Sperling, Jens

[["dc.bibliographiccitation.firstpage","57"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Clinical & Experimental Metastasis"],["dc.bibliographiccitation.lastpage","66"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Kauffels, Anne"],["dc.contributor.author","Kitzmüller, Marie"],["dc.contributor.author","Gruber, Andrea"],["dc.contributor.author","Nowack, Hannah"],["dc.contributor.author","Bohnenberger, Hanibal"],["dc.contributor.author","Spitzner, Melanie"],["dc.contributor.author","Kuthning, Anja"],["dc.contributor.author","Sprenger, Thilo"],["dc.contributor.author","Czejka, Martin"],["dc.contributor.author","Ghadimi, Michael"],["dc.contributor.author","Sperling, Jens"],["dc.date.accessioned","2020-12-10T14:11:27Z"],["dc.date.available","2020-12-10T14:11:27Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s10585-019-09954-5"],["dc.identifier.eissn","1573-7276"],["dc.identifier.issn","0262-0898"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71079"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Hepatic arterial infusion of irinotecan and EmboCept® S results in high tumor concentration of SN-38 in a rat model of colorectal liver metastases"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Oncology Research and Treatment"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Sperling, Jens"],["dc.contributor.author","Ziemann, C."],["dc.contributor.author","Gittler, Anika"],["dc.contributor.author","Benz-Weisser, Anna"],["dc.contributor.author","Menger, Michael D."],["dc.contributor.author","Kollmar, Otto"],["dc.date.accessioned","2018-11-07T09:44:06Z"],["dc.date.available","2018-11-07T09:44:06Z"],["dc.date.issued","2014"],["dc.format.extent","49"],["dc.identifier.isi","000332306700162"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34323"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","2296-5262"],["dc.relation.issn","2296-5270"],["dc.title","Locoregional application of temsirolimus is effective to inhibit tumor growth of CC531 colorectal liver metastases even after stimulation by hepatectomy or portal branch ligation"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Cancer"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Ziemann, Christian"],["dc.contributor.author","Roller, Jonas"],["dc.contributor.author","Malter, Markus M."],["dc.contributor.author","Keller, Kira"],["dc.contributor.author","Kollmar, Otto"],["dc.contributor.author","Glanemann, Matthias"],["dc.contributor.author","Menger, Michael D."],["dc.contributor.author","Sperling, Jens"],["dc.date.accessioned","2020-12-10T18:38:54Z"],["dc.date.available","2020-12-10T18:38:54Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1186/s12885-019-6135-x"],["dc.identifier.eissn","1471-2407"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16951"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77472"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Intra-arterial EmboCept S® and DC Bead® effectively inhibit tumor growth of colorectal rat liver metastases"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1015"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Der Chirurg"],["dc.bibliographiccitation.lastpage","1024"],["dc.bibliographiccitation.volume","87"],["dc.contributor.author","Sperling, Jens"],["dc.contributor.author","Kauffels, Anne"],["dc.contributor.author","Grade, Marian"],["dc.contributor.author","Alves, Frauke"],["dc.contributor.author","Kuehn, P."],["dc.contributor.author","Ghadimi, B. Michael"],["dc.date.accessioned","2018-11-07T10:05:08Z"],["dc.date.available","2018-11-07T10:05:08Z"],["dc.date.issued","2016"],["dc.description.abstract","Modern intraoperative techniques of visualization are increasingly being applied in general and visceral surgery. The combination of diverse techniques provides the possibility of multidimensional intraoperative visualization of specific anatomical structures. Thus, it is possible to differentiate between normal tissue and tumor tissue and therefore exactly define tumor margins. The aim of intraoperative visualization of tissue that is to be resected and tissue that should be spared is to lead to a rational balance between oncological and functional results. Moreover, these techniques help to analyze the physiology and integrity of tissues. Using these methods surgeons are able to analyze tissue perfusion and oxygenation. However, to date it is not clear to what extent these imaging techniques are relevant in the clinical routine. The present manuscript reviews the relevant modern visualization techniques focusing on intraoperative computed tomography and magnetic resonance imaging as well as augmented reality, fluorescence imaging and optoacoustic imaging."],["dc.identifier.doi","10.1007/s00104-016-0314-y"],["dc.identifier.isi","000389902200004"],["dc.identifier.pmid","27796416"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38840"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1433-0385"],["dc.relation.issn","0009-4722"],["dc.title","Intraoperative