Zilles, David

[["dc.bibliographiccitation.firstpage","809"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","European Archives of Psychiatry and Clinical Neuroscience"],["dc.bibliographiccitation.lastpage","817"],["dc.bibliographiccitation.volume","268"],["dc.contributor.author","Krech, Lisa"],["dc.contributor.author","Belz, Michael"],["dc.contributor.author","Besse, Matthias"],["dc.contributor.author","Methfessel, Isabel"],["dc.contributor.author","Wedekind, D."],["dc.contributor.author","Zilles, David"],["dc.date.accessioned","2019-02-26T10:15:46Z"],["dc.date.available","2019-02-26T10:15:46Z"],["dc.date.issued","2018"],["dc.description.abstract","Electroconvulsive therapy (ECT) is the most effective therapy for severe depressive disorders. Though there are known clinical predictors of response (e.g., higher age, presence of psychotic symptoms), there is a lack of knowledge concerning the impact of patients' expectations on treatment outcome and tolerability in terms of possible placebo/nocebo effects. In 31 patients with unipolar or bipolar depressive disorder, we used a questionnaire to investigate the patients' expectations of ECT effectiveness and tolerability prior to and in the course of the treatment. Additionally, the questionnaire was used after the ECT course for a final assessment. Depressive symptoms and putative side-effects were measured at each time point. General linear models were used to analyze the course of depressive symptoms and patients' expectation of ECT effectiveness and tolerability. ECT significantly reduced depressive symptoms with large effect sizes. Patients' rating of ECT effectiveness decreased in parallel: While responders' rating of ECT effectiveness remained stable on a high level, non-responders' rating decreased significantly. Group difference was significant after, but not prior to and during the treatment. Regarding tolerability, there was a (temporary) significant increase in the severity of self-rated symptoms such as headache and memory impairment. In contrast, patients' expectation and assessment of ECT tolerability remained unchanged, and their expectations prior to ECT had no impact on the occurrence of side-effects. These findings contradict the presence of relevant placebo/nocebo effects in the context of ECT when investigating a population of mostly chronic or treatment resistant patients with moderate to severe depressive disorder."],["dc.identifier.doi","10.1007/s00406-017-0840-8"],["dc.identifier.eissn","1433-8491"],["dc.identifier.pmid","28940099"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57612"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.title","Influence of depressed patients' expectations prior to electroconvulsive therapy on its effectiveness and tolerability (Exp-ECT): a prospective study"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

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[["dc.bibliographiccitation.firstpage","1062"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Der Nervenarzt"],["dc.bibliographiccitation.lastpage","1062"],["dc.bibliographiccitation.volume","89"],["dc.contributor.author","Zilles, D."],["dc.contributor.author","Koller, M."],["dc.contributor.author","Methfessel, I."],["dc.contributor.author","Trost, S."],["dc.contributor.author","Simon, A."],["dc.date.accessioned","2020-12-10T14:08:36Z"],["dc.date.available","2020-12-10T14:08:36Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1007/s00115-018-0595-0"],["dc.identifier.eissn","1433-0407"],["dc.identifier.issn","0028-2804"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70497"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.iserratumof","/handle/2/70495"],["dc.title","Erratum zu: Ethik, Evidenz und Elektrokonvulsionstherapie"],["dc.title.alternative","Erratum to: Ethics, evidence and electroconvulsive therapy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","erratum_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Pharmacopsychiatry"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Meyer, J."],["dc.contributor.author","Zilles, David"],["dc.contributor.author","Gruber, Eva"],["dc.contributor.author","Falkai, Peter