Kossen, Robert

[["dc.bibliographiccitation.journal","Frontiers in Psychiatry"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Corthals, Kristina"],["dc.contributor.author","Heukamp, Alina Sophia"],["dc.contributor.author","Kossen, Robert"],["dc.contributor.author","Großhennig, Isabel"],["dc.contributor.author","Hahn, Nina"],["dc.contributor.author","Gras, Heribert"],["dc.contributor.author","Göpfert, Martin C."],["dc.contributor.author","Heinrich, Ralf"],["dc.contributor.author","Geurten, Bart R. H."],["dc.date.accessioned","2019-07-09T11:43:34Z"],["dc.date.available","2019-07-09T11:43:34Z"],["dc.date.issued","2017"],["dc.description.abstract","The genome of Drosophila melanogaster includes homologs to approximately one-third of the currently known human disease genes. Flies and humans share many biological processes, including the principles of information processing by excitable neurons, synaptic transmission, and the chemical signals involved in intercellular communication. Studies on the molecular and behavioral impact of genetic risk factors of human neuro- developmental disorders [autism spectrum disorders (ASDs), schizophrenia, attention deficit hyperactivity disorders, and Tourette syndrome] increasingly use the well-studied social behavior of D. melanogaster, an organism that is amenable to a large variety of genetic manipulations. Neuroligins (Nlgs) are a family of phylogenetically conserved postsynaptic adhesion molecules present (among others) in nematodes, insects, and mammals. Impaired function of Nlgs (particularly of Nlg 3 and 4) has been associated with ASDs in humans and impaired social and communication behavior in mice. Making use of a set of behavioral and social assays, we, here, analyzed the impact of two Drosophila Nlgs, Dnlg2 and Dnlg4, which are differentially expressed at excitatory and inhibitory central nervous synapses, respectively. Both Nlgs seem to be associated with diurnal activity and social behavior. Even though deficiencies in Dnlg2 and Dnlg4 appeared to have no effects on sensory or motor systems, they differentially impacted on social interactions, suggesting that social behavior is distinctly regulated by these Nlgs."],["dc.identifier.doi","10.3389/fpsyt.2017.00113"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14580"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58919"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1664-0640"],["dc.relation.issn","1664-0640"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","570"],["dc.title","Neuroligins Nlg2 and Nlg4 Affect Social Behavior in Drosophila melanogaster"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Kusch, Harald"],["dc.contributor.author","Bauer, Christian Robert"],["dc.contributor.author","Bender, Theresa"],["dc.contributor.author","Hügel, Jonas"],["dc.contributor.author","Kossen, Robert"],["dc.contributor.author","Nußbeck, Sara Yasemin"],["dc.contributor.author","Sax, Ulrich"],["dc.date.accessioned","2022-02-23T08:37:09Z"],["dc.date.available","2022-02-23T08:37:09Z"],["dc.date.created","2021"],["dc.date.issued","2021"],["dc.identifier.doi","10.25625/8vukqa"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/100224"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/349"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/407"],["dc.identifier.url","https://sfb1190.med.uni-goettingen.de/production/literature/publications/158"],["dc.identifier.url","https://sfb1286.uni-goettingen.de/literature/publications/136"],["dc.publisher","GRO.data"],["dc.publisher.place","Göttingen"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1190: Transportmaschinen und Kontaktstellen zellulärer Kompartimente"],["dc.relation","SFB 1286: Quantitative Synaptologie"],["dc.relation.orgunit","Institut für Medizinische Informatik"],["dc.relation.workinggroup","RG Kusch"],["dc.relation.workinggroup","RG Nußbeck"],["dc.relation.workinggroup","RG Rehling (Mitochondrial Protein Biogenesis)"],["dc.relation.workinggroup","RG Bonn"],["dc.title","GMDS2021 ePoster and video teaser for DOI 10.3205/21gmds072"],["dc.type","research_data"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","59"],["dc.bibliographiccitation.lastpage","68"],["dc.contributor.author","Kusch, Harald"],["dc.contributor.author","Kossen, Robert"],["dc.contributor.author","Suhr, Markus"],["dc.contributor.author","Freckmann, Luca"],["dc.contributor.author","Weber, Linus"],["dc.contributor.author","Henke, Christian"],["dc.contributor.author","Lehmann, Christoph"],["dc.contributor.author","Rheinländer, Sophia"],["dc.contributor.author","Aschenbrandt, Georg"],["dc.contributor.author","Kühlborn, Lea K."],["dc.contributor.author","Marzec, Bartlomiej"],["dc.contributor.author","Menzel, Julia"],["dc.contributor.author","Schwappach, Blanche"],["dc.contributor.author","Zelarayán, Laura