Happe, Svenja

[["dc.bibliographiccitation.firstpage","1401"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.lastpage","1406"],["dc.bibliographiccitation.volume","254"],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Kundmueller, Lotte"],["dc.contributor.author","Reichelt, Doris"],["dc.contributor.author","Husstedt, Ingo-W."],["dc.contributor.author","Evers, Stefan"],["dc.date.accessioned","2018-11-07T10:58:13Z"],["dc.date.available","2018-11-07T10:58:13Z"],["dc.date.issued","2007"],["dc.description.abstract","Background The lifetime prevalence of restless legs syndrome (RLS) is about 10 % in the general population. The association of RLS with HIV infection is unknown. We aimed to investigate the prevalence of RLS in HIV positive patients and to define predictors. Methods A standardized questionnaire was presented to 228 HIV infected patients of the HIV outpatient clinic at the Department of Neurology,University of Munster, Germany. 129 patients (57% recall; 15% female, 44 +/- 9 years; mean CD4(+) cell count 333 +/- 274/mu l, 82% under highly active antiretroviral treatment) were included in the statistical analysis. 100 age- and sex-matched controls (20 % female, 42 +/- 13 years) were recruited from waiting relatives of surgical patients. Beside demographic and disease-specific data, the questionnaire included the diagnostic questions for RLS and the RLS severity scale by the International RLS Study Group. Diagnosis of RLS was confirmed by experienced neurologists. Results 33.3% of the HIV infected patients and 7% of the controls (p < 0.001) fulfilled the diagnostic criteria for RLS. The mean RLS severity score was higher in HIV infected patients (19.5 +/- 7.2) than in controls (7.3 +/- 1.5; p < 0.001) and correlated inversely with the CD4(+) cell count (r = -0.381; p = 0.024) and the BMI (r = -0.548; p < 0.001) but not with other disease-specific factors. Conclusions HIV infected patients show a significantly higher prevalence rate for RLS than the general population. The HIV infection itself with its immunological changes and involvement of the central nervous system may predispose for a risk of RLS in HIV infected patients."],["dc.identifier.doi","10.1007/s00415-007-0563-2"],["dc.identifier.isi","000250442500015"],["dc.identifier.pmid","17934881"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50430"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.relation.issn","0340-5354"],["dc.title","Comorbidity of restless legs syndrome and HIV infection"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","184"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Sleep Medicine"],["dc.bibliographiccitation.lastpage","185"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Steinig, Jana"],["dc.contributor.author","Kloesch, Gerhard"],["dc.contributor.author","Sauter, Cornelia"],["dc.contributor.author","Zeitlhofer, Josef"],["dc.contributor.author","Happe, Svenja"],["dc.date.accessioned","2018-11-07T11:04:50Z"],["dc.date.available","2018-11-07T11:04:50Z"],["dc.date.issued","2007"],["dc.identifier.doi","10.1016/j.sleep.2006.08.008"],["dc.identifier.isi","000245090900015"],["dc.identifier.pmid","17275406"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51932"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1389-9457"],["dc.title","Actigraphy in irregular sleep-wake rhythm"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","646"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.lastpage","652"],["dc.bibliographiccitation.volume","257"],["dc.contributor.author","Boentert, Matthias"],["dc.contributor.author","Dziewas, Rainer"],["dc.contributor.author","Heidbreder, Anna"],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Kleffner, Ilka"],["dc.contributor.author","Evers, Stefan"],["dc.contributor.author","Young, Peter"],["dc.date.accessioned","2018-11-07T08:44:39Z"],["dc.date.available","2018-11-07T08:44:39Z"],["dc.date.issued","2010"],["dc.description.abstract","To investigate the prevalence of fatigue, daytime sleepiness, reduced sleep quality, and restless legs syndrome (RLS) in a large cohort of patients with Charcot-Marie-Tooth disease (CMT) and their impact on health-related quality of life (HRQoL). Participants of a web-based survey answered the Epworth Sleepiness Scale, the Pittsburgh Sleep Quality Index, the Multidimensional Fatigue Inventory, and, if the diagnostic criteria of RLS were met, the International RLS Severity Scale. Diagnosis of RLS was affirmed in screen-positive patients by means of a standardized telephone interview. HRQoL was assessed by using the SF-36 questionnaire. Age- and sex-matched control subjects were recruited from waiting relatives of surgical outpatients. 