multidimensional visualization"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","555"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","International Journal of Colorectal Disease"],["dc.bibliographiccitation.lastpage","562"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Sperling, Jens"],["dc.contributor.author","Schaefer, Thilo"],["dc.contributor.author","Benz-Weisser, Anna"],["dc.contributor.author","Ziemann, Christian"],["dc.contributor.author","Scheuer, Claudia"],["dc.contributor.author","Kollmar, Otto"],["dc.contributor.author","Schilling, Martin Karl"],["dc.contributor.author","Menger, Michael D."],["dc.date.accessioned","2018-11-07T09:26:19Z"],["dc.date.available","2018-11-07T09:26:19Z"],["dc.date.issued","2013"],["dc.description.abstract","Systemic chemotherapy still represents the gold standard in the treatment of irresectable colorectal liver metastases. Modern anticancer agents like the monoclonal antibody cetuximab have improved the outcome of patients in clinical studies. As hepatic arterial infusion (HAI) is capable to potentially increase the anticancer effect of cytostatics, we herein studied whether HAI of cetuximab (CE) as a single agent or in combination with oxaliplatin (OX) exerts increased anticancer effects compared to the systemic application (SYS) of the drugs. WAG/Rij rats were randomized to eight groups and underwent 10 days after subcapsular hepatic tumor implantation either HAI or SYS of CE, OX, or the combination of both agents (CE + OX). Saline-treated animals served as controls. Tumor volume was measured at days 10 and 13 using three-dimensional ultrasound. On day 13, liver and tumor tissue was sampled for histological and immunohistochemical analysis. In controls, the tumor volume significantly increased from day 10 to 13. Application of OX alone via HAI or SYS did not inhibit tumor growth compared to controls. SYS of CE or CE + OX did also not reduce tumor growth. In contrast, HAI of CE and CE + OX significantly inhibited tumor growth. HAI of CE significantly reduced tumor vascularization as measured by the number of platelet endothelial cell adhesion molecule-1-positive cells and significantly increased the number of apoptotic tumor cells as measured by the cellular caspase-3 expression. HAI of CE and CE + OX reduces tumor growth of colorectal rat liver metastases involving the inhibition of angiogenesis and induction of tumor cell apoptosis."],["dc.identifier.doi","10.1007/s00384-012-1617-1"],["dc.identifier.isi","000318368300014"],["dc.identifier.pmid","23242249"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10946"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30274"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0179-1958"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Hepatic arterial infusion but not systemic application of cetuximab in combination with oxaliplatin significantly reduces growth of CC531 colorectal rat liver metastases"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Die Chirurgie"],["dc.contributor.author","Sperling, J."],["dc.contributor.author","Grade, M."],["dc.contributor.author","von Heesen, M."],["dc.contributor.author","Ghadim, M."],["dc.date.accessioned","2022-09-01T09:51:23Z"],["dc.date.available","2022-09-01T09:51:23Z"],["dc.date.issued","2022"],["dc.description.abstract","Die Insuffizienz gastrointestinaler Anastomosen stellt für die betroffenen Patient*innen ein relevantes Morbiditäts- und Mortalitätsrisiko dar. Die Perfusionsqualität der Darmenden ist der entscheidende Parameter zur Gewährleistung einer suffizienten Anastomosenheilung. Zur Beurteilung der Gewebeperfusion findet in der modernen Viszeralchirurgie vor der Anfertigung gastrointestinaler Anastomosen zunehmend die intraoperative fluoreszenzgestützte Perfusionsmessung mit Indocyaningrün Anwendung. Mit dieser Technik kann zwischen adäquat und inadäquat perfundiertem Gewebe unterschieden werden und somit die Anastomose in einem möglichst optimal durchbluteten Bereich angelegt werden. Die Chirurgie verfügt damit über ein Messinstrument, dass es erlaubt, additiv zur rein subjektiven makroskopisch-visuellen Einschätzung der Perfusionsqualität, eine objektivierbare Beurteilung des Gewebes vorzunehmen und somit ein besseres funktionelles Ergebnis für die Patient*innen zu erzielen. Aktuell ist der Stellenwert dieser Technik jedoch noch nicht abschließend geklärt. Ziel des vorliegenden Leitthemenbeitrags ist es, den Nutzen der intraoperativen fluoreszenzgestützten Perfusionsmessung näher zu charakterisieren und hinsichtlich seiner Bedeutung für den klinischen Alltag einzuordnen."],["dc.identifier.doi","10.1007/s00104-022-01679-8"],["dc.identifier.pii","1679"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113952"],["dc.language.iso","de"],["dc.notes.intern","DOI-Import GROB-597"],["dc.relation.eissn","2731-698X"],["dc.relation.issn","2731-6971"],["dc.relation.orgunit","Klinik für Allgemein-, Viszeral- und Kinderchirurgie"],["dc.rights.uri","https://www.springer.com/tdm"],["dc.title","Intraoperative fluoreszenzgestützte Perfusionsmessung mit Indocyaningrün – erhöhte Sicherheit bei gastrointestinalen Anastomosen?"],["dc.title.translated","Intraoperative fluorescence-guided perfusion assessment using indocyanine green—Increased safety in gastrointestinal anastomoses?