Havemann-Reinecke, Ursula

[["dc.bibliographiccitation.journal","European Psychiatry"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Havemann-Reinecke, Ursula"],["dc.contributor.author","Tomas-Roig, Jordi"],["dc.contributor.author","Piscitelli, Fabiana"],["dc.contributor.author","Di Marzo, Vincenzo"],["dc.contributor.author","Del Rio, J. A."],["dc.contributor.author","Falkai, Peter Gaston"],["dc.date.accessioned","2018-11-07T09:45:27Z"],["dc.date.available","2018-11-07T09:45:27Z"],["dc.date.issued","2014"],["dc.identifier.isi","000347280701241"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34621"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier France-editions Scientifiques Medicales Elsevier"],["dc.publisher.place","Paris"],["dc.relation.issn","1778-3585"],["dc.relation.issn","0924-9338"],["dc.title","PSYCHOSOCIAL STRESS AND PSYCHIATRIC PHENOTYPES: ENDOCANNABINOIDS AND CANNABINOID RECEPTOR (CBR) EXPRESSION IN CORTICO-STRIATAL CONNECTIVITY"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","485"],["dc.bibliographiccitation.issue","5-6"],["dc.bibliographiccitation.journal","Behavioural Pharmacology"],["dc.bibliographiccitation.lastpage","486"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Havemann-Reinecke, Ursula"],["dc.contributor.author","Lojewski, I."],["dc.contributor.author","Wismann, B."],["dc.contributor.author","Hoger, C."],["dc.contributor.author","Rothenberger, A."],["dc.date.accessioned","2018-11-07T10:03:59Z"],["dc.date.available","2018-11-07T10:03:59Z"],["dc.date.issued","2002"],["dc.identifier.isi","000178828200043"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38594"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.issn","0955-8810"],["dc.title","Does methylphenidate therapy in childhood increase the risk of addiction disease?"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Psychiatry"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Havemann-Reinecke, Ursula"],["dc.contributor.author","Manouchehr, S."],["dc.date.accessioned","2018-11-07T08:34:27Z"],["dc.date.available","2018-11-07T08:34:27Z"],["dc.date.issued","2009"],["dc.identifier.isi","000208663800311"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17818"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier France-editions Scientifiques Medicales Elsevier"],["dc.publisher.place","Paris"],["dc.relation.issn","0924-9338"],["dc.title","PRINCIPLES OF ANALGESIC EFFECTS OF OPIOIDS AND DEPENDENCE OF OPIOIDS (FE TRAMADOL)"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","271"],["dc.bibliographiccitation.issue","16"],["dc.bibliographiccitation.journal","DEUTSCHES ARZTEBLATT INTERNATIONAL"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","112"],["dc.contributor.author","Hoch, Eva"],["dc.contributor.author","Bonnet, Udo"],["dc.contributor.author","Thomasius, Rainer"],["dc.contributor.author","Ganzer, Florian"],["dc.contributor.author","Havemann-Reinecke, Ursula"],["dc.contributor.author","Preuss, Ulrich W."],["dc.date.accessioned","2018-11-07T09:58:27Z"],["dc.date.available","2018-11-07T09:58:27Z"],["dc.date.issued","2015"],["dc.description.abstract","Background: Cannabis is the most commonly consumed illicit drug around the world; in Germany, about 4.5% of all adults use it each year. Intense cannabis use is associated with health risks. Evidence-based treatments are available for health problems caused by cannabis use. Methods: Selective literature review based on a search of the PubMed database, with special emphasis on systematic reviews, meta-analyses, cohort studies, randomized controlled trials (RCTs), case-control studies, and treatment guidelines. Results: The delta-9-tetrahydrocannabinol content of cannabis products is rising around the world as a result of plant breeding, while cannabidiol, in contrast, is often no longer detectable. Various medical conditions can arise acutely after cannabis use, depending on the user's age, dose, frequency, mode and situation of use, and individual disposition; these include panic attacks, psychotic symptoms, deficient attention, impaired concentration, motor incoordination, and nausea. In particular, intense use of high doses of cannabis over many years, and the initiation of cannabis use in adolescence, can be associated with substance dependence (DSM-5; ICD-10), specific withdrawal symptoms, cognitive impairment, affective disorders, psychosis, anxiety disorders, and physical disease outside the brain (mainly respiratory and cardiovascular conditions). At present, the most effective way to treat cannabis dependence involves a combination of motivational encouragement, cognitive behavioral therapy, and contingency management (level 1a evidence). For adolescents, family therapy is also recommended (level 1a evidence). No pharmacological treatments can be recommended to date, as evidence for their efficacy is lacking. Conclusion: Further research is needed to elucidate the causal relationships between intense cannabis use and potential damage to physical and mental health. Health problems due to cannabis use can be effectively treated."],["dc.description.sponsorship","Servier"],["dc.identifier.doi","10.3238/arztebl.2015.0271"],["dc.identifier.isi","000354642500001"],["dc.identifier.pmid","25939318"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37364"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Deutscher Aerzte-verlag Gmbh"],["dc.relation.issn","1866-0452"],["dc.title","Risks Associated With the Non-Medicinal Use of