Schilling, Arndt Friedrich

[["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Biomedicines"],["dc.bibliographiccitation.volume","10"],["dc.contributor.affiliation","Jiang, Jun; 1Experimental Plastic Surgery, Clinic for Plastic, Reconstructive and Hand Surgery, Klinikum Rechts der Isar, Technische Universität München, D-81675 Munich, Germany; junqing.jiang@mri.tum.de (J.J.); lynn.roeper@mri.tum.de (L.R.); sarah.alageel@mri.tum.de (S.A.); e.hadjipanayi@googlemail.com (E.H.)"],["dc.contributor.affiliation","Röper, Lynn; 1Experimental Plastic Surgery, Clinic for Plastic, Reconstructive and Hand Surgery, Klinikum Rechts der Isar, Technische Universität München, D-81675 Munich, Germany; junqing.jiang@mri.tum.de (J.J.); lynn.roeper@mri.tum.de (L.R.); sarah.alageel@mri.tum.de (S.A.); e.hadjipanayi@googlemail.com (E.H.)"],["dc.contributor.affiliation","Alageel, Sarah; 1Experimental Plastic Surgery, Clinic for Plastic, Reconstructive and Hand Surgery, Klinikum Rechts der Isar, Technische Universität München, D-81675 Munich, Germany; junqing.jiang@mri.tum.de (J.J.); lynn.roeper@mri.tum.de (L.R.); sarah.alageel@mri.tum.de (S.A.); e.hadjipanayi@googlemail.com (E.H.)"],["dc.contributor.affiliation","Dornseifer, Ulf; 2Department of Plastic, Reconstructive and Aesthetic Surgery, Isar Klinikum, D-80331 Munich, Germany; ulf.dornseifer@isarklinikum.de"],["dc.contributor.affiliation","Schilling, Arndt F.; 3Department of Trauma Surgery, Orthopedics and Plastic Surgery, Universitätsmedizin Göttingen, D-37075 Göttingen, Germany; arndt.schilling@med.uni-goettingen.de"],["dc.contributor.affiliation","Hadjipanayi, Ektoras; 1Experimental Plastic Surgery, Clinic for Plastic, Reconstructive and Hand Surgery, Klinikum Rechts der Isar, Technische Universität München, D-81675 Munich, Germany; junqing.jiang@mri.tum.de (J.J.); lynn.roeper@mri.tum.de (L.R.); sarah.alageel@mri.tum.de (S.A.); e.hadjipanayi@googlemail.com (E.H.)"],["dc.contributor.affiliation","Machens, Hans-Günther; 1Experimental Plastic Surgery, Clinic for Plastic, Reconstructive and Hand Surgery, Klinikum Rechts der Isar, Technische Universität München, D-81675 Munich, Germany; junqing.jiang@mri.tum.de (J.J.); lynn.roeper@mri.tum.de (L.R.); sarah.alageel@mri.tum.de (S.A.); e.hadjipanayi@googlemail.com (E.H.)"],["dc.contributor.affiliation","Moog, Philipp; 1Experimental Plastic Surgery, Clinic for Plastic, Reconstructive and Hand Surgery, Klinikum Rechts der Isar, Technische Universität München, D-81675 Munich, Germany; junqing.jiang@mri.tum.de (J.J.); lynn.roeper@mri.tum.de (L.R.); sarah.alageel@mri.tum.de (S.A.); e.hadjipanayi@googlemail.com (E.H.)"],["dc.contributor.author","Jiang, Jun"],["dc.contributor.author","Röper, Lynn"],["dc.contributor.author","Alageel, Sarah"],["dc.contributor.author","Dornseifer, Ulf"],["dc.contributor.author","Schilling, Arndt F."],["dc.contributor.author","Hadjipanayi, Ektoras"],["dc.contributor.author","Machens, Hans-Günther"],["dc.contributor.author","Moog, Philipp"],["dc.date.accessioned","2022-08-04T08:38:41Z"],["dc.date.available","2022-08-04T08:38:41Z"],["dc.date.issued","2022-07-07"],["dc.date.updated","2022-08-03T10:01:16Z"],["dc.description.abstract","Interest in discovering new methods of employing natural growth factor preparations to promote bone fracture healing is becoming increasingly popular in the field of regenerative medicine. In this study, we were able to demonstrate the osteogenic potential of hypoxia preconditioned serum (HPS) on human osteoblasts in vitro. Human osteoblasts were stimulated with two HPS concentrations (10% and 40%) and subsequently analyzed at time points of days 2 and 4. In comparison to controls, a time- and dose-dependent (up to 14.2× higher) proliferation of osteoblasts was observed after 4 days of HPS-40% stimulation with lower lactate dehydrogenase (LDH)-levels detected than controls, indicating the absence of cytotoxic/stress effects of HPS on human osteoblasts. With regards to cell migration, it was found to be significantly faster with HPS-10% application after 72 h in comparison to controls. Further osteogenic response to HPS treatment was evaluated by employing culture supernatant analysis, which exhibited significant upregulation of OPG (Osteoprotegerin) with higher dosage (HPS-10% vs. HPS-40%) and longer duration (2 d vs. 4 d) of HPS stimulation. There was no detection of anti-osteogenic sRANKL (soluble Receptor Activator of NF-κB Ligand) after 4 days of HPS stimulation. In addition, ALP (alkaline phosphatase)-enzyme activity, was found to be