-elicited MEP amplitudes, and motor thresholds. Intracortical effects of stimulation were obtained by cortical silent period (CSP), short latency intracortical inhibition (SICI) and facilitation (ICF), and I wave facilitation. The above-mentioned protocols were recorded both before and immediately after tDCS in randomized order. Additionally, single-pulse MEPs, motor thresholds, SICI and ICF were recorded every 30min up to 2h after stimulation end, evening of the same day, next morning, next noon and next evening. Anodal as well as cathodal tDCS at 2mA resulted in a significant increase of MEP amplitudes, whereas 1mA cathodal tDCS decreased corticospinal excitability. A significant shift of SICI and ICF towards excitability enhancement after both 2mA cathodal and anodal tDCS was observed. At 1mA, cathodal tDCS reduced single-pulse TMS-elicited MEP amplitudes and shifted SICI and ICF towards inhibition. No significant changes were observed in the other protocols. Sham tDCS did not induce significant MEP alterations. These results suggest that an enhancement of tDCS intensity does not necessarily increase efficacy of stimulation, but might also shift the direction of excitability alterations. This should be taken into account for applications of the stimulation technique using different intensities and durations in order to achieve stronger or longer lasting after-effects."],["dc.identifier.doi","10.1113/jphysiol.2012.249730"],["dc.identifier.isi","000316918300032"],["dc.identifier.pmid","23339180"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30366"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0022-3751"],["dc.title","Partially non-linear stimulation intensity-dependent effects of direct current stimulation on motor cortex excitability in humans"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1273"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The Journal of Physiology"],["dc.bibliographiccitation.lastpage","1288"],["dc.bibliographiccitation.volume","595"],["dc.contributor.author","Jamil, Asif"],["dc.contributor.author","Batsikadze, Giorgi"],["dc.contributor.author","Kuo, Hsiao-I."],["dc.contributor.author","Labruna, Ludovica"],["dc.contributor.author","Hasan, Alkomiet"],["dc.contributor.author","Paulus, Walter"],["dc.contributor.author","Nitsche, Michael A."],["dc.date.accessioned","2020-12-10T18:36:34Z"],["dc.date.available","2020-12-10T18:36:34Z"],["dc.date.issued","2017"],["dc.description.abstract","Contemporary non-invasive neuromodulatory techniques, such as transcranial direct current stimulation (tDCS), have shown promising potential in both restituting impairments in cortical physiology in clinical settings, as well as modulating cognitive abilities in the healthy population. However, neuroplastic after-effects of tDCS are highly dependent on stimulation parameters, relatively short lasting, and not expectedly uniform between individuals. The present study systematically investigates the full range of current intensity between 0.5 and 2.0mA on left primary motor cortex (M1) plasticity, as well as the impact of individual-level covariates on explaining inter-individual variability. Thirty-eight healthy subjects were divided into groups of anodal and cathodal tDCS. Five DC intensities (sham, 0.5, 1.0, 1.5 and 2.0mA) were investigated in separate sessions. Using transcranial magnetic stimulation (TMS), 25 motor-evoked potentials (MEPs) were recorded before, and 10 time points up to 2h following 15min of tDCS. Repeated-measures ANOVAs indicated a main effect of intensity for both anodal and cathodal tDCS. With anodal tDCS, all active intensities resulted in equivalent facilitatory effects relative to sham while for cathodal tDCS, only 1.0mA resulted in sustained excitability diminution. An additional experiment conducted to assess intra-individual variability revealed generally good reliability of 1.0mA anodal tDCS (ICC(2,1)=0.74 over the first 30min). A post hoc analysis to discern sources of inter-individual variability confirmed a previous finding in which individual TMS SI1mV (stimulus intensity for 1mV MEP amplitude) sensitivity correlated negatively with 1.0mA anodal tDCS effects on excitability. Our study thus provides further insights on the extent of non-linear intensity-dependent neuroplastic after-effects of anodal and cathodal tDCS."],["dc.identifier.doi","10.1113/JP272738"],["dc.identifier.isi","000394581400030"],["dc.identifier.issn","0022-3751"],["dc.identifier.pmid","27723104"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76672"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Wiley"],["dc.relation.issn","1469-7793"],["dc.relation.issn","0022-3751"],["dc.title","Systematic evaluation of the impact of stimulation intensity on neuroplastic after-effects induced by transcranial direct current stimulation"],["dc.title.alternative","Effects