Stürmer, Klaus Michael

[["dc.bibliographiccitation.firstpage","521"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Der Unfallchirurg"],["dc.bibliographiccitation.lastpage","527"],["dc.bibliographiccitation.volume","110"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.contributor.author","Hingelbaum, S."],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Roessler, M."],["dc.contributor.author","Stuermer, Klaus-Michael"],["dc.date.accessioned","2018-11-07T11:02:18Z"],["dc.date.available","2018-11-07T11:02:18Z"],["dc.date.issued","2007"],["dc.description.abstract","Background. The anatomic region on the lateral cortex of the ileum, where a palpable \"groove\" is formed by angulations of the lateral cortex of the iliac wing, is recommended as the insertion point for the pelvic emergency clamp by many authors. In our opinion this technique often leads to an incomplete closure of the anterior pelvic ring as well as to bacterial contamination of the access for the sacroiliac joint screw fixation and is accompanied by a risk for nerve and vessel injuries. To reduce these risks the pelvic clamp was placed at a supra-acetabular location. The goal of our study was to report on our experiences with the supra-acetabular position of the pelvic emergency clamp and to compare our results with the current literature. Material and method. From September 1998 to February 2006 the pelvic emergency clamp was applied in 15 polytraumatized patients (9 male, 6 female), with a mean age of 46 years (19-93) and a mean injury severity score (ISS) of 40 points (25-66) with mechanically and hemodynamically unstable pelvic ring fractures. According to the AO classification the injury pattern was type B2 in four cases, type B3 in one case, type C1 in seven cases, type C2 in two cases and type C3 in one case. The pelvic clamp was percutaneously applied 2-3 cm cranial to the acetabular roof. The duration from hospital admission until the pelvic emergency clamp was applied amounted to an average of 54 min (15-150); the procedure itself was performed in all cases in less than 15 min. The mean Hb at arrival in the emergency department was 7.4 (2.4-13.8) mg/dl and the mean systolic blood pressure 69 (0-130) mmHg. Results. In 14 patients a complete closure of the anterior and posterior pelvic ring could be achieved; in 1 patient an overcompression of the anterior pelvic ring was observed. Four patients died due to massive bleeding. Three patients with isolated pelvic ring fractures became hemodynamically stable within 20 min after treatment with the supra-acetabular pelvic clamp. Nine patients needed additional emergency surgery because of intracerebral, intrathoracic or intra-abdominal injuries. On average in the first 6 h, 36.7 (9-175) units of erythrocyte concentrates and 34.5 (4-200) units of fresh frozen plasma were transfused. Conclusions. The supra-acetabular pelvic clamp leads to a homogeneous force distribution to the pelvic ring and enables complete closure of the anterior and posterior pelvic ring in unstable pelvic fractures. Reduction of the intrapelvic volume and compression of the posterior pelvic ring can thus be achieved. Risks for intrapelvic perforation or injuries of vessels and nerves are low. No bacterial contamination of the access for the sacroiliac screw fixation occurs. To avoid overcompression of the unstable pelvic ring, manual or radiological control of the closure of the ventral pelvic ring is necessary."],["dc.identifier.doi","10.1007/s00113-007-1228-4"],["dc.identifier.isi","000247257500005"],["dc.identifier.pmid","17318312"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51348"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0177-5537"],["dc.title","The supra-acetabular pelvic clamp. Emergency treatment for unstable pelvic ring fractures"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1026"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Der Chirurg"],["dc.bibliographiccitation.lastpage","1033"],["dc.bibliographiccitation.volume","74"],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Pouwels, Claudia"],["dc.contributor.author","Bonsack, S."],["dc.contributor.author","Oellerich, M."],["dc.contributor.author","Schworer, H."],["dc.contributor.author","Uy, Angela"],["dc.contributor.author","Sturmer, K. M."],["dc.date.accessioned","2018-11-07T10:34:55Z"],["dc.date.available","2018-11-07T10:34:55Z"],["dc.date.issued","2003"],["dc.description.abstract","Background. Trauma