Jablonski, Lukasz Adam

[["dc.bibliographiccitation.firstpage","86"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Herz"],["dc.bibliographiccitation.lastpage","94"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Hadem, J."],["dc.contributor.author","Rossnick, R."],["dc.contributor.author","Hesse, B."],["dc.contributor.author","Herr, M."],["dc.contributor.author","Hansen, M."],["dc.contributor.author","Bergmann, A."],["dc.contributor.author","Kensah, G."],["dc.contributor.author","Maess, C."],["dc.contributor.author","Baraki, H."],["dc.contributor.author","Kümpers, P."],["dc.contributor.author","Lukasz, A."],["dc.contributor.author","Kutschka, I."],["dc.date.accessioned","2020-12-10T14:07:55Z"],["dc.date.available","2020-12-10T14:07:55Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1007/s00059-018-4708-0"],["dc.identifier.eissn","1615-6692"],["dc.identifier.issn","0340-9937"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70333"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Endotheliale Dysfunktion nach koronarer Bypass-Operation"],["dc.title.alternative","Endothelial dysfunction following coronary artery bypass grafting. Influence of patient and procedural factors"],["dc.title.subtitle","Einfluss von Patientenfaktoren und Operationstechnik"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","E3075"],["dc.bibliographiccitation.issue","23"],["dc.bibliographiccitation.journal","Proceedings of the National Academy of Sciences of the United States of America"],["dc.bibliographiccitation.lastpage","E3084"],["dc.bibliographiccitation.volume","112"],["dc.contributor.author","Delvendahl, Igor"],["dc.contributor.author","Jablonski, Lukasz"],["dc.contributor.author","Baade, Carolin"],["dc.contributor.author","Matveev, Victor"],["dc.contributor.author","Neher, Erwin"],["dc.contributor.author","Hallermann, Stefan"],["dc.date.accessioned","2019-01-24T13:12:31Z"],["dc.date.available","2019-01-24T13:12:31Z"],["dc.date.issued","2015"],["dc.description.abstract","Fast synchronous neurotransmitter release at the presynaptic active zone is triggered by local Ca(2+) signals, which are confined in their spatiotemporal extent by endogenous Ca(2+) buffers. However, it remains elusive how rapid and reliable Ca(2+) signaling can be sustained during repetitive release. Here, we established quantitative two-photon Ca(2+) imaging in cerebellar mossy fiber boutons, which fire at exceptionally high rates. We show that endogenous fixed buffers have a surprisingly low Ca(2+)-binding ratio (∼ 15) and low affinity, whereas mobile buffers have high affinity. Experimentally constrained modeling revealed that the low endogenous buffering promotes fast clearance of Ca(2+) from the active zone during repetitive firing. Measuring Ca(2+) signals at different distances from active zones with ultra-high-resolution confirmed our model predictions. Our results lead to the concept that reduced Ca(2+) buffering enables fast active zone Ca(2+) signaling, suggesting that the strength of endogenous Ca(2+) buffering limits the rate of synchronous synaptic transmission."],["dc.identifier.doi","10.1073/pnas.1508419112"],["dc.identifier.pmid","26015575"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57367"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1091-6490"],["dc.title","Reduced endogenous Ca2+ buffering speeds active zone Ca2+ signaling"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Witkowska, Agata"],["dc.contributor.author","Jablonski, Lukasz"],["dc.contributor.author","Jahn, Reinhard"],["dc.date.accessioned","2020-12-10T18:10:11Z"],["dc.date.available","2020-12-10T18:10:11Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1038/s41598-018-27456-4"],["dc.identifier.eissn","2045-2322"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15438"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73877"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","A convenient protocol for generating giant unilamellar vesicles containing SNARE proteins using electroformation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4693"],["dc.bibliographiccitation.issue","19"],["dc.bibliographiccitation.journal","The Journal of