of DC intensity on cortical excitability"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","90"],["dc.bibliographiccitation.journal","Addictive behaviors"],["dc.bibliographiccitation.lastpage","97"],["dc.bibliographiccitation.volume","74"],["dc.contributor.author","Grundey, J."],["dc.contributor.author","Amu, R."],["dc.contributor.author","Batsikadze, G."],["dc.contributor.author","Paulus, W."],["dc.contributor.author","Nitsche, M.A."],["dc.date.accessioned","2020-12-10T14:14:53Z"],["dc.date.available","2020-12-10T14:14:53Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1016/j.addbeh.2017.05.017"],["dc.identifier.issn","0306-4603"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71538"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Diverging effects of nicotine on motor learning performance: Improvement in deprived smokers and attenuation in non-smokers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","544"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Cerebral Cortex"],["dc.bibliographiccitation.lastpage","553"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Valladao Lugon, Marcelo Di Marcello"],["dc.contributor.author","Batsikadze, Giorgi"],["dc.contributor.author","Fresnoza, Shane"],["dc.contributor.author","Grundey, Jessica"],["dc.contributor.author","Kuo, Min-Fang"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Nakamura-Palacios, Ester Miyuki"],["dc.contributor.author","Nitsche, Michael A."],["dc.date.accessioned","2018-11-07T10:28:44Z"],["dc.date.available","2018-11-07T10:28:44Z"],["dc.date.issued","2017"],["dc.description.abstract","The impact of nicotine (NIC) on plasticity is thought to be primarily determined via calcium channel properties of nicotinic receptor subtypes, and glutamatergic plasticity is likewise calcium-dependent. Therefore glutamatergic plasticity is likely modulated by the impact of nicotinic receptor-dependent neuronal calcium influx. We tested this hypothesis for transcranial direct current stimulation (tDCS)-induced long-term potentiation-like plasticity, which is abolished by NIC in nonsmokers. To reduce calcium influx under NIC, we blocked N-methyl-d-aspartate (NMDA) receptors. We applied anodal tDCS combined with 15 mg NIC patches and the NMDA-receptor antagonist dextromethorphan (DMO) in 3 different doses (50, 100, and 150 mg) or placebo medication. Corticospinal excitability was monitored by single-pulse transcranial magnetic stimulation-induced motor-evoked potential amplitudes after plasticity induction. NIC abolished anodal tDCS-induced motor cortex excitability enhancement, which was restituted under medium dosage of DMO. Low-dosage DMO did not affect the impact of NIC on tDCS induced plasticity and high-dosage DMO abolished plasticity. For DMO alone, the low dosage had no effect, but medium and high dosages abolished tDCS-induced plasticity. These results enhance our knowledge about the proposed calcium-dependent impact of NIC on plasticity in humans and might be relevant for the development of novel nicotinic treatments for cognitive dysfunction."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft (DFG) [NI 683/4-2]; CAPES, Brazil"],["dc.identifier.doi","10.1093/cercor/bhv252"],["dc.identifier.isi","000397064800044"],["dc.identifier.pmid","26494801"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43493"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Oxford Univ Press Inc"],["dc.relation.issn","1460-2199"],["dc.relation.issn","1047-3211"],["dc.title","Mechanisms of Nicotinic Modulation of Glutamatergic Neuroplasticity in Humans"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3249"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Cerebral Cortex"],["dc.bibliographiccitation.lastpage","3259"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Batsikadze, Giorgi"],["dc.contributor.author","Paulus, Walter"],["dc.contributor.author","Grundey, Jessica"],["dc.contributor.author","Kuo, Min-Fang"],["dc.contributor.author","Nitsche, Michael A."],["dc.date.accessioned","2018-10-10T11:33:27Z"],["dc.date.available","2018-10-10T11:33:27Z"],["dc.date.issued","2015"],["dc.description.abstract","Nicotine alters cognitive functions in animals and humans most likely by modification of brain plasticity. In the human brain, it alters plasticity induced by transcranial direct current stimulation (tDCS) and paired associative stimulation (PAS), probably by interference with calcium-dependent modulation of the glutamatergic system. We aimed to test this hypothesis further by exploring the impact of the α4β2-nicotinic receptor partial agonist varenicline on focal and non-focal plasticity, induced by PAS and tDCS, respectively. We administered low (0.1 mg), medium (0.3 mg), and high (1.0 mg) single doses of varenicline or placebo medication before PAS or tDCS on the left motor