Nitsche, Michael A.

[["dc.bibliographiccitation.firstpage","3053"],["dc.bibliographiccitation.issue","13"],["dc.bibliographiccitation.journal","The Journal of Physiology"],["dc.bibliographiccitation.lastpage","3054"],["dc.bibliographiccitation.volume","589"],["dc.contributor.author","Nitsche, Michael A."],["dc.date.accessioned","2018-11-07T08:54:50Z"],["dc.date.available","2018-11-07T08:54:50Z"],["dc.date.issued","2011"],["dc.identifier.doi","10.1113/jphysiol.2011.211599"],["dc.identifier.isi","000292206800003"],["dc.identifier.pmid","21724583"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22762"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0022-3751"],["dc.title","Beyond the target area: remote effects of non-invasive brain stimulation in humans"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","14442"],["dc.bibliographiccitation.issue","52"],["dc.bibliographiccitation.journal","Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","14447"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Kuo, Min-Fang"],["dc.contributor.author","Grosch, Jan"],["dc.contributor.author","Fregni, Felipe"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Nitsche, Michael A."],["dc.date.accessioned","2018-11-07T10:43:58Z"],["dc.date.available","2018-11-07T10:43:58Z"],["dc.date.issued","2007"],["dc.description.abstract","Cholinergic neuromodulation is pivotal for arousal, attention, and cognitive processes. Loss or dysregulation of cholinergic inputs leads to cognitive impairments like those manifested in Alzheimer's disease. Such dysfunction can be at least partially restored by an increase of acetylcholine (ACh). In animal studies, ACh selectively facilitates long-term excitability changes induced by feed-forward afferent input. Consequently, it has been hypothesized that ACh enhances the signal-to-noise ratio of input processing. However, the neurophysiological foundation for its ability to enhance cognition in humans is not well documented. In this study we explore the effects of rivastigmine, a cholinesterase inhibitor, on global and synapse-specific forms of cortical plasticity induced by transcranial direct current stimulation (tDCS) and paired associative stimulation (PAS) on 10-12 healthy subjects, respectively. Rivastigmine essentially blocked the induction of the global excitability enhancement elicited by anodal tDCS and revealed a tendency to first reduce and then stabilize cathodal tDCS-induced inhibitory aftereffects. However, ACh enhanced the synapse-specific excitability enhancement produced by facilitatory PAS and consolidated the inhibitory PAS-induced excitability diminution. These findings are in line with a cholinergic focusing effect that optimizes the detection of relevant signals during information processing in humans."],["dc.identifier.doi","10.1523/JNEUROSCI.4104-07.2007"],["dc.identifier.isi","000251911100024"],["dc.identifier.pmid","18160652"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47168"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc Neuroscience"],["dc.relation.issn","0270-6474"],["dc.title","Focusing effect of acetylcholine on neuroplasticity in the human motor cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","386"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Brain Stimulation"],["dc.bibliographiccitation.lastpage","387"],["dc.bibliographiccitation.volume","1"],["dc.contributor.author","Pahn, Ulrich"],["dc.contributor.author","Keeser, Daniel"],["dc.contributor.author","Schiller, Christina"],["dc.contributor.author","Fintescu, Zoe"],["dc.contributor.author","Reisinger, Eva"],["dc.contributor.author","Nitsche, Michael"],["dc.contributor.author","Padberg, Frank"],["dc.date.accessioned","2018-11-07T11:10:24Z"],["dc.date.available","2018-11-07T11:10:24Z"],["dc.date.issued","2008"],["dc.identifier.doi","10.1016/j.brs.2008.04.003"],["dc.identifier.isi","000262717000008"],["dc.identifier.pmid","20633396"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53200"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1876-4754"],["dc.relation.issn","1935-861X"],["dc.title","Skin lesions after treatment with transcranial direct current stimulation (tDCS)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.volume","180"],["dc.contributor.author","Nitsche, M."],["dc.contributor.author","Hermann, Robert