Physiology"],["dc.bibliographiccitation.lastpage","4707"],["dc.bibliographiccitation.volume","596"],["dc.contributor.author","Ritzau-Jost, Andreas"],["dc.contributor.author","Jablonski, Lukasz"],["dc.contributor.author","Viotti, Julio"],["dc.contributor.author","Lipstein, Noa"],["dc.contributor.author","Eilers, Jens"],["dc.contributor.author","Hallermann, Stefan"],["dc.date.accessioned","2020-12-10T18:36:35Z"],["dc.date.available","2020-12-10T18:36:35Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1113/JP275911"],["dc.identifier.issn","0022-3751"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76677"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Apparent calcium dependence of vesicle recruitment"],["dc.title.alternative","Apparent calcium dependence of vesicle recruitment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","EMBO Molecular Medicine"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Dieter, Alexander"],["dc.contributor.author","Klein, Eric"],["dc.contributor.author","Keppeler, Daniel"],["dc.contributor.author","Jablonski, Lukasz"],["dc.contributor.author","Harczos, Tamas"],["dc.contributor.author","Hoch, Gerhard"],["dc.contributor.author","Rankovic, Vladan"],["dc.contributor.author","Paul, Oliver"],["dc.contributor.author","Jeschke, Marcus"],["dc.contributor.author","Ruther, Patrick"],["dc.contributor.author","Moser, Tobias"],["dc.date.accessioned","2021-04-14T08:25:11Z"],["dc.date.available","2021-04-14T08:25:11Z"],["dc.date.issued","2020"],["dc.description.abstract","Abstract Electrical cochlear implants (eCIs) partially restore hearing and enable speech comprehension to more than half a million users, thereby re‐connecting deaf patients to the auditory scene surrounding them. Yet, eCIs suffer from limited spectral selectivity, resulting from current spread around each electrode contact and causing poor speech recognition in the presence of background noise. Optogenetic stimulation of the auditory nerve might overcome this limitation as light can be conveniently confined in space. Here, we combined virus‐mediated optogenetic manipulation of cochlear spiral ganglion neurons (SGNs) and microsystems engineering to establish acute multi‐channel optical cochlear implant (oCI) stimulation in adult Mongolian gerbils. oCIs based on 16 microscale thin‐film light‐emitting diodes (μLEDs) evoked tonotopic activation of the auditory pathway with high spectral selectivity and modest power requirements in hearing and deaf gerbils. These results prove the feasibility of μLED‐based oCIs for spectrally selective activation of the auditory nerve."],["dc.description.abstract","Synopsis image Electrical cochlear implants effectiveness in individuals remains limited by the spread of the electric current in the cochlea. This study explores the potential of optogenetics for hearing restoration through combining optogenetic manipulation of the auditory nerve with microsystems engineering. μLED‐based optical cochlear implants (oCI) enable stimulation of the rodent auditory nerve. The strength of induced responses scales with the number of recruited emitters. μLED‐evoked neural responses are tonotopic and spectrally selective. The combination of gene therapy and microsystems engineering enables optical activation of the auditory nerve with higher spectral precision in gerbils."],["dc.description.abstract","Electrical cochlear implants effectiveness in individuals remains limited by the spread of the electric current in the cochlea. This study explores the potential of optogenetics for hearing restoration through combining optogenetic manipulation of the auditory nerve with microsystems engineering. image"],["dc.description.sponsorship","H2020 European Research Council (ERC) http://dx.doi.org/10.13039/100010663"],["dc.description.sponsorship","Bundesministerium für Bildung und Forschung (BMBF) http://dx.doi.org/10.13039/501100002347"],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft (DFG) http://dx.doi.org/10.13039/501100001659"],["dc.identifier.doi","10.15252/emmm.202012387"],["dc.identifier.pmid","32596983"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81549"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/52"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation.eissn","1757-4684"],["dc.relation.issn","1757-4676"],["dc.relation.workinggroup","RG Moser (Molecular Anatomy, Physiology and Pathology of Sound Encoding)"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited."],["dc.title","μLED‐based optical cochlear implants for spectrally selective activation of the auditory nerve"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]