cortex of 25 healthy non-smokers. Corticospinal excitability was monitored by single-pulse transcranial magnetic stimulation-induced motor evoked potential amplitudes up to 36 h after plasticity induction. Whereas low-dose varenicline had no impact on stimulation-induced neuroplasticity, medium-dose abolished tDCS-induced facilitatory after-effects, favoring focal excitatory plasticity. High-dose application preserved cathodal tDCS-induced excitability diminution and focal excitatory PAS-induced facilitatory plasticity. These results are comparable to the impact of nicotine receptor activation and might help to further explain the involvement of specific receptor subtypes in the nicotinic impact on neuroplasticity and cognitive functions in healthy subjects and patients with neuropsychiatric diseases."],["dc.identifier.doi","10.1093/cercor/bhu126"],["dc.identifier.pmid","24917274"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15957"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","1460-2199"],["dc.title","Effect of the Nicotinic α4β2-receptor Partial Agonist Varenicline on Non-invasive Brain Stimulation-Induced Neuroplasticity in the Human Motor Cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","509"],["dc.bibliographiccitation.journal","NeuroImage"],["dc.bibliographiccitation.lastpage","517"],["dc.bibliographiccitation.volume","124"],["dc.contributor.author","Meincke, Jonna"],["dc.contributor.author","Hewitt, Manuel"],["dc.contributor.author","Batsikadze, Giorgi"],["dc.contributor.author","Liebetanz, David"],["dc.date.accessioned","2018-11-07T10:21:46Z"],["dc.date.available","2018-11-07T10:21:46Z"],["dc.date.issued","2016"],["dc.description.abstract","Background: Although neuronavigation is increasingly used for optimizing coil positioning, the inter-session reliability of hotspot location remains unsatisfactory, probably due to the variability of motor evoked potentials (MEPs) and residual investigator bias. Purpose: To increase the reliability and accuracy of hotspot location we introduce a novel automated hotspot-hunting procedure (AHH). Methods: AHH is based on resting motor thresholds (RMTs) instead of MEP amplitudes. By combining robotic coil positioning with a closed loop target search algorithm AHH runs independently from the investigator. AHH first identifies all targets with an RMT below a defined intensity of stimulator output (MEP-positive) and then locates the motor hotspot of a target muscle by measuring RMTs at all identified MEP-positive targets. Results were compared to robotic MEP amplitude TMS mapping (MAM) using a 7 x 7 predefined target grid and suprathreshold intensities and manual hotspot search (MHS). Sequence of stimulation was randomized from pulse to pulse in AHH and MAM. Each procedure was tested in 8 subjects. Results: Inter-session CoG shift was significantly reduced with AHH (1.4 mm (SEM: 0.4)) as compared to MAM (7.0 mm (SEM: 1.8)) (p=0.018) and MHS (9.6 mm (SEM: 2.2)) (p=0.007). No statistical difference was observed between MAM and MHS. RMTs were reliable between sessions. Conclusion: Our method represents the first fully automated, i.e. investigator-independent, TMS hotspot-hunting procedure. Measuring RMTs instead of MEP amplitudes leads to significantly increased accuracy and reliability of CoG locations. Moreover, by assessing thresholds AHH is the first procedure to fulfill the original hotspot definition. (C) 2015 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.neuroimage.2015.09.013"],["dc.identifier.isi","000366646700047"],["dc.identifier.pmid","26385012"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42150"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","1095-9572"],["dc.relation.issn","1053-8119"],["dc.title","Automated TMS hotspot-hunting using a closed loop threshold-based algorithm"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","8"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Brain Stimulation"],["dc.bibliographiccitation.lastpage","15"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Labruna, Ludovica"],["dc.contributor.author","Jamil, Asif"],["dc.contributor.author","Fresnoza, Shane"],["dc.contributor.author","Batsikadze, Giorgi"],["dc.contributor.author","Kuo, Min-Fang"],["dc.contributor.author","Vanderschelden, Benjamin"],["dc.contributor.author","Ivry, Richard B."],["dc.contributor.author","Nitsche, Michael A."],["dc.date.accessioned","2018-11-07T10:21:23Z"],["dc.date.available","2018-11-07T10:21:23Z"],["dc.date.issued","2016"],["dc.description.abstract","Background: Transcranial direct current stimulation (tDCS) has become an important non-invasive brain stimulation tool for basic human brain physiology and cognitive neuroscience, with potential applications in cognitive and motor rehabilitation. To date, tDCS studies have employed a fixed stimulation level, without