Claussen, Maike

[["dc.bibliographiccitation.firstpage","13"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","FEBS Letters"],["dc.bibliographiccitation.lastpage","18"],["dc.bibliographiccitation.volume","583"],["dc.contributor.author","El Bounkari, Omar"],["dc.contributor.author","Guria, Anuja"],["dc.contributor.author","Klebba-Faerber, Sabine"],["dc.contributor.author","Claussen, Maike"],["dc.contributor.author","Pieler, Tomas"],["dc.contributor.author","Griffiths, John R."],["dc.contributor.author","Whetton, Anthony D."],["dc.contributor.author","Koch, Alexandra"],["dc.contributor.author","Tamura, Teruko"],["dc.date.accessioned","2018-11-07T08:33:34Z"],["dc.date.available","2018-11-07T08:33:34Z"],["dc.date.issued","2009"],["dc.description.abstract","THOC7 and Fms-interacting protein (FMIP) are members of the THO complex that associate with the mRNA export apparatus. FMIP is a nucleocytoplasmic shuttling protein with a nuclear localization signal (NLS), whereas THOC7 does not contain a typical NLS motif. We show here that THOC7 (50-137, amino acid numbers) binds to the N-terminal portion (1-199) of FMIP directly. FMIP is detected mainly in the nucleus. In the absence of exogenous FMIP, THOC7 resides mainly in the cytoplasm, while in the presence of FMIP, THOC7 is transported into the nucleus with FMIP. Furthermore, THOC7 lacking the FMIP binding site does not co-localize with FMIP, indicating that THOC7/FMIP interaction is required for nuclear localization of THOC7."],["dc.identifier.doi","10.1016/j.febslet.2008.11.024"],["dc.identifier.isi","000261949200003"],["dc.identifier.pmid","19059247"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17610"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0014-5793"],["dc.title","Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP)"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","214"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Developmental Biology"],["dc.bibliographiccitation.lastpage","224"],["dc.bibliographiccitation.volume","405"],["dc.contributor.author","Bauermeister, Diana"],["dc.contributor.author","Claussen, Maike"],["dc.contributor.author","Pieler, Tomas"],["dc.date.accessioned","2018-11-07T09:51:39Z"],["dc.date.available","2018-11-07T09:51:39Z"],["dc.date.issued","2015"],["dc.description.abstract","The localization of certain mRNAs to the vegetal cortex of Xenopus oocytes is of crucial importance for germ cell development and early embryonic patterning. Vegetal RNA localization is mediated by cis-acting RNA localization elements (LE). Several proteins assemble on the RNA LE and direct transport to the vegetal cortex. Although a number of localization RNP components have been identified, their full composition is unknown. In an RNA affinity purification approach, using the dead end 1 (dnd1) RNA LE, we identified Xenopus Celf1 as a novel component of vegetal localization RNP complexes. Celf1 is part of an RNP complex together with known vegetal localization factors and shows specific interactions with LEs from several but not all vegetally localizing RNAs. Immunostaining experiments reveal co-localization of Celf1 with vegetally localizing RNA and with known localization factors. Inhibition of Celf1 protein binding by localization element mutagenesis as well as Celf1 overexpression interfere with vegetal RNA localization. These results argue for a role of Celf1 in vegetal RNA localization during Xeno pus oogenesis. (C) 2015 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.ydbio.2015.07.005"],["dc.identifier.isi","000360255800004"],["dc.identifier.pmid","26164657"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35956"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","1095-564X"],["dc.relation.issn","0012-1606"],["dc.title","A novel role for Celf1 in vegetal RNA localization during Xenopus oogenesis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Developmental Biology"],["dc.bibliographiccitation.lastpage","11"],["dc.bibliographiccitation.volume","291"],["dc.contributor.author","Horvay, K."],["dc.contributor.author","Claussen, M."],["dc.contributor.author","Katzer, M."],["dc.contributor.author","Landgrebe, J."],["dc.contributor.author","Pieler, T."],["dc.date.accessioned","2018-11-07T10:10:51Z"],["dc.date.available","2018-11-07T10:10:51Z"],["dc.date.issued","2006"],["dc.description.abstract","Germ plasm formation is considered to define the first step in germ cell development. Xenopus Dead end represents a germ plasm specific transcript that is homologous to the previously characterized zebrafish dead end, which is required for germ cell migration and survival. XDead end mRNA localizes to the vegetal pole of Xenopus oocytes; in contrast to all other known germ plasm associated transcripts in Xenopus, XDead end is transported via the late transport pathway, suggesting a different mode of genii plasm restriction. Vegetal localization in the oocyte is achieved via a localization element mapping to a 251 nucleotide element in the 3'-UTR. This RNA sequence binds to a set of proteins characteristic for the late localization pathway and to one additional protein of 38 kDa. Inhibition of XDead end translation in Xenopus embryos results in a loss of primordial germ cells at tadpole stages of development. Early specification events do not seem to be affected, but the primordial germ cells fail to migrate dorsally and eventually disappear. This