Chebbok, Mohammed

[["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Chebbok, M."],["dc.contributor.author","Squires, Amgad"],["dc.contributor.author","Schroeder-Schetelig, Johannes"],["dc.contributor.author","Zabel, M."],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Bodenschatz, Eberhard"],["dc.contributor.author","Fenton, F."],["dc.contributor.author","Luther, S."],["dc.date.accessioned","2018-11-07T09:07:27Z"],["dc.date.available","2018-11-07T09:07:27Z"],["dc.date.issued","2012"],["dc.format.extent","381"],["dc.identifier.isi","000308012403155"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25800"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.eventlocation","Munchen, GERMANY"],["dc.relation.issn","0195-668X"],["dc.title","Low-energy anti-fibrillation pacing (LEAP): a gentle, non traumatic defibrillation Option"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","299"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Cardiovascular Disorders"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Sadlonova, Monika"],["dc.contributor.author","Vogelgsang, Jonathan"],["dc.contributor.author","Lange, Claudia"],["dc.contributor.author","Günther, Irina"],["dc.contributor.author","Wiesent, Adriana"],["dc.contributor.author","Eberhard, Charlotte"],["dc.contributor.author","Ehrentraut, Julia"],["dc.contributor.author","Kirsch, Mareike"],["dc.contributor.author","Hansen, Niels"],["dc.contributor.author","Esselmann, Hermann"],["dc.contributor.author","Timäus, Charles"],["dc.contributor.author","Asendorf, Thomas"],["dc.contributor.author","Breitling, Benedict"],["dc.contributor.author","Chebbok, Mohammed"],["dc.contributor.author","Heinemann, Stephanie"],["dc.contributor.author","Celano, Christopher"],["dc.contributor.author","Kutschka, Ingo"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Baraki, Hassina"],["dc.contributor.author","von Arnim, Christine A. F."],["dc.date.accessioned","2022-08-04T12:01:17Z"],["dc.date.available","2022-08-04T12:01:17Z"],["dc.date.issued","2022-06-30"],["dc.date.updated","2022-07-25T11:18:49Z"],["dc.description.abstract","Background Postoperative delirium is a common complication of cardiac surgery associated with higher morbidity, longer hospital stay, risk of cognitive decline, dementia, and mortality. Geriatric patients, patients undergoing cardiac surgery, and intensive care patients are at a high risk of developing postoperative delirium. Gold standard assessments or biomarkers to predict risk factors for delirium, cognitive decline, and dementia in patients undergoing cardiac surgery are not yet available. Methods The FINDERI trial (FINd DElirium RIsk factors) is a prospective, single-center, observational study. In total, 500 patients aged ≥ 50 years undergoing cardiac surgery at the Department of Cardiovascular and Thoracic Surgery of the University of Göttingen Medical Center will be recruited. Our primary aim is to validate a delirium risk assessment in context of cardiac surgery. Our secondary aims are to identify specific preoperative and perioperative factors associated with delirium, cognitive decline, and accelerated dementia after cardiac surgery, and to identify blood-based biomarkers that predict the incidence of postoperative delirium, cognitive decline, or dementia in patients undergoing cardiac surgery. Discussion This prospective, observational study might help to identify patients at high risk for delirium prior to cardiac surgery, and to identify important biological mechanisms by which cardiac surgery is associated with delirium. The predictive value of a delirium screening questionnaire in cardiac surgery might be revealed. Finally, the identification of specific blood biomarkers might help to predict delirium, cognitive decline, and dementia in patients undergoing cardiac surgery. Trial registration: Ethics approval for this study was obtained from the IRB of the University of Göttingen Medical Center. The investigators registered this study in the German Clinical Trials Register (DRKS; https://www.drks.de ) (DRKS00025095) on April 19th, 2021."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.citation","BMC Cardiovascular Disorders. 2022 Jun 30;22(1):299"],["dc.identifier.doi","10.1186/s12872-022-02732-4"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112643"],["dc.language.iso","en"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.subject","Delirium"],["dc.subject","Cognitive decline"],["dc.subject","Dementia"],["dc.subject","Delirium risk assessment"],["dc.subject","Cardiac surgery"],["dc.subject","Biomarkers"],["dc.title","Identification of risk factors for delirium, cognitive decline, and dementia after cardiac surgery (FINDERI—find delirium risk factors): a study protocol of a prospective observational study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","667"],["dc.bibliographiccitation.issue","7698"],["dc.bibliographiccitation.journal","Nature"],["dc.bibliographiccitation.lastpage","672"],["dc.bibliographiccitation.volume","555"],["dc.contributor.author","Christoph, J."],["dc.contributor.author","Chebbok, M."],["dc.contributor.author","Richter, C."],["dc.contributor.author","Schröder-Schetelig, J."],["dc.contributor.author","Bittihn, P."],["dc.contributor.author","Stein, S."],["dc.contributor.author","Uzelac, I."],["dc.contributor.author","Fenton, F. H."],["dc.contributor.author","Hasenfuß, G."],["dc.contributor.author","Gilmour Jr., R. F."],["dc.contributor.author","Luther, S."],["dc.date.accessioned","2018-04-23T11:47:56Z"],["dc.date.available","2018-04-23T11:47:56Z"],["dc.date.issued","2018"],["dc.description.abstract","The self-organized dynamics of vortex-like rotating waves, which are also known as scroll