Perske, Christina

[["dc.bibliographiccitation.firstpage","35"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","CANCER GENETICS AND CYTOGENETICS"],["dc.bibliographiccitation.lastpage","47"],["dc.bibliographiccitation.volume","176"],["dc.contributor.author","Schulten, Hans Juergen"],["dc.contributor.author","Perske, Christina"],["dc.contributor.author","Thelen, Paul"],["dc.contributor.author","Polten, Andreas"],["dc.contributor.author","Borst, Christoph"],["dc.contributor.author","Gunawan, Bastian"],["dc.contributor.author","Nagel, Holger"],["dc.date.accessioned","2018-11-07T11:00:53Z"],["dc.date.available","2018-11-07T11:00:53Z"],["dc.date.issued","2007"],["dc.description.abstract","We describe two newly established malignant mesothelioma (MM) cell lines derived from a pleural effusion of a male. One cell line, designated as MM-Z03E, reveals an epithelioid cobblestone morphology, while the second one, designated as MM-Z03S and subcloned after in vivo selection, exhibits a sarcomatoid storiform growth pattern. Both cell lines showed the immunologic profile characteristic for MM (i.e., expression of cytokeratin, CK18, calretinin, and vimentin in both phenotypes). Cytogenetics, multicolor fluorescence in situ hybridization, comparative genomic hybridization, and oligonucleotide array CGH were performed on both cell lines. Aberrations shared by both cell lines included chromosomal losses of 1q34 similar to qter, 4, 9p, 10p, 13, 14, 16q, 18, and 22, as well as a complex structural aberration involving chromosome 17. Aberrations exclusive to MM-Z03E included gains of 3q11q27 and 5p, while gain of 9q and losses of 3q27qter, 11q, and 18 in MM-Z03S were exclusive to MM-Z03E. Both cell lines were able to develop solid transplant tumors in nude mice within 16 weeks, and immunophenotyping of tumor xenografts revealed an overall retained expression profile of the markers used. Remarkably, one xenograft from MM-Z03E revealed overexpression of p53 and widely invasive growth. In conclusion, both cell lines are useful in vivo and in vitro model systems to study the underlying genetic mechanisms of biphasic differentiation in MM, which can be of certain value considering the increasing relevance of assessing MM tumor biology for the clinical management of this disease. (c) 2007 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.cancergencyto.2007.03.005"],["dc.identifier.isi","000247710100004"],["dc.identifier.pmid","17574962"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51027"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","0165-4608"],["dc.title","Establishment and characterization of two distinct malignant mesothelioma cell lines with common clonal origin"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1182"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Intensive Care Medicine"],["dc.bibliographiccitation.lastpage","1191"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Heuer, J. F."],["dc.contributor.author","Pelosi, Paolo"],["dc.contributor.author","Hermann, Peter"],["dc.contributor.author","Perske, Christina"],["dc.contributor.author","Crozier, Thomas A."],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Quintel, Michael"],["dc.date.accessioned","2018-11-07T08:54:47Z"],["dc.date.available","2018-11-07T08:54:47Z"],["dc.date.issued","2011"],["dc.description.abstract","To determine reciprocal and synergistic effects of acute intracranial hypertension and ARDS on neuronal and pulmonary damage and to define possible mechanisms. Twenty-eight mechanically ventilated pigs were randomized to four groups of seven each: control; acute intracranial hypertension (AICH); acute respiratory distress syndrome (ARDS); acute respiratory distress syndrome in combination with acute intracranial hypertension (ARDS + AICH). AICH was induced with an intracranial balloon catheter and the inflation volume was adjusted to keep intracranial pressure (ICP) at 30-40 cmH(2)O. ARDS was induced by oleic acid infusion. Respiratory function, hemodynamics, extravascular lung water index (ELWI), lung and brain computed tomography (CT) scans, as well as inflammatory mediators, S100B, and neuronal serum enolase (NSE) were measured over a 4-h period. Lung and brain tissue were collected and examined at the end of the experiment. In both healthy and injured lungs, AICH caused increases in NSE and TNF-alpha plasma concentrations, extravascular lung water, and lung density in CT, the extent of poorly aerated (dystelectatic) and atelectatic lung regions, and an increase in the brain tissue water content. ARDS and AICH in combination induced damage in the hippocampus and decreased density in brain CT. AICH induces lung injury and also exacerbates pre-existing damage. Increased extravascular lung water is an early marker. ARDS has a detrimental effect on the brain and acts synergistically with intracranial hypertension to cause histological hippocampal