phenotype is very similar to what has been observed in the zebrafish, indicating that the role of XDead end in genu cell development has been conserved in evolution. (c) 2005 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.ydbio.2005.06.013"],["dc.identifier.isi","236128300001"],["dc.identifier.pmid","16448642"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39936"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","0012-1606"],["dc.title","Xenopus Dead end mRNA is a localized maternal determinant that serves a conserved function in germ cell development"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","277"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Mechanisms of Development"],["dc.bibliographiccitation.lastpage","288"],["dc.bibliographiccitation.volume","120"],["dc.contributor.author","Chen, Y."],["dc.contributor.author","Juergens, K."],["dc.contributor.author","Hollemann, T."],["dc.contributor.author","Claussen, M."],["dc.contributor.author","Ramadori, Giuliano"],["dc.contributor.author","Pieler, T."],["dc.date.accessioned","2018-11-07T10:40:41Z"],["dc.date.available","2018-11-07T10:40:41Z"],["dc.date.issued","2003"],["dc.description.abstract","Early regulatory events in respect to the embryonic development of the vertebrate liver are only poorly defined. A better understanding of the gene network that mediates the formation of hepatocytes from pluripotent embryonic precursor cells may help to establish in vitro protocols for hepatocyte differentiation. Here, we describe our first attempts to make use of early embryonic explants from the amphibian Xenopus laevis in order to address these questions. We have identified several novel embryonic liver and intestine marker genes in a random expression pattern screen with cDNA libraries derived from the embryonic liver anlage and from the adult liver of Xenopus laevis. Based on their embryonic expression characteristics, these genes, together with the previously known ones, can be categorized into four different groups: the liver specific group (LS), the liver and intestine group A (LIA), the liver and intestine group B (LIB), and the intestine specific group (IS). Dissociation of endodermal explants isolated from early neurula stage embryos reveals that all genes in the LIB and IS groups are expressed in a cell-autonomous manner. In contrast, expression of genes in the LS and LIA groups requires cell-cell interactions. The regular temporal expression profile of genes in all four groups is mimicked in ectodermal explants from early embryos, reprogrammed by co-injection of VegT and P-catenin mRNAs. FGF signaling is found to be required for the induction of liver specific marker (LS group) gene expression in the same system. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved."],["dc.identifier.doi","10.1016/S0925-4773(02)00460-4"],["dc.identifier.isi","000181258700002"],["dc.identifier.pmid","12591597"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46359"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0925-4773"],["dc.title","Cell-autonomous and signal-dependent expression of liver and intestine marker genes in pluripotent precursor cell's from Xenopus embryos"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","475"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","American Journal of Medical Genetics"],["dc.bibliographiccitation.lastpage","478"],["dc.bibliographiccitation.volume","71"],["dc.contributor.author","Heim, P."],["dc.contributor.author","Claussen, M."],["dc.contributor.author","Hoffmann, B."],["dc.contributor.author","Conzelmann, E."],["dc.contributor.author","Gärtner, J."],["dc.contributor.author","Harzer, K."],["dc.contributor.author","Hunneman, D. H."],["dc.contributor.author","Kohler, W."],["dc.contributor.author","Kurlemann, G."],["dc.contributor.author","Kohlschütter, A."],["dc.date.accessioned","2018-04-23T11:47:32Z"],["dc.date.available","2018-04-23T11:47:32Z"],["dc.date.issued","1997"],["dc.description.abstract","Through a survey of all departments of pediatrics, neurology and neuropathology in Germany, we calculated the incidence of all major forms of leukodystrophy. Only diagnoses based on specific biochemical tests in association with typical findings and/or neuroradiologically proven white matter involvement were accepted, In accordance with these strict criteria, 617 cases of leuko-dystrophy were found (incidence of all forms: app. 2.0/100,000), Minimal incidence was estimated at 0.8/100,000 for adrenoleugodystrophy/adrenomyeloneuropathy (ALD/AMN), 0.6/100,000 for metachromatic leukodystrophy (MLD), and 0.6/100,000 for Krabbe disease. Thus ALD/AMN is apparently underdiagnosed in Germany. A considerable proportion of leukodystrophies could not be classified in spite of adequate diagnostic procedures in experienced centers."],["dc.identifier.gro","3144591"],["dc.identifier.isi","A1997XT64000020"],["dc.identifier.pmid","9286459"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/2231"],["dc.language.iso","en"],["dc.notes.intern","lifescience updates Crossref Import"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0148-7299"],["dc.relation.issn","0148-7299"],["dc.title","Leukodystrophy incidence in