Gollisch, Tim

[["dc.contributor.author","Brás, Inês Caldeira"],["dc.contributor.author","Khani, Mohammad Hossein"],["dc.contributor.author","Vasili, Eftychia"],["dc.contributor.author","Möbius, Wiebke"],["dc.contributor.author","Riedel, Dietmar"],["dc.contributor.author","Parfentev, Iwan"],["dc.contributor.author","Gerhardt, Ellen"],["dc.contributor.author","Fahlbusch, Christiane"],["dc.contributor.author","Urlaub, Henning"],["dc.contributor.author","Zweckstetter, Markus"],["dc.contributor.author","Gollisch, Tim"],["dc.contributor.author","Outeiro, Tiago Fleming"],["dc.date.accessioned","2022-02-23T16:36:34Z"],["dc.date.available","2022-02-23T16:36:34Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1101/2021.07.18.452825"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/100391"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/327"],["dc.identifier.url","https://sfb1286.uni-goettingen.de/literature/publications/128"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation","SFB 1286: Quantitative Synaptologie"],["dc.relation","SFB 1286 | B08: Definition von Kaskaden molekularer Veränderungen bei Synucleinopathien während der Neurodegeneration"],["dc.relation.workinggroup","RG Gollisch (Sensory Processing in the Retina)"],["dc.relation.workinggroup","RG Möbius"],["dc.relation.workinggroup","RG Outeiro (Experimental Neurodegeneration)"],["dc.relation.workinggroup","RG Urlaub (Bioanalytische Massenspektrometrie)"],["dc.title","Common molecular mechanisms underlie the transfer of alpha-synuclein, Tau and huntingtin and modulate spontaneous activity in neuronal cells"],["dc.type","preprint"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","915"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Neuron"],["dc.bibliographiccitation.lastpage","928"],["dc.bibliographiccitation.volume","77"],["dc.contributor.author","Garvert, Mona M."],["dc.contributor.author","Gollisch, Tim"],["dc.date.accessioned","2018-11-07T09:27:07Z"],["dc.date.available","2018-11-07T09:27:07Z"],["dc.date.issued","2013"],["dc.description.abstract","Retinal ganglion cells react to changes in visual contrast by adjusting their sensitivity and temporal filtering characteristics. This contrast adaptation has primarily been studied under spatially homogeneous stimulation. Yet, ganglion cell receptive fields are often characterized by spatial subfields, providing a substrate for nonlinear spatial processing. This raises the question whether contrast adaptation follows a similar subfield structure or whether it occurs globally over the receptive field even for local stimulation. We therefore recorded ganglion cell activity in isolated salamander retinas while locally changing visual contrast. Ganglion cells showed primarily global adaptation characteristics, with notable exceptions in certain aspects of temporal filtering. Surprisingly, some changes in filtering were most pronounced for locations where contrast did not change. This seemingly paradoxical effect can be explained by a simple computational model, which emphasizes the importance of local nonlinearities in the retina and suggests a reevaluation of previously reported local contrast adaptation."],["dc.identifier.doi","10.1016/j.neuron.2012.12.030"],["dc.identifier.isi","000316162600012"],["dc.identifier.pmid","23473321"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30462"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cell Press"],["dc.relation.issn","0896-6273"],["dc.title","Local and Global Contrast Adaptation in Retinal Ganglion Cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Khani, Mohammad Hossein"],["dc.contributor.author","Gollisch, Tim"],["dc.date.accessioned","2021-03-05T08:58:52Z"],["dc.date.available","2021-03-05T08:58:52Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1101/2020.06.29.176859"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/80283"],["dc.notes.intern","DOI Import GROB-393"],["dc.title","Linear and nonlinear chromatic integration in the mouse retina"],["dc.type","preprint"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Trends in Neurosciences"],["dc.contributor.author","Zapp, Sören J."],["dc.contributor.author","Nitsche, Steffen"],["dc.contributor.author","Gollisch, Tim"],["dc.date.accessioned","2022-05-02T07:47:03Z"],["dc.date.available","2022-05-02T07:47:03Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1016/j.tins.2022.03.005"],["dc.identifier.pii","S016622362200056X"],["dc.identifier.pmid","35422357"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/107201"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/498"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-561"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation.issn","0166-2236"],["dc.relation.workinggroup","RG Gollisch (Sensory Processing in the Retina)"],["dc.rights","CC BY 4.0"],["dc.title","Retinal receptive-field substructure: scaffolding for coding and