damage."],["dc.identifier.doi","10.1007/s00134-011-2232-2"],["dc.identifier.isi","000292286800020"],["dc.identifier.pmid","21544692"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7288"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22752"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0342-4642"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Acute effects of intracranial hypertension and ARDS on pulmonary and neuronal damage: a randomized experimental study in pigs"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","306"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","European Journal of Pediatrics"],["dc.bibliographiccitation.lastpage","310"],["dc.bibliographiccitation.volume","164"],["dc.contributor.author","Jerkic, S."],["dc.contributor.author","Rosewich, Hendrik"],["dc.contributor.author","Scharf, J. G."],["dc.contributor.author","Perske, Christina"],["dc.contributor.author","Fuzesi, L"],["dc.contributor.author","Wilichowski, E"],["dc.contributor.author","Gärtner, Jutta"],["dc.date.accessioned","2017-09-07T11:54:27Z"],["dc.date.available","2017-09-07T11:54:27Z"],["dc.date.issued","2005"],["dc.description.abstract","Familial adenomatous polyposis (FAP) is an autosomal dominant disorder that characteristically presents with colon cancer in early adult life. We describe a Pakistani FAP family in which two sons had an unusually early manifestation of colorectal cancer. The index patient presented at 11 years of age with abdominal pain, rectal bleeding and iron deficiency anaemia. Colonoscopy showed that the colon was carpeted with a myriad of polyps. Oesophago-gastric and duodenal endoscopy revealed that polyps had also developed in the duodenum. Multiple biopsies indicated neoplastic lesions. The patient underwent a proctocolectomy and endoscopic duodenal mucosectomy. The diagnosis of an adenocarcinoma of the colon and further adenomatous polyps with low-grade and high-grade dysplasia was confirmed by histology. Family screening including a blood test for anaemia and bowel examination revealed that his 12-year-old brother was also affected. Conclusion:Children with familial adenomatous polyposis are at risk for colon cancer and emphasise the need for early tumour recognition. Gastrointestinal symptoms in children should be thoroughly evaluated and standard screening for colonic polyposis should be performed in all individuals with a positive family history and/or known mutations in cancer-associated genes, particularly in children who are under 10 years of age."],["dc.identifier.doi","10.1007/s00431-004-1602-y"],["dc.identifier.gro","3143858"],["dc.identifier.isi","000228640700010"],["dc.identifier.pmid","15726412"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/1418"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0340-6199"],["dc.title","Colorectal cancer in two pre-teenage siblings with familial adenomatous polyposis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","81"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","83"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Claßen, Anna"],["dc.contributor.author","Kitz, Julia"],["dc.contributor.author","Perske, Christina"],["dc.contributor.author","Overbeck, Tobias"],["dc.contributor.author","Bertsch, Hans Peter"],["dc.contributor.author","Schön, Michael P."],["dc.contributor.author","Lippert, Undine"],["dc.date.accessioned","2020-12-10T18:27:17Z"],["dc.date.available","2020-12-10T18:27:17Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1111/ddg.13398"],["dc.identifier.issn","1610-0379"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76294"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Leukemia cutis in a patient with chronic myelomonocytic leukemia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Pathology - Research and Practice"],["dc.bibliographiccitation.volume","203"],["dc.contributor.author","Perske, Christina"],["dc.contributor.author","Kosz, L."],["dc.contributor.author","Radzun, H.-J."],["dc.contributor.author","Hemmerlein, Bernhard"],["dc.date.accessioned","2018-11-07T11:07:22Z"],["dc.date.available","2018-11-07T11:07:22Z"],["dc.date.issued","2007"],["dc.format.extent","323"],["dc.identifier.isi","000247312300178"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52543"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Gmbh, Urban & Fischer Verlag"],["dc.publisher.place","Jena"],["dc.relation.issn","0344-0338"],["dc.title","Epigenetic effects on the mRNA-Expression of MMPs, EMMPRIN, and TIMPs in urothelial carcinoma cell lines"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","150"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","The Journal of Infectious Diseases"],["dc.bibliographiccitation.lastpage","158"],["dc.bibliographiccitation.volume","215"],["dc.contributor.author","Ribes, Sandra"],["dc.contributor.author","Nessler, Stefan"],["dc.contributor.author","Heide, Ev-Christin"],["dc.contributor.author","Malzahn, Dörthe"],["dc.contributor.author","Perske, Christina"],["dc.contributor.author","Brück, Wolfgang"],["dc.contributor.author","Nau, Roland"],["dc.date.accessioned","2018-11-07T10:28:48Z"],["dc.date.available","2018-11-07T10:28:48Z"],["dc.date.issued","2017"],["dc.description.abstract","Background. The