and emergency surgeons (S) are in contact with high-risk patients (P) infected with HBV, HCV, and HIV without knowing which P is and which is not infected. The aim of this paper was to analyze routine screening (SCR) in trauma care. Method. Microparticle enzyme immunoassays (MEIA) (Abbott Axym system) were analyzed from routine blood samples: HBsAg (Q), HCV version 3.0, HIV 1/2gO. All positive or uncertain samples were confirmed with ELISA/PCR. Results. From January 2002 to October 2002 a total of 1074 emergency P were examined. The results were available within 50 min after admittance to the emergency room. In 53 of 1074 (4.9%) the MEIA was positive or in threshold margins (LV): HBV 15 P plus 3 LV (9 secured by ELISA/PCR), prevalence (PV) 0.84%. HCV 34 P plus I LV (31 secured with ELISA/PCR), PV 2.9%. HIV 2 P, PV 1.86parts per thousand, 1 in co-infection with HCV, I with HBV. Of 42 infections, 21 were unknown before screening, and in 5 P the S suspected an infection. After screening, nine surgical procedures were changed to safer procedures. Conclusion. MEIA is a good tool for quick SCR of HCV, HBV, and HIV in emergency surgery (ES). When the infection is known the S is more aware to perform only safe procedures during surgery (no touch technique) or to use more protective devices (e.g., fluid shield, double gloves). Our results indicate that surgeons and nurses in ES are exposed four to six times more often to infection with HCV, HBV, and HIV than represented by officially published data. We recommend routine SCR of HBV, HCV, and HIV for all P in ES. Prevention procedures are discussed."],["dc.identifier.doi","10.1007/s00104-003-0741-4"],["dc.identifier.isi","000187002800008"],["dc.identifier.pmid","14605720"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/44981"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0009-4722"],["dc.title","HCV, HBV, and HIV infection: risk for surgeon and staff. Results and consequences of routine screening in emergency patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","GMS Medizinische Informatik, Biometrie und Epidemiologie"],["dc.bibliographiccitation.lastpage","7"],["dc.contributor.author","Stürmer, Klaus Michael"],["dc.contributor.author","Wagner, Markus"],["dc.contributor.author","Duwenkamp, Christopher"],["dc.contributor.author","Ahrens, Christoph Alexander"],["dc.contributor.author","Plischke, Maik"],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Bott, Oliver Johannes"],["dc.date.accessioned","2019-07-09T11:52:48Z"],["dc.date.available","2019-07-09T11:52:48Z"],["dc.date.issued","2009"],["dc.description.abstract","Hintergrund und Fragestellung: Die durch röntgentechnische Diagnoseverfahren in der Medizin entstehende Strahlenbelastung für Patient und Personal soll laut Strahlenschutzverordnung so gering wie möglich gehalten werden. Um dieses zu erreichen ist ein professioneller und bedachter Umgang mit den Röntgengeräten unabdingbar. Dieses Verhalten kann derzeit jedoch nur theoretisch vermittelt werden, da sich ein Üben mit realer Strahlung von selbst verbietet. Daher stellt sich die Frage wie man die Strahlenschutzausbildung durch eine verbesserte Vermittlung der komplexen Thematik unterstützen kann. Methoden: Das CBT-System (Computer Based Training) virtX, welches das Erlernen der korrekten Handhabung mobiler Röntgengeräte unterstützt, wurde um Aspekte aus dem Bereich des Strahlenschutzes erweitert. Es wurde eine prototypische Visualisierung der entstehenden Streustrahlung sowie die Darstellung des Nutzstrahlenganges integriert. Des Weiteren wurde die Berechnung und Anzeige der virtuellen Einfallsdosis für das durchstrahlte Volumen sowie für den Bereich des Bildverstärkers hinzugefügt. Für die Berechnung und Visualisierung all dieser Komponenten werden die in virtX parametrisierbaren C-Bogen-Einstellungen, z.B. Stellung der Blenden, Positionierung des Röntgengerätes zum durchstrahlten Volumen und Strahlenintensität, herangezogen. Das so erweiterte System wurde auf einem dreitägigen Kurs für OP-Personal mit über 120 Teilnehmern eingesetzt und auf der Basis von Fragebögen evaluiert. Ergebnisse: Von den Teilnehmern gaben 55 einen ausgefüllten Evaluations-Fragebogen ab (Responserate 82%). Das Durchschnittsalter der 39 weiblichen und 15 männlichen Teilnehmer (einer o.A.) lag bei 33±8 Jahren, die Berufserfahrung bei 9,37±7 Jahren. Die Erfahrung mit dem C-Bogen wurde von einem Teilnehmer (2%) mit „Keine oder bisher nur Einführung erhalten“, von acht Teilnehmern (14%) mit „bediene einen C-Bogen gelegentlich“ und von 46 (84%) mit „bediene einen C-Bogen regelmäßig“ angegeben. 