Eckardstein, Kajetan L. von

[["dc.bibliographiccitation.firstpage","1376"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Journal of Neurosurgery"],["dc.bibliographiccitation.lastpage","1383"],["dc.bibliographiccitation.volume","127"],["dc.contributor.author","Scheller, Christian"],["dc.contributor.author","Wienke, Andreas"],["dc.contributor.author","Tatagiba, Marcos"],["dc.contributor.author","Gharabaghi, Alireza"],["dc.contributor.author","Ramina, Kristofer F."],["dc.contributor.author","Ganslandt, Oliver"],["dc.contributor.author","Bischoff, Barbara"],["dc.contributor.author","Zenk, Johannes"],["dc.contributor.author","Engelhorn, Tobias"],["dc.contributor.author","Matthies, Cordula"],["dc.contributor.author","Westermaier, Thomas"],["dc.contributor.author","Antoniadis, Gregor"],["dc.contributor.author","Pedro, Maria Teresa"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","von Eckardstein, Kajetan"],["dc.contributor.author","Kretschmer, Thomas"],["dc.contributor.author","Kornhuber, Malte"],["dc.contributor.author","Steighardt, Jörg"],["dc.contributor.author","Richter, Michael"],["dc.contributor.author","Barker, Fred G."],["dc.contributor.author","Strauss, Christian"],["dc.date.accessioned","2020-12-10T18:44:04Z"],["dc.date.available","2020-12-10T18:44:04Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.3171/2016.8.JNS16626"],["dc.identifier.eissn","1933-0693"],["dc.identifier.issn","0022-3085"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78314"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Prophylactic nimodipine treatment and improvement in hearing outcome after vestibular schwannoma surgery: a combined analysis of a randomized, multicenter, Phase III trial and its pilot study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","67"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Imaging"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Hadjidemetriou, Stathis"],["dc.contributor.author","Psychogios, Marios"],["dc.contributor.author","Lingor, Paul"],["dc.contributor.author","von Eckardstein, Kajetan"],["dc.contributor.author","Papageorgiou, Ismini"],["dc.date.accessioned","2020-12-10T18:47:13Z"],["dc.date.available","2020-12-10T18:47:13Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.3390/jimaging3040067"],["dc.identifier.eissn","2313-433X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78687"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.publisher","MDPI"],["dc.relation.eissn","2313-433X"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Restoration of Bi-Contrast MRI Data for Intensity Uniformity with Bayesian Coring of Co-Occurrence Statistics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","733"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Acta Neurochirurgica"],["dc.bibliographiccitation.lastpage","738"],["dc.bibliographiccitation.volume","159"],["dc.contributor.author","Scheller, Christian"],["dc.contributor.author","Wienke, Andreas"],["dc.contributor.author","Tatagiba, Marcos"],["dc.contributor.author","Gharabaghi, Alireza"],["dc.contributor.author","Ramina, Kristofer F."],["dc.contributor.author","Scheller, Konstanze"],["dc.contributor.author","Prell, Julian"],["dc.contributor.author","Zenk, Johannes"],["dc.contributor.author","Ganslandt, Oliver"],["dc.contributor.author","Bischoff, Barbara"],["dc.contributor.author","Matthies, Cordula"],["dc.contributor.author","Westermaier, Thomas"],["dc.contributor.author","Antoniadis, Gregor"],["dc.contributor.author","Pedro, Maria Teresa"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","von Eckardstein, Kajetan L."],["dc.contributor.author","Kretschmer, Thomas"],["dc.contributor.author","Kornhuber, Malte"],["dc.contributor.author","Barker, Fred G., II"],["dc.contributor.author","Strauss, Christian"],["dc.date.accessioned","2018-11-07T10:25:39Z"],["dc.date.available","2018-11-07T10:25:39Z"],["dc.date.issued","2017"],["dc.description.abstract","Background Evidence of a high interobserver variability of the subjective House-Brackmann facial nerve grading system (HBGS) would justify cost- and time-consuming technological enhancements of objective classifications for facial nerve paresis. Method A total of 112 patients were recruited for a randomized multi-center trial to investigate the efficacy of prophylactic nimodipine treatment in vestibular schwannoma (VS) surgery. For the present investigation both treatment groups were pooled for the assessment of facial nerve function preoperatively, in the