Rost, Ulrike

[["dc.bibliographiccitation.artnumber","1008"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Reviews of Geophysics"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Rost, S."],["dc.contributor.author","Thomas, Christoph"],["dc.date.accessioned","2018-11-07T09:42:30Z"],["dc.date.available","2018-11-07T09:42:30Z"],["dc.date.issued","2002"],["dc.description.abstract","[1] Since their development in the 1960s, seismic arrays have given a new impulse to seismology. Recordings from many uniform seismometers in a well-defined, closely spaced configuration produce high-quality and homogeneous data sets, which can be used to study the Earth's structure in great detail. Apart from an improvement of the signal-to-noise ratio due to the simple summation of the individual array recordings, seismological arrays can be used in many different ways to study the fine-scale structure of the Earth's interior. They have helped to study such different structures as the interior of volcanos, continental crust and lithosphere, global variations of seismic velocities in the mantle, the core-mantle boundary and the structure of the inner core. For this purpose many different, specialized array techniques have been developed and applied to an increasing number of high-quality array data sets. Most array methods use the ability of seismic arrays to measure the vector velocity of an incident wave front, i.e., slowness and back azimuth. This information can be used to distinguish between different seismic phases, separate waves from different seismic events and improve the signal-to-noise ratio by stacking with respect to the varying slowness of different phases. The vector velocity information of scattered or reflected phases can be used to determine the region of the Earth from whence the seismic energy comes and with what structures it interacted. Therefore seismic arrays are perfectly suited to study the small-scale structure and variations of the material properties of the Earth. In this review we will give an introduction to various array techniques which have been developed since the 1960s. For each of these array techniques we give the basic mathematical equations and show examples of applications. The advantages and disadvantages and the appropriate applications and restrictions of the techniques will also be discussed. The main methods discussed are the beam-forming method, which forms the basis for several other methods, different slant stacking techniques, and frequency-wave number analysis. Finally, some methods used in exploration geophysics that have been adopted for global seismology are introduced. This is followed by a description of temporary and permanent arrays installed in the past, as well as existing arrays and seismic networks. We highlight their purposes and discuss briefly the advantages and disadvantages of different array configurations."],["dc.identifier.doi","10.1029/2000RG000100"],["dc.identifier.isi","000181023300002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33967"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Geophysical Union"],["dc.relation.issn","1944-9208"],["dc.relation.issn","8755-1209"],["dc.title","Array seismology: Methods and applications"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Chem. Sci."],["dc.contributor.author","Rost, U."],["dc.contributor.author","Steinem, Claudia"],["dc.contributor.author","Diederichsen, U."],["dc.date.accessioned","2016-06-09T11:12:42Z"],["dc.date.accessioned","2021-10-27T13:12:22Z"],["dc.date.available","2016-06-09T11:12:42Z"],["dc.date.available","2021-10-27T13:12:22Z"],["dc.date.issued","2016"],["dc.description.abstract","Transmembrane b-peptide helices and their association in lipid membranes are still widely unexplored. We designed and synthesized transmembrane b-peptides harboring different numbers of D-b3-glutamine residues (hGln) by solid phase peptide synthesis. By means of circular dichroism spectroscopic measurements, the secondary structure of the b-peptides reconstituted into unilamellar vesicles was determined to be similar to a right-handed 314-helix. Fluorescence spectroscopy using D-b3-tryptophan residues strongly suggested a transmembrane orientation. Two or three hGln served as recognition units between the helices to allow helix–helix assembly driven by hydrogen bond formation. The association state of the transmembrane b-peptides as a function of the number of hGln residues was investigated by fluorescence resonance energy transfer (FRET). Therefore, two fluorescence probes (NBD, TAMRA) were covalently attached to the side chains of the transmembrane b-peptide helices. The results clearly demonstrate that only b-peptides with hGln