Germany"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4263"],["dc.bibliographiccitation.issue","17"],["dc.bibliographiccitation.journal","Development"],["dc.bibliographiccitation.lastpage","4273"],["dc.bibliographiccitation.volume","131"],["dc.contributor.author","Claussen, M."],["dc.contributor.author","Horvay, K."],["dc.contributor.author","Pieler, T."],["dc.date.accessioned","2018-11-07T10:45:54Z"],["dc.date.available","2018-11-07T10:45:54Z"],["dc.date.issued","2004"],["dc.description.abstract","RNAs that localize to the vegetal cortex of Xenopus oocytes are involved in early embryonic patterning and cell fate specification. Two mechanistically distinct pathways lead to RNA enrichment at the vegetal cortex: the early and the late. While several candidate proteins that seem to operate in the late localization pathway have been identified, proteins involved in the early pathway remain to be identified. In this study, we report on the isolation of a novel vegetally localized RNA in Xenopus oocytes that makes use of the early pathway and encodes a protein with a conserved but functionally uncharacterized NIF-motif. The localization signal of XNIF was mapped to a 300-nucleotide region in the 5'-UTR, which is able to mediate both accumulation to the mitochondrial cloud in stage I oocytes, as well as vegetal transport in later stage oocytes. The XNIF-LE contains 16 copies of the previously defined CAC-containing signal motifs for RNA localization. A critical number of such repeats seems to be required for accumulation in the mitochondrial cloud along the early pathway, but additional repeats seem to be required for localization along the late pathway. Cross-linking experiments identify two novel proteins of 62 and 64 kDa that interact with the XNIF-LE but not with the Vg1-LE that operates in the late pathway. Conversely, at least two of the previously identified VgRBPs, Vg1RBP1 and Prrp, also bind to the XNIF-LE. Thus, overlapping, but not identical, protein machineries mediate vegetal RNA localization along early and late pathways in Xenopus oocytes."],["dc.identifier.doi","10.1242/dev.01283"],["dc.identifier.isi","000224138000013"],["dc.identifier.pmid","15294863"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47611"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Company Of Biologists Ltd"],["dc.relation.issn","0950-1991"],["dc.title","Evidence for overlapping, but not identical, protein machineries operating in vegetal RNA localization along early and late pathways in Xenopus oocytes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","270"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Developmental Biology"],["dc.bibliographiccitation.lastpage","284"],["dc.bibliographiccitation.volume","266"],["dc.contributor.author","Claussen, M."],["dc.contributor.author","Pieler, T."],["dc.date.accessioned","2018-11-07T10:51:08Z"],["dc.date.available","2018-11-07T10:51:08Z"],["dc.date.issued","2004"],["dc.description.abstract","Vegetally localized RNAs in Xenopus laevis oocytes are involved in the patterning of the early embryo as well as in cell fate specification. Here we report on the isolation and characterization of a novel, vegetally localized RNA in Xenopus oocytes termed Xvelo1. It encodes a protein of unknown biological function and it represents an antisense RNA for XPcl over a length of more than 1.8 kb. Xvelo1 exhibits a localization pattern reminiscent of the late pathway RNAs Vg1 and VegT; it contains RNA localization elements (LE) which do not match with the consensus structural features as deduced from Vg1 and VegT LEs. Nevertheless, the protein binding pattern as observed for Xvelo1-LE in UV cross-linking experiments and coimmunoprecipitation assays is largely overlapping with the one obtained for Vg1-LE. These observations suggest that the structural features recognized by the protein machinery that drives localization of maternal mRNAs along the late pathway in Xenopus oocytes must be redefined. (C) 2003 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.ydbio.2003.09.043"],["dc.identifier.isi","189129300004"],["dc.identifier.pmid","14738876"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48819"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","0012-1606"],["dc.title","Xvelo1 uses a novel 75-nucleotide signal sequence that drives vegetal localization along the late pathway in Xenopus oocytes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3777"],["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","Molecular Biology of the Cell"],["dc.bibliographiccitation.lastpage","3787"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Claussen, Maike"],["dc.contributor.author","Lingner, Thomas"],["dc.contributor.author","Pommerenke, Claudia"],["dc.contributor.author","Opitz, Lennart"],["dc.contributor.author","Salinas, Gabriela"],["dc.contributor.author","Pieler, Tomas"],["dc.date.accessioned","2018-11-07T09:49:18Z"],["dc.date.available","2018-11-07T09:49:18Z"],["dc.date.issued","2015"],["dc.description.abstract","RNAs that localize to the vegetal cortex during Xenopus laevis oogenesis have been reported to function in germ layer patterning, axis determination, and development of the primordial germ cells. Here we report on the genome-wide, comparative analysis of differentially localizing RNAs in Xenopus laevis and Xenopus tropicalis oocytes, revealing a surprisingly weak degree of conservation in respect to the identity of animally as well as vegetally enriched transcripts in these closely related species. Heterologous RNA injections and protein binding studies indicate that