waves, are the basis of the formation of complex spatiotemporal patterns in many excitable chemical and biological systems1,2,3,4. In the heart, filament-like phase singularities5,6 that are associated with three-dimensional scroll waves7 are considered to be the organizing centres of life-threatening cardiac arrhythmias7,8,9,10,11,12,13. The mechanisms that underlie the onset, maintenance and control14,15,16 of electromechanical turbulence in the heart are inherently three-dimensional phenomena. However, it has not previously been possible to visualize the three-dimensional spatiotemporal dynamics of scroll waves inside cardiac tissues. Here we show that three-dimensional mechanical scroll waves and filament-like phase singularities can be observed deep inside the contracting heart wall using high-resolution four-dimensional ultrasound-based strain imaging. We found that mechanical phase singularities co-exist with electrical phase singularities during cardiac fibrillation. We investigated the dynamics of electrical and mechanical phase singularities by simultaneously measuring the membrane potential, intracellular calcium concentration and mechanical contractions of the heart. We show that cardiac fibrillation can be characterized using the three-dimensional spatiotemporal dynamics of mechanical phase singularities, which arise inside the fibrillating contracting ventricular wall. We demonstrate that electrical and mechanical phase singularities show complex interactions and we characterize their dynamics in terms of trajectories, topological charge and lifetime. We anticipate that our findings will provide novel perspectives for non-invasive diagnostic imaging and therapeutic applications."],["dc.identifier.doi","10.1038/nature26001"],["dc.identifier.gro","3142312"],["dc.identifier.pmid","29466325"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/13445"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/208"],["dc.language.iso","en"],["dc.notes.intern","lifescience updates Crossref Import"],["dc.notes.status","final"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation","SFB 1002 | D01: Erholung aus der Herzinsuffizienz – Einfluss von Fibrose und Transkriptionssignatur"],["dc.relation.issn","0028-0836"],["dc.relation.workinggroup","RG Hasenfuß (Transition zur Herzinsuffizienz)"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.title","Electromechanical vortex filaments during cardiac fibrillation"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","118"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Neurology"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Schnieder, Marlena"],["dc.contributor.author","Chebbok, Mohammed"],["dc.contributor.author","Didié, Michael"],["dc.contributor.author","Wolf, Frieder"],["dc.contributor.author","Badr, Mostafa"],["dc.contributor.author","Allam, Ibrahim"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Schroeter, Marco R."],["dc.date.accessioned","2021-04-14T08:28:09Z"],["dc.date.accessioned","2022-08-18T12:34:55Z"],["dc.date.available","2021-04-14T08:28:09Z"],["dc.date.available","2022-08-18T12:34:55Z"],["dc.date.issued","2021-03-17"],["dc.date.updated","2022-07-29T12:07:15Z"],["dc.description.abstract","Abstract\r\n \r\n Background\r\n Echocardiography is one of the main diagnostic tools for the diagnostic workup of stroke and is already well integrated into the clinical workup. However, the value of transthoracic vs. transesophageal echocardiography (TTE/TEE) in stroke patients is still a matter of debate. Aim of this study was to characterize relevant findings of TTE and TEE in the management of stroke patients and to correlate them with subsequent clinical decisions and therapies.\r\n \r\n \r\n Methods\r\n We evaluated n = 107 patients admitted with an ischemic stroke or transient ischemic attack to our stroke unit of our university medical center. They underwent TTE and TEE examination by different blinded investigators.\r\n \r\n \r\n Results\r\n Major cardiac risk factors were found in 8 of 98 (8.2%) patients and minor cardiac risk factors for stroke were found in 108 cases. We found a change in therapeutic regime after TTE or TEE in 22 (22.5%) cases, in 5 (5%) cases TEE leads to the change of therapeutic regime, in 4 (4%) TTE and in 13 cases (13.3%) TTE and TEE lead to the same change in therapeutic regime. The major therapy change was the indication to close a patent foramen ovale (PFO) in 9 (9.2%) patients with TTE and in 10 (10.2%) patients with TEE (p = 1.000).\r\n \r\n \r\n Conclusion\r\n Major finding with clinical impact on therapy change is the detection of PFO. But for the detection of PFO, TTE is non inferior to TEE, implicating that TTE serves as a good screening tool for detection of PFO, especially in young age patients.\r\n \r\n \r\n Trial registration\r\n The trial was registered and approved prior to inclusion by our local ethics committee (1/3/17)."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.citation","BMC Neurology. 2021 Mar 17;21(1):118"],["dc.identifier.doi","10.1186/s12883-021-02136-5"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17746"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82515"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112935"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","BioMed Central"],["dc.relation.eissn","1471-2377"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject","Stroke"],["dc.subject","Echocardiography"],["dc.subject","Patent foramen ovale"],["dc.subject","Cardio-embolic stroke"],["dc.title","Comparing the diagnostic value of Echocardiography In Stroke (CEIS) – results of a prospective observatory cohort study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]