computation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","overview_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","183"],["dc.bibliographiccitation.lastpage","189"],["dc.bibliographiccitation.seriesnr","723"],["dc.bibliographiccitation.volume","723"],["dc.contributor.author","Michalakis, Stylianos"],["dc.contributor.author","Mühlfriedel, Regine"],["dc.contributor.author","Tanimoto, Naoyuki"],["dc.contributor.author","Krishnamoorthy, Vidhyasankar"],["dc.contributor.author","Koch, Susanne"],["dc.contributor.author","Fischer, M. Dominik"],["dc.contributor.author","Becirovic, Elvir"],["dc.contributor.author","Bai, Lin"],["dc.contributor.author","Huber, Gesine"],["dc.contributor.author","Beck, Susanne C."],["dc.contributor.author","Fahl, Edda"],["dc.contributor.author","Büning, Hildegard"],["dc.contributor.author","Schmidt, Jennifer"],["dc.contributor.author","Zong, Xiangang"],["dc.contributor.author","Gollisch, Tim"],["dc.contributor.author","Biel, Martin"],["dc.contributor.author","Seeliger, Mathias W."],["dc.contributor.editor","LaVail, Matthew M."],["dc.contributor.editor","Ash, John D."],["dc.contributor.editor","Anderson, Robert E."],["dc.contributor.editor","Hollyfield, Joe G."],["dc.contributor.editor","Grimm, Christian"],["dc.date.accessioned","2021-03-05T08:58:54Z"],["dc.date.available","2021-03-05T08:58:54Z"],["dc.date.issued","2012"],["dc.identifier.doi","10.1007/978-1-4614-0631-0_25"],["dc.identifier.eisbn","978-1-4614-0631-0"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/80293"],["dc.notes.intern","DOI Import GROB-393"],["dc.publisher","Springer US"],["dc.publisher.place","Boston, MA"],["dc.relation.crisseries","Advances in Experimental Medicine and Biology"],["dc.relation.eisbn","978-1-4614-0631-0"],["dc.relation.isbn","978-1-4614-0630-3"],["dc.relation.ispartof","Retinal Degenerative Diseases"],["dc.relation.issn","0065-2598"],["dc.title","Gene Therapy Restores Missing Cone-Mediated Vision in the CNGA3−/− Mouse Model of Achromatopsia"],["dc.type","book_chapter"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Rozenblit, Fernando"],["dc.contributor.author","Gollisch, Tim"],["dc.date.accessioned","2021-03-05T08:59:14Z"],["dc.date.available","2021-03-05T08:59:14Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.20944/preprints202003.0076.v2"],["dc.identifier.doi","10.20944/preprints202003.0076.v1"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/80409"],["dc.notes.intern","DOI Import GROB-393"],["dc.title","What the Salamander Eye Has Been Telling the Vision Scientist’s Brain"],["dc.type","preprint"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4754"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Investigative ophthalmology & visual science"],["dc.bibliographiccitation.lastpage","4767"],["dc.bibliographiccitation.volume","58"],["dc.contributor.author","Bemme, Sebastian"],["dc.contributor.author","Weick, Michael"],["dc.contributor.author","Gollisch, Tim"],["dc.date.accessioned","2019-07-09T11:44:50Z"],["dc.date.available","2019-07-09T11:44:50Z"],["dc.date.issued","2017-09-01"],["dc.description.abstract","Purpose: Phosphene perception is a characteristic side effect of heart rate-reducing medication that acts on hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels. It is hypothesized that these phosphenes are caused by blocking HCN channels in photoreceptors and neurons of the retina, yet the underlying changes in visual signal processing in the retina caused by the HCN channel block are still unknown. Methods: We examined the effects of pharmacologic HCN channel block on the encoding of visual signals in retinal ganglion cells by recording ganglion cell spiking activity from isolated mouse retinas mounted on multielectrode arrays. Spontaneous activity and responses to various visual stimuli were measured before, during, and after administration of 3 μM ivabradine. Results: Retinal ganglion cells generally showed slower response kinetics and reduced sensitivity to high temporal frequencies under ivabradine. Moreover, ivabradine differentially affected the sensitivity of On and Off ganglion cells. On cells showed reduced response gain, whereas Off cells experienced an increase in response threshold. In line with these differential effects, Off cells, in contrast to On cells, also showed reduced baseline activity during visual stimulation and reduced spontaneous activity. Furthermore, Off cells, but not On cells, showed increased burst-like spiking activity in the presence of ivabradine. Conclusions: Our data suggest that pharmacologic HCN channel block in the retina leads to a shift in the relative activity of the On and Off pathways of the retina. We hypothesize that this imbalance may underlie the medication-induced perception of phosphenes."],["dc.identifier.doi","10.1167/iovs.17-21572"],["dc.identifier.pmid","28973319"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14921"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59108"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation","info:eu-repo/grantAgreement/EC/H2020/724822/EU//CODE4Vision"],["dc.relation.issn","1552-5783"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.subject.ddc","006"],["dc.subject.ddc","573"],["dc.subject.ddc","612"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Benzazepines"],["dc.subject.mesh","Cardiovascular