227 adult self-reported CMT patients answered the above questionnaires, 42.9% were male, and 57.1% were female. Age ranged from 18 to 78 years. Compared to controls (n = 234), CMT patients reported significantly higher fatigue, a higher extent and prevalence of daytime sleepiness and worse sleep quality. Prevalence of RLS was 18.1% in CMT patients and 5.6% in controls (p = 0.001). RLS severity was correlated with worse sleep quality and reduced HRQoL. Women with CMT were affected more often and more severely by RLS than male patients. With regard to fatigue, sleep quality, daytime sleepiness, RLS prevalence, RLS severity, and HRQoL, we did not find significant differences between genetically distinct subtypes of CMT. HRQoL is reduced in CMT patients which may be due to fatigue, sleep-related symptoms, and RLS in particular. Since causative treatment for CMT is not available, sleep-related symptoms should be recognized and treated in order to improve quality of life."],["dc.identifier.doi","10.1007/s00415-009-5390-1"],["dc.identifier.isi","000276254900022"],["dc.identifier.pmid","19937049"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6748"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20248"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.relation.issn","0340-5354"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Fatigue, reduced sleep quality and restless legs syndrome in Charcot-Marie-Tooth disease: a web-based survey"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","SLEEP"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Stiasny-Kolster, Karin"],["dc.contributor.author","Peglau, Ines"],["dc.contributor.author","Mayer, G."],["dc.contributor.author","Giani, Guido"],["dc.contributor.author","Geraedts, Max"],["dc.contributor.author","Trenkwalder, Claudia"],["dc.contributor.author","Dodel, R."],["dc.date.accessioned","2018-11-07T11:07:35Z"],["dc.date.available","2018-11-07T11:07:35Z"],["dc.date.issued","2007"],["dc.format.extent","A281"],["dc.identifier.isi","000246224900820"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52601"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Academy Sleep Medicine"],["dc.publisher.place","Westchester"],["dc.relation.conference","21st Annual Meeting of the Association-Professional-Sleep-Societies"],["dc.relation.eventlocation","Minneapolis, MN"],["dc.relation.issn","0161-8105"],["dc.title","Direct and indirect costs of restless legs syndrome (RLS)"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","SLEEP"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Garcia-Borreguero, Diego"],["dc.contributor.author","Hogl, Birgit"],["dc.contributor.author","Gschliesser, V."],["dc.contributor.author","Ferini-Strambi, Luigi"],["dc.contributor.author","Hadjigeorgiu, G."],["dc.contributor.author","Hornyak, Magdolna"],["dc.contributor.author","Stiasny-Kolster, Karin"],["dc.contributor.author","de Weerd, Al W."],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Kohnen, Ralf"],["dc.date.accessioned","2018-11-07T08:48:03Z"],["dc.date.available","2018-11-07T08:48:03Z"],["dc.date.issued","2005"],["dc.format.extent","A272"],["dc.identifier.isi","000228906101316"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21113"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Academy Sleep Medicine"],["dc.publisher.place","Westchester"],["dc.relation.conference","19th Annual Meeting of the Associated-Professional-Sleep-Societies"],["dc.relation.eventlocation","Denver, CO"],["dc.relation.issn","0161-8105"],["dc.title","Augmentation during long-term treatment with L-DOPA in restless legs syndrome: Results of a multicentric study in Europe"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","696"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Movement Disorders"],["dc.bibliographiccitation.lastpage","703"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Trenkwalder, Claudia"],["dc.contributor.author","Benes, Heike"],["dc.contributor.author","Grote, Ludger"],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Hoegl, Birgit"],["dc.contributor.author","Mathis, Johannes"],["dc.contributor.author","Saletu-Zyhlarz, Gerda M."],["dc.contributor.author","Kohnen, Ralf"],["dc.date.accessioned","2018-11-07T11:03:11Z"],["dc.date.available","2018-11-07T11:03:11Z"],["dc.date.issued","2007"],["dc.description.abstract","We report the first large-scale double-blind, randomly assigned study to compare two active dopaminergic therapies for Restless Legs Syndrome (RLS), the dopamine agonist cabergoline (CAB) and levodopa/benserazide (levodopa). Methods: Patients with idiopathic RLS were treated with fixed daily doses of 2 or 3 mg CAB or 200 or 300 mg levodopa for 30 weeks. Efficacy was assessed by changes in the IRLS (International RLS Severity Scale) and by time to disconfirmation of treatment due to loss of efficacy or augmentation. 