Götz, Magdalena

[["dc.bibliographiccitation.journal","Geburtshilfe und Frauenheilkunde"],["dc.bibliographiccitation.volume","82"],["dc.contributor.author","Götze, TO"],["dc.contributor.author","Al-Batran, S-E"],["dc.contributor.author","Bankstahl, US"],["dc.contributor.author","Fleckenstein, A-S"],["dc.contributor.author","Engel, JB"],["dc.contributor.author","Aktas, B"],["dc.contributor.author","Martin, M"],["dc.contributor.author","Weisgerber, C"],["dc.contributor.author","Hunold, P"],["dc.contributor.author","Gallwas, J"],["dc.contributor.author","Kulenkampff, D"],["dc.contributor.author","Maintz, D"],["dc.contributor.author","Morgenstern, B"],["dc.contributor.author","Püsken, M"],["dc.contributor.author","Keim, S"],["dc.contributor.author","Matzko, M"],["dc.contributor.author","Düx, M"],["dc.date.accessioned","2022-11-01T10:16:51Z"],["dc.date.available","2022-11-01T10:16:51Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1055/s-0042-1756822"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/116670"],["dc.notes.intern","DOI-Import GROB-605"],["dc.publisher","Georg Thieme Verlag"],["dc.relation.conference","64. Kongress der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe e. V."],["dc.relation.eventend","2022-10-15"],["dc.relation.eventlocation","München"],["dc.relation.eventstart","2022-10-12"],["dc.title","Multizentrische, randomisierte Phase III-Studie zur Magnetresonanztomographie-gesteuerten hochfokussierten Ultraschalltherapie zur Behandlung des Uterusmyoms (MRgFUS-TUF) im Vergleich zur Myomektomie bei symptomatischen und medikamentös nicht ausreichend therapierbaren Uterusmyomen (MARGI-T)"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e2104979"],["dc.bibliographiccitation.issue","16"],["dc.bibliographiccitation.journal","Advanced science"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Bauer, Amelie"],["dc.contributor.author","Puglisi, Matteo"],["dc.contributor.author","Nagl, Dennis"],["dc.contributor.author","Schick, Joel A."],["dc.contributor.author","Werner, Thomas"],["dc.contributor.author","Klingl, Andreas"],["dc.contributor.author","El Andari, Jihad"],["dc.contributor.author","Hornung, Veit"],["dc.contributor.author","Kessler, Horst"],["dc.contributor.author","Götz, Magdalena"],["dc.contributor.author","Grimm, Dirk"],["dc.contributor.author","Brack-Werner, Ruth"],["dc.date.accessioned","2022-08-19T08:05:19Z"],["dc.date.available","2022-08-19T08:05:19Z"],["dc.date.issued","2022"],["dc.description.abstract","Astrocytes have crucial functions in the central nervous system (CNS) and are major players in many CNS diseases. Research on astrocyte-centered diseases requires efficient and well-characterized gene transfer vectors. Vectors derived from the Adeno-associated virus serotype 9 (AAV9) target astrocytes in the brains of rodents and nonhuman primates. A recombinant (r) synthetic peptide-displaying AAV9 variant, rAAV9P1, that efficiently and selectively transduces cultured human astrocytes, has been described previously. Here, it is shown that rAAV9P1 retains astrocyte-targeting properties upon intravenous injection in mice. Detailed analysis of putative receptors on human astrocytes shows that rAAV9P1 utilizes integrin subunits αv, β8, and either β3 or β5 as well as the AAV receptor AAVR. This receptor pattern is distinct from that of vectors derived from wildtype AAV2 or AAV9. Furthermore, a CRISPR/Cas9 genome-wide knockout screening revealed the involvement of several astrocyte-associated intracellular signaling pathways in the transduction of human astrocytes by rAAV9P1. This study delineates the unique receptor and intracellular pathway signatures utilized by rAAV9P1 for targeting human astrocytes. These results enhance the understanding of the transduction biology of synthetic rAAV vectors for