upregulated, dose-dependently, after 4 days of HPS-40% application. When assessing ossification through Alizarin-Red staining, HPS dose-dependently achieved greater (up to 2.8× higher) extracellular deposition of calcium-phosphate with HPS-40% in comparison to controls. These findings indicate that HPS holds the potential to accelerate bone regeneration by osteogenic promotion of human osteoblasts."],["dc.description.sponsorship","Technical University of Munich"],["dc.identifier.doi","10.3390/biomedicines10071631"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112636"],["dc.language.iso","en"],["dc.relation.eissn","2227-9059"],["dc.rights","CC BY 4.0"],["dc.title","Hypoxia Preconditioned Serum (HPS) Promotes Osteoblast Proliferation, Migration and Matrix Deposition"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","443"],["dc.bibliographiccitation.journal","Molecular Therapy - Nucleic Acids"],["dc.bibliographiccitation.lastpage","452"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Hoffmann, Daniel B."],["dc.contributor.author","Gruber, Jens"],["dc.contributor.author","Böker, Kai O."],["dc.contributor.author","Deppe, Delia"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Schilling, Arndt F."],["dc.contributor.author","Lemus-Diaz, Nicolas"],["dc.contributor.author","Komrakova, Marina"],["dc.contributor.author","Schneider, Stefan"],["dc.date.accessioned","2019-07-09T11:45:51Z"],["dc.date.available","2019-07-09T11:45:51Z"],["dc.date.issued","2018"],["dc.description.abstract","Rebalancing of the RANKL/OPG system seems to be an effective treatment strategy in postmenopausal osteoporosis. Here, we evaluate the knockdown of RANKL by in-vivo-delivered siRNA in a rat model of osteoporosis. Virus-like-particles (VLPs) derived from polyoma JC virus were used for delivering RANKL siRNA in ovariectomized (OVX) rats. 48 rats were ovariectomized and treated with either 17β-estradiol (E2), VLPs containing RANKL siRNA (siRANKL), or VLPs containing non-cognate siRNA (siCtrl). All OVX groups were subdivided into the prophylaxis group (PG) and the therapy group (TG). The PG received treatment directly after being OVX for 10 weeks. The TG received treatment 5 weeks after being OVX for 5 weeks. Rats were sacrificed 10 weeks after being OVX. Bone and blood samples were analyzed. E2 and siRANKL showed a significant knockdown of RANKL mRNA. A protein knockdown was observed with E2 and siRANKL in the TG but not in the PG. No distinct improvements in biomechanical and morphological properties of the bones were observed after siRANKL treatment. In the PG, E2 protected the bone structure. We demonstrated successful mRNA and protein knockdown by VLP-mediated RNAi in vivo. Knockdown of membranous RANKL did not result in significant improvements of bone properties in this model of early-stage postmenopausal osteoporosis."],["dc.identifier.doi","10.1016/j.omtn.2018.06.001"],["dc.identifier.pmid","30195781"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15329"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59322"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2162-2531"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.subject.ddc","610"],["dc.title","Effects of RANKL Knockdown by Virus-like Particle-Mediated RNAi in a Rat Model of Osteoporosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Neurorobotics"],["dc.bibliographiccitation.volume","15"],["dc.contributor.affiliation","Mouchoux, Jérémy; 1Applied Rehabilitation Technology Lab, Department of Trauma Surgery, Orthopedics and Plastic Surgery, University Medical Center Göttingen, Georg-August University, Göttingen, Germany"],["dc.contributor.affiliation","Bravo-Cabrera, Miguel A.; 1Applied Rehabilitation Technology Lab, Department of Trauma Surgery, Orthopedics and Plastic Surgery, University Medical Center Göttingen, Georg-August University, Göttingen, Germany"],["dc.contributor.affiliation","Dosen, Strahinja; 2Faculty of Medicine, Department of Health Science and Technology Center for Sensory-Motor Interaction, Aalborg University, Aalborg, Denmark"],["dc.contributor.affiliation","Schilling, Arndt F.; 1Applied Rehabilitation Technology Lab, Department of Trauma Surgery, Orthopedics and Plastic Surgery, University Medical Center Göttingen, Georg-August University, Göttingen, Germany"],["dc.contributor.affiliation","Markovic, Marko; 1Applied Rehabilitation Technology Lab, Department of Trauma Surgery, Orthopedics and Plastic Surgery, University Medical Center Göttingen, Georg-August