Weiser, Lukas

[["dc.bibliographiccitation.firstpage","277"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Medicina (Kaunas)"],["dc.bibliographiccitation.volume","58"],["dc.contributor.affiliation","Koepke, Leon-Gordian; 1Division of Spine Surgery, Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; m.stangenberg@uke.de (M.S.); m.dreimann@uke.de (M.D.); ann.heuer@uke.de (A.H.); l.viezens@uke.de (L.V.)"],["dc.contributor.affiliation","Weiser, Lukas; 2Clinic for Trauma, Orthopedics and Plastic Surgery, University Medical Center Göttingen, Georg-August-Universität, 37075 Göttingen, Germany; lukas.weiser@med.uni-goettingen.de"],["dc.contributor.affiliation","Stangenberg, Martin; 1Division of Spine Surgery, Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; m.stangenberg@uke.de (M.S.); m.dreimann@uke.de (M.D.); ann.heuer@uke.de (A.H.); l.viezens@uke.de (L.V.)"],["dc.contributor.affiliation","Dreimann, Marc; 1Division of Spine Surgery, Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; m.stangenberg@uke.de (M.S.); m.dreimann@uke.de (M.D.); ann.heuer@uke.de (A.H.); l.viezens@uke.de (L.V.)"],["dc.contributor.affiliation","Heuer, Annika; 1Division of Spine Surgery, Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; m.stangenberg@uke.de (M.S.); m.dreimann@uke.de (M.D.); ann.heuer@uke.de (A.H.); l.viezens@uke.de (L.V.)"],["dc.contributor.affiliation","Strahl, André; 4Division of Orthopedics, Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; a.strahl@uke.de"],["dc.contributor.affiliation","Viezens, Lennart; 1Division of Spine Surgery, Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; m.stangenberg@uke.de (M.S.); m.dreimann@uke.de (M.D.); ann.heuer@uke.de (A.H.); l.viezens@uke.de (L.V.)"],["dc.contributor.author","Koepke, Leon-Gordian"],["dc.contributor.author","Weiser, Lukas"],["dc.contributor.author","Stangenberg, Martin"],["dc.contributor.author","Dreimann, Marc"],["dc.contributor.author","Heuer, Annika"],["dc.contributor.author","Strahl, André"],["dc.contributor.author","Viezens, Lennart"],["dc.date.accessioned","2022-04-01T10:03:22Z"],["dc.date.available","2022-04-01T10:03:22Z"],["dc.date.issued","2022"],["dc.date.updated","2022-09-03T20:07:05Z"],["dc.description.abstract","Background and Objectives: In osteoporotic fractures of the spine with resulting kyphosis and threatening compression of neural structures, therapeutic decisions are difficult. The posterior vertebral column resection (pVCR) has been described by different authors as a surgical treatment in a single-stage posterior procedure. The aim of this study is to evaluate midterm outcomes of patients treated by pVCR due to severe osteoporotic fractures. Materials and Methods: Retrospective data analysis of all the patients treated for osteoporotic fractures by pVCR from 2012–2020 at two centers was performed. Demographic data, visual analog scale (VAS), Frankel scale (FS), Karnofsky performance status (KPS), radiological result and spinal fusion rates were evaluated. Results: A total of 17 patients were included. The mean age was 70 ± 10.2 y. The mean VAS decreased significantly from 7.7 ± 2.8 preoperatively to 3.0 ± 1.6 at last follow-up (p < 0.001) and the segmental kyphosis decreased from 29.4 ± 14.1° to 7.9 ± 8.0° (p < 0.001). The neurologic function on the FS did not worsen in any and improved in four of the patients. The median KPS remained stable over the whole observation period (70% vs. 70%). Spinal fusion was observed in nine out of nine patients who received CT follow-up >120 days after index surgery. Conclusions: This study showed that pVCR is a safe surgical technique with few surgical complications and no neurological deterioration considering the cohort. The patients’ segmental kyphosis and VAS improved significantly, while the KPS remained stable."],["dc.identifier.doi","10.3390/medicina58020277"],["dc.identifier.pii","medicina58020277"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/106152"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","1648-9144"],["dc.rights","CC BY 4.0"],["dc.title","Outcome after Posterior Vertebral Column Resection in Patients with Severe Osteoporotic Fractures—A Retrospective Analysis from Two Centers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","221"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Neurosurgical Review"],["dc.bibliographiccitation.lastpage","228"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Dreimann, Marc"],["dc.contributor.author","Hempfing, Axel"],["dc.contributor.author","Stangenberg, Martin"],["dc.contributor.author","Viezens, Lennart"],["dc.contributor.author","Weiser, Lukas"],["dc.contributor.author","Czorlich, Patrick"],["dc.contributor.author","Eicker, Sven