astrocytes and can promote the development of advanced astrocyte-selective gene delivery vehicles for research and clinical applications."],["dc.identifier.doi","10.1002/advs.202104979"],["dc.identifier.pmid","35398994"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113026"],["dc.identifier.url","https://rdp.sfb274.de/literature/publications/66"],["dc.language.iso","en"],["dc.relation","TRR 274: Checkpoints of Central Nervous System Recovery"],["dc.relation","TRR 274 | C05: Checkpoints for circuit integration of nascent neurons in the injured brain"],["dc.relation.issn","2198-3844"],["dc.relation.workinggroup","RG Götz (Neurogenesis)"],["dc.title","Molecular Signature of Astrocytes for Gene Delivery by the Synthetic Adeno-Associated Viral Vector rAAV9P1"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","520"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Cells"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Sanchez-Gonzalez, Rosario"],["dc.contributor.author","Koupourtidou, Christina"],["dc.contributor.author","Lepko, Tjasa"],["dc.contributor.author","Zambusi, Alessandro"],["dc.contributor.author","Novoselc, Klara Tereza"],["dc.contributor.author","Durovic, Tamara"],["dc.contributor.author","Aschenbroich, Sven"],["dc.contributor.author","Schwarz, Veronika"],["dc.contributor.author","Breunig, Christopher T."],["dc.contributor.author","Straka, Hans"],["dc.contributor.author","Huttner, Hagen B."],["dc.contributor.author","Irmler, Martin"],["dc.contributor.author","Beckers, Johannes"],["dc.contributor.author","Wurst, Wolfgang"],["dc.contributor.author","Zwergal, Andreas"],["dc.contributor.author","Schauer, Tamas"],["dc.contributor.author","Straub, Tobias"],["dc.contributor.author","Czopka, Tim"],["dc.contributor.author","Trümbach, Dietrich"],["dc.contributor.author","Götz, Magdalena"],["dc.contributor.author","Stricker, Stefan H."],["dc.contributor.author","Ninkovic, Jovica"],["dc.date.accessioned","2022-08-19T07:43:41Z"],["dc.date.available","2022-08-19T07:43:41Z"],["dc.date.issued","2022"],["dc.description.abstract","The oligodendrocyte progenitors (OPCs) are at the front of the glial reaction to the traumatic brain injury. However, regulatory pathways steering the OPC reaction as well as the role of reactive OPCs remain largely unknown. Here, we compared a long-lasting, exacerbated reaction of OPCs to the adult zebrafish brain injury with a timely restricted OPC activation to identify the specific molecular mechanisms regulating OPC reactivity and their contribution to regeneration. We demonstrated that the influx of the cerebrospinal fluid into the brain parenchyma after injury simultaneously activates the toll-like receptor 2 (Tlr2) and the chemokine receptor 3 (Cxcr3) innate immunity pathways, leading to increased OPC proliferation and thereby exacerbated glial reactivity. These pathways were critical for long-lasting OPC accumulation even after the ablation of microglia and infiltrating monocytes. Importantly, interference with the Tlr1/2 and Cxcr3 pathways after injury alleviated reactive gliosis, increased new neuron recruitment, and improved tissue restoration."],["dc.identifier.doi","10.3390/cells11030520"],["dc.identifier.pmid","35159329"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113023"],["dc.identifier.url","https://rdp.sfb274.de/literature/publications/61"],["dc.language.iso","en"],["dc.relation","TRR 274: Checkpoints of Central Nervous System Recovery"],["dc.relation.issn","2073-4409"],["dc.relation.workinggroup","RG Götz (Neurogenesis)"],["dc.relation.workinggroup","RG Ninkovic (Neurogenesis and Regeneration)"],["dc.title","Innate Immune Pathways Promote Oligodendrocyte Progenitor Cell Recruitment to the Injury Site in Adult Zebrafish Brain"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]