University, Göttingen, Germany"],["dc.contributor.author","Mouchoux, Jérémy"],["dc.contributor.author","Bravo-Cabrera, Miguel A."],["dc.contributor.author","Dosen, Strahinja"],["dc.contributor.author","Schilling, Arndt F."],["dc.contributor.author","Markovic, Marko"],["dc.date.accessioned","2022-02-01T10:31:40Z"],["dc.date.available","2022-02-01T10:31:40Z"],["dc.date.issued","2021"],["dc.date.updated","2022-02-09T13:20:13Z"],["dc.description.abstract","Semi-autonomous (SA) control of upper-limb prostheses can improve the performance and decrease the cognitive burden of a user. In this approach, a prosthesis is equipped with additional sensors (e.g., computer vision) that provide contextual information and enable the system to accomplish some tasks automatically. Autonomous control is fused with a volitional input of a user to compute the commands that are sent to the prosthesis. Although several promising prototypes demonstrating the potential of this approach have been presented, methods to integrate the two control streams (i.e., autonomous and volitional) have not been systematically investigated. In the present study, we implemented three shared control modalities (i.e., sequential, simultaneous , and continuous ) and compared their performance, as well as the cognitive and physical burdens imposed on the user. In the sequential approach, the volitional input disabled the autonomous control. In the simultaneous approach, the volitional input to a specific degree of freedom (DoF) activated autonomous control of other DoFs, whereas in the continuous approach, autonomous control was always active except for the DoFs controlled by the user. The experiment was conducted in ten able-bodied subjects, and these subjects used an SA prosthesis to perform reach-and-grasp tasks while reacting to audio cues (dual tasking). The results demonstrated that, compared to the manual baseline (volitional control only), all three SA modalities accomplished the task in a shorter time and resulted in less volitional control input. The simultaneous SA modality performed worse than the sequential and continuous SA approaches. When systematic errors were introduced in the autonomous controller to generate a mismatch between the goals of the user and controller, the performance of SA modalities substantially decreased, even below the manual baseline. The sequential SA scheme was the least impacted one in terms of errors. The present study demonstrates that a specific approach for integrating volitional and autonomous control is indeed an important factor that significantly affects the performance and physical and cognitive load, and therefore these should be considered when designing SA prostheses."],["dc.description.abstract","Semi-autonomous (SA) control of upper-limb prostheses can improve the performance and decrease the cognitive burden of a user. In this approach, a prosthesis is equipped with additional sensors (e.g., computer vision) that provide contextual information and enable the system to accomplish some tasks automatically. Autonomous control is fused with a volitional input of a user to compute the commands that are sent to the prosthesis. Although several promising prototypes demonstrating the potential of this approach have been presented, methods to integrate the two control streams (i.e., autonomous and volitional) have not been systematically investigated. In the present study, we implemented three shared control modalities (i.e., sequential, simultaneous , and continuous ) and compared their performance, as well as the cognitive and physical burdens imposed on the user. In the sequential approach, the volitional input disabled the autonomous control. In the simultaneous approach, the volitional input to a specific degree of freedom (DoF) activated autonomous control of other DoFs, whereas in the continuous approach, autonomous control was always active except for the DoFs controlled by the user. The experiment was conducted in ten able-bodied subjects, and these subjects used an SA prosthesis to perform reach-and-grasp tasks while reacting to audio cues (dual tasking). The results demonstrated that, compared to the manual baseline (volitional control only), all three SA modalities accomplished the task in a shorter time and resulted in less volitional control input. The simultaneous SA modality performed worse than the sequential and continuous SA approaches. When systematic errors were introduced in the autonomous controller to generate a mismatch between the goals of the user and controller, the performance of SA modalities substantially