Emons, Georg

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Cellular Oncology"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Ried, Thomas"],["dc.contributor.author","Grade, Marian"],["dc.contributor.author","Heselmeyer-Haddad, Kerstin"],["dc.contributor.author","Camps, Jordi"],["dc.contributor.author","Hummon, Amanda"],["dc.contributor.author","Emons, Georg"],["dc.contributor.author","Auer, Gert"],["dc.contributor.author","Liersch, Torsten"],["dc.contributor.author","Difilippantonio, Michael J."],["dc.contributor.author","Ghadimi, B. Michael"],["dc.date.accessioned","2018-11-07T11:19:37Z"],["dc.date.available","2018-11-07T11:19:37Z"],["dc.date.issued","2008"],["dc.format.extent","91"],["dc.identifier.isi","000254301100002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55325"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Ios Press"],["dc.publisher.place","Amsterdam"],["dc.relation.conference","Meeting of the International-Society-for-Cellular-Oncology (ISCO 2008)"],["dc.relation.eventlocation","Amsterdam, NETHERLANDS"],["dc.relation.issn","1570-5870"],["dc.title","Exploiting the genome and transcriptome for individualized cancer diagnosis and treatment stratification"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2035"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Journal of Cancer Research and Clinical Oncology"],["dc.bibliographiccitation.lastpage","2045"],["dc.bibliographiccitation.volume","147"],["dc.contributor.author","Huber, D."],["dc.contributor.author","Seitz, S."],["dc.contributor.author","Kast, K."],["dc.contributor.author","Emons, G."],["dc.contributor.author","Ortmann, O."],["dc.date.accessioned","2021-06-01T09:42:51Z"],["dc.date.available","2021-06-01T09:42:51Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract Purpose BRCA mutation carriers have an increased risk of developing breast or ovarian cancer. Risk-reducing bilateral salpingo-oophorectomy (RRBSO) is associated with a decrease in risk for tubal and ovarian cancer. Hormone replacement therapy (HRT) may increase breast, ovarian, and endometrial cancer risk in the general population. This review analyses the published data on HRT and risk of cancer in BRCA mutation carriers with and without RRBSO. Methods We included all relevant articles published in English from 1995 to October 2020. Sources were identified through a search on PubMed and Cochrane Library. Results We included one case–control and one retrospective cohort study on ovarian and one case–control study on endometrial cancer risk and HRT in BRCA mutation carriers. Regarding breast cancer risk, one case–control study on BRCA mutation carriers with and without RRBSO and one case–control study, one Markov chain decision model, two prospective cohort studies, and one metaanalysis on carriers after RRBSO were included. For ovarian cancer, results were ambiguous. For breast cancer, most studies did not find an adverse effect associated with HRT. However, some of the studies found a risk modification associated with different formulations and duration of use. Conclusion Although data are limited, HRT does not seem to have a relevant effect on cancer risk in BRCA mutation carriers. RRBSO should not be postponed to avoid subsequent HRT in this population. Adequate HRT after RRBSO should be offered to avoid chronic diseases resulting from low estrogen levels. However, further data on the safety of different formulations are needed."],["dc.identifier.doi","10.1007/s00432-021-03629-z"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85374"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1432-1335"],["dc.relation.issn","0171-5216"],["dc.title","Hormone replacement therapy in BRCA mutation carriers and risk of ovarian, endometrial, and breast cancer: a systematic review"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","156"],["dc.bibliographiccitation.issue","S2"],["dc.bibliographiccitation.journal","Der Gynäkologe"],["dc.bibliographiccitation.lastpage","160"],["dc.bibliographiccitation.volume","53"],["dc.contributor.author","Ortmann, O."],["dc.contributor.author","Emons, G."],["dc.contributor.author","Tempfer, C."],["dc.date.accessioned","2020-12-10T14:08:45Z"],["dc.date.available","2020-12-10T14:08:45Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00129-020-04569-4"],["dc.identifier.eissn","1433-0393"],["dc.identifier.issn","0017-5994"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70548"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Hormonersatztherapie nach hormonabhängigen Krebserkrankungen gemäß S3‑Leitlinie"],["dc.title.alternative","Hormone replacement therapy after hormone-dependent cancer according to the S3 guidelines"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","45"],["dc.bibliographiccitation.issue","01"],["dc.bibliographiccitation.journal","Zentralblatt für