adaptive immune system has been considered to play a minimal role in the early host response during bacterial meningitis. Methods. We investigated the progression and outcome of pneumococcal meningitis in Rag1(-/-) mice lacking functional B and T cells by assessing overall and symptom-free survival, bacteriological and histological studies, as well as flow cytometry and measurements of proinflammatory mediators. Results. The intracerebral injection of S. pneumoniae D39 induced the recruitment of B and T cells (CD4+, gamma delta and natural killer) into the brain of wild-type mice. Mice with no functional B and T cells developed clinical symptoms and succumbed to the infection earlier than the wild-type group. In the CNS, Rag1(-/-) mice showed lower levels of interleukin 1 beta, reduced microglial proliferation, and impaired granulocyte recruitment with an earlier spread of pneumococci into the bloodstream, compared with wild-type mice. Lack of B and T cells resulted in a severe impairment of bacterial clearance in blood, spleen, and liver and an exaggerated systemic inflammatory response. Conclusions. B and T cells are important effector cells delaying the spread of pneumococci from the brain to the systemic circulation and shaping the immune response, thereby prolonging the survival of the host in the absence of antibiotic treatment."],["dc.identifier.doi","10.1093/infdis/jiw517"],["dc.identifier.isi","000397203500022"],["dc.identifier.pmid","27803171"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43504"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1537-6613"],["dc.relation.issn","0022-1899"],["dc.title","The Early Adaptive Immune Response in the Pathophysiological Process of Pneumococcal Meningitis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","313"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Nature Microbiology"],["dc.bibliographiccitation.lastpage","326"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Soliman, Sameh S. M."],["dc.contributor.author","Baldin, Clara"],["dc.contributor.author","Gu, Yiyou"],["dc.contributor.author","Singh, Shakti"],["dc.contributor.author","Gebremariam, Teclegiorgis"],["dc.contributor.author","Swidergall, Marc"],["dc.contributor.author","Alqarihi, Abdullah"],["dc.contributor.author","Youssef, Eman G."],["dc.contributor.author","Alkhazraji, Sondus"],["dc.contributor.author","Pikoulas, Antonis"],["dc.contributor.author","Perske, Christina"],["dc.contributor.author","Venkataramani, Vivek"],["dc.contributor.author","Rich, Abigail"],["dc.contributor.author","Bruno, Vincent M."],["dc.contributor.author","Hotopp, Julie Dunning"],["dc.contributor.author","Mantis, Nicolas J."],["dc.contributor.author","Edwards, John E."],["dc.contributor.author","Filler, Scott G."],["dc.contributor.author","Chamilos, Georgios"],["dc.contributor.author","Vitetta, Ellen S."],["dc.contributor.author","Ibrahim, Ashraf S."],["dc.date.accessioned","2021-04-14T08:30:18Z"],["dc.date.available","2021-04-14T08:30:18Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1038/s41564-020-00837-0"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83181"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","2058-5276"],["dc.title","Mucoricin is a ricin-like toxin that is critical for the pathogenesis of mucormycosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Molecular and Clinical Oncology"],["dc.contributor.author","Sievers, Denise"],["dc.contributor.author","Bunzendahl, Jens"],["dc.contributor.author","Frosch, Alice"],["dc.contributor.author","Perske, Christina"],["dc.contributor.author","Hemmerlein, Bernhard"],["dc.contributor.author","Schliephake, Henning"],["dc.contributor.author","Brockmeyer, Phillipp"],["dc.date.accessioned","2021-06-01T10:48:53Z"],["dc.date.available","2021-06-01T10:48:53Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.3892/mco.2017.1514"],["dc.identifier.eissn","2049-9469"],["dc.identifier.issn","2049-9450"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86085"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","2049-9469"],["dc.relation.issn","2049-9450"],["dc.title","Generation of highly differentiated BHY oral squamous cell carcinoma multicellular spheroids"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","6770"],["dc.bibliographiccitation.issue","16"],["dc.bibliographiccitation.journal","Oncotarget"],["dc.bibliographiccitation.lastpage","6787"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Zatula, Nathalie"],["dc.contributor.author","Wiese, Maria"],["dc.contributor.author","Bunzendahl, Jens"],["dc.contributor.author","Birchmeier, Walter"],["dc.contributor.author","Perske, Christina"],["dc.contributor.author","Bleckmann, Annalen"],["dc.contributor.author","Brembeck, Felix H."],["dc.date.accessioned","2019-07-09T11:42:11Z"],["dc.date.available","2019-07-09T11:42:11Z"],["dc.date.issued","2014-08-30"],["dc.description.abstract","The