early postoperative course and 1 year after the surgery. Facial nerve function was documented photographically at rest and in motion and classified according to the HBGS by three independent observers (neurosurgeon, neurologist, ENT) and by the investigator of each center. Result Interobserver variability was considerably different with respect to the three time points depending upon the severity of facial nerve paresis. Preoperative facial nerve function was normal or only mildly impaired (HB grade I or II) and was assessed consistently in 97%. Facial nerve function deteriorated during the early postoperative course and was subsequently documented without dissent in only 36%, with one grade difference in 45%, two grade difference in 17% and three grade difference in 2%. One year after surgery, facial nerve function predominantly improved resulting in a consistent assessment in 66%. Differing ratings were observed in 34% with one grade deviation in 88% and of two grades in 12%. Patients with differing ratings of two or more grades exhibited considerably worse facial nerve function (p < 0.001). Conclusions The HBGS produced comparable results between different observers in patients with normal or only mildly impaired facial nerve function. Interobserver variability increased depending on the severity of facial nerve paresis. The results suggest that the HBGS does not promote uniformity of reporting and comparison of outcomes in patients with moderate or severe facial nerve paresis."],["dc.identifier.doi","10.1007/s00701-017-3109-0"],["dc.identifier.isi","000398164500021"],["dc.identifier.pmid","28188418"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42898"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Springer"],["dc.publisher.place","Wien"],["dc.relation.issn","0942-0940"],["dc.relation.issn","0001-6268"],["dc.title","Interobserver variability of the House-Brackmann facial nerve grading system for the analysis of a randomized multi-center phase III trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1819"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Acta Neurochirurgica"],["dc.bibliographiccitation.lastpage","1823"],["dc.bibliographiccitation.volume","157"],["dc.contributor.author","Schatlo, Bawarjan"],["dc.contributor.author","Martinez, Ramon"],["dc.contributor.author","Alaid, Awad"],["dc.contributor.author","von Eckardstein, Kajetan L."],["dc.contributor.author","Akhavan-Sigari, Reza"],["dc.contributor.author","Hahn, Anselm W."],["dc.contributor.author","Stockhammer, Florian"],["dc.contributor.author","Rohde, Veit"],["dc.date.accessioned","2018-11-07T09:51:13Z"],["dc.date.available","2018-11-07T09:51:13Z"],["dc.date.issued","2015"],["dc.description.abstract","Robotic assistance for the placement of pedicle screws has been established as a safe technique. Nonetheless rare instances of screw misplacement have been reported.The aim of the present retrospective study is to assess whether experience and time affect the accuracy of screws placed with the help of the SpineAssist (TM) robot system. Postoperative computed tomography (CT) scans of 258 patients requiring thoracolumbar pedicle screw instrumentation from 2008 to 2013 were reviewed. Overall, 13 surgeons performed the surgeries. A pedicle breach of > 3 mm was graded as a misplacement. Surgeons were dichotomised into an early and experienced period in increments of five surgeries. In 258 surgeries, 1,265 pedicle screws were placed with the aid of the robot system. Overall, 1,217 screws (96.2 %) were graded as acceptable. When displayed by surgeon, the development of percent misplacement rates peaked between 5 and 25 surgeries in 12 of 13 surgeons. The overall misplacement rate in the first five surgeries was 2.4 % (6/245). The misplacement rate rose to 6.3 % between 11 and 15 surgeries (10/158; p = 0.20), and reached a significant peak between 16 and 20 surgeries with a rate of 7.1 % (8/112; p = 0.03). Afterwards, misplacement rates declined. A major peak in screw inaccuracies occurred between cases 10 and 20, and a second, smaller one at about 40 surgeries. One potential explanation could be a transition from decreased supervision (unskilled but aware) to increased confidence of a surgeon (unskilled but unaware) who adopts this new technique prior to mastering it (skilled). We therefore advocate ensuring competent supervision for new surgeons at least during the first 25 procedures of robotic spine surgery to optimise the accuracy of robot-assisted