decreased, even below the manual baseline. The sequential SA scheme was the least impacted one in terms of errors. The present study demonstrates that a specific approach for integrating volitional and autonomous control is indeed an important factor that significantly affects the performance and physical and cognitive load, and therefore these should be considered when designing SA prostheses."],["dc.identifier.doi","10.3389/fnbot.2021.768619"],["dc.identifier.eissn","1662-5218"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/98918"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-517"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1662-5218"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Impact of Shared Control Modalities on Performance and Usability of Semi-autonomous Prostheses"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Endocrinological Investigation"],["dc.contributor.author","Komrakova, M."],["dc.contributor.author","Büchler, G."],["dc.contributor.author","Böker, K. O."],["dc.contributor.author","Lehmann, W."],["dc.contributor.author","Schilling, A. F."],["dc.contributor.author","Roch, P. J."],["dc.contributor.author","Taudien, S."],["dc.contributor.author","Hoffmann, D. B."],["dc.contributor.author","Sehmisch, S."],["dc.date.accessioned","2022-09-01T09:49:26Z"],["dc.date.available","2022-09-01T09:49:26Z"],["dc.date.issued","2022"],["dc.description.abstract","Abstract\n \n Purpose\n Enobosarm (EN), a selective androgen receptor modulator and raloxifene (RAL), a selective estrogen receptor modulator, have been shown to improve bone tissue in osteoporotic males. The present study evaluated the effects of a combination therapy of EN and RAL on bone properties in orchiectomized rats compared to the respective single treatments.\n \n \n Methods\n Eight-month-old male Sprague–Dawley rats were either left intact (Non-Orx) or orchiectomized (Orx). The Orx rats were divided into four groups (n = 15 each): 1) Orx, 2) EN treatment (Orx + EN), 3) RAL treatment (Orx + RAL), 4) combined treatment (Orx + EN + RAL). EN and RAL (0.4 mg and 7 mg/kg body weight/day) were applied immediately after Orx with a soy-free pelleted diet for up to 18 weeks. The lumbar spine and femora were examined by micro-CT, biomechanical, histomorphological, ashing, and gene expression analyses.\n \n \n Results\n EN exhibited an anabolic effect on bone, improving some of its parameters in Orx rats, but did not affect biomechanical properties. RAL exhibited antiresorptive activity, maintaining the biomechanical and trabecular parameters of Orx rats at the levels of Non-Orx rats. EN + RAL exerted a stronger effect than the single treatments, improving most of the bone parameters. Liver weight increased after all treatments; the kidney, prostate, and levator ani muscle weights increased after EN and EN + RAL treatments. BW was reduced due to a decreased food intake in the Orx + RAL group and due a reduced visceral fat weight in the Orx + EN + RAL group.\n \n \n Conclusion\n The EN + RAL treatment appeared to be promising in preventing male osteoporosis, but given the observed side effects on liver, kidney, and prostate weights, it requires further investigation."],["dc.description.sponsorship"," Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659"],["dc.description.sponsorship"," Georg-August-Universität Göttingen 501100003385"],["dc.identifier.doi","10.1007/s40618-022-01865-9"],["dc.identifier.pii","1865"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113421"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-597"],["dc.relation.eissn","1720-8386"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","A combined treatment with selective androgen and estrogen receptor modulators prevents bone loss in orchiectomized rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1143"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The Knee"],["dc.bibliographiccitation.lastpage","1150"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Mull, Carolin"],["dc.contributor.author","Wohlmuth, Peter"],["dc.contributor.author","Krause, Matthias"],["dc.contributor.author","Alm, Lena"],["dc.contributor.author","Kling, Henning"],["dc.contributor.author","Schilling, Arndt F."],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.date.accessioned","2021-04-14T08:24:34Z"],["dc.date.available","2021-04-14T08:24:34Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1016/j.knee.2020.05.001"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81338"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.issn","0968-0160"],["dc.title","Hepatocyte