as recognition units assemble into oligomers, presumably trimers. Temperature dependent FRET experiments further show that the strength of the helix–helix association is a function of the number of hGln residues in the helix."],["dc.identifier.doi","10.1039/C6SC01147K"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13340"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91685"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.issn","2041-6539"],["dc.relation.issn","2041-6520"],["dc.relation.orgunit","Fakultät für Chemie"],["dc.rights","Goescholar"],["dc.rights.access","openAccess"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject","b-peptides;"],["dc.title","β-Glutamine-mediated self-association of transmembrane β-peptides within lipid bilayers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","143"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Molecular Cell Biology"],["dc.bibliographiccitation.lastpage","153"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Menck, Kerstin"],["dc.contributor.author","Scharf, Christian"],["dc.contributor.author","Bleckmann, Annalen"],["dc.contributor.author","Dyck, Lydia"],["dc.contributor.author","Rost, Ulrike"],["dc.contributor.author","Wenzel, Dirk"],["dc.contributor.author","Dhople, Vishnu M."],["dc.contributor.author","Siam, Laila"],["dc.contributor.author","Pukrop, Tobias"],["dc.contributor.author","Binder, Claudia"],["dc.contributor.author","Klemm, Florian"],["dc.date.accessioned","2018-11-07T09:58:48Z"],["dc.date.available","2018-11-07T09:58:48Z"],["dc.date.issued","2015"],["dc.description.abstract","Tumor cells secrete not only a variety of soluble factors, but also extracellular vesicles that are known to support the establishment of a favorable tumor niche by influencing the surrounding stroma cells. Here we show that tumor-derived microvesicles (T-MV) also directly influence the tumor cells by enhancing their invasion in a both autologousand heterologous manner. Neither the respective vesicle-free supernatant nor MV from benign mammary cells mediate invasion. Uptake of T-MV is essential for the proinvasive effect. We further identify the highly glycosylated form of the extracellular matrix metalloproteinase inducer (EMMPRIN) as a marker for proinvasive MV. EMMPRIN is also present at high levels on MV from metastatic breast cancer patients in vivo. Anti-EMMPRIN strategies, such as MV deglycosylation, gene knockdown, and specific blocking peptides, inhibit MV-induced invasion. Interestingly, the effect of EMMPRIN-bearing MV is not mediated by matrix metalloproteinases but by activation of the p38/MAPK signaling pathway in the tumor cells. In conclusion, T-MV stimulate cancer cell invasion via a direct feedback mechanism dependent on highly glycosylated EMMPRIN."],["dc.description.sponsorship","Deutsche Krebshilfe [109615]; DFG [BI 703/3-2]; eBIO MetastaSys (BMBF)"],["dc.identifier.doi","10.1093/jmcb/mju047"],["dc.identifier.isi","000355232100006"],["dc.identifier.pmid","25503107"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13819"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37445"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","1759-4685"],["dc.relation.issn","1674-2788"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Tumor-derived microvesicles mediate human breast cancer invasion through differentially glycosylated EMMPRIN"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","937"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Thrombosis and Haemostasis"],["dc.bibliographiccitation.lastpage","941"],["dc.bibliographiccitation.volume","84"],["dc.contributor.author","Oldenburg, Johannes"],["dc.contributor.author","von Brederlow, B."],["dc.contributor.author","Fregin, A."],["dc.contributor.author","Rost, S."],["dc.contributor.author","Wolz, W."],["dc.contributor.author","Eberl, W."],["dc.contributor.author","Eber, S."],["dc.contributor.author","Lenz, E."],["dc.contributor.author","Schwabb, R."],["dc.contributor.author","Brackmann, H. H."],["dc.contributor.author","Effenberger, W."],["dc.contributor.author","Harbrecht, U."],["dc.contributor.author","Schurgers, L. J."],["dc.contributor.author","Vermeer, C."],["dc.contributor.author","Mueller, C. R."],["dc.date.accessioned","2018-11-07T11:23:07Z"],["dc.date.available","2018-11-07T11:23:07Z"],["dc.date.issued","2000"],["dc.description.abstract","Hereditary combined deficiency of the vitamin K dependent coagulation factors is a rare bleeding disorder. To date, only eleven families have been reported in the literature. The phenotype varies considerably with respect to bleeding tendency, response to vitamin K substitution and the presence of skeletal abnormalities, suggesting genetic