C."],["dc.contributor.author","Cyganek, Lukas"],["dc.contributor.author","Antonios, Gregory"],["dc.contributor.author","Kohl, Tobias"],["dc.contributor.author","Lehnart, Stephan E."],["dc.contributor.author","Zoremba, Marcel"],["dc.contributor.author","Sax, Ulrich"],["dc.contributor.author","Nussbeck, Sara Y."],["dc.contributor.editor","Röhrig, Rainer"],["dc.contributor.editor","Beißbarth, Tim"],["dc.contributor.editor","König, Jochem"],["dc.contributor.editor","Ose, Claudia"],["dc.contributor.editor","Rauch, Geraldine"],["dc.contributor.editor","Sax, Ulrich"],["dc.contributor.editor","Schreiweis, Björn"],["dc.contributor.editor","Sedlmayr, Martin"],["dc.date.accessioned","2022-02-22T13:44:48Z"],["dc.date.available","2022-02-22T13:44:48Z"],["dc.date.issued","2021-09-21"],["dc.description.abstract","Ensuring scientific reproducibility and compliance with documentation guidelines of funding bodies and journals is a topic of greatly increasing importance in biomedical research. Failure to comply, or unawareness of documentation standards can have adverse effects on the translation of research into patient treatments, as well as economic implications. In the context of the German Research Foundation-funded collaborative research center (CRC) 1002, an IT-infrastructure sub-project was designed. Its goal has been to establish standardized metadata documentation and information exchange benefitting the participating research groups with minimal additional documentation efforts."],["dc.identifier.doi","10.3233/SHTI210542"],["dc.identifier.pmid","34545820"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/100182"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/344"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/403"],["dc.identifier.url","https://sfb1190.med.uni-goettingen.de/production/literature/publications/155"],["dc.identifier.url","https://sfb1286.uni-goettingen.de/literature/publications/133"],["dc.language.iso","en"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | S01: In vivo und in vitro Krankheitsmodelle"],["dc.relation","SFB 1002 | S02: Hochauflösende Fluoreszenzmikroskopie und integrative Datenanalyse"],["dc.relation","SFB 1002 | INF: Unterstützung der SFB 1002 Forschungsdatenintegration, -visualisierung und -nachnutzung"],["dc.relation","SFB 1190: Transportmaschinen und Kontaktstellen zellulärer Kompartimente"],["dc.relation","SFB 1190 | Z03: Synthetische genetische Analyse, automatisierte Mikroskopie und Bildanalyse"],["dc.relation","SFB 1286: Quantitative Synaptologie"],["dc.relation","SFB 1286 | Z02: Integrative Datenanalyse und -interpretation. Generierung einer synaptisch-integrativen Datenstrategie (SynIDs)"],["dc.relation.ispartof","German Medical Data Sciences 2021: Digital Medicine: Recognize – Understand – Heal"],["dc.relation.orgunit","Institut für Medizinische Informatik"],["dc.relation.workinggroup","RG Kusch"],["dc.relation.workinggroup","RG Lehnart"],["dc.relation.workinggroup","RG Schwappach (Membrane Protein Biogenesis)"],["dc.relation.workinggroup","RG Zelarayán-Behrend (Developmental Pharmacology)"],["dc.relation.workinggroup","RG Zimmermann (Engineered Human Myocardium)"],["dc.relation.workinggroup","RG Cyganek (Stem Cell Unit)"],["dc.relation.workinggroup","RG Nußbeck"],["dc.relation.workinggroup","RG Bonn"],["dc.title","Management of Metadata Types in Basic Cardiological Research"],["dc.type","book_chapter"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Kusch, Harald"],["dc.contributor.author","Bauer, Christian R."],["dc.contributor.author","Bender, Theresa"],["dc.contributor.author","Hügel, Jonas"],["dc.contributor.author","Kossen, Robert"],["dc.contributor.author","Nussbeck, Sara Yasemin"],["dc.contributor.author","Sax, Ulrich"],["dc.date.accessioned","2022-02-23T08:36:16Z"],["dc.date.available","2022-02-23T08:36:16Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.3205/21gmds072"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/100216"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/345"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation.conference","66. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e. V. (GMDS), 12. Jahreskongress der Technologie- und Methodenplattform für die vernetzte medizinische Forschung e. V. (TMF)"],["dc.relation.eventend","2021-09-30"],["dc.relation.eventlocation","virtuell"],["dc.relation.eventstart","2021-09-26"],["dc.relation.orgunit","Institut für Medizinische Informatik"],["dc.relation.orgunit","Campus-Institut Data Science"],["dc.relation.workinggroup","RG Kusch"],["dc.title","The bumpy road of FAIRification in practice"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]