majority of human breast cancers express estrogen receptor alpha (ER), which is important for therapy with anti-estrogens. Here we describe the role of BCL9-2, a proto-oncogene previously characterized as co-activator of Wnt/ß-catenin signaling, for mammary tumorigenesis in mice and human. ER positive human breast cancers showed overexpression of BCL9-2 and tamoxifen treated patients with high BCL9-2 demonstrated a better survival. BCL9-2 was upregulated during puberty and pregnancy in normal mammary epithelia, but downregulated in the involuted gland. BCL9-2 overexpression in vivo delayed the mammary involution and induced alveolar hyperplasia. Moreover, aged BCL9-2 transgenic mice developed ductal-like mammary tumors with high nuclear ER expression. We found, that primary cell cultures of BCL9-2 breast tumors responded to tamoxifen treatment. Moreover, BCL9-2 regulated the expression of ER and the proliferation of human breast cancer cells independently of ß-catenin. Finally, we describe a novel mechanism, how BCL9-2 regulates ER transcription by interaction with Sp1 through the proximal ESR1 gene promoter. In summary, BCL9-2 induces ER positive breast cancers in vivo, regulates ER expression by a novel ß-catenin independent mechanism in breast cancer cells, and might predict the therapy response to tamoxifen treatment."],["dc.identifier.doi","10.18632/oncotarget.2252"],["dc.identifier.pmid","25149534"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12963"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58610"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1949-2553"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Breast Neoplasms"],["dc.subject.mesh","Carcinogenesis"],["dc.subject.mesh","DNA-Binding Proteins"],["dc.subject.mesh","Estrogen Receptor alpha"],["dc.subject.mesh","Female"],["dc.subject.mesh","Humans"],["dc.subject.mesh","Mammary Neoplasms, Experimental"],["dc.subject.mesh","Mice"],["dc.subject.mesh","Mice, Transgenic"],["dc.subject.mesh","Tamoxifen"],["dc.subject.mesh","Transcription Factors"],["dc.subject.mesh","Transcriptional Activation"],["dc.subject.mesh","Wnt Signaling Pathway"],["dc.subject.mesh","beta Catenin"],["dc.title","The BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast tumorigenesis."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","599"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Translational oncology"],["dc.bibliographiccitation.lastpage","603"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Wienbeck, Susanne"],["dc.contributor.author","Fischer, Uwe"],["dc.contributor.author","Perske, Christina"],["dc.contributor.author","Wienke, Andreas"],["dc.contributor.author","Meyer, Hans Jonas"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Surov, Alexey"],["dc.date.accessioned","2019-07-09T11:43:26Z"],["dc.date.available","2019-07-09T11:43:26Z"],["dc.date.issued","2017-06-27"],["dc.description.abstract","PURPOSE: Recently, cone-beam breast computed tomography (CBCT) is established for the breast investigation. The purpose of the present study was to investigate possible associations between CBCT findings and histopathological features in breast cancer. METHODS: Overall, 59 female patients, mean age of 64.6 years with histological proven breast cancer were included into the study. In all cases, non-contrast CBCT examination was done. The diagnosis of the identified lesions was confirmed histologically by biopsy. Immunohistochemical staining against estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and Ki-67 was performed for every lesion. Collected data were evaluated by means of descriptive statistics. Spearman's correlation coefficient was used to analyze the association between CT density and Ki-67 values. P values <0.05 were taken to indicate statistical significance in all instances. RESULTS: The size of the lesion varied from 2.7 to 90.0, mean size, 15.88±13.0 mm. The mean value of CT density of the lesions was 63.95±38.18 HU. The density tended to be higher in tubular carcinoma. Correlation analysis identified no significant correlations between CT density and Ki-67 level (r=-0.031, P=.784). There were no statistically significant differences of CT density between tumors with different receptor status. CONCLUSIONS: No significant associations between CT density and receptor status in breast cancer. Tubular carcinoma tended to have higher CT density in comparison to other subtypes of breast carcinomas."],["dc.identifier.doi","10.1016/j.tranon.2017.05.004"],["dc.identifier.pmid","28666188"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14534"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58889"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1936-5233"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.subject.ddc","610"],["dc.title","Cone-beam Breast Computed Tomography: CT Density Does Not Reflect Proliferation Potential and Receptor Expression of Breast Carcinoma."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]