considering the impact of individual anatomy and physiology on the efficacy of the stimulation. This approach contrasts with the standard procedure for transcranial magnetic stimulation (TMS) where stimulation levels are usually tailored on an individual basis. Objective/Hypothesis: The present study tests whether the efficacy of tDCS-induced changes in corticospinal excitability varies as a function of individual differences in sensitivity to TMS. Methods: We performed an archival review to examine the relationship between the TMS intensity required to induce 1 mV motor-evoked potentials (MEPs) and the efficacy of (fixed-intensity) tDCS over the primary motor cortex (M1). For the latter, we examined tDCS-induced changes in corticospinal excitability, operationalized by comparing MEPs before and after anodal or cathodal tDCS. For comparison, we performed a similar analysis on data sets in which MEPs had been obtained before and after paired associative stimulation (PAS), a non-invasive brain stimulation technique in which the stimulation intensity is adjusted on an individual basis. Results: MEPs were enhanced following anodal tDCS. This effect was larger in participants more sensitive to TMS as compared to those less sensitive to TMS, with sensitivity defined as the TMS intensity required to produce MEPs amplitudes of the size of 1 mV. While MEPs were attenuated following cathodal tDCS, the magnitude of this attenuation was not related to TMS sensitivity nor was there a relationship between TMS sensitivity and responsiveness to PAS. Conclusion: Accounting for variation in individual sensitivity to non-invasive brain stimulation may enhance the utility of tDCS as a tool for understanding brain-behavior interactions and as a method for clinical interventions. Published by Elsevier Inc."],["dc.identifier.doi","10.1016/j.brs.2015.08.014"],["dc.identifier.isi","000368089500002"],["dc.identifier.pmid","26493498"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42071"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1876-4754"],["dc.relation.issn","1935-861X"],["dc.title","Efficacy of Anodal Transcranial Direct Current Stimulation is Related to Sensitivity to Transcranial Magnetic Stimulation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1223"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Neuropsychopharmacology"],["dc.bibliographiccitation.lastpage","1230"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Kuo, Hsiao-I"],["dc.contributor.author","Paulus, Walter"],["dc.contributor.author","Batsikadze, Giorgi"],["dc.contributor.author","Jamil, Asif"],["dc.contributor.author","Kuo, Min-Fang"],["dc.contributor.author","Nitsche, Michael A."],["dc.date.accessioned","2018-10-10T11:05:50Z"],["dc.date.available","2018-10-10T11:05:50Z"],["dc.date.issued","2016"],["dc.description.abstract","Serotonin affects memory formation via modulating long-term potentiation (LTP) and depression (LTD). Accordingly, acute selective serotonin reuptake inhibitor (SSRI) administration enhanced LTP-like plasticity induced by transcranial direct current stimulation (tDCS) in humans. However, it usually takes some time for SSRI to reduce clinical symptoms such as anxiety, negative mood, and related symptoms of depression and anxiety disorders. This might be related to an at least partially different effect of chronic serotonergic enhancement on plasticity, as compared with single-dose medication. Here we explored the impact of chronic application of the SSRI citalopram (CIT) on plasticity induced by tDCS in healthy humans in a partially double-blinded, placebo (PLC)-controlled, randomized crossover study. Furthermore, we explored the dependency of plasticity induction from the glutamatergic system via N-methyl-D-aspartate receptor antagonism. Twelve healthy subjects received PLC medication, combined with anodal or cathodal tDCS of the primary motor cortex. Afterwards, the same subjects took CIT (20 mg/day) consecutively for 35 days. During this period, four additional interventions were performed (CIT and PLC medication with anodal/cathodal tDCS, CIT and dextromethorphan (150 mg) with anodal/cathodal tDCS). Plasticity was monitored by motor-evoked potential amplitudes elicited by transcranial magnetic stimulation. Chronic application of CIT increased and prolonged the LTP-like plasticity induced by anodal tDCS for over 24 h, and converted cathodal tDCS-induced LTD-like plasticity into facilitation. These effects were abolished by dextromethorphan. Chronic serotonergic enhancement results in a strengthening of LTP-like glutamatergic plasticity, which might partially explain the therapeutic impact of SSRIs in depression and other neuropsychiatric diseases."],["dc.identifier.doi","10.1038/npp.2015.270"],["dc.identifier.pmid","26329381"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15950"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","1740-634X"],["dc.title","Chronic