Oliver"],["dc.date.accessioned","2020-12-10T14:11:12Z"],["dc.date.available","2020-12-10T14:11:12Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s10143-017-0840-1"],["dc.identifier.eissn","1437-2320"],["dc.identifier.issn","0344-5607"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70996"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Posterior vertebral column resection with 360-degree osteosynthesis in osteoporotic kyphotic deformity and spinal cord compression"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","301"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Operative Orthopädie und Traumatologie"],["dc.bibliographiccitation.lastpage","310"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Viezens, L."],["dc.contributor.author","Sehmisch, S."],["dc.contributor.author","Lehmann, W."],["dc.contributor.author","Weiser, L."],["dc.date.accessioned","2020-12-10T14:08:03Z"],["dc.date.available","2020-12-10T14:08:03Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00064-019-0609-5"],["dc.identifier.eissn","1439-0981"],["dc.identifier.issn","0934-6694"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16565"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70360"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Pedikelsubtraktionsosteotomie zur Korrektur rigider Deformitäten"],["dc.title.alternative","Pedicle subtraction osteotomy to correct rigid deformities"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","The Spine Journal"],["dc.contributor.author","Roch, Paul Jonathan"],["dc.contributor.author","Çelik, Bahar"],["dc.contributor.author","Jäckle, Katharina"],["dc.contributor.author","Reinhold, Maximilian"],["dc.contributor.author","Meier, Marc-Pascal"],["dc.contributor.author","Hawellek, Thelonius"],["dc.contributor.author","Kowallick, Johannes Tammo"],["dc.contributor.author","Klockner, Friederike Sophie"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Weiser, Lukas"],["dc.date.accessioned","2022-12-01T08:30:44Z"],["dc.date.available","2022-12-01T08:30:44Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1016/j.spinee.2022.10.013"],["dc.identifier.pii","S1529943022009986"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/117963"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-621"],["dc.relation.issn","1529-9430"],["dc.rights.uri","https://www.elsevier.com/tdm/userlicense/1.0/"],["dc.title","Combination of vertebral bone quality scores from different magnetic resonance imaging sequences improves prognostic value for the estimation of osteoporosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","275"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Operative Orthopädie und Traumatologie"],["dc.bibliographiccitation.lastpage","283"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Viezens, Lennart"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Weiser, Lukas"],["dc.contributor.author","Dreimann, Marc"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.date.accessioned","2020-12-10T14:08:03Z"],["dc.date.available","2020-12-10T14:08:03Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00064-019-0615-7"],["dc.identifier.eissn","1439-0981"],["dc.identifier.issn","0934-6694"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16357"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70363"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Dorsale Stabilisation der Halswirbelkörper HWK1/HWK2 modifiziert nach Goel-Harms mit HWK-1-Pedikelschrauben"],["dc.title.alternative","Dorsal stabilization of C1/C2 modified according to Goel-Harms with C1 pedicle screws"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","243"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Bone and Mineral Metabolism"],["dc.bibliographiccitation.lastpage","255"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Hoffmann, D. B."],["dc.contributor.author","Komrakova, M."],["dc.contributor.author","Pflug, S."],["dc.contributor.author","Oertzen, M. von"],["dc.contributor.author","Saul, D."],["dc.contributor.author","Weiser, L."],["dc.contributor.author","Walde, T. A."],["dc.contributor.author","Wassmann, M."],["dc.contributor.author","Schilling, A. F."],["dc.contributor.author","Lehmann, W."],["dc.contributor.author","Sehmisch, S."],["dc.date.accessioned","2020-06-15T13:52:01Z"],["dc.date.available","2020-06-15T13:52:01Z"],["dc.date.issued","2018"],["dc.description.abstract","We investigated the combinatorial effects of whole-body vertical vibration (WBVV) with the primarily osteoanabolic parathyroid hormone (PTH) and the mainly antiresorptive strontium ranelate (SR) in a rat model of osteoporosis. Ovariectomies were performed on 76 three-month-old Sprague-Dawley rats (OVX, n = 76; NON-OVX, n = 12). After 