pedicle screws."],["dc.identifier.doi","10.1007/s00701-015-2535-0"],["dc.identifier.isi","000361389600031"],["dc.identifier.pmid","26287268"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35872"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Wien"],["dc.relation.issn","0942-0940"],["dc.relation.issn","0001-6268"],["dc.title","Unskilled unawareness and the learning curve in robotic spine surgery"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","71"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Neuro-Oncology"],["dc.bibliographiccitation.lastpage","80"],["dc.bibliographiccitation.volume","102"],["dc.contributor.author","Elstner, Anja"],["dc.contributor.author","Stockhammer, Florian"],["dc.contributor.author","Nguyen-Dobinsky, Trong-Nghia"],["dc.contributor.author","Quang Long Nguyen, Quang Long Nguyen"],["dc.contributor.author","Pilgermann, Ingo"],["dc.contributor.author","Gill, Amanjit"],["dc.contributor.author","Guhr, Anke"],["dc.contributor.author","Zhang, T."],["dc.contributor.author","von Eckardstein, Kajetan L."],["dc.contributor.author","Picht, Thomas"],["dc.contributor.author","Veelken, Julian"],["dc.contributor.author","Martuza, Robert L."],["dc.contributor.author","von Deimling, Andreas"],["dc.contributor.author","Kurtz, Andreas"],["dc.date.accessioned","2018-11-07T08:58:45Z"],["dc.date.available","2018-11-07T08:58:45Z"],["dc.date.issued","2011"],["dc.description.abstract","Diagnosis of a glioblastoma (GBM) is triggered by the onset of symptoms and is based on cerebral imaging and histological examination. Serum-based biomarkers may support detection of GBM. Here, we explored serum protein concentrations of GBM patients and used data mining to explore profiles of biomarkers and determine whether these are associated with the clinical status of the patients. Gene and protein expression data for astrocytoma and GBM were used to identify secreted proteins differently expressed in tumors and in normal brain tissues. Tumor expression and serum concentrations of 14 candidate proteins were analyzed for 23 GBM patients and nine healthy subjects. Data-mining methods involving all 14 proteins were used as an initial evaluation step to find clinically informative profiles. Data mining identified a serum protein profile formed by BMP2, HSP70, and CXCL10 that enabled correct assignment to the GBM group with specificity and sensitivity of 89 and 96%, respectively (p < 0.0001, Fischer's exact test). Survival for more than 15 months after tumor resection was associated with a profile formed by TSP1, HSP70, and IGFBP3, enabling correct assignment in all cases (p < 0.0001, Fischer's exact test). No correlation was found with tumor size or age of the patient. This study shows that robust serum profiles for GBM may be identified by data mining on the basis of a relatively small study cohort. Profiles of more than one biomarker enable more specific assignment to the GBM and survival group than those based on single proteins, confirming earlier attempts to correlate single markers with cancer. These conceptual findings will be a basis for validation in a larger sample size."],["dc.description.sponsorship","Berliner Krebsgesellschaft e.V; Goldhirsh Foundation, Boston, USA"],["dc.identifier.doi","10.1007/s11060-010-0284-8"],["dc.identifier.isi","000287504400009"],["dc.identifier.pmid","20617365"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7363"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23721"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0167-594X"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Identification of diagnostic serum protein profiles of glioblastoma patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","E13"],["dc.bibliographiccitation.firstpage","E13"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Neurosurgical Focus"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Solomiichuk, Volodymyr"],["dc.contributor.author","Fleischhammer, Julius"],["dc.contributor.author","Molliqaj, Granit"],["dc.contributor.author","Warda, Jwad"],["dc.contributor.author","Alaid, Awad"],["dc.contributor.author","von Eckardstein, Kajetan"],["dc.contributor.author","Schaller, Karl"],["dc.contributor.author","Tessitore, Enrico"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Schatlo, Bawarjan"],["dc.date.accessioned","2020-12-10T18:44:04Z"],["dc.date.available","2020-12-10T18:44:04Z"],["dc.date.issued","2017"],["dc.description.abstract","OBJECTIVE Robot-guided pedicle screw