Kulanga, Miroslav

[["dc.bibliographiccitation.firstpage","663"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Der Ophthalmologe"],["dc.bibliographiccitation.lastpage","668"],["dc.bibliographiccitation.volume","115"],["dc.contributor.author","Fischer, C. V."],["dc.contributor.author","Kulanga, M."],["dc.contributor.author","Hoerauf, H."],["dc.date.accessioned","2020-12-10T14:10:15Z"],["dc.date.available","2020-12-10T14:10:15Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s00347-017-0559-y"],["dc.identifier.eissn","1433-0423"],["dc.identifier.issn","0941-293X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70699"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.haserratum","/handle/2/70700"],["dc.title","Trends in der Ablatiochirurgie"],["dc.title.alternative","Trends in retinal detachment surgery. What has changed compared to 2001?"],["dc.title.subtitle","Was hat sich im Vergleich zu 2001 geändert?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","12904"],["dc.bibliographiccitation.issue","50"],["dc.bibliographiccitation.journal","Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","12913"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Liu, Yang"],["dc.contributor.author","Hao, Wenlin"],["dc.contributor.author","Letiembre, Maryse"],["dc.contributor.author","Walter, Silke"],["dc.contributor.author","Kulanga, Miroslav"],["dc.contributor.author","Neumann, Harald"],["dc.contributor.author","Fassbender, Klaus"],["dc.date.accessioned","2018-11-07T08:50:57Z"],["dc.date.available","2018-11-07T08:50:57Z"],["dc.date.issued","2006"],["dc.description.abstract","Multiple sclerosis (MS) is pathologically characterized by inflammatory demyelination and neuronal injury. Although phagocytosis of myelin debris by microglia and macrophages in acute MS lesions is well documented, its pathophysiological significance is unclear. Using real-time quantitative PCR, flow cytometry, ELISA, and reactive oxygen species (ROS) measurement assays, we demonstrated that phagocytosis of myelin modulates activation of microglial cells prestimulated by interferon-gamma (IFN-gamma) or a combination of IFN-gamma and lipopolysaccharide with a biphasic temporal pattern, i.e., enhanced production of proinflammatory mediators during the first phase (<= 6 h), followed by suppression during the second (6-24 h) phase. In this second phase, myelin phagocytosis leads to an enhanced release of prostaglandin E2 and ROS in microglia, whereas the production of anti-inflammatory cytokines (particularly interleukin-10) remains unchanged. Suppression of inflammatory microglial activation by myelin phagocytosis was reversed by treatment with superoxide dismutase and catalase, by inhibition of the NADPH-oxidase complex, or by specific knockdown of the NADPH-oxidase- required adaptor p47-phagocyte oxidase (PHOX). Furthermore, we observed that myelin phagocytosis destabilized tumor necrosis factor-alpha and interferon-induced protein-10 mRNA through an adenine-uridine-rich elements-involved mechanism, which was reversed by blocking the function of NADPH-oxidase complex. We conclude that phagocytosis of myelin suppresses microglial inflammatory activities via enhancement of p47-PHOX-mediated ROS generation. These results suggest that intervention in ROS generation could represent a novel therapeutic strategy to reduce neuroinflammation in MS."],["dc.identifier.doi","10.1523/JNEUROSCI.2531-06.2006"],["dc.identifier.isi","000242996200007"],["dc.identifier.pmid","17167081"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21813"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc Neuroscience"],["dc.relation.issn","0270-6474"],["dc.title","Suppression of microglial inflammatory activity by myelin phagocytosis: Role of p47-PHOX-mediated generation of reactive oxygen species"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1006"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Der Ophthalmologe"],["dc.bibliographiccitation.lastpage","1010"],["dc.bibliographiccitation.volume","112"],["dc.contributor.author","Kulanga, Miroslav"],["dc.contributor.author","Schittkowski, Michael P."],["dc.date.accessioned","2018-11-07T09:48:21Z"],["dc.date.available","2018-11-07T09:48:21Z"],["dc.date.issued","2015"],["dc.description.abstract","In ophthalmological emergencies, patients often present with injuries after falling on their face in particular involving the periocular region. Often these