Welz, Christian

[["dc.bibliographiccitation.firstpage","1631"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Head & Neck"],["dc.bibliographiccitation.lastpage","1638"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Weiss, Bernhard G."],["dc.contributor.author","Ihler, Friedrich"],["dc.contributor.author","Wolff, Hendrik A."],["dc.contributor.author","Schneider, Simon"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Steiner, Wolfgang"],["dc.contributor.author","Welz, Christian"],["dc.date.accessioned","2020-12-10T14:06:36Z"],["dc.date.available","2020-12-10T14:06:36Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1002/hed.v39.8"],["dc.identifier.issn","1043-3074"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/69956"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Transoral laser microsurgery for treatment for hypopharyngeal cancer in 211 patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","963"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Head & Neck"],["dc.bibliographiccitation.lastpage","972"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Baumeister, Philipp"],["dc.contributor.author","Baumüller, Konstantin"],["dc.contributor.author","Harréus, Ulrich"],["dc.contributor.author","Reiter, Maximilian"],["dc.contributor.author","Welz, Christian"],["dc.date.accessioned","2020-12-10T14:06:36Z"],["dc.date.available","2020-12-10T14:06:36Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1002/hed.v40.5"],["dc.identifier.issn","1043-3074"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/69957"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Evaluation of margins in head and neck squamous cell carcinoma from the surgeon's perspective"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2201"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Anticancer Research"],["dc.bibliographiccitation.lastpage","2210"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Hagemann, Jan"],["dc.contributor.author","Jacobi, Christian"],["dc.contributor.author","Hahn, Moritz"],["dc.contributor.author","Schmid, Vanessa"],["dc.contributor.author","Welz, Christian"],["dc.contributor.author","Schwenk-Zieger, Sabina"],["dc.contributor.author","Stauber, Roland"],["dc.contributor.author","Baumeister, Philipp"],["dc.contributor.author","Becker, Sven"],["dc.date.accessioned","2018-11-07T10:24:11Z"],["dc.date.available","2018-11-07T10:24:11Z"],["dc.date.issued","2017"],["dc.description.abstract","Background/Aim: Chemo-radiation currently serves as first-line therapy of advanced and recurrent head and neck cancer, while new chemotherapy regimens are emerging. However, response rates to any treatment are difficult to predict and underlie broad variation. This study shows the development of a standardized, high-throughput in vitro assay to assess patients' individual response to therapy regimens as a future tool for personalized tumor therapy. Materials and Methods: Viability and proliferation analyses after chemo +/- radiation treatment of single spheroids (low adhesion plates/Hanging Drop (HD)) were generated from head and neck squamous cell carcinoma (HNSCC) cell lines and primary human cells from fresh tumor specimens. Results: All cell lines showed reliable growth in all cell culture methods. The spheroids showed significant delay of growth and/or necrosis compared to control groups when exposed to current standard chemotherapeutic regimens. Single 3D spheroids ready for therapy susceptibility testing could be generated from actual tumor specimens after enzymatic and mechanical separation. Conclusion: In its current form, this single spheroid-based in vitro assay was able to test individual therapy susceptibility to current standard therapy regimens or, potentially, for testing new targeted drugs in HNSCC treatment. With recent discoveries regarding tumor heterogeneity and individual mutation status, a reliable assay is a prerequisite for personalized therapy in head and neck cancer."],["dc.description.sponsorship","Universitat Munchen"],["dc.identifier.doi","10.21873/anticanres.11555"],["dc.identifier.isi","000402173300005"],["dc.identifier.pmid","28476783"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42610"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Int Inst Anticancer Research"],["dc.relation.issn","1791-7530"],["dc.relation.issn","0250-7005"],["dc.title","Spheroid-based 3D Cell Cultures Enable Personalized Therapy Testing and Drug Discovery in Head and Neck Cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0141827"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Welz, Christian"],["dc.contributor.author","Emmert, Steffen"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Becker, Sven"],["dc.contributor.author","Baumeister, Philipp"],["dc.contributor.author","Shimizu, Tetsuji"],["dc.contributor.author","Morfill, Gregor