placement is an established technique for the placement of pedicle screws. However, most studies have focused on degenerative disease. In this paper, the authors focus on metastatic spinal disease, which is associated with osteolysis. The associated lack of dense bone may potentially affect the automatic recognition accuracy of radiography-based surgical assistance systems. The aim of the present study is to compare the accuracy of the SpineAssist robot system with conventional fluoroscopy-guided pedicle screw placement for thoracolumbar metastatic spinal disease. METHODS Seventy patients with metastatic spinal disease who required instrumentation were included in this retrospective matched-cohort study. All 70 patients underwent surgery performed by the same team of experienced surgeons. The decision to use robot-assisted or fluoroscopy-guided pedicle screw placement was based the availability of the robot system. In patients who underwent surgery with robot guidance, pedicle screws were inserted after preoperative planning and intraoperative fluoroscopic matching. In the \"conventional\" group, anatomical landmarks and anteroposterior and lateral fluoroscopy guided placement of the pedicle screws. The primary outcome measure was the accuracy of screw placement on the Gertzbein-Robbins scale. Grades A and B (<2-mm pedicle breach) were considered clinically acceptable, and all other grades indicated misplacement. Secondary outcome measures included an intergroup comparison of direction of screw misplacement, surgical site infection, and radiation exposure. RESULTS A total of 406 screws were placed at 206 levels. Sixty-one (29.6%) surgically treated levels were in the upper thoracic spine (T1-6), 74 (35.9%) were in the lower thoracic spine, and the remaining 71 (34.4%) were in the lumbosacral region. In the robot-assisted group (Group I; n = 35, 192 screws), trajectories were Grade A or B in 162 (84.4%) of screws. The misplacement rate was 15.6% (30 of 192 screws). In the conventional group (Group II; n = 35, 214 screws), 83.6% (179 of 214) of screw trajectories were acceptable, with a misplacement rate of 16.4% (35 of 214). There was no difference in screw accuracy between the groups (chi-square, 2-tailed Fisher's exact, p = 0.89). One screw misplacement in the fluoroscopy group required a second surgery (0.5%), but no revisions were required in the robot group. There was no difference in surgical site infections between the 2 groups (Group I, 5 patients [14.3%]; Group II, 8 patients [22.9%]) or in the duration of surgery between the 2 groups (Group I, 226.1 +/- 78.8 minutes; Group II, 264.1 +/- 124.3 minutes; p = 0.13). There was also no difference in radiation time between the groups (Group I, 138.2 +/- 73.0 seconds; Group II, 126.5 +/- 95.6 seconds; p = 0.61), but the radiation intensity was higher in the robot group (Group I, 2.8 +/- 0.2 mAs; Group II, 2.0 +/- 0.6 mAs; p < 0.01). CONCLUSIONS Pedicle screw placement for metastatic disease in the thoracolumbar spine can be performed effectively and safely using robot-guided assistance. Based on this retrospective analysis, accuracy, radiation time, and post-operative infection rates are comparable to those of the conventional technique."],["dc.identifier.doi","10.3171/2017.3.FOCUS1710"],["dc.identifier.eissn","1092-0684"],["dc.identifier.isi","000400609800017"],["dc.identifier.pmid","28463620"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78315"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Amer Assoc Neurological Surgeons"],["dc.relation.issn","1092-0684"],["dc.title","Robotic versus fluoroscopy-guided pedicle screw insertion for metastatic spinal disease: a matched-cohort comparison"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","249"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Neurosurgery"],["dc.bibliographiccitation.lastpage","256"],["dc.bibliographiccitation.volume","133"],["dc.contributor.author","Scheller, Christian"],["dc.contributor.author","Rampp, Stefan"],["dc.contributor.author","Tatagiba, Marcos"],["dc.contributor.author","Gharabaghi, Alireza"],["dc.contributor.author","Ramina, Kristofer F."],["dc.contributor.author","Ganslandt, Oliver"],["dc.contributor.author","Bischoff, Barbara"],["dc.contributor.author","Matthies, Cordula"],["dc.contributor.author","Westermaier, Thomas"],["dc.contributor.author","Pedro, Maria Teresa"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","von