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","215"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes"],["dc.bibliographiccitation.lastpage","222"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Schäfer, T."],["dc.contributor.author","Sperling, J."],["dc.contributor.author","Slotta, J. E."],["dc.contributor.author","Kollmar, O."],["dc.contributor.author","Schilling, M. K."],["dc.contributor.author","Menger, M. D."],["dc.contributor.author","Richter, S."],["dc.date.accessioned","2019-07-09T11:40:02Z"],["dc.date.available","2019-07-09T11:40:02Z"],["dc.date.issued","2012"],["dc.description.abstract","BACKGROUND: Hepatic arterial infusion (HAI) has been developed for high-dose regional chemotherapy of unresectable liver metastases or primary liver malignancies. While it is well known that high concentrations of tumor necrosis factor (TNF)-α damage tumor blood perfusion, there is no information on whether autochthonous liver perfusion is affected by HAI with TNF-α. Therefore, we investigated the effects of HAI with TNF-α on hepatic macro- and microvascular perfusion. METHODS: Swabian Hall pigs were randomized into three groups. HAI was performed with either 20 or 40 µg/kg body weight TNF-α (n = 6 each group). Saline-treated animals served as controls (n = 6). Analyses during a 2-hour post-HAI observation period included systemic hemodynamics, portal venous and hepatic arterial blood flow, portal venous pressure, and the blood flow in the hepatic microcirculation. RESULTS: HAI with TNF-α caused a slight decrease of mean arterial blood pressure (p < 0.001), which was compensated by a moderate increase of heart rate (p < 0.001). No further systemic side effects of TNF-α were observed. HAI with TNF-α further caused a slight but not significant decrease of portal venous blood flow (p = 0.737) in both experimental groups, paralleled by an increase of hepatic arterial blood flow (p = 0.023, 20 µg/kg; p = 0.034, 40 µg/kg) resulting in an overall hepatic hyperperfusion. The hepatic hyperperfusion after HAI with 20 µg/kg TNF-α was more pronounced and associated with a 40% decrease of the blood flow in the hepatic microcirculation (p = 0.009). HAI with 40 µg/kg TNF-α was only associated with a temporary and moderate total hepatic hyperperfusion and did not affect the blood flow in the hepatic microcirculation. CONCLUSION: HAI with TNF-α causes a decrease of portal venous flow; however, this is overcompensated by an increased hepatic arterial blood flow, resulting in a total hepatic hyperperfusion. Moderate total hepatic hyperperfusion does not affect the blood flow in the hepatic microcirculation, while a persistent and more pronounced hyperperfusion may cause hepatic microcirculatory disturbances."],["dc.identifier.doi","10.1159/000339306"],["dc.identifier.fs","594196"],["dc.identifier.pmid","22739241"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10601"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58078"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1421-9921"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Blood Pressure"],["dc.subject.mesh","Female"],["dc.subject.mesh","Heart Rate"],["dc.subject.mesh","Hepatic Artery"],["dc.subject.mesh","Liver Circulation"],["dc.subject.mesh","Male"],["dc.subject.mesh","Microcirculation"],["dc.subject.mesh","Portal Vein"],["dc.subject.mesh","Swine"],["dc.subject.mesh","Tumor Necrosis Factor-alpha"],["dc.subject.mesh","Venous Pressure"],["dc.title","Hepatic arterial infusion with tumor necrosis factor-α induces early hepatic hyperperfusion."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","447"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Clinical & Experimental Metastasis"],["dc.bibliographiccitation.lastpage","455"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Sperling, Jens"],["dc.contributor.author","Brandhorst, David"],["dc.contributor.author","Schäfer, Thilo"],["dc.contributor.author","Ziemann, Christian"],["dc.contributor.author","Benz-Weißer, Anna"],["dc.contributor.author","Scheuer, Claudia"],["dc.contributor.author","Kollmar, Otto"],["dc.contributor.author","Schilling, Martin"],["dc.contributor.author","Menger, Michael"],["dc.date.accessioned","2019-07-09T11:39:49Z"],["dc.date.available","2019-07-09T11:39:49Z"],["dc.date.issued","2012"],["dc.description.abstract","Colorectal carcinoma is, through to its high rate of liver metastasis (mCRC), the second most cause of cancer death worldwide. Tumor resection represents the only potential cure. In cases of unresectable disease systemic chemotherapy (sCHT) remains the therapy