Cannabis"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","67"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","PSYCHOPHARMAKOTHERAPIE"],["dc.bibliographiccitation.lastpage","74"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Ulrich, Sven"],["dc.contributor.author","Laux, Gerd"],["dc.contributor.author","Moller-Oerlinghausen, Bruno"],["dc.contributor.author","Havemann-Reinecke, Ursula"],["dc.contributor.author","Riederer, Peter"],["dc.contributor.author","Zernig, Gerald"],["dc.contributor.author","Baumann, Pierre"],["dc.contributor.author","Lausanne, Prilly"],["dc.contributor.author","Hiemke, Christoph"],["dc.date.accessioned","2018-11-07T11:18:02Z"],["dc.date.available","2018-11-07T11:18:02Z"],["dc.date.issued","2008"],["dc.description.abstract","Therapeutic drug monitoring (TDM) of psycho-pharmaceuticals is the practical therapeutic application of pharmacokinetic principles in pharmacopsychiatry. The prescription information (summary of product characteristics, SPC) is provided by pharmaceutical companies according to requirements of regulatory authorities and determines the framework of clinical application of a drug. The present study investigated the degree of agreement of German SPCs for 48 psychopharmaceuticals with the existing medico-scientific evidence in the area of TDM. For this aim, an empirical summary score of SPC-content related to TDM (SPCCTDM) was calculated and compared with the level of recommendation of TDM (LOR) of the AGNP-TDM expert group consensus guidelines. Considerable disagreement was found between the information on TDM in SPCs and existing medico-scientific evidence, e. g. in case of antidepressant and antipsychotic drugs. No correlation was found between SPCCTDM and LOR. Even for well studied compounds in TDM such as amitriptyline and clozapine, insufficient information on TDM is included in German SPCs. Generally, it must be concluded that deficits exist in the preparation of German SPCs of psychopharmaceutical drugs with respect to empirical pharmacokinetic data, i.e. TDM-relevant information. It is recommended that SPCs of psychopharmaceuticals should be improved in terms of TDM-related information and that target plasma concentrations have to be adjusted according to the guidelines of the AGNP-TDM expert group. A higher level of good pharmacokinetic practice may be thus achieved."],["dc.identifier.isi","000254795300006"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54953"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wissenschaftliche Verlag Mbh"],["dc.relation.issn","0944-6877"],["dc.title","Value and actuality of the prescription information for therapeutic drug monitoring of psychopharmaceuticals: a comparison with the medico-scientific evidence"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S22"],["dc.bibliographiccitation.journal","Schizophrenia Bulletin"],["dc.bibliographiccitation.lastpage","S33"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Brzozka, Magdalena M."],["dc.contributor.author","Havemann-Reinecke, Ursula"],["dc.contributor.author","Wichert, Sven P."],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Rossner, Moritz J."],["dc.date.accessioned","2018-11-07T10:11:48Z"],["dc.date.available","2018-11-07T10:11:48Z"],["dc.date.issued","2016"],["dc.description.abstract","Chronic psychosocial stress is an important environmental risk factor of psychiatric diseases such as schizophrenia. Social defeat in rodents has been shown to be associated with maladaptive cellular and behavioral consequences including cognitive impairments. Although gene expression changes upon psychosocial stress have been described, a comprehensive transcriptome profiling study at the global level in precisely defined hippocampal subregions which are associated with learning has been lacking. In this study, we exposed adult C57Bl/6N mice for 3 weeks to \"resident-intruder\" paradigm and combined laser capture microdissection with microarray analyses to identify transcriptomic signatures of chronic psychosocial stress in dentate gyrus and CA3 subregion of the dorsal hippocampus. At the individual transcript level, we detected subregion specific stress responses whereas gene set enrichment analyses (GSEA) identified several common pathways upregulated upon chronic psychosocial stress related to proteasomal function and energy supply. Behavioral profiling revealed stress-associated impairments most prominent in fear memory formation which was prevented by chronic lithium treatment. Thus, we again microdissected the CA3 region and performed global transcriptome analysis to search for molecular signatures altered by lithium treatment in stressed animals. By combining GSEA with unsupervised clustering, we detected pathways that are regulated by stress and lithium in the CA3 region of the hippocampus including proteasomal components, oxidative phosphorylation, and anti-oxidative mechanisms. Our study thus provides insight into hidden molecular phenotypes of chronic psychosocial stress and lithium treatment and proves a beneficial role for lithium treatment as an agent attenuating negative effects of psychosocial stress on cognition."],["dc.identifier.doi","10.1093/schbul/sbv194"],["dc.identifier.isi","000386210400004"],["dc.identifier.pmid","26714764"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40115"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","1745-1701"],["dc.relation.issn","0586-7614"],["dc.title","Molecular Signatures of Psychosocial Stress and Cognition Are Modulated by Chronic Lithium Treatment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","The International Journal of