Werner, Carola

[["dc.bibliographiccitation.firstpage","595"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Annals of the Rheumatic Diseases"],["dc.bibliographiccitation.lastpage","600"],["dc.bibliographiccitation.volume","65"],["dc.contributor.author","Scheel, Alexander Konrad"],["dc.contributor.author","Hermann, Kay Geert A."],["dc.contributor.author","Ohrndorf, S."],["dc.contributor.author","Werner, C."],["dc.contributor.author","Schirmer, Claudia"],["dc.contributor.author","Detert, J."],["dc.contributor.author","Bollow, M."],["dc.contributor.author","Hamm, Bernd"],["dc.contributor.author","Mueller, Gerhard A."],["dc.contributor.author","Burmester, Gerd-Ruediger"],["dc.contributor.author","Backhaus, M."],["dc.date.accessioned","2018-11-07T09:50:42Z"],["dc.date.available","2018-11-07T09:50:42Z"],["dc.date.issued","2006"],["dc.description.abstract","Objective: To perform a prospective long term follow up study comparing conventional radiography (CR), ultrasonography ( US), and magnetic resonance imaging (MRI) in the detection of bone erosions and synovitis in rheumatoid arthritis ( RA) finger joints. Methods: The metacarpophalangeal and proximal interphalangeal joints II - V ( 128 joints) of the clinically dominant hand of 16 patients with RA were included. Follow up joint by joint comparisons for erosions and synovitis were made. Results: At baseline, CR detected erosions in 5/128 (4%) of all joints, US in 12/128 (9%), and MRI in 34/ 128 (27%). Seven years later, an increase of joints with erosions was found with CR (26%), US (49%) ( p< 0.001 each), and MRI (32%, NS). In contrast, joint swelling and tenderness assessed by clinical examination were decreased at follow up ( p = 0.2, p< 0.001). A significant reduction in synovitis with US and MRI ( p< 0.001 each) was seen. In CR, 12 patients did not have any erosions at baseline, while in 10/ 12 patients erosions were detected in 25/96 ( 26%) joints after 7 years. US initially detected erosions in 9 joints, of which two of these joints with erosions were seen by CR at follow up. MRI initially found 34 erosions, of which 14 (41%) were then detected by CR. Conclusion: After 7 years, an increase of bone erosions was detected by all imaging modalities. In contrast, clinical improvement and regression of synovitis were seen only with US and MRI. More than one third of erosions previously detected by MRI were seen by CR 7 years later."],["dc.identifier.doi","10.1136/ard.2005.041814"],["dc.identifier.isi","000236764900007"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35757"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","B M J Publishing Group"],["dc.relation.issn","0003-4967"],["dc.title","Prospective 7 year follow up imaging study comparing radiography, ultrasonography, and magnetic resonance imaging in rheumatoid arthritis finger joints"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","89"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","PERCEPTION & PSYCHOPHYSICS"],["dc.bibliographiccitation.lastpage","103"],["dc.bibliographiccitation.volume","66"],["dc.contributor.author","Diedrichsen, J."],["dc.contributor.author","Werner, S."],["dc.contributor.author","Schmidt, T."],["dc.contributor.author","Trommershauser, J."],["dc.date.accessioned","2018-11-07T10:53:02Z"],["dc.date.available","2018-11-07T10:53:02Z"],["dc.date.issued","2004"],["dc.description.abstract","We tested the influence of two horizontally aligned visual landmarks on pointing movements to memorized targets, to investigate whether the visuomotor system can make use of an egocentric representation unaffected by visual context. The endpoints of pointing movements were systematically distorted toward the nearest visual landmark, indicating that spatial representations included both target and nontarget information. These distortions were not due to the presence of the landmarks during the movement but, rather, to their presence in the encoding phase. Qualitatively similar distortions were present even with the shortest possible retention phase, when the target was extinguished at movement onset. Finally, we found the same pattern of distortion when participants were forced to remember the target within an allocentric frame of reference. We argue that even early memory representations for pointing movements are influenced by visual information in the surrounding visual field."],["dc.identifier.doi","10.3758/BF03194864"],["dc.identifier.isi","000220232900008"],["dc.identifier.pmid","15095943"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49257"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Psychonomic Soc Inc"],["dc.relation.issn","0031-5117"],["dc.title","Immediate spatial distortions of pointing movements induced by visual landmarks"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1022"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","The Angle Orthodontist"],["dc.bibliographiccitation.lastpage","1027"],["dc.bibliographiccitation.volume","76"],["dc.contributor.author","Attin, Rengin"],["dc.contributor.author","Ilse, Anika"],["dc.contributor.author","Werner, Carola"],["dc.contributor.author","Wiegand, Annette"],["dc.contributor.author","Attin, Thomas"],["dc.date.accessioned","2018-11-07T08:59:27Z"],["dc.date.available","2018-11-07T08:59:27Z"],["dc.date.issued","2006"],["dc.description.abstract","Objective: To evaluate the recolonization pattern of Mutans streptococci (ms) on densely colonized teeth with fixed orthodontic appliances after treatment with a highly concentrated (36%) chlorhexidine varnish. Materials and Methods: Healthy subjects (n = 19) with fixed orthodontic appliances and high bacterial ms counts in saliva were recruited. In order to establish a baseline registration, plaque adjacent to brackets was sampled and cultivated on Dentocult(R) strips. Following professional tooth cleaning, chlorhexidine varnish was applied on all teeth for 8 minutes. The degree of recolonization with ms was assessed 2 weeks after varnish application in plaque around the brackets. For statistical analysis, the data were subjected to a repeated measures design. Results: After 2 weeks, ms counts were reduced as compared to baseline values. However, the reduction only weakly met statistical significance (P =.049). Conclusions: The application of a highly concentrated chlorhexidine varnish in patients with fixed orthodontic appliances does not result in a distinct reduction of ms numbers 2 weeks after treatment."],["dc.identifier.doi","10.2319/070605-218"],["dc.identifier.isi","000241788000017"],["dc.identifier.pmid","17090155"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23901"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0003-3219"],["dc.relation.orgunit","Poliklinik für Präventive Zahnmedizin, Parodontologie und Kariologie"],["dc.title","Antimicrobial effectiveness of a highly concentrated chlorhexidine varnish treatment in teenagers with fixed orthodontic appliances"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","489"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","European Journal of Orthodontics"],["dc.bibliographiccitation.lastpage","493"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Attin, Rengin"],["dc.contributor.author","Thon, C."],["dc.contributor.author","Schlagenhauf, U."],["dc.contributor.author","Werner, C."],["dc.contributor.author","Wiegand, Annette"],["dc.contributor.author","Hannig, C."],["dc.contributor.author","Attin, T."],["dc.date.accessioned","2018-11-07T10:55:16Z"],["dc.date.available","2018-11-07T10:55:16Z"],["dc.date.issued","2005"],["dc.description.abstract","The aim of the present study was to compare the recolonization pattern of mutans streptococci on densely colonized teeth with and without fixed orthodontic appliances after treatment with a 40 per cent chlorhexidine (CHX) varnish (EC 40 (R), Explore). Healthy subjects free of carious lesions requiring fixed orthodontic appliance treatment but with high bacterial mutans streptococci saliva counts were recruited (n = 10). For baseline registration, plaque from buccal sites was sampled and cultivated on Dentocult (R) strips. Following professional tooth cleaning, CHX varnish was applied to all teeth for 8 minutes. Subsequently, orthodontic brackets and bands were inserted in either the upper or lower arch. Eight weeks after varnish application the degree of recolonization with mutans streptococci was reassessed on the buccal sites. Statistical analysis showed that recolonization with mutans streptococci was significantly higher (P < 0.05) on teeth with orthodontic appliances. The results indicate that the use of fixed orthodontic appliances creates artificial environments suitable for the proliferation of mutans streptococci after CHX varnish suppression."],["dc.identifier.doi","10.1093/ejo/cji018"],["dc.identifier.isi","000232425400011"],["dc.identifier.pmid","15961573"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49750"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","0141-5387"],["dc.title","Recolonization of mutans steptococci on teeth with orthodontic appliances after antimicrobial therapy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","416"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Computational Statistics & Data Analysis"],["dc.bibliographiccitation.lastpage","427"],["dc.bibliographiccitation.volume","53"],["dc.contributor.author","Ahmad, Mohiuddin"],["dc.contributor.author","Werner, C."],["dc.contributor.author","Brunner, E."],["dc.date.accessioned","2018-11-07T11:07:56Z"],["dc.date.available","2018-11-07T11:07:56Z"],["dc.date.issued","2008"],["dc.description.abstract","A one sample statistic is derived for the analysis of repeated measures design when the data are multivariate normal and the dimension, d, can be large compared to the sample size, n, i.e. d > n. Quadratic and bilinear forms are used to define the statistic based on Box's approximation [Box, G.E.P., 1954. Some theorems on quadratic forms applied in the study of analysis of variance problems 1: Effect of inequality of variance in the one-way classification. Annals of Mathematical Statistics 25 (2), 290-302]. The statistic has an approximate x(f)(2) distribution, even for moderately large n. One of the main advantages of the statistic is that it can be used both for unstructured and factorially structured repeated measures designs. In the asymptotic derivations, it is assumed that IT -> infinity while d remains finite and fixed. However, it is demonstrated through simulations that for n as