Gaston"],["dc.date.accessioned","2018-11-07T10:59:21Z"],["dc.date.available","2018-11-07T10:59:21Z"],["dc.date.issued","2007"],["dc.format.extent","221"],["dc.identifier.isi","000249873600085"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50679"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.publisher.place","Stuttgart"],["dc.relation.conference","25th Symposium of the Arbeitsgemeinschaft-Neuropsychopharmakologie-und-Pharmakopsychiatrie"],["dc.relation.eventlocation","Munich, GERMANY"],["dc.relation.issn","0176-3679"],["dc.title","Genetic polymorphisms of serotonergic and dopaminergic neurotransmission differentially affect neurofunctional subsystems of working memory"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","547"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Molecular Psychiatry"],["dc.bibliographiccitation.lastpage","553"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","van Erp, Theo G. M."],["dc.contributor.author","Hibar, D. P."],["dc.contributor.author","Rasmussen, J. M."],["dc.contributor.author","Glahn, D. C."],["dc.contributor.author","Pearlson, G. D."],["dc.contributor.author","Andreassen, Ole A."],["dc.contributor.author","Agartz, Ingrid"],["dc.contributor.author","Westlye, L. T."],["dc.contributor.author","Haukvik, Unn K."],["dc.contributor.author","Dale, Anders M."],["dc.contributor.author","Melle, Ingrid"],["dc.contributor.author","Hartberg, C. B."],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Kraemer, Bernd"],["dc.contributor.author","Zilles, David"],["dc.contributor.author","Donohoe, Gary"],["dc.contributor.author","Kelly, S."],["dc.contributor.author","McDonald, Colm"],["dc.contributor.author","Morris, D. W."],["dc.contributor.author","Cannon, Dara M."],["dc.contributor.author","Corvin, Aiden"],["dc.contributor.author","Machielsen, M. W. J."],["dc.contributor.author","Koenders, L."],["dc.contributor.author","de Haan, Laurens"],["dc.contributor.author","Veltman, D. J."],["dc.contributor.author","Satterthwaite, T. D."],["dc.contributor.author","Wolf, D. H."],["dc.contributor.author","Gur, Ruben C."],["dc.contributor.author","Gur, R. E."],["dc.contributor.author","Potkin, Steven G."],["dc.contributor.author","Mathalon, D. H."],["dc.contributor.author","Mueller, B. A."],["dc.contributor.author","Preda, A."],["dc.contributor.author","Macciardi, F."],["dc.contributor.author","Ehrlich, S."],["dc.contributor.author","Walton, E."],["dc.contributor.author","Hass, J."],["dc.contributor.author","Calhoun, V. D."],["dc.contributor.author","Bockholt, H. J."],["dc.contributor.author","Sponheim, S. R."],["dc.contributor.author","Shoemaker, J. M."],["dc.contributor.author","van Haren, Neeltje E. M."],["dc.contributor.author","Pol, H. E. H."],["dc.contributor.author","Ophoff, Roel A."],["dc.contributor.author","Kahn, Rene S."],["dc.contributor.author","Roiz-Santianez, R."],["dc.contributor.author","Crespo-Facorro, B."],["dc.contributor.author","Wang, L."],["dc.contributor.author","Alpert, K. I."],["dc.contributor.author","Jonsson, E. G."],["dc.contributor.author","Dimitrova, R."],["dc.contributor.author","Bois, C."],["dc.contributor.author","Whalley, H. C."],["dc.contributor.author","McIntosh, Andrew M."],["dc.contributor.author","Lawrie, Stephen M."],["dc.contributor.author","Hashimoto, Ryota"],["dc.contributor.author","Thompson, Paul M."],["dc.contributor.author","Turner, Jessica A."],["dc.date.accessioned","2018-11-07T10:16:34Z"],["dc.date.available","2018-11-07T10:16:34Z"],["dc.date.issued","2016"],["dc.description.abstract","The profile of brain structural abnormalities in schizophrenia is still not fully understood, despite decades of research using brain scans. To validate a prospective meta-analysis approach to analyzing multicenter neuroimaging data, we analyzed brain MRI scans from 2028 schizophrenia patients and 2540 healthy controls, assessed with standardized methods at 15 centers worldwide. We identified subcortical brain volumes that differentiated patients from controls, and ranked them according to their effect sizes. Compared with healthy controls, patients with schizophrenia had smaller hippocampus (Cohen's d = -0.46), amygdala (d = -0.31), thalamus (d = -0.31), accumbens (d = -0.25) and intracranial volumes (d = -0.12), as well as larger pallidum (d = 0.21) and lateral ventricle volumes (d = 0.37). Putamen and pallidum volume augmentations were positively associated with duration of illness and hippocampal