growth factor and matrix metalloprotease 2 levels in synovial fluid of the knee joint are correlated with clinical outcome of meniscal repair"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e0237116"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","PLoS One"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Sariisik, Ediz"],["dc.contributor.author","Zistl, Domenik"],["dc.contributor.author","Docheva, Denitsa"],["dc.contributor.author","Schilling, Arndt F."],["dc.contributor.author","Benoit, Martin"],["dc.contributor.author","Sudhop, Stefanie"],["dc.contributor.author","Clausen-Schaumann, Hauke"],["dc.contributor.editor","Dague, Etienne"],["dc.date.accessioned","2021-04-14T08:32:43Z"],["dc.date.available","2021-04-14T08:32:43Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1371/journal.pone.0237116"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/84000"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1932-6203"],["dc.title","Inadequate tissue mineralization promotes cancer cell attachment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","904"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Journal of Wound Care"],["dc.bibliographiccitation.lastpage","914"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Ernst, Jennifer"],["dc.contributor.author","Tanyeli, Murat"],["dc.contributor.author","Borchardt, Thomas"],["dc.contributor.author","Ojugo, Moses"],["dc.contributor.author","Helmke, Andreas"],["dc.contributor.author","Viöl, Wolfgang"],["dc.contributor.author","Schilling, Arndt F"],["dc.contributor.author","Felmerer, Gunther"],["dc.date.accessioned","2021-12-01T09:22:31Z"],["dc.date.available","2021-12-01T09:22:31Z"],["dc.date.issued","2021"],["dc.description.abstract","Objective: The response of different critical acute and hard-to-heal wounds to an innovative wound care modality—direct application of cold atmospheric plasma (CAP)—was investigated in this clinical case series. Method: Over an observation period of two years, acute wounds with at least one risk factor for chronification, as well as hard-to-heal wounds were treated for 180 seconds three times per week with CAP. CAP treatment was additional to standard wound care. Photographs were taken for wound documentation. The wound sizes before the first CAP treatment, after four weeks, after 12 weeks and at wound closure/end of observation time were determined using image processing software, and analysed longitudinally for the development of wound size. Results: A total of 27 wounds (19 hard-to-heal and eight acute wounds) with a mean wound area of 15cm 2 and a mean wound age of 49 months were treated with CAP and analysed. All (100%) of the acute wounds and 68% of the hard-to-heal wounds healed after an average treatment duration of 14.2 weeks. At the end of the observation period, 21% of hard-to-heal wounds were not yet closed but were reduced in size by >80%. In 11% of the hard-to-heal wounds (n=2) therapy failed. Conclusion: The results suggested a beneficial effect of additional CAP therapy on wound healing. Declaration of interest: This work was carried out within the research projects \\‘Plasma for Life\\’ (funding reference no. 13FH6I04IA) with financial support from the German Federal Ministry of Education and Research (BMBF). In the past seven years AFS has provided consulting services to Evonik and has received institutional support by Heraeus, Johnson & Johnson and Evonik. There are no royalties to disclose. The Department for Trauma Surgery, Orthopaedics and Plastic Surgery received charitable donations by CINOGY GmbH. CINOGY GmbH released the di_CAP devices and electrodes for the study. WV and AH were involved in the development of the used di_CAP device (Plasmaderm, CINOGY GmbH). WV is shareholder of the outsourced start-up company CINOGY GmbH."],["dc.identifier.doi","10.12968/jowc.2021.30.11.904"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94420"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-478"],["dc.relation.eissn","2052-2916"],["dc.relation.issn","0969-0700"],["dc.title","Effect on healing rates of wounds treated with direct cold atmospheric plasma: a case series"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","224"],["dc.bibliographiccitation.issue","03"],["dc.bibliographiccitation.journal","OP-JOURNAL"],["dc.bibliographiccitation.lastpage","230"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Oberthür, Swantje"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Schilling, Arndt"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Siggelkow, Heide"],["dc.contributor.author","Hoffmann, Daniel"],["dc.date.accessioned","2019-10-14T07:07:03Z"],["dc.date.available","2019-10-14T07:07:03Z"],["dc.date.issued","2018"],["dc.description.abstract","Zusammenfassung