Gynäkologie"],["dc.bibliographiccitation.lastpage","50"],["dc.bibliographiccitation.volume","124"],["dc.contributor.author","Krauß, T."],["dc.contributor.author","Huschmand, H."],["dc.contributor.author","Hinney, B."],["dc.contributor.author","Viereck, V."],["dc.contributor.author","Emons, G."],["dc.date.accessioned","2021-06-01T10:50:59Z"],["dc.date.available","2021-06-01T10:50:59Z"],["dc.date.issued","2002"],["dc.identifier.doi","10.1055/s-2002-20309"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86848"],["dc.language.iso","de"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1438-9762"],["dc.relation.issn","0044-4197"],["dc.title","Hormon- und Chemotherapie beim Endometriumkarzinom"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Cancer Research"],["dc.bibliographiccitation.volume","71"],["dc.contributor.author","Grade, Marian"],["dc.contributor.author","Spitzner, Melanie"],["dc.contributor.author","Emons, Georg"],["dc.contributor.author","Kramer, Frank"],["dc.contributor.author","Gaedcke, Jochen"],["dc.contributor.author","Rave-Fränk, Margret"],["dc.contributor.author","Scharf, Jens-Gerd"],["dc.contributor.author","Burfeind, Peter"],["dc.contributor.author","Becker, Heinz"],["dc.contributor.author","Beißbarth, Tim"],["dc.contributor.author","Ghadimi, Michael B."],["dc.contributor.author","Ried, Thomas"],["dc.date.accessioned","2018-11-07T08:57:01Z"],["dc.date.available","2018-11-07T08:57:01Z"],["dc.date.issued","2011"],["dc.identifier.doi","10.1158/1538-7445.AM2011-2508"],["dc.identifier.isi","000209701302047"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23286"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Assoc Cancer Research"],["dc.publisher.place","Philadelphia"],["dc.relation.issn","1538-7445"],["dc.relation.issn","0008-5472"],["dc.title","Identification of potential relevant pathways and genes for resistance to chemoradiotherapy in colorectal cancer cells"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","906"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Der Gynäkologe"],["dc.bibliographiccitation.lastpage","913"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Hellriegel, M."],["dc.contributor.author","Bauerschmitz, G."],["dc.contributor.author","Emons, G."],["dc.date.accessioned","2020-12-10T14:08:44Z"],["dc.date.available","2020-12-10T14:08:44Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s00129-017-4162-8"],["dc.identifier.eissn","1433-0393"],["dc.identifier.issn","0017-5994"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70535"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Palliativmedizinische Konzepte beim Mammakarzinom"],["dc.title.alternative","Palliative medical concepts in breast cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","15"],["dc.bibliographiccitation.journal","European Journal of Cancer"],["dc.bibliographiccitation.lastpage","22"],["dc.bibliographiccitation.volume","85"],["dc.contributor.author","van Dam, P.A."],["dc.contributor.author","Tomatis, M."],["dc.contributor.author","Marotti, L."],["dc.contributor.author","Heil, J."],["dc.contributor.author","Mansel, R.E."],["dc.contributor.author","Rosselli del Turco, M."],["dc.contributor.author","van Dam, P.J."],["dc.contributor.author","Casella, D."],["dc.contributor.author","Bassani, L.G."],["dc.contributor.author","Danei, M."],["dc.contributor.author","Denk, A."],["dc.contributor.author","Egle, D."],["dc.contributor.author","Emons, G."],["dc.contributor.author","Friedrichs, K."],["dc.contributor.author","Harbeck, N."],["dc.contributor.author","Kiechle, M."],["dc.contributor.author","Kimmig, R."],["dc.contributor.author","Koehler, U."],["dc.contributor.author","Kuemmel, S."],["dc.contributor.author","Maass, N."],["dc.contributor.author","Mayr, C."],["dc.contributor.author","Prové, A."],["dc.contributor.author","Rageth, C."],["dc.contributor.author","Regolo, L."],["dc.contributor.author","Lorenz-Salehi, F."],["dc.contributor.author","Sarlos, D."],["dc.contributor.author","Singer, C."],["dc.contributor.author","Sohn, C."],["dc.contributor.author","Staelens, G."],["dc.contributor.author","Tinterri, C."],["dc.contributor.author","Audisio, R."],["dc.contributor.author","Ponti, A."],["dc.contributor.author","Badbanchi, F."],["dc.contributor.author","Catalano, G."],["dc.contributor.author","Cretella, E."],["dc.contributor.author","Daniaux, M."],["dc.contributor.author","Emons, A."],["dc.contributor.author","van Eygen, K."],["dc.contributor.author","Ettl, J."],["dc.contributor.author","Gatzemeier, W."],["dc.contributor.author","Kern, P."],["dc.contributor.author","Schneeweiss, A."],["dc.contributor.author","Stoeblen, F."],["dc.contributor.author","Van As, A."],["dc.contributor.author","Wuerstlein, R."],["dc.contributor.author","Zanini, V."],["dc.date.accessioned","2020-12-10T14:23:39Z"],["dc.date.available","2020-12-10T14:23:39Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1016/j.ejca.2017.07.040"],["dc.identifier.issn","0959-8049"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72001"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Time trends (2006–2015) of quality indicators in EUSOMA-certified breast centres"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","177"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Der Onkologe"],["dc.bibliographiccitation.lastpage","188"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Bock, N."],["dc.contributor.author","Vordermark, D."],["dc.contributor.author","Emons, G."],["dc.date.accessioned","2020-12-10T14:10:59Z"],["dc.date.available","2020-12-10T14:10:59Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s00761-017-0316-5"],["dc.identifier.eissn","1433-0415"],["dc.identifier.issn","0947-8965"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70932"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Endometriumkarzinom"],["dc.title.alternative","Endometrial cancer. A review with current aspects"],["dc.title.subtitle","Eine Übersicht mit aktuellen Aspekten"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1481"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Molecular Cancer Research"],["dc.bibliographiccitation.lastpage","1490"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Emons, Georg"],["dc.contributor.author","Spitzner, Melanie"],["dc.contributor.author","Reineke, Sebastian"],["dc.contributor.author","Möller, Janneke"],["dc.contributor.author","Auslander, Noam"],["dc.contributor.author","Kramer, Frank"],["dc.contributor.author","Hu, Yue"],["dc.contributor.author","Beissbarth, Tim"],["dc.contributor.author","Wolff, Hendrik A."],["dc.contributor.author","Rave-Fränk, Margret"],["dc.contributor.author","Heßmann, Elisabeth"],["dc.contributor.author","Gaedcke, Jochen"],["dc.contributor.author","Ghadimi, B. Michael"],["dc.contributor.author","Johnsen, Steven A."],["dc.contributor.author","Ried, Thomas"],["dc.contributor.author","Grade, Marian"],["dc.date.accessioned","2020-12-10T18:37:47Z"],["dc.date.available","2020-12-10T18:37:47Z"],["dc.date.issued","2017"],["dc.description.abstract","Activation of Wnt/β-catenin signaling plays a central role in the development and progression of colorectal cancer. The Wnt-transcription factor, TCF7L2, is overexpressed in primary rectal cancers that are resistant to chemoradiotherapy and TCF7L2 mediates resistance to chemoradiotherapy. However, it is unclear whether the resistance is mediated by a TCF7L2 inherent mechanism or Wnt/β-catenin signaling in general. Here, inhibition of β-catenin by siRNAs or a small-molecule inhibitor (XAV-939) resulted in sensitization of colorectal cancer cells to chemoradiotherapy. To investigate the potential role of Wnt/β-catenin signaling in controlling therapeutic responsiveness, nontumorigenic RPE-1 cells were stimulated with Wnt-3a, a physiologic ligand of Frizzled receptors, which increased resistance to chemoradiotherapy. This effect could be recapitulated by overexpression of a degradation-resistant mutant of β-catenin (S33Y), also boosting resistance of RPE-1 cells to chemoradiotherapy, which was, conversely, abrogated by siRNA-mediated silencing of β-catenin. Consistent with these findings, higher expression levels of active β-catenin were observed as well as increased TCF/LEF reporter activity in SW1463 cells that evolved radiation resistance due to repeated radiation treatment. Global gene expression profiling identified several altered pathways, including PPAR signaling and other metabolic pathways, associated with cellular response to radiation. In summary, aberrant activation of Wnt/β-catenin signaling not only regulates the development and progression of colorectal cancer, but also mediates resistance of rectal cancers to chemoradiotherapy.Implications: Targeting Wnt/β-catenin signaling or one of the downstream pathways represents a promising strategy to increase response to chemoradiotherapy. Mol Cancer Res; 15(11); 1481-90. ©2017 AACR."],["dc.identifier.doi","10.1158/1541-7786.MCR-17-0205"],["dc.identifier.eissn","1557-3125"],["dc.identifier.issn","1541-7786"],["dc.identifier.pmid","28811361"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77090"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.eissn","1557-3125"],["dc.relation.issn","1541-7786"],["dc.title","Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","900"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Der Gynäkologe"],["dc.bibliographiccitation.lastpage","900"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Emons, G."],["dc.contributor.author","Nauck, F."],["dc.date.accessioned","2020-12-10T14:08:43Z"],["dc.date.available","2020-12-10T14:08:43Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s00129-017-4154-8"],["dc.identifier.eissn","1433-0393"],["dc.identifier.issn","0017-5994"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70533"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.orgunit","Klinik für Palliativmedizin"],["dc.title","Palliativmedizin in der Gynäkologie"],["dc.title.alternative","Palliative care in gynecology"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]