Laatsch, Hartmut G.

[["dc.bibliographiccitation.firstpage","787"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Planta Medica"],["dc.bibliographiccitation.lastpage","792"],["dc.bibliographiccitation.volume","78"],["dc.contributor.author","Dzoyem, Jean P."],["dc.contributor.author","NKuete, Antoine H. L."],["dc.contributor.author","Kuete, Victor"],["dc.contributor.author","Tala, Michel Feussi"],["dc.contributor.author","Wabo, Hippolyte Kamdem"],["dc.contributor.author","Guru, Santosh K."],["dc.contributor.author","Rajput, Vikrant S."],["dc.contributor.author","Sharma, Akash"],["dc.contributor.author","Tane, Pierre"],["dc.contributor.author","Khan, Inshad A."],["dc.contributor.author","Saxena, Anil K."],["dc.contributor.author","Laatsch, Hartmut"],["dc.contributor.author","Tan, Ning-Hua"],["dc.date.accessioned","2018-11-07T09:10:43Z"],["dc.date.available","2018-11-07T09:10:43Z"],["dc.date.issued","2012"],["dc.description.abstract","The present study was designed to investigate the antimicrobial activity and the cytotoxicity of the methanol extract (PLA) as well as fractions (PLA1-4) and compounds [cardamomin (1), (+/-)-polygohomoisoflavanone (2), (S)-(-)-pinostrobin (3), 2',4'-dihydroxy-3',6'-dimethoxychalcone (4), (2S)-(-)-5-hydroxy-6,7-dimethoxyflavanone (5), and (2S)-(-)-5,7-dimethoxyflavanone (6)] obtained from leaves of Polygonum limbatum. The microbroth dilution was used to determine the minimal inhibitory concentration (MIC) of the samples against 11 microbial strains including Candida albicans, C. krusei, C. tropicalis, Aspergillus fumigatus, Pseudomonas aeruginosa, Escherichia coli, vancomycin-resistant Enterococcus faecalis (VRE), Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), S. epidermidis, and Mycobacterium tuberculosis H37Rv. The sulphorhodamine B cell growth inhibition assay was used to assess the cytotoxicity of the above samples on lung A549 adenocarcinoma, breast carcinoma MCF-7, prostate carcinoma PC-3, cervical carcinoma HeLa, and the acute monocytic leukemia cell line THP-1. The results of the MIC determination indicated that, apart from fraction PLA3, all other fractions as well as PLA and compound 3 were selectively active. MIC values were noted on 100% of the 11 tested microorganisms for fraction PLA3, 72.7% for PLA, fraction PLA2, and compound 4, 63.6% for PLA1, and 54.5% for fraction PLA4. The results of the cytotoxicity assay revealed that, except for A459 cells, more than 50% inhibition of the proliferation was obtained with each of the tested samples on at least one of the four other cell lines. IC50 values below 4 mu g/mL were obtained with 1 and 4 on THP-1 cells. The overall results of the present study provided baseline information for the possible use of Polygonum limbatum as well as some of the isolated compounds for the control of cancer diseases and mostly leukemia."],["dc.identifier.doi","10.1055/s-0031-1298431"],["dc.identifier.isi","000304449300007"],["dc.identifier.pmid","22495442"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26555"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0032-0943"],["dc.title","Cytotoxicity and Antimicrobial Activity of the Methanol Extract and Compounds from Polygonum limbatum"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","no"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","ChemInform"],["dc.bibliographiccitation.lastpage","no"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","FAROOQ BIABANI, M. A."],["dc.contributor.author","LAATSCH, H."],["dc.date.accessioned","2021-12-08T12:28:27Z"],["dc.date.available","2021-12-08T12:28:27Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1002/chin.199904230"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/95703"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.eissn","1522-2667"],["dc.relation.issn","0931-7597"],["dc.rights.uri","http://doi.wiley.com/10.1002/tdm_license_1.1"],["dc.title","ChemInform Abstract: Advances in Chemical Studies on Low-Molecular Weight Metabolites of Marine Fungi"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1159"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Zeitschrift für Naturforschung B"],["dc.bibliographiccitation.lastpage","1165"],["dc.bibliographiccitation.volume","67"],["dc.contributor.author","Donfack, Erik V."],["dc.contributor.author","Lenta, Bruno N."],["dc.contributor.author","Kongue, Michel D. T."],["dc.contributor.author","Fongang, Yannick F."],["dc.contributor.author","Ngouela, Silvere"],["dc.contributor.author","Tsamo, Etienne"],["dc.contributor.author","Dittrich, Birger"],["dc.contributor.author","Laatsch, Hartmut"],["dc.date.accessioned","2018-11-07T09:03:42Z"],["dc.date.available","2018-11-07T09:03:42Z"],["dc.date.issued","2012"],["dc.description.abstract","Phytochemical investigation of the roots and fruits of Mitragyna inermis (Rubiaceae) resulted in the isolation of a new indole alkaloid, named naucleactonin D (1), together with fourteen known compounds: nauclefiline (2), naucleficine (3), nauclefidine (4), angustoline (5), angustine (6), barbinervic acid (7), quinovic acid 3-O-alpha-L-rhamnopyranoside (8), betulinic acid (9), a mixture of ursolic (10) and oleanolic acid (11), a