Eckardstein, Kajetan"],["dc.contributor.author","Strauss, Christian"],["dc.date.accessioned","2021-04-14T08:23:53Z"],["dc.date.available","2021-04-14T08:23:53Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.3171/2019.1.JNS181784"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81083"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1933-0693"],["dc.relation.issn","0022-3085"],["dc.title","A critical comparison between the semisitting and the supine positioning in vestibular schwannoma surgery: subgroup analysis of a randomized, multicenter trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","657"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Neurosurgery"],["dc.bibliographiccitation.lastpage","664"],["dc.bibliographiccitation.volume","124"],["dc.contributor.author","Scheller, Christian"],["dc.contributor.author","Wienke, Andreas"],["dc.contributor.author","Tatagiba, Marcos"],["dc.contributor.author","Gharabaghi, Alireza"],["dc.contributor.author","Ramina, Kristofer F."],["dc.contributor.author","Ganslandt, Oliver"],["dc.contributor.author","Bischoff, Barbara"],["dc.contributor.author","Zenk, Johannes"],["dc.contributor.author","Engelhorn, Tobias"],["dc.contributor.author","Matthies, Cordula"],["dc.contributor.author","Westermaier, Thomas"],["dc.contributor.author","Antoniadis, Gregor"],["dc.contributor.author","Pedro, Maria Teresa"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Kretschmer, Thomas"],["dc.contributor.author","Kornhuber, Malte"],["dc.contributor.author","Steighardt, Jörg"],["dc.contributor.author","Richter, Michael"],["dc.contributor.author","Barker, Fred G."],["dc.contributor.author","Strauss, Christian"],["dc.contributor.author","von Eckardstein, Kajetan L."],["dc.date.accessioned","2020-12-10T18:44:03Z"],["dc.date.available","2020-12-10T18:44:03Z"],["dc.date.issued","2016"],["dc.description.abstract","OBJECTIVE A pilot study of prophylactic nimodipine and hydroxyethyl starch treatment showed a beneficial effect on facial and cochlear nerve preservation following vestibular schwannoma (VS) surgery. A prospective Phase III trial was undertaken to confirm these results. METHODS An open-label, 2-arm, randomized parallel group and multicenter Phase III trial with blinded expert review was performed and included 112 patients who underwent VS surgery between January 2010 and February 2013 at 7 departments of neurosurgery to investigate the efficacy and safety of the prophylaxis. The was performed after the patients were randomly assigned to one of 2 groups using online randomization. The treatment group (n = 56) received parenteral nimodipine (1-2 mg/hr) and hydroxyethyl starch (hematocrit 30%-35%) from the day before surgery until the 7th postoperative day. The control group (n = 56) was not treated prophylactically. RESULTS Intent-to-treat analysis showed no statistically significant effects of the treatment on either preservation of facial nerve function (35 [67.3%] of 52 [treatment group] compared with 34 [72.3%] of 47 [control group]) (p = 0.745) or hearing preservation (11 [23.4%] of 47 [treatment group] compared with 15 [31.2%] of 48 [control group]) (p = 0.530) 12 months after surgery. Since tumor sizes were significantly larger in the treatment group than in the control group, logistic regression analysis was required. The risk for deterioration of facial nerve function was adjusted nearly the same in both groups (OR 1.07 [95% CI 0.34-3.43], p = 0.91). In contrast, the risk for postoperative hearing loss was adjusted 2 times lower in the treatment group compared with the control group (OR 0.49 [95% CI 0.18-1.30], p = 0.15). Apart from dose dependent hypotension (p < 0.001), no clinically relevant adverse reactions were observed. CONCLUSIONS There were no statistically significant effects of the treatment. Despite the width of the confidence intervals, the odds ratios may suggest but do not prove a clinically relevant effect of the safe study medication on the preservation of cochlear nerve function after VS surgery. Further study is needed before prophylactic nimodipine can be recommended in VS surgery."],["dc.identifier.doi","10.3171/2015.1.JNS142001"],["dc.identifier.eissn","1933-0693"],["dc.identifier.isi","000370915200008"],["dc.identifier.issn","0022-3085"],["dc.identifier.pmid","26274985"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78311"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Assoc Neurological Surgeons"],["dc.relation.issn","1933-0693"],["dc.relation.issn","0022-3085"],["dc.title","Prophylactic