small as 10, the new statistic very closely approximates the target distribution, unaffected by even large values of d (d > n). The application is illustrated using a sleep lab example with n = 10, d = 18. (C) 2008 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.csda.2008.08.013"],["dc.identifier.isi","000261670000015"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6062"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52683"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0167-9473"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Analysis of high-dimensional repeated measures designs: The one sample case"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Arthritis & Rheumatism"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Song, In-Ho"],["dc.contributor.author","Hermann, Kay-Geert"],["dc.contributor.author","Scheel, Alexander Konrad"],["dc.contributor.author","Werner, Carola"],["dc.contributor.author","Knetsch, Torsten"],["dc.contributor.author","Schoenharting, Martin"],["dc.contributor.author","Burmester, Gerd-Ruediger"],["dc.contributor.author","Backhaus, Marina"],["dc.date.accessioned","2018-11-07T09:17:19Z"],["dc.date.available","2018-11-07T09:17:19Z"],["dc.date.issued","2006"],["dc.format.extent","S159"],["dc.identifier.isi","000240877200331"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28135"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.publisher.place","Hoboken"],["dc.relation.conference","70th Annual Scientific Meeting of the American-College-of-Rheumatology/41st Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals"],["dc.relation.eventlocation","Washington, DC"],["dc.relation.issn","0004-3591"],["dc.title","Comparison of the efficacy of contrast-enhanced ultrasonography and magnetic resonance imaging in detecting synovial process in patients with knee osteoarthritis compared to healthy subjects."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","56"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Caries Research"],["dc.bibliographiccitation.lastpage","60"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Wiegand, Annette"],["dc.contributor.author","Wegehaupt, Florian Just"],["dc.contributor.author","Werner, C."],["dc.contributor.author","Attin, T."],["dc.date.accessioned","2018-11-07T11:06:10Z"],["dc.date.available","2018-11-07T11:06:10Z"],["dc.date.issued","2007"],["dc.description.abstract","The study aimed to compare the amounts of softened enamel removable by ultrasonication and by toothbrushing abrasion of briefly eroded samples. Thirty bovine enamel samples were demineralized in hydrochloric acid (pH 2.1) for 60 s and were then either brushed with 350 brushing strokes in toothpaste slurry (group A) or distilled water (group B) or were ultrasonicated for 120 s (group C). Enamel loss was measured after 10, 20, 50 and then after every 50 brushing strokes or after 5, 30, 60 and 120 s ultrasonication. Samples were indented with a Knoop diamond after erosion, and enamel loss due to abrasion or wear was calculated from the change in indentation depth after mechanical treatment. Within- and between-group comparisons were performed by ANOVA or t test. Initially, enamel loss increased with increasing brushing treatment or ultrasonication time. Enamel loss did not increase after 300 brushing strokes in group A (534 +/- 169 nm) or 250 brushing strokes in group B (423 +/- 80 nm), or after 60 s ultrasonication (231 +/- 72 nm). Enamel loss was significantly higher in groups A and B than in group C. The results confirm that ultrasonication removes only the outer, more highly demineralized part of the softened enamel layer. Results also indicate that toothbrushing abrasion removes more softened enamel from briefly eroded enamel than ultrasonication, and therefore probably removes partly demineralized enamel from the deeper part of the softened layer. In vivo, excessive toothbrushing might remove the softened enamel layer almost completely. Copyright (c) 2007 S. Karger AG, Basel."],["dc.identifier.doi","10.1159/000096106"],["dc.identifier.isi","000242847100008"],["dc.identifier.pmid","17167260"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52244"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","0008-6568"],["dc.title","Susceptibility of acid-softened enamel to mechanical wear - Ultrasonication versus toothbrushing abrasion"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","290"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Bioinformatics"],["dc.bibliographiccitation.lastpage","294"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Morgenstern, B."],["dc.contributor.author","Frech, K."],["dc.contributor.author","Dress, A."],["dc.contributor.author","Werner, T."],["dc.date.accessioned","2022-06-08T07:59:03Z"],["dc.date.available","2022-06-08T07:59:03Z"],["dc.date.issued","1998"],["dc.identifier.doi","10.1093/bioinformatics/14.3.290"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/110620"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-575"],["dc.relation.eissn","1460-2059"],["dc.relation.issn","1367-4803"],["dc.title","DIALIGN: finding local similarities by multiple sequence alignment"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1184"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.lastpage","1188"],["dc.bibliographiccitation.volume","254"],["dc.contributor.author","von