45 (92%) der Teilnehmer gaben an, durch die Visualisierung der Streustrahlung etwas Neues zur Vermeidung unnötiger Strahlenbelastung dazugelernt zu haben. Schlussfolgerung: Trotz einer bislang nur prototypischen Visualisierung der Streustrahlung können mit virtX zentrale Aspekte und Verhaltensweisen zur Vermeidung unnötiger Strahlenbelastung erfolgreich vermittelt werden und so Lücken der traditionellen Strahlenschutzausbildung geschlossen werden."],["dc.identifier.doi","10.3205/mibe000081"],["dc.identifier.fs","568165"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5967"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60279"],["dc.language.iso","de"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1860-9171"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","virtX: ein Lehr- und Lernsystem für mobile Röntgengeräte zur Verbesserung der Ausbildung im Strahlenschutz"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","261"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","ACTA ORTHOPAEDICA BELGICA"],["dc.bibliographiccitation.lastpage","265"],["dc.bibliographiccitation.volume","74"],["dc.contributor.author","Balcarek, Peter"],["dc.contributor.author","Sawallich, Tobias"],["dc.contributor.author","Losch, Andreas"],["dc.contributor.author","Stuermer, Klaus Michael"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.date.accessioned","2018-11-07T11:16:16Z"],["dc.date.available","2018-11-07T11:16:16Z"],["dc.date.issued","2008"],["dc.description.abstract","Loss of knee extension after reconstruction of the anterior cruciate ligament may occur due to a neo-proliferative fibrous nodule located anterolateral to the tibial tunnel, termed cyclops syndrome. This nodule occurs usually within the early postoperative period and results in diminished knee extension due to impingement on the intercondylar notch. We report a case of a 24-year-old female patient with an uncommon delayed-onset loss of knee extension due to a cyclops syndrome four years after anterior cruciate ligament reconstruction."],["dc.identifier.isi","000256232500019"],["dc.identifier.pmid","18564486"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54545"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Acta Medica Belgica"],["dc.relation.issn","0001-6462"],["dc.title","Delayed cyclops syndrome : Symptomatic extension block four years after anterior cruciate ligament reconstruction"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","91"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Technology and Health Care"],["dc.bibliographiccitation.lastpage","102"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Floerkemeier, Thilo"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.contributor.author","Wachowski, Martin"],["dc.contributor.author","Kubein-Meesenburg, Dietmar"],["dc.contributor.author","Gezzi, Riccardo"],["dc.contributor.author","Fanghaenel, Jochen"],["dc.contributor.author","Stuermer, Klaus Michael"],["dc.contributor.author","Naegerl, Hans"],["dc.date.accessioned","2018-11-07T09:02:04Z"],["dc.date.available","2018-11-07T09:02:04Z"],["dc.date.issued","2011"],["dc.description.abstract","After total knee replacement the persistence of pain represents a significant problem. In this study, a novel knee arthroplasty (Aequos G1 knee arthroplasty) is investigated that was designed to replicate main features of human knee morphology to reduce the periodically occurring pain after knee replacement. Previous work showed theoretically that this arthroplasty design may reconstruct the four-bar linkage mechanism as it occurs in human knee by contriving a convex lateral tibial compartment and a sagittal offset of the centre of the medial and lateral femur condyles - inducing a roll-back mechanism as it exists in human. The aim of this study was to determine whether this potential roll-back mechanism can be confirmed by in-vivo measurements. This retrospective study showed that the patellar tendon angle decreases during flexion of 0.21 degrees per degree of flexion on average in the 16 knees studied. This amount is similar to physiological