Portugues, Ruben

[["dc.bibliographiccitation.firstpage","4870.e5"],["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","Current Biology"],["dc.bibliographiccitation.lastpage","4878.e5"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Engerer, Peter"],["dc.contributor.author","Petridou, Eleni"],["dc.contributor.author","Williams, Philip R."],["dc.contributor.author","Suzuki, Sachihiro C."],["dc.contributor.author","Yoshimatsu, Takeshi"],["dc.contributor.author","Portugues, Ruben"],["dc.contributor.author","Misgeld, Thomas"],["dc.contributor.author","Godinho, Leanne"],["dc.date.accessioned","2022-08-19T07:08:06Z"],["dc.date.available","2022-08-19T07:08:06Z"],["dc.date.issued","2021"],["dc.description.abstract","Neuronal identity has long been thought of as immutable, so that once a cell acquires a specific fate, it is maintained for life.1 Studies using the overexpression of potent transcription factors to experimentally reprogram neuronal fate in the mouse neocortex2,3 and retina4,5 have challenged this notion by revealing that post-mitotic neurons can switch their identity. Whether fate reprogramming is part of normal development in the central nervous system (CNS) is unclear. While there are some reports of physiological cell fate reprogramming in invertebrates,6,7 and in the vertebrate peripheral nervous system,8 endogenous fate reprogramming in the vertebrate CNS has not been documented. Here, we demonstrate spontaneous fate re-specification in an interneuron lineage in the zebrafish retina. We show that the visual system homeobox 1 (vsx1)-expressing lineage, which has been associated exclusively with excitatory bipolar cell (BC) interneurons,9-12 also generates inhibitory amacrine cells (ACs). We identify a role for Notch signaling in conferring plasticity to nascent vsx1 BCs, allowing suitable transcription factor programs to re-specify them to an AC fate. Overstimulating Notch signaling enhances this physiological phenotype so that both daughters of a vsx1 progenitor differentiate into ACs and partially differentiated vsx1 BCs can be converted into ACs. Furthermore, this physiological re-specification can be mimicked to allow experimental induction of an entirely distinct fate, that of retinal projection neurons, from the vsx1 lineage. Our observations reveal unanticipated plasticity of cell fate during retinal development."],["dc.identifier.doi","10.1016/j.cub.2021.08.049"],["dc.identifier.pmid","34534440"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113017"],["dc.identifier.url","https://rdp.sfb274.de/literature/publications/42"],["dc.language.iso","en"],["dc.relation","TRR 274: Checkpoints of Central Nervous System Recovery"],["dc.relation","TRR 274 | C04: Checkpoints of visual circuit repair after acute retinal cell injury"],["dc.relation.eissn","1879-0445"],["dc.relation.issn","0960-9822"],["dc.relation.workinggroup","RG Misgeld"],["dc.relation.workinggroup","RG Portugues (Sensorimotor Control)"],["dc.title","Notch-mediated re-specification of neuronal identity during central nervous system development"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2104.e4"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Current Biology"],["dc.bibliographiccitation.lastpage","2115.e4"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Siju, K. P."],["dc.contributor.author","Štih, Vilim"],["dc.contributor.author","Aimon, Sophie"],["dc.contributor.author","Gjorgjieva, Julijana"],["dc.contributor.author","Portugues, Ruben"],["dc.contributor.author","Grunwald Kadow, Ilona C."],["dc.date.accessioned","2022-08-19T10:24:16Z"],["dc.date.available","2022-08-19T10:24:16Z"],["dc.date.issued","2020"],["dc.description.abstract","Neuromodulation permits flexibility of synapses, neural circuits, and ultimately behavior. One neuromodulator, dopamine, has been studied extensively in its role as a reward signal during learning and memory across animal species. Newer evidence suggests that dopaminergic neurons (DANs) can modulate sensory perception acutely, thereby allowing an animal to adapt its behavior and decision making to its internal and behavioral state. In addition, some data indicate that DANs are not homogeneous but rather convey different types of information as a heterogeneous population. We have investigated DAN population activity and how it could encode relevant information about sensory stimuli and state by taking advantage of the confined anatomy of DANs innervating the mushroom body (MB) of the fly Drosophila melanogaster. Using in vivo calcium imaging and a custom 3D image registration method, we found that the activity of the population of MB DANs encodes innate valence information of an odor or taste as well as the physiological state of the animal. Furthermore, DAN population activity is strongly correlated with movement, consistent with a role of dopamine in conveying behavioral state to the MB. Altogether, our data and analysis suggest that DAN population activities encode innate odor and taste valence, movement, and physiological state in a MB-compartment-specific manner. We propose that dopamine shapes innate perception through combinatorial population coding of sensory valence, physiological, and behavioral context."],["dc.identifier.doi","10.1016/j.cub.2020.04.037"],["dc.identifier.pmid","32386530"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113050"],["dc.identifier.url","https://for2705.de/literature/publications/22"],["dc.language.iso","en"],["dc.relation","FOR 2705: Dissection of a Brain Circuit: Structure, Plasticity and Behavioral Function of the Drosophila Mushroom Body"],["dc.relation","FOR 2705 | TP 3: Infection and behavior: The role of the mushroom body, AMPs and octopamine in brain-body communication"],["dc.relation.eissn","1879-0445"],["dc.relation.issn","0960-9822"],["dc.relation.workinggroup","RG Kadow (Behavioral Neurogenetics)"],["dc.rights","CC BY 4.0"],["dc.title","Valence and State-Dependent Population Coding in Dopaminergic Neurons in the Fly Mushroom Body"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]