E."],["dc.contributor.author","Harreus, Uli"],["dc.contributor.author","Zimmermann, Julia L."],["dc.date.accessioned","2018-11-07T09:48:49Z"],["dc.date.available","2018-11-07T09:48:49Z"],["dc.date.issued","2015"],["dc.description.abstract","Head and neck squamous cell cancer (HNSCC) is the 7th most common cancer worldwide. Despite the development of new therapeutic agents such as monoclonal antibodies, prognosis did not change for the last decades. Cold atmospheric plasma (CAP) presents the most promising new technology in cancer treatment. In this study the efficacy of a surface micro discharging (SMD) plasma device against two head and neck cancer cell lines was proved. Effects on the cell viability, DNA fragmentation and apoptosis induction were evaluated with the MTT assay, alkaline microgel electrophoresis (comet assay) and Annexin-V/PI staining. MTT assay revealed that the CAP treatment markedly decreases the cell viability for all tested treatment times (30, 60, 90, 120 and 180 s). IC 50 was reached within maximal 120 seconds of CAP treatment. Comet assay analysis showed a dose dependent high DNA fragmentation being one of the key players in anti-cancer activity of CAP. Annexin-V/PI staining revealed induction of apoptosis in CAP treated HNSCC cell lines but no significant dose dependency was seen. Thus, we confirmed that SMD Plasma technology is definitely a promising new approach on cancer treatment."],["dc.description.sponsorship","Friedrich-Baur-Stiftung Munich [40/13]"],["dc.identifier.doi","10.1371/journal.pone.0141827"],["dc.identifier.isi","000365251500006"],["dc.identifier.pmid","26588072"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12554"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35387"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Cold Atmospheric Plasma: A Promising Complementary Therapy for Squamous Head and Neck Cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e1711"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Plastic & Reconstructive Surgery"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Spiegel, Jennifer L."],["dc.contributor.author","Pilavakis, Yiannis"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Welz, Christian"],["dc.date.accessioned","2020-12-10T18:19:54Z"],["dc.date.available","2020-12-10T18:19:54Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1097/GOX.0000000000001711"],["dc.identifier.issn","2169-7574"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75416"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Shoulder Morbidity in Patients after Head and Neck Reconstruction with the Pedicled Supraclavicular Island Flap"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","294"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Auris Nasus Larynx"],["dc.bibliographiccitation.lastpage","301"],["dc.bibliographiccitation.volume","46"],["dc.contributor.author","Becker, Sven"],["dc.contributor.author","Zimmermann, Julia L."],["dc.contributor.author","Baumeister, Philipp"],["dc.contributor.author","Brunner, Theresa F."],["dc.contributor.author","Shimizu, Tetsuji"],["dc.contributor.author","Li, Yang-Fang"],["dc.contributor.author","Morfill, Gregor E."],["dc.contributor.author","Harréus, Ulrich"],["dc.contributor.author","Welz, Christian"],["dc.date.accessioned","2020-12-10T14:22:24Z"],["dc.date.available","2020-12-10T14:22:24Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.anl.2018.07.008"],["dc.identifier.issn","0385-8146"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71598"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Effects of cold atmospheric plasma (CAP) on bacteria and mucosa of the upper aerodigestive tract"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","878"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Otolaryngology–Head and Neck Surgery"],["dc.bibliographiccitation.lastpage","881"],["dc.bibliographiccitation.volume","158"],["dc.contributor.author","Baumeister, Philipp"],["dc.contributor.author","Welz, Christian"],["dc.contributor.author","Jacobi, Christian"],["dc.contributor.author","Reiter, Maximilian"],["dc.date.accessioned","2020-12-10T18:38:24Z"],["dc.date.available","2020-12-10T18:38:24Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1177/0194599817750354"],["dc.identifier.eissn","1097-6817"],["dc.identifier.issn","0194-5998"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77301"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Is Perineural Invasion of Head and Neck Squamous Cell Carcinomas Linked to Tobacco Consumption?