Enhancement of Serotonin Facilitates Excitatory Transcranial Direct Current Stimulation-Induced Neuroplasticity"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1305"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The Journal of Physiology"],["dc.bibliographiccitation.lastpage","1314"],["dc.bibliographiccitation.volume","595"],["dc.contributor.author","Kuo, Hsiao-I."],["dc.contributor.author","Paulus, Walter"],["dc.contributor.author","Batsikadze, Giorgi"],["dc.contributor.author","Jamil, Asif"],["dc.contributor.author","Kuo, Min-Fang"],["dc.contributor.author","Nitsche, Michael A."],["dc.date.accessioned","2020-12-10T18:36:34Z"],["dc.date.available","2020-12-10T18:36:34Z"],["dc.date.issued","2017"],["dc.description.abstract","Chronic administration of the selective noradrenaline reuptake inhibitor (NRI) reboxetine (RBX) increased and prolonged the long-term potentiation-like plasticity induced by anodal transcranial direct current stimulation (tDCS) for over 24 h. Chronic administration of RBX converted cathodal tDCS-induced long-term depression-like plasticity into facilitation for 120 min. Chronic noradrenergic activity enhancement on plasticity of the human brain might partially explain the delayed therapeutic impact of selective NRIs in depression and other neuropsychiatric diseases."],["dc.identifier.doi","10.1113/JP273137"],["dc.identifier.issn","0022-3751"],["dc.identifier.pmid","27925214"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76673"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","final"],["dc.relation.issn","1469-7793"],["dc.title","Acute and chronic effects of noradrenergic enhancement on transcranial direct current stimulation-induced neuroplasticity in humans"],["dc.title.alternative","Long-term impact of noradrenaline on neuroplasticity"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","845"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","European Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","855"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Rivera-Urbina, Guadalupe Nathzidy"],["dc.contributor.author","Batsikadze, Giorgi"],["dc.contributor.author","Molero-Chamizo, Andres"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Kuo, Min-Fang"],["dc.contributor.author","Nitsche, Michael A."],["dc.date.accessioned","2018-11-07T10:00:15Z"],["dc.date.available","2018-11-07T10:00:15Z"],["dc.date.issued","2015"],["dc.description.abstract","The posterior parietal cortex is part of the cortical network involved in motor learning and is structurally and functionally connected with the primary motor cortex (M1). Neuroplastic alterations of neuronal connectivity might be an important basis for learning processes. These have however not been explored for parieto-motor connections in humans by transcranial direct current stimulation (tDCS). Exploring tDCS effects on parieto-motor cortical connectivity might be functionally relevant, because tDCS has been shown to improve motor learning. We aimed to explore plastic alterations of parieto-motor cortical connections by tDCS in healthy humans. We measured neuroplastic changes of corticospinal excitability via motor evoked potentials (MEP) elicited by single-pulse transcranial magnetic stimulation (TMS) before and after tDCS over the left posterior parietal cortex (P3), and 3cm posterior or lateral to P3, to explore the spatial specificity of the effects. Furthermore, short-interval intracortical inhibition/intracortical facilitation (SICI/ICF) over M1, and parieto-motor cortical connectivity were obtained before and after P3 tDCS. The results show polarity-dependent M1 excitability alterations primarily after P3 tDCS. Single-pulse TMS-elicited MEPs, M1 SICI/ICF at 5 and 7ms and 10 and 15ms interstimulus intervals (ISIs), and parieto-motor connectivity at 10 and 15ms ISIs were all enhanced by anodal stimulation. Single pulse-TMS-elicited MEPs, and parieto-motor connectivity at 10 and 15ms ISIs were reduced by cathodal tDCS. The respective corticospinal excitability alterations lasted for at least 120min after stimulation. These results show an effect of remote stimulation of parietal areas on M1 excitability. The spatial specificity of the effects and the impact on parietal cortex-motor cortex connections suggest a relevant connectivity-driven effect."],["dc.identifier.doi","10.1111/ejn.12840"],["dc.identifier.isi","000351439000011"],["dc.identifier.pmid","25645274"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37763"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1460-9568"],["dc.relation.issn","0953-816X"],["dc.title","Parietal transcranial direct current stimulation modulates primary motor cortex excitability"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]