of choice. Modern sCHT regimens including biological agents can induce tumor response that leads to curative surgery of initially unresectable mCRC. However, liver-directed therapy via hepatic arterial infusion (HAI) may produce higher response rates than sCHT. Herein we studied whether a HAI of cetuximab (CE) plus bevacizumab (BE) with or without oxaliplatin (OX) can inhibit tumor growth in a rat model. WAG/Rij rats underwent subcapsular hepatic tumor implantation. After 10 days animals received either HAI or sCHT of CE plus BE, OX or all three drugs. Saline-treated animals served as controls. Tumor growth was estimated at day 10 and 13. On day 13 liver and tumor tissue was studied histologically and immunohistochemically. In controls the tumors grew about 50 %. OX alone was not capable of inhibiting tumor growth. In contrast, CE plus BE given as HAI significantly reduced tumor growth compared to sCHT (p < 0.05). HAI of CE plus BE combined with OX yielded an even more pronounced inhibition of tumor growth. Immunohistochemistry revealed a decreased tumor cell proliferation and tumor vascularization. The present study demonstrates that HAI of CE plus BE is effective to inhibit tumor growth. This effect is even more pronounced in combination with OX. Systemic application of these agents cannot achieve comparable effects."],["dc.identifier.doi","10.1007/s10585-012-9550-9"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10342"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58044"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","Springer"],["dc.publisher.place","Dordrecht"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Liver-directed chemotherapy of cetuximab and bevacizumab in combination with oxaliplatin is more effective to inhibit tumor growth of CC531 colorectal rat liver metastases than systemic chemotherapy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","198"],["dc.bibliographiccitation.journal","World Journal of Surgical Oncology"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Sperling, Jens"],["dc.contributor.author","Justinger, Christoph"],["dc.contributor.author","Schuld, Jochen"],["dc.contributor.author","Ziemann, Christian"],["dc.contributor.author","Seidel, Roland"],["dc.contributor.author","Kollmar, Otto"],["dc.date.accessioned","2018-11-07T09:38:11Z"],["dc.date.available","2018-11-07T09:38:11Z"],["dc.date.issued","2014"],["dc.description.abstract","Intra- or extrahepatic cholangiocarcinomas are the second most common primary liver malignancies behind hepatocellular carcinoma. Whereas the incidence for intrahepatic cholangiocarcinoma is rising, the occurrence of extrahepatic cholangiocarcinoma is trending downwards. The treatment of choice for intrahepatic cholangiocarcinoma remains liver resection. However, a case of liver resection after selective internal radiation therapy in order to treat a recurrent intrahepatic cholangiocarcinoma in a transplant liver is unknown in the literature so far. Herein, we present a case of a patient undergoing liver transplantation for Wilson's disease with an accidental finding of an intrahepatic cholangiocarcinoma within the explanted liver. Due to a recurrent intrahepatic cholangiocarcinoma after liver transplantation, a selective internal radiation therapy with yttrium-90 microspheres was performed followed by right hemihepatectomy. Four years later, the patient is tumor-free and in a healthy condition."],["dc.identifier.doi","10.1186/1477-7819-12-198"],["dc.identifier.isi","000339373600001"],["dc.identifier.pmid","24980217"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10439"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33016"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1477-7819"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Intrahepatic cholangiocarcinoma in a transplant liver - selective internal radiation therapy followed by right hemihepatectomy: report of a case"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","361"],["dc.bibliographiccitation.issue","04"],["dc.bibliographiccitation.journal","Zentralblatt für Chirurgie"],["dc.bibliographiccitation.lastpage","366"],["dc.bibliographiccitation.volume","143"],["dc.contributor.author","Jo, Peter"],["dc.contributor.author","Kesruek, Hatice"],["dc.contributor.author","Nietert, Manuel"],["dc.contributor.author","Sahlmann, Carsten"],["dc.contributor.author","Gaedcke, Jochen"],["dc.contributor.author","Ghadimi, Michael"],["dc.contributor.author","Sperling, Jens"],["dc.date.accessioned","2020-12-10T18:12:02Z"],["dc.date.available","2020-12-10T18:12:02Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1055/a-0651-0878"],["dc.identifier.eissn","1438-9592"],["dc.identifier.issn","0044-409X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74230"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Inzidenz und prädiktive Faktoren des bilateralen papillären Schilddrüsenkarzinoms"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]