Michael"],["dc.contributor.author","Christiansen, H."],["dc.contributor.author","Weiss, Elisabeth"],["dc.date.accessioned","2018-11-07T10:48:46Z"],["dc.date.available","2018-11-07T10:48:46Z"],["dc.date.issued","2004"],["dc.format.extent","37"],["dc.identifier.isi","000221877000143"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48271"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.conference","10th Annual Congress of the Deutschen-Gesellschaft-fur-Radioonkologie"],["dc.relation.eventlocation","Erfurt, GERMANY"],["dc.relation.issn","0179-7158"],["dc.title","Paraganglioma of the cerebellum - Case report"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","10701"],["dc.bibliographiccitation.issue","32"],["dc.bibliographiccitation.journal","Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","10709"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Fresnoza, Shane"],["dc.contributor.author","Stiksrud, Elisabeth"],["dc.contributor.author","Klinker, Florian"],["dc.contributor.author","Liebetanz, David"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Kuo, Min-Fang"],["dc.contributor.author","Nitsche, Michael A."],["dc.date.accessioned","2018-11-07T09:36:45Z"],["dc.date.available","2018-11-07T09:36:45Z"],["dc.date.issued","2014"],["dc.description.abstract","The neuromodulator dopamine plays an important role in synaptic plasticity. The effects depend on receptor subtypes, affinity, concentration level, and the kind of neuroplasticity induced. In animal experiments, dopamine D-2-like receptor stimulation revealed partially antagonistic effects on plasticity, which might be explained by dosage dependency. In humans, D-2 receptor block abolishes plasticity, and the D-2/D-3, but predominantly D-3, receptor agonist ropinirol has a dosage-dependent nonlinear affect on plasticity. Here we aimed to determine the specific affect of D-2 receptor activation on neuroplasticity in humans, because physiological effects of D-2 and D-3 receptors might differ. Therefore, we combined application of the selective D-2 receptor agonist bromocriptine (2.5, 10, and 20 mg or placebo medication) with anodal and cathodal transcranial direct current stimulation (tDCS), which induces nonfocal plasticity, and with paired associative stimulation (PAS) generating a more focal kind of plasticity in the motor cortex of healthy humans. Plasticity was monitored by transcranial magnetic stimulation-induced motor-evoked potential amplitudes. For facilitatory tDCS, bromocriptine prevented plasticity induction independent from drug dosage. However, its application resulted in an inverted U-shaped dose-response curve on inhibitory tDCS, excitability-diminishing PAS, and to a minor degree on excitability-enhancing PAS. These data support the assumption that modulation of D-2-like receptor activity exerts a nonlinear dose-dependent effect on neuroplasticity in the human motor cortex that differs from predominantly D-3 receptor activation and that the kind of plasticity-induction procedure is relevant for its specific impact."],["dc.description.sponsorship","German Research Foundation [NI 683/6-1]"],["dc.identifier.doi","10.1523/JNEUROSCI.0832-14.2014"],["dc.identifier.isi","000341017300023"],["dc.identifier.pmid","25100602"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32687"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc Neuroscience"],["dc.relation.issn","0270-6474"],["dc.title","Dosage-Dependent Effect of Dopamine D-2 Receptor Activation on Motor Cortex Plasticity in Humans"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2287"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","NeuroImage"],["dc.bibliographiccitation.lastpage","2296"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Polania, Rafael"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Nitsche, Michael A."],["dc.date.accessioned","2018-11-07T08:59:55Z"],["dc.date.available","2018-11-07T08:59:55Z"],["dc.date.issued","2011"],["dc.description.abstract","Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that alters cortical excitability and activity in a polarity-dependent way. Stimulation for a few minutes has been shown to induce plastic alterations of cortical excitability and to improve cognitive performance. These effects might be related to stimulation-induced alterations of functional cortical network connectivity. We aimed to investigate the impact of tDCS on cortical network function by functional connectivity and graph theoretical