deficits scaled with the proportion of unmedicated patients. Worldwide cooperative analyses of brain imaging data support a profile of subcortical abnormalities in schizophrenia, which is consistent with that based on traditional meta-analytic approaches. This first ENIGMA Schizophrenia Working Group study validates that collaborative data analyses can readily be used across brain phenotypes and disorders and encourages analysis and data sharing efforts to further our understanding of severe mental illness."],["dc.identifier.doi","10.1038/mp.2015.63"],["dc.identifier.isi","000372421500014"],["dc.identifier.pmid","26033243"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13363"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41060"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1476-5578"],["dc.relation.issn","1359-4184"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","229"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Pharmacopsychiatry"],["dc.bibliographiccitation.lastpage","230"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Zilles, David"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Burke, Sarah"],["dc.contributor.author","Falkai, Peter Gaston"],["dc.date.accessioned","2018-11-07T10:59:22Z"],["dc.date.available","2018-11-07T10:59:22Z"],["dc.date.issued","2007"],["dc.identifier.isi","000249873600125"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50683"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.publisher.place","Stuttgart"],["dc.relation.conference","25th Symposium of the Arbeitsgemeinschaft-Neuropsychopharmakologie-und-Pharmakopsychiatrie"],["dc.relation.eventlocation","Munich, GERMANY"],["dc.relation.issn","0176-3679"],["dc.title","The influence of genetic loading on working memory performance in schizophrenia"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Australian and New Zealand Journal of Psychiatry"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Zilles, David"],["dc.contributor.author","Hasan, Alkomiet"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Degner, Detlef"],["dc.date.accessioned","2018-11-07T08:43:23Z"],["dc.date.available","2018-11-07T08:43:23Z"],["dc.date.issued","2010"],["dc.format.extent","489"],["dc.identifier.doi","10.3109/00048671003614163"],["dc.identifier.isi","000276761100013"],["dc.identifier.pmid","20397795"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19951"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Informa Healthcare"],["dc.relation.issn","0004-8674"],["dc.title","Acute Polydipsia and Water Intoxication in First Episode Schizophrenia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","127"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Archives of Psychiatry and Clinical Neuroscience"],["dc.bibliographiccitation.lastpage","136"],["dc.bibliographiccitation.volume","265"],["dc.contributor.author","Kittel-Schneider, Sarah"],["dc.contributor.author","Wobrock, Thomas"],["dc.contributor.author","Scherk, Harald"],["dc.contributor.author","Schneider-Axmann, Thomas"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Zilles, David"],["dc.contributor.author","Wolf, C."],["dc.contributor.author","Schmitt, A."],["dc.contributor.author","Malchow, Berend"],["dc.contributor.author","Hasan, Alkomiet"],["dc.contributor.author","Backens, Martin"],["dc.contributor.author","Reith, W."],["dc.contributor.author","Falkai, Peter Gaston"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Reif, A."],["dc.date.accessioned","2018-11-07T10:00:31Z"],["dc.date.available","2018-11-07T10:00:31Z"],["dc.date.issued","2015"],["dc.description.abstract","The diacylglycerol kinase eta (DGKH) gene, first identified in a genome-wide association study, is one of the few replicated risk genes of bipolar affective disorder (BD). Following initial positive studies, it not only was found to be associated with BD but also implicated in the etiology of other psychiatric disorders featuring affective symptoms, rendering DGKH a cross-disorder risk gene. However, the (patho-)physiological role of the encoded enzyme is still elusive. In the present study, we investigated primarily the influence of a risk haplotype on amygdala volume in patients suffering from schizophrenia or BD as well as healthy controls and four single nucleotide polymorphisms conveying risk. There