mixture of stigmasterol and beta-sitosterol, beta-sitosterol 3-O-beta-D-glucopyranoside, and strictosamide (12) as the major compound. The structures of the isolated compounds were elucidated by detailed spectroscopic analysis and by comparison with published data. No C-13 NMR data for 2 and 3 exist in the literature and compounds 2, 3, 5, 7, and 12 are reported for the first time from the genus Mitragyna. The crude extract and isolated compounds were tested in vitro for their preliminary cytotoxicity against brine shrimps (Artemia sauna)."],["dc.identifier.doi","10.5560/ZNB.2012-0115"],["dc.identifier.isi","000313533500006"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24952"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Verlag Z Naturforsch"],["dc.relation.issn","0932-0776"],["dc.title","Naucleactonin D, an Indole Alkaloid and other Chemical Constituents from Roots and Fruits of Mitragyna inermis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","56"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","African Journal of Traditional Complementary and Alternative Medicines"],["dc.bibliographiccitation.lastpage","58"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Abdalla, Muna Ali"],["dc.contributor.author","Laatsch, Hartmut"],["dc.date.accessioned","2018-11-07T09:16:24Z"],["dc.date.available","2018-11-07T09:16:24Z"],["dc.date.issued","2012"],["dc.description.abstract","Three flavonoids were isolated for the first time from the Sudanese medicinal plants Albizia zygia. Compounds 1-3 were identified by interpretation of ESI mass data, (1)H, (13)C and 2D NMR as well as by comparison with published data as 4',7-dihydroxyflavanone (1) 3',4',7-trihydroxyflavone (2), 3-O-methylfisetin (3',4',7-trihydroxy-3-methoxyflavone, 3). All flavonoids were tested against Plasmodium falciparum, and only compound 2 showed high antimalarial activity (IC(50) 0.078 mu g/ml)."],["dc.description.sponsorship","German Academic Exchange Service (DAAD)"],["dc.identifier.doi","10.4314/ajtcam.v9i1.8"],["dc.identifier.isi","000295532300008"],["dc.identifier.pmid","23983320"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27926"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","African Networks Ethnomedicines"],["dc.relation.issn","0189-6016"],["dc.title","FLAVONOIDS FROM SUDANESE ALBIZIA ZYGIA (LEGUMINOSAE, SUBFAMILY MIMOSOIDEAE), A PLANT WITH ANTIMALARIAL POTENCY"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1595"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Journal of Natural Products"],["dc.bibliographiccitation.lastpage","1599"],["dc.bibliographiccitation.volume","71"],["dc.contributor.author","Lang, Gerhard"],["dc.contributor.author","Mayhudin, Nor Ainy"],["dc.contributor.author","Mitova, Maya I."],["dc.contributor.author","Sun, Lin"],["dc.contributor.author","van der Sar, Sonia"],["dc.contributor.author","Blunt, John W."],["dc.contributor.author","Cole, Anthony L. J."],["dc.contributor.author","Ellis, Gill"],["dc.contributor.author","Laatsch, Hartmut"],["dc.contributor.author","Munro, Murray H. G."],["dc.date.accessioned","2018-11-07T11:11:36Z"],["dc.date.available","2018-11-07T11:11:36Z"],["dc.date.issued","2008"],["dc.description.abstract","The use of an HPLC bioactivity profiling/microtiter plate technique in conjunction with capillary probe NMR instrumentation and access to appropriate databases effectively short-circuits conventional dereplication procedures, necessarily based on multimilligram extracts, to a single, more rapid submilligram operation. This approach to dereplication is illustrated using fungal or bacterial extracts that contain known compounds. In each case the dereplication steps were carried out on microgram quantities of extract and demonstrate the discriminating power of H-1 NMR spectroscopy as a definitive dereplication tool."],["dc.identifier.doi","10.1021/np8002222"],["dc.identifier.isi","000259574900017"],["dc.identifier.pmid","18710284"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53474"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Chemical Soc"],["dc.relation.issn","0163-3864"],["dc.title","Evolving trends in the dereplication of natural product extracts: New methodology for rapid, small-scale investigation of natural product extracts"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","49"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","NATURAL PRODUCT COMMUNICATIONS"],["dc.bibliographiccitation.lastpage","52"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Ganapaty, Seru"],["dc.contributor.author","Srilakshmi, Guttula Veera Kantha"],["dc.contributor.author","Pannakal, Steve Thomas"],["dc.contributor.author","Laatsch, Hartmut"],["dc.date.accessioned","2018-11-07T11:20:27Z"],["dc.date.available","2018-11-07T11:20:27Z"],["dc.date.issued","2008"],["dc.description.abstract","A new 2',6'-dimethoxy-4',5'-(2 ',2 '-dimethyl)-pyranochalcone (1) and three known flavanones, namely 5-hydroxy-7-methoxy-8-(3,3-dimethylallyl)-flavanone (methyl glabranin) (2), 5,7-dimethoxy-8-(3,3-dimethylallyl)-flavanone (candinone) (3) and 5-O-methyl obovatin (pongachin) (4), have been isolated from the chloroform extract of the roots of Tephrosia