knee kinematics and in contrast to existing results in the literature after implantation of conventional total knee replacements which lack physiological knee kinematics. The results suggest that physiological motion after implantation of the Aequos G1 knee arthroplasty occurs during loaded motion up to approximately 45 degrees knee flexion."],["dc.identifier.doi","10.3233/THC-2011-0616"],["dc.identifier.isi","000208598900003"],["dc.identifier.pmid","21422533"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24586"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Ios Press"],["dc.relation.issn","0928-7329"],["dc.title","Physiologically shaped knee arthroplasty induces natural roll-back"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","317"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Cells Tissues Organs"],["dc.bibliographiccitation.lastpage","326"],["dc.bibliographiccitation.volume","189"],["dc.contributor.author","Drengk, Anja"],["dc.contributor.author","Zapf, Antonia"],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.contributor.author","Stuermer, Klaus Michael"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.date.accessioned","2018-11-07T08:34:01Z"],["dc.date.available","2018-11-07T08:34:01Z"],["dc.date.issued","2009"],["dc.description.abstract","Background/Aims: Autologous chondrocyte (CC) transplantation has the disadvantages of requiring two surgical interventions and in vitro expansion of cells, implying the risk of cellular dedifferentiation. Our clinical aim is to develop a one-step procedure for autologous CC transplantation, i.e. harvesting, isolation and reimplantation of CC performed in one single surgical procedure. Platelet-rich plasma (PRP) is a source of autologous growth factors reported to have mitogenic effects. The objective of this study was to test the influence of PRP as an autologous scaffold on freshly isolated CC and mesenchymal stem cells (MSC). Methods: CC and MSC were subjected to two- or three-dimensional (3D) growth systems, either with or without PRP. Chondrogenic differentiation was determined via quantification of collagen type II mRNA and immunohistochemical staining. Results: We observed a proliferative effect for MSCs exposed to PRP in monolayer culture and an increase in the expression of chondrogenic markers when cells are exposed to a 3D environment. CCs exposed to PRP show a decrease in the chondrogenic phenotype with increasing proliferative activity. Conclusion: PRP has a proliferative effect on CCs and MSCs. In a one-step procedure for autologous CC transplantation, this might be an advantage over other scaffold materials, but confirmation in in vivo studies is required. Copyright (C) 2008 S. Karger AG, Basel"],["dc.identifier.doi","10.1159/000151290"],["dc.identifier.isi","000265178600002"],["dc.identifier.pmid","18689989"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9312"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17722"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","1422-6405"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Influence of Platelet-Rich Plasma on Chondrogenic Differentiation and Proliferation of Chondrocytes and Mesenchymal Stem Cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Cytotherapy"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.contributor.author","Hingelbaum, S."],["dc.contributor.author","Drengk, Anja"],["dc.contributor.author","Jennissen, H. P."],["dc.contributor.author","Chatzinikolaidou, M."],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.contributor.author","Stuermer, Klaus-Michael"],["dc.date.accessioned","2018-11-07T10:32:54Z"],["dc.date.available","2018-11-07T10:32:54Z"],["dc.date.issued","2006"],["dc.format.extent","8"],["dc.identifier.isi","000239337800021"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/44468"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Taylor & Francis As"],["dc.publisher.place","Oslo"],["dc.relation.issn","1465-3249"],["dc.title","BMP-2 and cell-coated titanium implants accelerate healing of osteochondral defects in a sheep model"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","214"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Cells Tissues Organs"],["dc.bibliographiccitation.lastpage","227"],["dc.bibliographiccitation.volume","170"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.contributor.author","Barvencik, F."],["dc.contributor.author","Lohmann, Christoph