361 of 418 screened patients (age 58 +/- 12 years, 71% females) were randomly assigned and treated (CAB: n = 178; levodopa: n = 183) in 51 centers of four European countries. Baseline IRLS total score was 25.7 +/- 6.8. The baseline-adjusted mean change from baseline to week 6 in IRLS sum score was d = -16.1 in the CAB group and d = -9.5 in the levodopa group (d = -6.6, P < 0.0001). More patients in the levodopa group (24.0%) than in the CAB group (11.9%, P = 0.0029, log-rank test) discontinued because of loss of efficacy (14.2% vs. 7.9%, P = 0.0290) or augmentation (9.8% vs. 4.0%, P = 0.0412). Adverse events (AEs) occurred in 83.1% of the CAB group and in 77.6% of the levodopa group. In both groups, most frequent AEs were gastrointestinal symptoms (CAB: 55.6%, levodopa: 30.6%, P < 0.0001). This first large-scale active controlled study in RLS showed superior efficacy of cabergoline versus levodopa after a 30-week long-term therapy. Tolerability was found more favorable with levodopa than with cabergoline. (c) 2007 Movement Disorder Society."],["dc.identifier.doi","10.1002/mds.21401"],["dc.identifier.isi","000246213100015"],["dc.identifier.pmid","17274039"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51559"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.relation.issn","0885-3185"],["dc.title","Cabergoline compared to levodopa in the treatment of patients with severe Restless Legs Syndrome: Results from a multi-center, randomized, active controlled trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","1955"],["dc.bibliographiccitation.journal","Frontiers in psychology"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Steinig, Jana"],["dc.contributor.author","Bazan, Ariane"],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Antonetti, Sarah"],["dc.contributor.author","Shevrin, Howard"],["dc.date.accessioned","2019-07-09T11:44:47Z"],["dc.date.available","2019-07-09T11:44:47Z"],["dc.date.issued","2017"],["dc.description.abstract","Primary and secondary processes are the foundational axes of the Freudian mental apparatus: one horizontally as a tendency to associate, the primary process, and one vertically as the ability for perspective taking, the secondary process. Primary process mentation is not only supposed to be dominant in the unconscious but also, for example, in dreams. The present study tests the hypothesis that the mental activity during REM-sleep has more characteristics of the primary process, while during non-REM-sleep more secondary process operations take place. Because the solving of a rebus requires the ability to non-contexually condensate the literal reading of single stimuli into a new one, rebus solving is a primary process operation by excellence. In a replication of the dream-rebus study of Shevrin and Fisher (1967), a rebus, which consisted of an image of a comb (German: \"Kamm\") and an image of a raft (German: \"Floß\"), resulting in the German rebus word \"kampflos\" (Engl.: without a struggle), was flashed subliminally (at 1 ms) to 20 participants before going to sleep. Upon consecutive awakenings participants were asked for a dream report, free associations and an image description. Based on objective association norms, there were significantly more conceptual associations referring to Kamm and Floß indexing secondary process mentation when subjects were awakened from non-REM sleep as compared to REM-awakenings. There were not significantly more rebus associations referring to kampflos indexing primary process mentation when awakened from REM-sleep as compared to non-REM awakenings. However, when the associations were scored on the basis of each subject's individual norms, there was a rebus effect with more idiosyncratic rebus associations in awakenings after REM than after non-REM-sleep. Our results support the general idea that REM-sleep is characterized by primary process thinking, while non-REM-sleep mentation follows the rules of the secondary process."],["dc.identifier.doi","10.3389/fpsyg.2017.01955"],["dc.identifier.pmid","29209244"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14900"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59095"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1664-1078"],["dc.relation.issn","1664-1078"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Processing of a Subliminal Rebus during Sleep: Idiosyncratic Primary versus Secondary Process Associations upon Awakening from REM- versus Non-REM-Sleep."