are only trivial injuries of the conjunctiva, eyelids or periocular skin, which require no further treatment. Small de-hiscences can be treated with sutures, fibrin glue or Steri-Strips; however, sometimes injuries that are more serious can be mistaken as being trivial but only represent the tip of the iceberg of the actual injury and, therefore, further diagnostics and therapy are required."],["dc.identifier.doi","10.1007/s00347-015-3249-7"],["dc.identifier.isi","000366322700012"],["dc.identifier.pmid","25744766"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35285"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1433-0423"],["dc.relation.issn","0941-293X"],["dc.title","Underestimated trivial injuries after a fall. Sometimes it is more serious"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1559"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Graefe's Archive for Clinical and Experimental Ophthalmology"],["dc.bibliographiccitation.lastpage","1564"],["dc.bibliographiccitation.volume","255"],["dc.contributor.author","Callizo, Josep"],["dc.contributor.author","Pfeiffer, Sebastian"],["dc.contributor.author","Lahme, Eva"],["dc.contributor.author","van Oterendorp, Christian"],["dc.contributor.author","Khattab, Mohammed"],["dc.contributor.author","Bemme, Sebastian"],["dc.contributor.author","Kulanga, Miroslav"],["dc.contributor.author","Hoerauf, Hans"],["dc.contributor.author","Feltgen, Nicolas"],["dc.date.accessioned","2018-10-08T09:22:04Z"],["dc.date.available","2018-10-08T09:22:04Z"],["dc.date.issued","2017-08"],["dc.description.abstract","To identify factors that may lead to a rapid progression in macula-on rhegmatogenous retinal detachment (RRD), in particular, those that may lead to macular involvement.Observational, prospective, single-center study. Patients referred for surgery due to primary rhegmatogenous retinal detachment with the macula on between 2009 and 2013 were included. Relevant factors analyzed included age, time delay until surgery, lens status, myopia, the detachment’s location and configuration as well as number, size and type of retinal breaks. Eyes underwent optical coherence tomography to detect macular detachment. A multivariate analysis was performed to investigate the effect of several factors in the progression of retinal detachment. A total of 116 eyes of 116 patients were included. Mean time delay between admission and surgery was 1.8 ± 1.4 days. Progression was observed in 19.8% of the eyes. Of those, 47.8% presented macular detachment. Ten of the 11 (90.9%) eyes presenting progression involving the macula also exhibited a bullous configuration, which was the only parameter that correlated significantly with detachment progression in patients with (p = 0.0036) and without (p = 0.0014) macular involvement. For the first time in a prospective trial, a bullous configuration was found to be a highly significant predictor for progression in macula-on detachments. Our data support prompt surgery in patients diagnosed with bullous macula-on RRD."],["dc.fs.pkfprnr","5911"],["dc.identifier.doi","10.1007/s00417-017-3696-8"],["dc.identifier.fs","627411"],["dc.identifier.pmid","28551879"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15876"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1435-702X"],["dc.title","Risk of progression in macula-on rhegmatogenous retinal detachment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","669"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Der Ophthalmologe"],["dc.bibliographiccitation.lastpage","669"],["dc.bibliographiccitation.volume","115"],["dc.contributor.author","Fischer, C. V."],["dc.contributor.author","Kulanga, M."],["dc.contributor.author","Hoerauf, H."],["dc.date.accessioned","2020-12-10T14:10:16Z"],["dc.date.available","2020-12-10T14:10:16Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s00347-017-0621-9"],["dc.identifier.eissn","1433-0423"],["dc.identifier.issn","0941-293X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70700"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.iserratumof","/handle/2/70699"],["dc.title","Correction: Trends in der Ablatiochirurgie"],["dc.title.alternative","Correction: Trends in retinal detachment surgery. What has changed compared to 2001?"],["dc.title.subtitle","Was hat sich im Vergleich zu 2001 geändert?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","erratum_ja"],["dspace.entity.type","Publication"]]