H."],["dc.contributor.author","Viereck, Volker"],["dc.contributor.author","Siggelkow, Heide"],["dc.contributor.author","Breme, J."],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Sturmer, K. M."],["dc.date.accessioned","2018-11-07T10:32:53Z"],["dc.date.available","2018-11-07T10:32:53Z"],["dc.date.issued","2002"],["dc.description.abstract","The goal of this study was to characterize growth, mineralization and bone formation of osteoblast-like cells in titanium pore channels of defined diameter. Titanium implants with continuous drill channels of diameters of 300, 400, 500, 600 and 1,000 mum were inserted into human osteoblast-like cell cultures. The ingrowth of the cells into the drill channels was investigated by transmitted-light microscopy and scanning electron microscopy. Immunofluorescence and histological analysis of 15-channel sections of each diameter were used to investigate the growth behavior and the matrix protein patterns. Mineralization was evidenced by Alizarin red staining and high-resolution microradiography. The ingrowth of human osteoblast-like cells in the drill channels occurred in a sequence of four characteristic stages. In stage 1, osteoblast precursor cells adhered to the wall of the channel and migrated three-dimensionally into the channel by forming foot-like protoplasmic processes. For all 15 sample drill channels that were investigated, the cell ingrowth over 20 days amounted on average to 793 mum (+/- 179) into 600-mum-diameter channels, where they migrated significantly faster than in all the other channels. In stage 2, approximately on day 5-7, the osteoblast-like cells began to anchor on the substrate wall by matrix proteins and to build up a dense network of matrix proteins in the drill channel. The mineralization of the extracellular matrix, while depending on cell stimulation, was initiated in stage 3, on average after 4 weeks. In drill channels of a diameter of 1,000 mum the cell growth was incomplete and no mineralization was found by radiological assessment. Starting in week 6, in the drill channels of diameters ranging from 300 to 600 mum, the network of extracellular matrix proteins and osteoblast-like cells began to form an osteon-like structure. Neither the highly developed migration behavior of osteoblastic cells nor the reorganization from a fiber-like matrix to a lamellar structure have so far been described for cell cultures."],["dc.identifier.doi","10.1159/000047925"],["dc.identifier.isi","000174840400002"],["dc.identifier.pmid","11919409"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/44464"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","1422-6405"],["dc.title","Migration, matrix production and lamellar bone formation of human osteoblast-like cells in porous titanium implants"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","850"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Planta Medica"],["dc.bibliographiccitation.lastpage","857"],["dc.bibliographiccitation.volume","76"],["dc.contributor.author","Kolios, Leila"],["dc.contributor.author","Schumann, Jacob"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Rack, Thomas"],["dc.contributor.author","Tezval, Mohammed"],["dc.contributor.author","Seidlova-Wuttke, Dana"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.contributor.author","Stuermer, Klaus Michael"],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.date.accessioned","2018-11-07T08:43:01Z"],["dc.date.available","2018-11-07T08:43:01Z"],["dc.date.issued","2010"],["dc.description.abstract","Osteoporosis and its accompanying, predominantly metaphyseal, fractures are a major health problem. Black cohosh (Cimicifuga racemosa) and estrogen positively influence osteoporotic bone. Both substances may improve fracture healing in early osteoporosis as well. In 48 twelve-week-old ovariectomized or, respectively, sham-operated (SHAM) rats, a standardized metaphyseal tibia osteotomy with bridging T-plate fixation was performed. During the healing process of 35 days, rats received soy-free (SHAM, osteopenic C), estrogen-(E) or Cimicifuga racemosa-(CR) supplemented diets. After sacrifice, the callus formation was analyzed with regard to biomechanical quality, morphology, quantity, time course of new bone built and gene expression. CR induced a high rate of metaphyseal callus formation. The