was a significant association of the DGKH risk haplotype with increased amygdala volume in BD, but not in schizophrenia or healthy controls. These findings add to the notion of a role of DGKH in the pathogenesis of BD."],["dc.description.sponsorship","DFG [RTG 1253/1, RE1632/5-1]; BMBF (DZHI) [01EO1004]; IZKF [Z3-24]"],["dc.identifier.doi","10.1007/s00406-014-0513-9"],["dc.identifier.isi","000350305500005"],["dc.identifier.pmid","24958494"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37825"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1433-8491"],["dc.relation.issn","0940-1334"],["dc.title","Influence of DGKH variants on amygdala volume in patients with bipolar affective disorder and schizophrenia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Pharmacopsychiatry"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Zilles, David"],["dc.contributor.author","Zerr, I."],["dc.contributor.author","Wedekind, Dirk"],["dc.date.accessioned","2018-11-07T08:52:01Z"],["dc.date.available","2018-11-07T08:52:01Z"],["dc.date.issued","2011"],["dc.identifier.doi","10.1055/s-0031-1292566"],["dc.identifier.isi","000296086300150"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22068"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.publisher.place","Stuttgart"],["dc.relation.conference","27th Symposium of the AGNP"],["dc.relation.eventlocation","Munich, GERMANY"],["dc.relation.issn","0176-3679"],["dc.title","Effectiveness of donepezil in the treatment of musical hallucinations: evidence from case reports and pathophysiological considerations"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","46"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Der Nervenarzt"],["dc.bibliographiccitation.lastpage","52"],["dc.bibliographiccitation.volume","88"],["dc.contributor.author","Besse, M."],["dc.contributor.author","Methfessel, I."],["dc.contributor.author","Wiltfang, J."],["dc.contributor.author","Zilles, D."],["dc.date.accessioned","2017-09-07T11:45:23Z"],["dc.date.available","2017-09-07T11:45:23Z"],["dc.date.issued","2017"],["dc.description.abstract","Hintergrund Die Elektrokonvulsionstherapie (EKT) ist ein potentes Therapieverfahren, das bei verschiedenen schwerwiegenden psychiatrischen Krankheitsbildern erfolgreich eingesetzt wird. Schwere depressive und psychotische Störungen können mit Einwilligungsunfähigkeit einhergehen. In bestimmten Konstellationen ist daher die Anwendung der EKT auch gegen den natürlichen Patientenwillen möglich. In Deutschland ist dies im Betreuungsrecht geregelt. Ziel der Arbeit Es werden Häufigkeit, Wirksamkeit und Verträglichkeit der EKT dargestellt, wenn sie als ärztliche Maßnahme gegen den natürlichen Willen des Patienten zur Anwendung kommt. Material und Methoden Kasuistik und Literaturübersicht. Ergebnisse Die Literatur zum Thema EKT als ärztliche Maßnahme gegen den natürlichen Willen ist sehr limitiert. Die Häufigkeit für Deutschland wurde 2008 mit weniger als 0,5 % aller mittels EKT behandelten Patienten angegeben. Kasuistiken und Fallserien sprechen für eine gleichermaßen gute Wirksamkeit im Vergleich zur EKT bei vorhandener Einwilligung. Im Behandlungsverlauf stimmte die Mehrzahl der Patienten der Therapie zu und beurteilte diese retrospektiv als hilfreich. Diskussion Die EKT ist bei schwerwiegenden psychiatrischen Störungen auch in ihrer Anwendung gegen den natürlichen Patientenwillen hochgradig wirksam. EKT kann dabei lebensrettend sein und auch aus Patientenperspektive zu einer raschen Besserung der Symptomatik mit Linderung schweren psychischen Leidens führen. Insofern erscheint es unethisch, die EKT in begründeten Einzelfällen nicht als Maßnahme gegen den natürlichen Patientenwillen in Betracht zu ziehen. Ein Konsens mit dem Patienten ist dabei sowohl aus ethischen wie auch aus juristischen Gründen immer zu bevorzugen und sollte im Verlauf schnellstmöglich angestrebt werden."],["dc.identifier.doi","10.1007/s00115-015-0043-3"],["dc.identifier.gro","3151743"],["dc.identifier.pmid","26781243"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8566"],["dc.language.iso","de"],["dc.notes.status","final"],["dc.notes.submitter","chake"],["dc.relation.issn","0028-2804"],["dc.title","Elektrokonvulsionstherapie gegen den natürlichen Patientenwillen"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]