8 weeks, the ovariectomized rats were divided into 6 groups. One group (OVX + PTH) received daily injections of PTH (40 µg/kg body weight/day) for 6 weeks. Another group (OVX + SR) was fed SR-supplemented chow (600 mg/kg body weight/day). Three groups (OVX + VIB, OVX + PTH + VIB, and OVX + SR + VIB) were treated with WBVV twice a day at 70 Hz for 15 min. Two groups (OVX + PTH + VIB, OVX + SR + VIB) were treated additionally with PTH and SR, respectively. The rats were killed at 14 weeks post-ovariectomy. The lumbar vertebrae and femora were removed for biomechanical and morphological assessment. PTH produced statistically significant improvements in biomechanical and structural properties, including bone mineral density (BMD) and trabecular bone quality. In contrast, SR treatment exerted mild effects, with significant effects in cortical thickness only. SR produced no significant improvement in biomechanical properties. WBVV as a single or an adjunctive therapy produced no significant improvements. In conclusion, vibration therapy administered as a single or dual treatment had no significant impact on bones affected by osteoporosis. PTH considerably improved bone quality in osteoporosis cases and is superior to treatment with SR."],["dc.identifier.doi","10.1007/s00774-018-0929-9"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66263"],["dc.language.iso","en"],["dc.relation.issn","0914-8779"],["dc.title","Evaluation of Ostarine as a Selective Androgen Receptor Modulator in a Rat Model of Postmenopausal Osteoporosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","284"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Operative Orthopädie und Traumatologie"],["dc.bibliographiccitation.lastpage","292"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Weiser, Lukas"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Viezens, Lennart"],["dc.date.accessioned","2020-12-10T14:08:03Z"],["dc.date.available","2020-12-10T14:08:03Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00064-019-0608-6"],["dc.identifier.eissn","1439-0981"],["dc.identifier.issn","0934-6694"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16356"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70359"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Techniken zur Steigerung der Pedikelschraubenstabilität im osteoporotischen Knochen"],["dc.title.alternative","Techniques to increase pedicle screw stability in osteoporotic vertebrae"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e739"],["dc.bibliographiccitation.journal","World Neurosurgery"],["dc.bibliographiccitation.lastpage","e747"],["dc.bibliographiccitation.volume","109"],["dc.contributor.author","Viezens, Lennart"],["dc.contributor.author","Reer, Phillip"],["dc.contributor.author","Strahl, Andre"],["dc.contributor.author","Weiser, Lukas"],["dc.contributor.author","Schroeder, Malte"],["dc.contributor.author","Beyerlein, Joerg"],["dc.contributor.author","Schaefer, Christian"],["dc.date.accessioned","2020-12-10T15:21:41Z"],["dc.date.available","2020-12-10T15:21:41Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.wneu.2017.10.074"],["dc.identifier.issn","1878-8750"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73120"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Safety and Efficacy of Single-Stage versus 2-Stage Spinal Fusion via Posterior Instrumentation and Anterior Thoracoscopy: A Retrospective Matched-Pair Cohort Study with 247 Consecutive Patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1224"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Medicina (Kaunas)"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Jäckle, Katharina"],["dc.contributor.author","Klockner, Friederike"],["dc.contributor.author","Hoffmann, Daniel Bernd"],["dc.contributor.author","Roch, Paul Jonathan"],["dc.contributor.author","Reinhold, Maximilian"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Weiser, Lukas"],["dc.date.accessioned","2022-01-11T14:07:53Z"],["dc.date.available","2022-01-11T14:07:53Z"],["dc.date.issued","2021"],["dc.date.updated","2022-09-03T16:52:39Z"],["dc.description.abstract","Background and Objectives: Hyponatremia is the most common electrolyte disorder in elderly and associated with increased risk of falls. Clinical studies as well as small animal experiments suggested an association between chronic hyponatremia and osteoporosis. Furthermore, it has been assumed that subtle hyponatremia may be an independent fracture risk in the elderly. Therefore, this study was designed to evaluate the possible influence of chronic hyponatremia on osteoporosis and low-energy fractures of the spine. Materials and Methods: 144 patients with a vertebral body fracture (mean age: 69.15 ± 16.08; 73 females and 71 males) due to low-energy trauma were treated in a level one trauma center within one year and were included in the study. Chronic hyponatremia was defined as serum sodium < 135 mmol/L at admission. Bone mineral density (BMD) of the spine was measured using quantitative computed tomography in each patient. Results: Overall, 19.44% (n = 28) of patients in the low-energy trauma group had hyponatremia. In the group with fractures caused by low-energy trauma, the proportion of hyponatremia of patients older than 65 years was significantly increased as compared to younger patients (p = 0.0016). Furthermore, there was no significant gender difference in the hyponatremia group. Of 28 patients with chronic hyponatremia, all patients had decreased bone quality. Four patients showed osteopenia and the other 24 patients even showed osteoporosis. In the low-energy trauma group, the BMD correlated significantly with serum sodium (r = 0.396; p < 0.001). Conclusions: The results suggest that chronic hyponatremia affects bone quality. Patients with chronic hyponatremia have an increased prevalence of fractures after low-energy trauma due to a decreased bone quality. Therefore, physicians from different specialties should focus on the treatment of chronic hyponatremia to reduce the fracture rate after low-energy trauma, particularly with elderly patients."],["dc.description.abstract","Background and Objectives: Hyponatremia is the most common electrolyte disorder in elderly and associated with increased risk of falls. Clinical studies as well as small animal experiments suggested an association between chronic hyponatremia and osteoporosis. Furthermore, it has been assumed that subtle hyponatremia may be an independent fracture risk in the elderly. Therefore, this study was designed to evaluate the possible influence of chronic hyponatremia on osteoporosis and low-energy fractures of the spine. Materials and Methods: 144 patients with a vertebral body fracture (mean age: 69.15 ± 16.08; 73 females and 71 males) due to low-energy trauma were treated in a level one trauma center within one year and were included in the study. Chronic hyponatremia was defined as serum sodium < 135 mmol/L at admission. Bone mineral density (BMD) of the spine was measured using quantitative computed tomography in each patient. Results: Overall, 19.44% (n = 28) of patients in the low-energy trauma group had hyponatremia. In the group with fractures caused by low-energy trauma, the proportion of hyponatremia of patients older than 65 years was significantly increased as compared to younger patients (p = 0.0016). Furthermore, there was no significant gender difference in the hyponatremia group. Of 28 patients with chronic hyponatremia, all patients had decreased bone quality. Four patients showed osteopenia and the other 24 patients even showed osteoporosis. In the low-energy trauma group, the BMD correlated significantly with serum sodium (r = 0.396; p < 0.001). Conclusions: The results suggest that chronic hyponatremia affects bone quality. Patients with chronic hyponatremia have an increased prevalence of fractures after low-energy trauma due to a decreased bone quality. Therefore, physicians from different specialties should focus on the treatment of chronic hyponatremia to reduce the fracture rate after low-energy trauma, particularly with elderly patients."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.3390/medicina57111224"],["dc.identifier.pii","medicina57111224"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/97886"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-507"],["dc.relation.eissn","1648-9144"],["dc.relation.orgunit","Klinik für Unfallchirurgie, Orthopädie und Plastische Chirurgie"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Influence of Hyponatremia on Spinal Bone Quality and Fractures Due to Low-Energy Trauma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","80"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Trauma und Berufskrankheit"],["dc.bibliographiccitation.lastpage","85"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Weiser, L."],["dc.contributor.author","Viezens, L."],["dc.contributor.author","Huber, G."],["dc.contributor.author","Lehmann, W."],["dc.date.accessioned","2018-10-10T07:58:47Z"],["dc.date.available","2018-10-10T07:58:47Z"],["dc.date.issued","2017"],["dc.fs.pkfprnr","74524"],["dc.identifier.doi","10.1007/s10039-017-0262-x"],["dc.identifier.fs","633993"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15923"],["dc.notes.status","zu prüfen"],["dc.title","Wirbelkörperfrakturen und Osteopenie: Augmentieren oder langstreckig?"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]