Atypische Femurfrakturen (AFF) stellen einen Sonderfall in der Alterstraumatologie dar und machen im Hinblick auf die Gesamtzahl der Femurfrakturen nur einen geringen Anteil aus. Im Gegensatz zur klassischen Fraktur des proximalen Femurs sind AFF subtrochantär bzw. im Schaftbereich lokalisiert, entstehen häufig ohne adäquates Unfallereignis und zeigen charakteristische Merkmale im Röntgenbild. In vielen Fällen kommt es zu einem bilateralen Auftreten von AFF. Klinisch besteht oftmals Tage bis Monate vor der Diagnose einer AFF ein Prodromalschmerz im entsprechenden Bein bzw. der Leistengegend. Durch die American Society for Bone and Mineral Research (ASBMR) wurden Haupt- und Nebenkriterien zur Definition einer atypischen Femurfraktur erstellt. Diese sollen die Diagnosestellung erleichtern. Zu den Hauptkriterium zählen u. a. die peri- oder endostale Verdickung der lateralen Kortikalis sowie das Fehlen einer Frakturtrümmerzone. Um eine Fraktur als AFF zu definieren, müssen mindestens 4 der 5 Hauptkriterien erfüllt sein. Es gibt Evidenz für eine Korrelation zwischen AFF und der (Langzeit-)Einnahme von Bisphosphonaten. Atypische Femurfrakturen können jedoch auch ohne Bisphosphonateinnahme auftreten. Ist eine AFF diagnostiziert, sollte die Bisphosphonattherapie pausiert werden. Für die Therapie unterscheidet man zwischen kompletter und inkompletter Fraktur. Komplette AFF werden operativ zumeist mit einer Marknagelosteosynthese stabilisiert. Inkomplette Frakturen können konservativ therapiert werden – es gibt jedoch eine hohe Versagerrate mit Progress in eine komplette Fraktur, sodass bei persistierenden Schmerzen eher die prophylaktische Marknagelosteosynthese empfohlen wird. Der Behandlungsverlauf nach bisphosphonatassoziierten AFF ist häufiger mit perioperativen Komplikationen vergesellschaftet als die Behandlung von „typischen“ Femurfrakturen. Somit ist die Kenntnis der Pathophysiologie und der Therapieoptionen der Schlüssel zur erfolgreichen Behandlung dieser Verletzung."],["dc.identifier.doi","10.1055/s-0043-117830"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62488"],["dc.language.iso","de"],["dc.relation.issn","0178-1715"],["dc.relation.issn","1439-2496"],["dc.title","Die atypische Femurfraktur als Sonderfall der Alterstraumatologie"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1777"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Biotechnology Letters"],["dc.bibliographiccitation.lastpage","1788"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Liu, Yuanxing"],["dc.contributor.author","Liu, Xi"],["dc.contributor.author","Ye, Pengxiang"],["dc.contributor.author","Zhang, Xiafei"],["dc.contributor.author","Schilling, Arndt F."],["dc.contributor.author","Yonezawa, Tomo"],["dc.contributor.author","Gao, Guifang"],["dc.contributor.author","Cui, Xiaofeng"],["dc.date.accessioned","2020-12-10T14:11:22Z"],["dc.date.available","2020-12-10T14:11:22Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s10529-020-02907-z"],["dc.identifier.eissn","1573-6776"],["dc.identifier.issn","0141-5492"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71059"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","MicroRNA-191 regulates differentiation and migration of mesenchymal stem cells and their paracrine effect on angiogenesis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","365"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Biomedicines"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Moog, Philipp"],["dc.contributor.author","Schams, Rahmin"],["dc.contributor.author","Schneidinger, Alexander"],["dc.contributor.author","Schilling, Arndt F."],["dc.contributor.author","Machens, Hans-Günther"],["dc.contributor.author","Hadjipanayi, Ektoras"],["dc.contributor.author","Dornseifer, Ulf"],["dc.date.accessioned","2021-04-14T08:32:36Z"],["dc.date.available","2021-04-14T08:32:36Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.3390/biomedicines8090365"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83962"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.publisher","MDPI"],["dc.relation.eissn","2227-9059"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Effect of Hypoxia Preconditioned Secretomes on Lymphangiogenic and Angiogenic Sprouting: An in Vitro Analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]