biomechanical properties and the amount of new callus formation indicated that fracture healing was still in progress. Therefore, gene expression of osteoblasts was comparatively high. Body weight and the trabecular structure were influenced little by CR. Estrogen improved the biomechanical properties of the callus. Resistance to microfracturing was significantly enhanced in the E group and even superior to SHAM. Remodeling of the callus formation had already begun. The trabecular network and the typical endosteal fracture healing were especially improved. Osteoporotic metaphyseal fracture healing was improved by estrogen more than by Cimicifuga racemosa. The process of fracture healing occurred nearly physiologically. The generation of callus formation was supported by Cimicifuga racemosa as well, but the five-week duration of application was too short for Cimicifuga racemosa to show its complete potential. Already-initiated Cimicifuga racemosa therapy for menopausal symptoms could be continued during fracture healing without hesitation."],["dc.description.sponsorship","DFG [STU 478/2-1]"],["dc.identifier.doi","10.1055/s-0029-1240798"],["dc.identifier.isi","000279668400002"],["dc.identifier.pmid","20104444"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19846"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0032-0943"],["dc.title","Effects of Black Cohosh (Cimicifuga racemosa) and Estrogen on Metaphyseal Fracture Healing in the Early Stage of Osteoporosis in Ovariectomized Rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","187"],["dc.bibliographiccitation.journal","Bone"],["dc.bibliographiccitation.lastpage","194"],["dc.bibliographiccitation.volume","64"],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.contributor.author","Komrakova, Marina"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Tezval, Mohammad"],["dc.contributor.author","Dullin, Christian"],["dc.contributor.author","Schaefer, Nadine"],["dc.contributor.author","Hallecker, Jan"],["dc.contributor.author","Stuermer, Klaus-Michael"],["dc.date.accessioned","2018-11-07T09:38:39Z"],["dc.date.available","2018-11-07T09:38:39Z"],["dc.date.issued","2014"],["dc.description.abstract","Current osteoporosis therapies aim to delay bone destruction and have additional anabolic effects. While they have demonstrated some positive effects on bone healing, more progress is needed in this area. This study used the well-known osteoporotic agents estrogen (E) and raloxifene (R) in conjunction with biomechanical whole body vibration (WBV) at a frequency of 70 Hz twice daily for six weeks to stimulate bone healing. Eighty-four 3-month old female Sprague-Dawley rats (12 per group) were bilaterally ovariectomized to develop osteopenia within eight weeks. Osteotomy of the metaphyseal tibiae was performed and fracture healing was then studied using mechanical tests, histomorphometry, computed tomography (mu CT), and gene analysis. We found that E and R improved the structure of osteopenic bones as did WBV alone, although significant levels for WBV were seldom reached. Combination treatments significantly enhanced stiffness (R + WBV; p < 0.05), endosteal bone (R + WBV; p < 0.01), and trabecular density (E + WBV; p < 0.05, R + WBV; p < 0.05). In addition, the expression of osteoclast-specific Trap was significantly reduced after treatment with E, R, or their combination with WBV (p < 0.01). The effects were additive and not inhibitory, leading us to conclude that the combined applications of WBV with E or R may improve the healing of osteopenic bones. The therapies studied are all currently approved for human use, suggesting ready applicability to clinical practice. To better understand the effects of WBV on osteopenic bones, the ideal vibration regime will require further study. (C) 2014 Elsevier Inc. All rights reserved."],["dc.description.sponsorship","German Research Foundation (DFG) [STU 478/3-1]"],["dc.identifier.doi","10.1016/j.bone.2014.04.008"],["dc.identifier.isi","337011500026"],["dc.identifier.pmid","24735975"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33112"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1873-2763"],["dc.relation.issn","8756-3282"],["dc.title","Whole body vibration during fracture healing intensifies the effects of estradiol and raloxifene in estrogen-deficient rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]