the different RNA localization patterns in these two species are due to gain/loss of cis-acting localization signals rather than to differences in the RNA-localizing machinery."],["dc.identifier.doi","10.1091/mbc.E15-02-0115"],["dc.identifier.isi","000366322200015"],["dc.identifier.pmid","26337391"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12732"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35480"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Cell Biology"],["dc.relation.issn","1939-4586"],["dc.relation.issn","1059-1524"],["dc.rights","CC BY-NC-SA 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-sa/3.0"],["dc.title","Global analysis of asymmetric RNA enrichment in oocytes reveals low conservation between closely related Xenopus species"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4722"],["dc.bibliographiccitation.issue","22"],["dc.bibliographiccitation.journal","FEBS Journal"],["dc.bibliographiccitation.lastpage","4731"],["dc.bibliographiccitation.volume","277"],["dc.contributor.author","Loeber, Jana"],["dc.contributor.author","Claussen, Maike"],["dc.contributor.author","Jahn, Olaf"],["dc.contributor.author","Pieler, Tomas"],["dc.date.accessioned","2018-11-07T08:37:31Z"],["dc.date.available","2018-11-07T08:37:31Z"],["dc.date.issued","2010"],["dc.description.abstract","Localization of a specific subset of maternal mRNAs to the vegetal cortex of Xenopus oocytes is important for the regulation of germ layer formation and germ cell development. It is driven by vegetal localization complexes that are formed with the corresponding signal sequences in the untranslated regions of the mRNAs and with a number of different so-called localization proteins. In the context of the present study, we incorporated tagged variants of the known localization protein Vg1RBP into vegetal localization complexes by means of oocyte microinjection. Immunoprecipitation of the corresponding RNPs allowed for the identification of novel Vg1RBP-associated proteins, such as the embryonic poly( A) binding protein, the Y-box RNA-packaging protein 2B and the oocyte-specific version of the elongation factor 1 alpha (42Sp50). Incorporation of 42Sp50 into localization RNPs could be confirmed by co-immunoprecipitation of Vg1RBP and Staufen1 with myc-tagged 42Sp50. Furthermore, myc-42Sp50 was found to co-sediment with the same two proteins in large, RNAse-sensitive complexes, as well as to associate specifically with several vegetally localizing mRNAs but not with nonlocalized control RNAs. Finally, oocyte microinjection experiments reveal that 42Sp50 is a protein that shuttles between the nucleus and cytoplasm. Taken together, these observations provide evidence for a novel function of 42Sp50 in the context of vegetal mRNA transport in Xenopus oocytes."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft"],["dc.identifier.doi","10.1111/j.1742-4658.2010.07878.x"],["dc.identifier.isi","000283600300014"],["dc.identifier.pmid","20977669"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18551"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1742-464X"],["dc.title","Interaction of 42Sp50 with the vegetal RNA localization machinery in Xenopus laevis oocytes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","873"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","RNA Biology"],["dc.bibliographiccitation.lastpage","882"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Claussen, Maike"],["dc.contributor.author","Tarbashevich, Katsiaryna"],["dc.contributor.author","Pieler, Tomas"],["dc.date.accessioned","2018-11-07T08:51:54Z"],["dc.date.available","2018-11-07T08:51:54Z"],["dc.date.issued","2011"],["dc.description.abstract","Grip2.1 is a conserved PDZ-domain protein with a function in the context of primordial germ cell development and migration in Xenopus embryos. Its mRNA is maternally supplied and found to be associated with the germ plasm, located at the tip of the vegetal cortex in Xenopus oocytes. Here, we demonstrate that the 3'-UTR of XGrip2.1 contains a 211 nucleotide RNA signal sequence that promotes localization to the mitochondrial cloud via the early localization pathway upon injection into stage I oocytes. The same element is also capable of using the late transport pathway if injected into stage III/IV oocytes. In vitro protein interaction studies reveal binding to ElrA/B, Vg1RBP and VgRBP60, proteins that have previously been associated with the vegetal localization machinery. Mutational interference with Vg1RBP and VgRBP60 binding severely reduces early and late localization activity. Selective interference with Vg1RBP binding significantly reduces late localization while having only a mild effect on localization to the mitochondrial cloud, indicating that the signal sequences and protein machinery required for early and late pathway localization though overlapping are not identical."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft"],["dc.identifier.doi","10.4161/rna.8.5.16028"],["dc.identifier.isi","000296567200021"],["dc.identifier.pmid","21788733"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22044"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Landes Bioscience"],["dc.relation.issn","1547-6286"],["dc.title","Functional dissection of the RNA signal sequence responsible for vegetal localization of XGrip2.1 mRNA in Xenopus oocytes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]