Agents"],["dc.subject.mesh","Cells, Cultured"],["dc.subject.mesh","Disease Models, Animal"],["dc.subject.mesh","Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels"],["dc.subject.mesh","Mice"],["dc.subject.mesh","Mice, Inbred C57BL"],["dc.subject.mesh","Phosphenes"],["dc.subject.mesh","Potassium Channel Blockers"],["dc.subject.mesh","Retina"],["dc.subject.mesh","Retinal Ganglion Cells"],["dc.title","Differential Effects of HCN Channel Block on On and Off Pathways in the Retina as a Potential Cause for Medication-Induced Phosphene Perception."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","7548"],["dc.bibliographiccitation.issue","22"],["dc.bibliographiccitation.journal","Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","7561"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Takeshita, Daisuke"],["dc.contributor.author","Gollisch, Tim"],["dc.date.accessioned","2018-11-07T09:39:56Z"],["dc.date.available","2018-11-07T09:39:56Z"],["dc.date.issued","2014"],["dc.description.abstract","Throughout different sensory systems, individual neurons integrate incoming signals over their receptive fields. The characteristics of this signal integration are crucial determinants for the neurons' functions. For ganglion cells in the vertebrate retina, receptive fields are characterized by the well-known center-surround structure and, although several studies have addressed spatial integration in the receptive field center, little is known about how visual signals are integrated in the surround. Therefore, we set out here to characterize signal integration and to identify relevant nonlinearities in the receptive field surround of ganglion cells in the isolated salamander retina by recording spiking activity with extracellular electrodes under visual stimulation of the center and surround. To quantify nonlinearities of spatial integration independently of subsequent nonlinearities of spike generation, we applied the technique of iso-response measurements as follows: using closed-loop experiments, we searched for different stimulus patterns in the surround that all reduced the center-evoked spiking activity by the same amount. The identified iso-response stimuli revealed strongly nonlinear spatial integration in the receptive field surrounds of all recorded cells. Furthermore, cell types that had been shown previously to have different nonlinearities in receptive field centers showed similar surround nonlinearities but differed systematically in the adaptive characteristics of the surround. Finally, we found that there is an optimal spatial scale of surround suppression; suppression was most effective when surround stimulation was organized into subregions of several hundred micrometers in diameter, indicating that the surround is composed of subunits that have strong center-surround organization themselves."],["dc.identifier.doi","10.1523/JNEUROSCI.0413-14.2014"],["dc.identifier.isi","000337131800015"],["dc.identifier.pmid","24872559"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33405"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-393"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc Neuroscience"],["dc.relation.eissn","1529-2401"],["dc.relation.issn","0270-6474"],["dc.title","Nonlinear Spatial Integration in the Receptive Field Surround of Retinal Ganglion Cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","430"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Current Opinion in Neurobiology"],["dc.bibliographiccitation.lastpage","436"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Benda, Jan"],["dc.contributor.author","Gollisch, Tim"],["dc.contributor.author","Machens, Christian K"],["dc.contributor.author","Herz, Andreas VM"],["dc.date.accessioned","2021-03-05T08:58:06Z"],["dc.date.available","2021-03-05T08:58:06Z"],["dc.date.issued","2007"],["dc.identifier.doi","10.1016/j.conb.2007.07.009"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/80003"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-393"],["dc.relation.issn","0959-4388"],["dc.title","From response to stimulus: adaptive sampling in sensory physiology"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","36"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","HFSP Journal"],["dc.bibliographiccitation.lastpage","46"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Gollisch, Tim"],["dc.date.accessioned","2021-03-05T08:59:15Z"],["dc.date.available","2021-03-05T08:59:15Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.2976/1.3027089"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/80412"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-393"],["dc.relation.issn","1955-2068"],["dc.title","Throwing a glance at the neural code: Rapid information transmission in the visual system"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]