Lewinski, Friederike"],["dc.contributor.author","Werner, Carola"],["dc.contributor.author","Joern, Torsten"],["dc.contributor.author","Mohr, Alexander"],["dc.contributor.author","Sixel-Doering, Friederike"],["dc.contributor.author","Trenkwalder, Claudia"],["dc.date.accessioned","2018-11-07T10:59:09Z"],["dc.date.available","2018-11-07T10:59:09Z"],["dc.date.issued","2007"],["dc.description.abstract","Background Putaminal iron deposition is a histopathological feature of multiple system atrophy (MSA), which is not observed in patients with idiopathic Parkinson's disease (PD). T2 -weighted magnetic resonance imaging (MRI) gradient echo (GE) sequences are sensitive for paramagnetic susceptibility changes and therefore may support the clinical differential diagnosis between MSA and PD. Methods We evaluated putaminal signal intensities on 1.0 Tesla scans of 52 MSA patients, 88 patients with PD and 29 healthy control subjects. Results The typical finding in T2 GE sequences of MSA patients was a signal loss of the dorsolateral putamen, which showed a high specificity (>0.91), but was present in only a subpopulation of patients (sensitivity 0.64-0.69). The combination of the latter with additional presence of a hyperintense lateral rim in fluid attenuated inversion recovery (FLAIR) sequences increased the specificity to 0.97. Using a quantitative evaluation of putaminal signal intensities in defined regions of interest MSA and PD could be discriminated with a diagnostic accuracy (r) of up to 0.82. Conclusion Although the separation of groups remains incomplete, the use of T2 -weighted GE sequences combined with FLAIR may be helpful for the differential diagnosis of MSA versus PD considering its fast application, easy evaluation, broad availability, the specificity of findings and the presence of putaminal signal loss already at early disease stages."],["dc.identifier.doi","10.1007/s00415-006-0496-1"],["dc.identifier.isi","000249893200004"],["dc.identifier.pmid","17361340"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50633"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.relation.issn","0340-5354"],["dc.title","T2 -weighted MRI in diagnosis of multiple system atrophy - A practical approach for clinicians"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1450"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Journal of Neurochemistry"],["dc.bibliographiccitation.lastpage","1460"],["dc.bibliographiccitation.volume","91"],["dc.contributor.author","Böttcher, Tobias"],["dc.contributor.author","Ren, Hao"],["dc.contributor.author","Goiny, Michel"],["dc.contributor.author","Gerber, Joachim"],["dc.contributor.author","Lykkesfeldt, Jens"],["dc.contributor.author","Kuhnt, Ulrich"],["dc.contributor.author","Lotz, Miriam"],["dc.contributor.author","Bunkowski, Stephanie"],["dc.contributor.author","Werner, Carola"],["dc.contributor.author","Schau, Ingmar"],["dc.contributor.author","Spreer, Annette"],["dc.contributor.author","Christen, Stephan"],["dc.contributor.author","Nau, Roland"],["dc.date.accessioned","2018-11-07T10:43:30Z"],["dc.date.available","2018-11-07T10:43:30Z"],["dc.date.issued","2004"],["dc.description.abstract","In animal models of Streptococcus pneumoniae meningitis, rifampin is neuroprotective in comparison to ceftriaxone. So far it is not clear whether this can be generalized for other protein synthesis-inhibiting antimicrobial agents. We examined the effects of the bactericidal protein synthesis-inhibiting clindamycin (n = 12) on the release of proinflammatory bacterial components, the formation of neurotoxic compounds and neuronal injury compared with the standard therapy with ceftriaxone (n = 12) in a rabbit model of pneumococcal meningitis. Analysis of the CSF and histological evaluation were combined with microdialysis from the hippocampal formation and the neocortex. Compared with ceftriaxone, clindamycin reduced the release of lipoteichoic acids from the bacteria (p = 0.004) into the CSF and the CSF leucocyte count (p = 0.011). This led to lower extracellular concentrations of hydroxyl radicals (p = 0.034) and glutamate (p = 0.016) in the hippocampal formation and a subsequent reduction of extracellular glycerol levels (p = 0.018) and neuronal apoptosis in the dentate gyrus (p = 0.008). The present data document beneficial effects of clindamycin compared with ceftriaxone on various parameters linked with the pathophysiology of pneumococcal meningitis and development of neuronal injury. This study suggests neuroprotection to be a group effect of bactericidal protein synthesis-inhibiting antimicrobial agents compared with the standard therapy with beta-lactam antibiotics in meningitis."],["dc.description.sponsorship","NINDS NIH HHS [R01 NS33997]"],["dc.identifier.doi","10.1111/j.1471-4159.2004.02837.x"],["dc.identifier.isi","000226115900020"],["dc.identifier.pmid","15584921"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47067"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0022-3042"],["dc.title","Clindamycin is neuroprotective in experimental Streptococcus pneumoniae meningitis compared with ceftriaxone"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]