heterogeneity. In only two of the reported families the cause of the disease has been elucidated as either a defect in the gamma -carboxylase enzyme (1) or in a protein of the vitamin K 2,3-epoxide reductase (VKOR) complex (2). Here we present a detailed phenotypic description of two new families with an autosomal recessive deficiency of all vitamin K dependent coagulation factors. In both families offspring had experienced severe or even fatal perinatal intracerebral haemorrhage. The affected children exhibit a mild deficiency of the vitamin K dependent coagulation factors that could be completely corrected by oral substitution of vitamin K. Sequencing and haplotype analysis excluded a defect within the gamma -carboxylase gene. The finding of highly increased amounts of vitamin K epoxide in all affected members of both families indicated a defect in a protein of the VKOR-multienzyme-complex. Further genetic analysis of such families will provide the basis for a more detailed understanding of the structure-function relation of the enzymes involved in vitamin K metabolism."],["dc.identifier.isi","000166080600002"],["dc.identifier.pmid","11154138"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56126"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","F K Schattauer Verlag Gmbh"],["dc.relation.issn","0340-6245"],["dc.title","Congenital deficiency of vitamin K dependent coagulation factors in two families presents as a genetic defect of the vitamin K-epoxide-reductase-complex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2525"],["dc.bibliographiccitation.issue","16"],["dc.bibliographiccitation.journal","ChemPhysChem"],["dc.bibliographiccitation.lastpage","2534"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Rost, Ulrike"],["dc.contributor.author","Xu, Yihui"],["dc.contributor.author","Salditt, Tim"],["dc.contributor.author","Diederichsen, Ulf"],["dc.date.accessioned","2017-11-28T09:52:28Z"],["dc.date.available","2017-11-28T09:52:28Z"],["dc.date.issued","2016"],["dc.description.abstract","Transmembrane β-peptides are promising candidates for the design of well-controlled membrane anchors in lipid membranes. Here, we present the synthesis of transmembrane β-peptides with and without tryptophan anchors, as well as a novel iodine-labeled d-β3-amino acid. By using one or more of the heavy-atom labeled amino acids as markers, the orientation of the helical peptide was inferred based on the electron-density profile determined by X-ray reflectivity. The β-peptides were synthesized through manual Fmoc-based solid-phase peptide synthesis (SPPS) and reconstituted in unilamellar vesicles forming a right-handed 314-helix secondary structure, as shown by circular dichroism spectroscopy. We then integrated the β-peptide into solid-supported membrane stacks and carried out X-ray reflectivity and grazing incidence small-angle X-ray scattering to determine the β-peptide orientation and its effect on the membrane bilayers. These β-peptides adopt a well-ordered transmembrane motif in the solid-supported model membrane, maintaining the basic structure of the original bilayer with some distinct alterations. Notably, the helical tilt angle, which accommodates the positive hydrophobic mismatch, induces a tilt of the acyl chains. The tilted chains, in turn, lead to a membrane thinning effect."],["dc.identifier.doi","10.1002/cphc.201600289"],["dc.identifier.fs","622329"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/10566"],["dc.language.iso","en"],["dc.notes.status","public"],["dc.relation.issn","1439-4235"],["dc.title","Heavy-Atom Labeled Transmembrane β-Peptides: Synthesis, CD-Spectroscopy, and X-ray Diffraction Studies in Model Lipid Multilayer"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","12"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Geophysical Journal International"],["dc.bibliographiccitation.lastpage","28"],["dc.bibliographiccitation.volume","147"],["dc.contributor.author","Rost, S."],["dc.contributor.author","Weber, M."],["dc.date.accessioned","2018-11-07T08:34:55Z"],["dc.date.available","2018-11-07T08:34:55Z"],["dc.date.issued","2001"],["dc.description.abstract","We present an analysis of precursors to PP produced by underside reflections from discontinuities in the upper mantle beneath the NW Pacific. The events used for this Study Occur in the western Pacific Rim (New Zealand, Fiji. Tonga. Solomon. New Guinea. Philippine Islands) and are recorded at the short-period Yellowknife Array (YKA) in northern Canada. The source-receiver combination results in PP reflection points which allow LIS to study the upper mantle structure in a corridor from the Hawaiian Islands to the Kuril subduction zone. To detect the weak