analysis of the BOLD fMRI spontaneous activity. fMRI resting-state datasets were acquired immediately before and after 10-min bipolar tDCS during rest, with the anode placed over the left primary motor cortex (M1) and the cathode over the contralateral frontopolar cortex. For each dataset, grey matter voxel-based synchronization matrices were calculated and thresholded to construct undirected graphs. Nodal connectivity degree and minimum path length maps were calculated and compared before and after tDCS. Nodal minimum path lengths significantly increased in the left somatomotor (SM1) cortex after anodal tDCS, which means that the number of direct functional connections from the left SM1 to topologically distant grey matter voxels significantly decreased. In contrast, functional coupling between premotor and superior parietal areas with the left SM1 significantly increased. Additionally, the nodal connectivity degree in the left posterior cingulate cortex (PCC) area as well as in the right dorsolateral prefrontal cortex (right DLPFC) significantly increased. In summary, we provide initial support that tDCS-induced neuroplastic alterations might be related to functional connectivity changes in the human brain. Additionally, we propose our approach as a powerful method to track for neuroplastic changes in the human brain. (C) 2010 Elsevier Inc. All rights reserved."],["dc.description.sponsorship","Rose Foundation"],["dc.identifier.doi","10.1016/j.neuroimage.2010.09.085"],["dc.identifier.isi","000286302000051"],["dc.identifier.pmid","20932916"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24019"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","1053-8119"],["dc.title","Introducing graph theory to track for neuroplastic alterations in the resting human brain: A transcranial direct current stimulation study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","55"],["dc.bibliographiccitation.journal","Epilepsia"],["dc.bibliographiccitation.lastpage","56"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Klinker, Florian"],["dc.contributor.author","Hering, Diana"],["dc.contributor.author","Koch, R."],["dc.contributor.author","Nitsche, M. A."],["dc.contributor.author","Potschka, Heidrun"],["dc.contributor.author","Loscher, W."],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Tergau, Frithjof"],["dc.contributor.author","Liebetanz, David"],["dc.date.accessioned","2018-11-07T11:06:29Z"],["dc.date.available","2018-11-07T11:06:29Z"],["dc.date.issued","2007"],["dc.identifier.isi","000246578400172"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52321"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.publisher.place","Oxford"],["dc.relation.conference","5th Joint Meeting of the German, Austrian, and Swiss Sections of the International League Against Epilepsy"],["dc.relation.eventlocation","Basle, SWITZERLAND"],["dc.relation.issn","0013-9580"],["dc.title","Anticonvulsive aftereffects of cathodal transcranial direct current stimulation (tDCS) in the rat transcranial ramp model of focal epilepsy"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Hoffmann, A. L."],["dc.contributor.author","Buhk, Jan-Hendrik"],["dc.contributor.author","Nitsche, M."],["dc.contributor.author","Strik, Herwig Matthias"],["dc.date.accessioned","2018-11-07T11:08:46Z"],["dc.date.available","2018-11-07T11:08:46Z"],["dc.date.issued","2008"],["dc.format.extent","1115"],["dc.identifier.isi","000261695800218"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52865"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Duke Univ Press"],["dc.publisher.place","Durham"],["dc.relation.conference","8th Congress of the European-Association-for-Neuro-Oncology (EANO)"],["dc.relation.eventlocation","Barcelona, SPAIN"],["dc.relation.issn","1522-8517"],["dc.title","LONG TERM STABILIZATION OF LEPTOMENINGEAL AND SOLID CNS METASTASES FROM BREAST CANCER WITH COMBINED INTRATHECAL LIPOSOMAL ARA-C AND SYSTEMIC TEMOZOLOMIDE"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Klinische Neurophysiologie"],["dc.bibliographiccitation.volume","46"],["dc.contributor.author","Grundey, Jessica"],["dc.contributor.author","Nitsche, M. A."],["dc.date.accessioned","2018-11-07T09:52:20Z"],["dc.date.available","2018-11-07T09:52:20Z"],["dc.date.issued","2015"],["dc.description.abstract","Pathological alterations of plasticity are increasingly discussed as pathophysiological foundation