Neuropsychopharmacology"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Rygula, Rafal"],["dc.contributor.author","Flugge, G."],["dc.contributor.author","Ruther, Eckart"],["dc.contributor.author","Hiemke, Christoph"],["dc.contributor.author","Havemann-Reinecke, Ursula"],["dc.date.accessioned","2018-11-07T10:48:30Z"],["dc.date.available","2018-11-07T10:48:30Z"],["dc.date.issued","2004"],["dc.format.extent","S458"],["dc.identifier.isi","000224663002518"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48208"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cambridge Univ Press"],["dc.publisher.place","New york"],["dc.relation.conference","24th CINP Congress"],["dc.relation.eventlocation","Paris, FRANCE"],["dc.relation.issn","1461-1457"],["dc.title","Chronic psychosocial stress in rats as a model of depression - Behavioral and pharmacological studies"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1282"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Alcoholism Clinical and Experimental Research"],["dc.bibliographiccitation.lastpage","1287"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Schmidt, Lutz G."],["dc.contributor.author","Bleich, Stefan"],["dc.contributor.author","Boening, J."],["dc.contributor.author","Buehringer, G."],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Weijers, H. G."],["dc.contributor.author","Wiesbeck, G. A."],["dc.contributor.author","Wolfgramm, J."],["dc.contributor.author","Havemann-Reinecke, Ursula"],["dc.date.accessioned","2018-11-07T08:47:47Z"],["dc.date.available","2018-11-07T08:47:47Z"],["dc.date.issued","2005"],["dc.description.abstract","This article presents the proceedings of a symposium at the 2004 International Society for Biomedical Research on Alcoholism meeting in Heidelberg/Mannheim, Germany, put together by the German Society of Addiction Therapy and Research (DG-Sucht e.V.). The aim was to give an overview on recent findings from animal to human studies that were conducted by several research groups engaged in the alcoholism field in Germany for longer periods. Results of his animal studies were presented by J. Wolfgramm; G. Buehringer reported on epidentiologic and psychotherapeutic research advances on alcohol-related disorders in Germany. L. G. Schmidt summarized results of novel diagnostic and therapeutic approaches in alcohol dependence, and J. Boening focused on biopsychological personality traits as predictors for relapse in alcoholism. Data relating hyperhomocysteinernia and brain shrinkage in patients with alcoholism were presented by J. Kornhuber. Four addiction research networks federally funded represented their results in separate symposia and were therefore deliberately excluded from this symposium."],["dc.identifier.doi","10.1097/01.ALC.0000171897.16149.E7"],["dc.identifier.isi","000230860500020"],["dc.identifier.pmid","16088985"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21046"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.conference","12th International Congress of the International-Society-for-Biomedical-Research-on-Alcoholism"],["dc.relation.eventlocation","Heidelberg, GERMANY"],["dc.relation.issn","0145-6008"],["dc.title","Advances in Alcoholism Research in Germany"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Psychiatry"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Croissant, B."],["dc.contributor.author","Boehler, J."],["dc.contributor.author","Lorenz, Jan L."],["dc.contributor.author","Diehl, A."],["dc.contributor.author","Wedekind, Dirk"],["dc.contributor.author","Mann, K."],["dc.contributor.author","Havemann-Reinecke, Ursula"],["dc.date.accessioned","2018-11-07T08:47:37Z"],["dc.date.available","2018-11-07T08:47:37Z"],["dc.date.issued","2010"],["dc.identifier.isi","000208225801265"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20999"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier France-editions Scientifiques Medicales Elsevier"],["dc.publisher.place","Paris"],["dc.relation.issn","0924-9338"],["dc.title","RCT: QUETIAPINE VS. PLACEBO IN ALCOHOL RELAPSE PREVENTION. RATIONAL, METHODS AND PRELIMINARY RESULTS"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","246"],["dc.bibliographiccitation.journal","Behavioural Brain Research"],["dc.bibliographiccitation.lastpage","249"],["dc.contributor.author","Adamcio, Bartosz"],["dc.contributor.author","Havemann-Reinecke, Ursula"],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.date.accessioned","2017-09-07T11:45:47Z"],["dc.date.available","2017-09-07T11:45:47Z"],["dc.date.issued","2009"],["dc.description.abstract","Chronic psychosocial stress has been suggested as “second hit” in the etiology of neuropsychiatric disease, but experimental evidence is scarce. We employed repetitive social defeat stress in juvenile mice, housed individually or in groups, and measured sensorimotor gating by pre-pulse inhibition (PPI), a marker of neuronal network function. Using the resident-intruder paradigm, 28-day old C57BL/6NCrl mice were subjected daily for 3 weeks to social defeat. PPI and basic behaviour were analyzed 10 weeks later. Whereas stress increased the level of anxiety in all animals, persistent PPI deficits were found only in individually housed mice. Thus, social support in situations of severe psychosocial stress may prevent lasting impairment in basic information processing."],["dc.identifier.doi","10.1016/j.bbr.2009.05.030"],["dc.identifier.gro","3150446"],["dc.identifier.pmid","19482043"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7211"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.title","Chronic psychosocial stress in the absence of social support induces pathological pre-pulse inhibition in mice"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]