precursors in the time window between the P arrival and the PP onset and to identify them as PP underside reflections. special array techniques are used. Our analysis indicates a reflector at a depth of similar to 200 km beneath the northwestern Pacific. This reflector show's strong topography of some tens of kilometres on length scales of several hundred kilometres. complicating the detection of this reflector in global or regional stacks of seismograms. Different models for the impedance jump across the reflector, the thickness and the possible fine structure of the reflector are modelled using synthetic seismograms and are compared with the data. The thickness of the reflector has to be less than 7 km and the P wave impedance contrast has to be larger than 5.0-6.5 per cent to be detected by this study. This corresponds to a P-velocity jump of similar to4 per cent assuming the PREM density model."],["dc.identifier.doi","10.1046/j.1365-246X.2001.00497.x"],["dc.identifier.isi","000171693500002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17938"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Science Ltd"],["dc.relation.issn","0956-540X"],["dc.title","A reflector at 200 km depth beneath the northwest Pacific"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1340745"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Extracellular Vesicles"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Menck, Kerstin"],["dc.contributor.author","Bleckmann, Annalen"],["dc.contributor.author","Wachter, Astrid"],["dc.contributor.author","Hennies, Bianca"],["dc.contributor.author","Ries, Lena"],["dc.contributor.author","Schulz, Matthias"],["dc.contributor.author","Balkenhol, Marko"],["dc.contributor.author","Pukrop, Tobias"],["dc.contributor.author","Schatlo, Bawarjan"],["dc.contributor.author","Rost, Ulrike"],["dc.contributor.author","Wenzel, Dirk"],["dc.contributor.author","Klemm, Florian"],["dc.contributor.author","Binder, Claudia"],["dc.date.accessioned","2020-12-10T18:15:29Z"],["dc.date.available","2020-12-10T18:15:29Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1080/20013078.2017.1340745"],["dc.identifier.eissn","2001-3078"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74861"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Characterisation of tumour-derived microvesicles in cancer patients’ blood and correlation with clinical outcome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","5900"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Chemical Science"],["dc.bibliographiccitation.lastpage","5907"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Rost, Ulrike"],["dc.contributor.author","Steinem, Claudia"],["dc.contributor.author","Diederichsen, Ulf"],["dc.date.accessioned","2017-09-07T11:54:43Z"],["dc.date.available","2017-09-07T11:54:43Z"],["dc.date.issued","2016"],["dc.description.abstract","Transmembrane beta-peptide helices and their association in lipid membranes are still widely unexplored. We designed and synthesized transmembrane beta-peptides harboring different numbers of D-beta(3)-glutamine residues ((h)Gln) by solid phase peptide synthesis. By means of circular dichroism spectroscopic measurements, the secondary structure of the beta-peptides reconstituted into unilamellar vesicles was determined to be similar to a right-handed 3(14)-helix. Fluorescence spectroscopy using D-beta(3)-tryptophan residues strongly suggested a transmembrane orientation. Two or three (h)Gln served as recognition units between the helices to allow helix-helix assembly driven by hydrogen bond formation. The association state of the transmembrane b-peptides as a function of the number of (h)Gln residues was investigated by fluorescence resonance energy transfer (FRET). Therefore, two fluorescence probes (NBD, TAMRA) were covalently attached to the side chains of the transmembrane beta-peptide helices. The results clearly demonstrate that only beta-peptides with (h)Gln as recognition units assemble into oligomers, presumably trimers. Temperature dependent FRET experiments further show that the strength of the helix-helix association is a function of the number of hGln residues in the helix."],["dc.identifier.doi","10.1039/c6sc01147k"],["dc.identifier.gro","3141748"],["dc.identifier.isi","000382488500038"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/635"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10 / Funder: Deutsche Forschungsgemeinschaft [A01, SFB 803]"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","2041-6539"],["dc.relation.issn","2041-6520"],["dc.title","β-Glutamine-mediated self-association of transmembrane beta-peptides within lipid bilayers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]