of diverse neurologic and psychiatric diseases. The tools of non-invasive brain stimulation (NIBS) offer the possibility to examine altered plasticity in patients and furthermore modulate pathological plasticity therapeutically. Multiple methods to affect human neuroplasticity were developed and established during the last years. These include repetitive transcranial magnetic stimulation (rTMS), paired associative stimulation (PAS), transcranial direct current stimulation (tDCS) and oscillatory electric stimulation procedures like transcranial alternating current stimulation (tACS) and random noise stimulation. The only FDA-approved and clinically implemented method of NIBS is the repetitive transcranial magnetic stimulation that is used for the treatment of major depressions. All other tools of NIBS have so far been mainly applied experimentally. In the following article we provide an overview of the different methods of NIBS, the present clinical and therapeutic data and future perspectives."],["dc.identifier.doi","10.1055/s-0035-1559716"],["dc.identifier.isi","000361847600005"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36105"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","1439-4081"],["dc.relation.issn","1434-0275"],["dc.title","Neuromodulatory Non-invasive Brain Stimulation: Methods and Clinical Application"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2097"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Neuropsychopharmacology"],["dc.bibliographiccitation.lastpage","2102"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Monte-Silva, Katia K."],["dc.contributor.author","Ruge, Diane"],["dc.contributor.author","Teo, James T."],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Rothwell, John C."],["dc.contributor.author","Nitsche, Michael A."],["dc.date.accessioned","2018-11-07T08:52:56Z"],["dc.date.available","2018-11-07T08:52:56Z"],["dc.date.issued","2011"],["dc.description.abstract","Dopamine (DA) is a neurotransmitter with an important influence on learning and memory, which is thought to be due to its modulatory effect on plasticity at central synapses, which in turn depends on activation of D1 and D2 receptors. Methods of brain stimulation (transcranial direct current stimulation, tDCS; paired associative stimulation, PAS) lead to after-effects on cortical excitability that are thought to resemble long-term potentization (LTP)/long-term depression (LTD) in reduced preparations. In a previous study we found that block of D2 receptors abolished plasticity induced by tDCS but had no effect on the facilitatory plasticity induced by PAS. We postulated that the different effect of D2 receptor block on tDCS-and PAS-induced plasticity may be due to the different focality and associativity of the stimulation techniques. However, alternative explanations for this difference could not be ruled out. tDCS also differs from PAS in other aspects, as tDCS induces plasticity by subthreshold neuronal activation, modulating spontaneous activity, whereas PAS induces plasticity via phasic suprathreshold stimulation. The present study in 12 volunteers examined effects of D2 receptor blockade (sulpiride (SULP) 400 mg), on the LTP/LTD-like effects of theta burst transcranial magnetic stimulation (TBS), which has less restricted effects on cortical synapses than that of PAS, and does not induce associative plasticity, similar to tDCS, but on the other hand induces cortical excitability shifts by suprathreshold (rhythmic) activation of cortical neurons similarly to PAS. Administration of SULP blocked both the excitatory and inhibitory effects of intermittent (iTBS) and continuous TBS (cTBS), respectively. As the reduced response to TBS following SULP resembles its effect on tDCS, the results support an effect of DA on plasticity, which might be related to the focality and associativity of the plasticity induced. Neuropsychopharmacology (2011) 36, 2097-2102; doi: 10.1038/npp.2011.100; published online 22 June 2011"],["dc.identifier.doi","10.1038/npp.2011.100"],["dc.identifier.isi","000293893100014"],["dc.identifier.pmid","21697824"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22284"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","0893-133X"],["dc.title","D2 Receptor Block Abolishes Theta Burst Stimulation-Induced Neuroplasticity in the Human Motor Cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]