nimodipine treatment for cochlear and facial nerve preservation after vestibular schwannoma surgery: a randomized multicenter Phase III trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","489"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Neurosurgical Review"],["dc.bibliographiccitation.lastpage","496"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Alaid, Awad"],["dc.contributor.author","von Eckardstein, Kajetan"],["dc.contributor.author","Smoll, Nicolas Roydon"],["dc.contributor.author","Solomiichuk, Volodymyr"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Martinez, Ramon"],["dc.contributor.author","Schatlo, Bawarjan"],["dc.date.accessioned","2020-12-10T14:11:12Z"],["dc.date.available","2020-12-10T14:11:12Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s10143-017-0877-1"],["dc.identifier.eissn","1437-2320"],["dc.identifier.issn","0344-5607"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70997"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Robot guidance for percutaneous minimally invasive placement of pedicle screws for pyogenic spondylodiscitis is associated with lower rates of wound breakdown compared to conventional fluoroscopy-guided instrumentation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1277"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Journal of Neurosurgery"],["dc.bibliographiccitation.lastpage","1282"],["dc.bibliographiccitation.volume","125"],["dc.contributor.author","Scheller, Christian"],["dc.contributor.author","Wienke, Andreas"],["dc.contributor.author","Tatagiba, Marcos"],["dc.contributor.author","Gharabaghi, Alireza"],["dc.contributor.author","Ramina, Kristofer F."],["dc.contributor.author","Ganslandt, Oliver"],["dc.contributor.author","Bischoff, Barbara"],["dc.contributor.author","Matthies, Cordula"],["dc.contributor.author","Westermaier, Thomas"],["dc.contributor.author","Antoniadis, Gregor"],["dc.contributor.author","Pedro, Maria Teresa"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Kretschmer, Thomas"],["dc.contributor.author","Zenk, Johannes"],["dc.contributor.author","Strauss, Christian"],["dc.contributor.author","von Eckardstein, Kajetan L."],["dc.date.accessioned","2020-12-10T18:44:03Z"],["dc.date.available","2020-12-10T18:44:03Z"],["dc.date.issued","2016"],["dc.description.abstract","OBJECTIVE The purpose of this research was to examine the stability of long-term hearing preservation and the regeneration capacity of the cochlear nerve following vestibular schwannoma (VS) surgery in a prospective study. METHODS A total of 112 patients were recruited for a randomized multicenter trial between January 2010 and April 2012 to investigate the efficacy of prophylactic nimodipine treatment versus no prophylactic nimodipine treatment in VS surgery. For the present investigation, both groups were pooled to compare hearing abilities in the early postoperative course and 1 year after the surgery. Hearing was examined using pure-tone audiometry with speech discrimination, which was performed preoperatively, in the early postoperative course, and 12 months after surgery and was subsequently classified by an independent otorhinolaryngologist using the Gardner-Robertson classification system. RESULTS Hearing abilities at 2 time points were compared by evaluation in the early postoperative course and 1 year after surgery in 102 patients. The chi-square test showed a very strong association between the 2 measurements in all 102 patients (p < 0.001) and in the subgroup of 66 patients with a preserved cochlear nerve (p < 0.001). CONCLUSIONS There is no significant change in cochlear nerve function between the early postoperative course and 1 year after VS surgery. The result of hearing performance, as evaluated by early postoperative audiometry after VS surgery, seems to be a reliable prognosticator for future hearing ability."],["dc.identifier.doi","10.3171/2015.10.JNS15926"],["dc.identifier.eissn","1933-0693"],["dc.identifier.isi","000386106100028"],["dc.identifier.issn","0022-3085"],["dc.identifier.pmid","26824379"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78310"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Assoc Neurological Surgeons"],["dc.relation.issn","1933-0693"],["dc.relation.issn","0022-3085"],["dc.title","Stability of hearing preservation and regeneration capacity of the cochlear nerve following vestibular schwannoma surgery via a retrosigmoid approach"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]