pulcherrima. The flavonoids were fully characterized by detailed 1D- and 2D-NMR spectroscopic investigations. The pyranochalcone 1 showed significant antimicrobial activity when tested against a series of micro-organisms."],["dc.identifier.isi","000252904000014"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55538"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Natural Products Inc"],["dc.relation.issn","1934-578X"],["dc.title","A pyranochalcone and prenylflavanones from Tephrosia pulcherrima (Baker) drumm"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","27"],["dc.bibliographiccitation.journal","ChemInform"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Lessmann, H."],["dc.contributor.author","Maskey, R. P."],["dc.contributor.author","Fotso, S."],["dc.contributor.author","Lackner, H."],["dc.contributor.author","Laatsch, H."],["dc.date.accessioned","2021-12-08T12:29:23Z"],["dc.date.available","2021-12-08T12:29:23Z"],["dc.date.issued","2005"],["dc.identifier.doi","10.1002/chin.200527201"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/96056"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.eissn","1522-2667"],["dc.relation.issn","0931-7597"],["dc.rights.uri","http://doi.wiley.com/10.1002/tdm_license_1.1"],["dc.title","Juglorescein, Juglocombins and Juglochromans: Structure of Juglomycin Dimers from Streptomycetes."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","13"],["dc.bibliographiccitation.journal","ChemInform"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Asolkar, Ratnakar N."],["dc.contributor.author","Maskey, Rajendra P."],["dc.contributor.author","Helmke, Elisabeth"],["dc.contributor.author","Laatsch, Hartmut"],["dc.date.accessioned","2021-12-08T12:29:04Z"],["dc.date.available","2021-12-08T12:29:04Z"],["dc.date.issued","2003"],["dc.identifier.doi","10.1002/chin.200313196"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/95950"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.eissn","1522-2667"],["dc.relation.issn","0931-7597"],["dc.rights.uri","http://doi.wiley.com/10.1002/tdm_license_1.1"],["dc.title","Marine Bacteria. Part 16. Chalcomycin B, a New Macrolide Antibiotic from the Marine Isolate Streptomyces sp. B7064."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","893"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","The Journal of Antibiotics"],["dc.bibliographiccitation.lastpage","898"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","Asolkar, R. N."],["dc.contributor.author","Maskey, Rajendra P."],["dc.contributor.author","Helmke, Elisabeth"],["dc.contributor.author","Laatsch, Hartmut"],["dc.date.accessioned","2018-11-07T10:00:23Z"],["dc.date.available","2018-11-07T10:00:23Z"],["dc.date.issued","2002"],["dc.description.abstract","In our screening of marine streptomycete isolates for bioactive components, a new macrolide antibiotic designated as chalcomycin B (1b) was isolated from the culture broth of a marine Streptomycete isolate B7064 together with chalcomycin (1a) as the active principles. The structure of the new antibiotic was determined by EI and ESI MS, H-1, C-13 and 2D NMR spectroscopy and by comparison of the NMR data with those of chalcomycin."],["dc.identifier.isi","000179023600006"],["dc.identifier.pmid","12523822"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37791"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Japan Antibiot Res Assn"],["dc.relation.issn","0021-8820"],["dc.title","Chalcomycin B, a new macrolide antibiotic from the marine isolate Streptomyces sp B7064"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1139"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Analytical and Bioanalytical Chemistry"],["dc.bibliographiccitation.lastpage","1147"],["dc.bibliographiccitation.volume","390"],["dc.contributor.author","Fitzner, Ansgar"],["dc.contributor.author","Frauendorf, Holm"],["dc.contributor.author","Laatsch, Hartmut"],["dc.contributor.author","Diederichsen, Ulf"],["dc.date.accessioned","2018-11-07T11:18:24Z"],["dc.date.available","2018-11-07T11:18:24Z"],["dc.date.issued","2008"],["dc.description.abstract","Formation and fragmentation of recognition complexes between trioxacarcin A and various DNA sequences were examined by temperature-dependent UV and CD spectroscopy, HPLC analysis, and ESI mass spectrometry with regard to reaction conditions, intermediates, products, mechanism, and sequence specificity. Cleavage of the trioxacarcin-DNA complexes provided the natural product gutingimycin by guanine abstraction. The resulting DNA with an abasic site was further cleaved into a DNA fragment with a furanyl unit at the 3'-end and an oligonucleotide with a phosphorylated 5'-end."],["dc.identifier.doi","10.1007/s00216-007-1737-6"],["dc.identifier.isi","000252918100017"],["dc.identifier.pmid","18210096"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/3482"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55029"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1618-2642"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Formation of gutingimycin: analytical investigation of trioxacarcin A-mediated alkylation of dsDNA"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]