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","343"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Environmental Pathology, Toxicology and Oncology"],["dc.bibliographiccitation.lastpage","354"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Welz, Christian"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Schwenk-Zieger, Sabina"],["dc.contributor.author","Becker, Sven"],["dc.contributor.author","Stucke, Vincent"],["dc.contributor.author","Ihler, Friedrich"],["dc.contributor.author","Baumeister, Philipp"],["dc.date.accessioned","2020-12-10T18:42:45Z"],["dc.date.available","2020-12-10T18:42:45Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1615/JEnvironPatholToxicolOncol.v35.i4"],["dc.identifier.issn","0731-8898"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78070"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Cytotoxic and Genotoxic Effects of Electronic Cigarette Liquids on Human Mucosal Tissue Cultures of the Oropharynx"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Trends in Hearing"],["dc.bibliographiccitation.lastpage","12"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Ihler, F."],["dc.contributor.author","Blum, J."],["dc.contributor.author","Berger, M.-U."],["dc.contributor.author","Weiss, B. G."],["dc.contributor.author","Welz, C."],["dc.contributor.author","Canis, M."],["dc.date.accessioned","2019-07-09T11:42:57Z"],["dc.date.available","2019-07-09T11:42:57Z"],["dc.date.issued","2016"],["dc.description.abstract","Semi-implantable transcutaneous bone conduction devices are treatment options for conductive and mixed hearing loss (CHL/MHL). For counseling of patients, realistic simulation of the functional result is desirable. This study compared speech recognition in noise with a semi-implantable transcutaneous bone conduction device to external stimulation with a bone conduction device fixed by a headband. Eight German-language adult patients were enrolled after a semi-implantable transcutaneous bone conduction device (Bonebridge, Med-El) was implanted and fitted. Patients received a bone conduction device for external stimulation (Baha BP110, Cochlear) fixed by a headband for comparison. The main outcome measure was speech recognition in noise (Oldenburg Sentence Test). Pure-tone audiometry was performed and subjective benefit was assessed using the Glasgow Benefit Inventory and Abbreviated Profile of Hearing Aid Benefit questionnaires. Unaided, patients showed a mean signal-to-noise ratio threshold of 4.6 4.2 dB S/N for speech recognition. The aided results were 3.3 7.2 dB S/N by external bone conduction stimulation and 1.2 4.0 dB S/N by the semi-implantable bone conduction device. The difference between the two devices was not statistically significant, while the difference was significant between unaided and aided situation for both devices. Both questionnaires for subjective benefit favored the semiimplantable device over external stimulation. We conclude that it is possible to simulate the result of speech recognition in noise with a semi-implantable transcutaneous bone conduction device by external stimulation. This should be part of preoperative counseling of patients with CHL/MHL before implantation of a bone conduction device."],["dc.identifier.doi","10.1177/2331216516669330"],["dc.identifier.pmid","27698259"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14017"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58795"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2331-2165"],["dc.rights","CC BY-NC 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/3.0"],["dc.title","The Prediction of Speech Recognition in Noise With a Semi-Implantable Bone Conduction Hearing System by External Bone Conduction Stimulation With Headband: A Prospective Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2311"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","European Archives of Oto-Rhino-Laryngology"],["dc.bibliographiccitation.lastpage","2318"],["dc.bibliographiccitation.volume","276"],["dc.contributor.author","Spiegel, Jennifer L."],["dc.contributor.author","Pilavakis, Yiannis"],["dc.contributor.author","Weiss, Bernhard G."],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Welz, Christian"],["dc.date.accessioned","2020-12-10T14:10:30Z"],["dc.date.available","2020-12-10T14:10:30Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00405-019-05478-6"],["dc.identifier.eissn","1434-4726"],["dc.identifier.issn","0937-4477"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70779"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Quality of life in patients after reconstruction with the supraclavicular artery island flap (SCAIF) versus the radial free forearm flap (RFFF)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]