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1037"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.lastpage","1043"],["dc.bibliographiccitation.volume","254"],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Baier, Paul Christian"],["dc.contributor.author","Helmschmied, Kathrin"],["dc.contributor.author","Meller, Johannes"],["dc.contributor.author","Tatsch, Klaus"],["dc.contributor.author","Paulus, Walter J."],["dc.date.accessioned","2018-11-07T11:00:13Z"],["dc.date.available","2018-11-07T11:00:13Z"],["dc.date.issued","2007"],["dc.description.abstract","Many patients with Parkinson's disease (PD) report daytime sleepiness. Its etiology, however, is still not fully understood. The aim of this study was to examine if the amount of nigrostriatal dopaminergic degeneration is associated with subjective daytime sleepiness in patients with PD. We investigated 21 patients with PD clinically and by means of [I-123] FP-CIT-SPECT (DaTSCAN(R)). Each patient filled in the Epworth sleepiness scale (ESS), the Parkinson's Disease Sleep Scale (PDSS), and the self-rating depression scale according to Zung (SDS) to assess sleepiness, sleep quality, and depressive symptoms. The mean specific dopamine transporter binding in the 21 PD patients (60.8 +/- 10.4 years, nine females, median Hoehn and Yahr stage 2.0) was decreased. Nine patients were in Hoehn and Yahr stage 1 (58.7 +/- 6.6 years, four females; ESS score 7.4 +/- 4.5; PDSS score 105.1 +/- 30.9), the other 12 patients were in Hoehn and Yahr stage 2 (62.4 +/- 12.6 years, five females; ESS score 6.7 +/- 4.7, PDSS score 97.1 +/- 25.6). Age, gender, ESS, and PDSS scores were not significantly different in both groups. However, ESS scores showed an inverse correlation with mean DAT binding in the striatum (r = -0.627, p = 0.03), the caudate nucleus (r = -0.708, p = 0.01), and the putamen (r = -0.599, p = 0.04) in patients with Hoehn and Yahr stage 2. There was no correlation of the ESS score with age, disease duration, UPDRS motor score, PDSS score, or depression score. Subjective daytime sleepiness seems to be associated with dopaminergic nigrostriatal degeneration in early PD."],["dc.identifier.doi","10.1007/s00415-006-0483-6"],["dc.identifier.isi","000249205900009"],["dc.identifier.pmid","17351722"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50880"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.relation.issn","0340-5354"],["dc.title","Association of daytime sleepiness with nigrostriatal dopaminergic degeneration in early Parkinson's disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1255"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Cephalalgia"],["dc.bibliographiccitation.lastpage","1260"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Rhode, A. M."],["dc.contributor.author","Hoesing, V. G."],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Biehl, K."],["dc.contributor.author","Young, P."],["dc.contributor.author","Evers, Stefan"],["dc.date.accessioned","2018-11-07T10:55:39Z"],["dc.date.available","2018-11-07T10:55:39Z"],["dc.date.issued","2007"],["dc.description.abstract","In order to evaluate a possible association between migraine and restless legs syndrome (RLS), we performed a case-control study on the comorbidity of RLS and migraine. Patients with migraine (n = 411) and 411 sex- and age-matched control subjects were included. Migraine was diagnosed according to International Headache Society criteria, RLS according to the criteria of the International Restless Legs Syndrome Study Group. Furthermore, all patients had to fill out a self-assessment test performance on depression [Beck's Depression Inventory (BDI)]. RLS frequency was significantly higher in migraine patients than in control subjects (17.3% vs. 5.6%, P < 0.001; odds ratio 3.5, confidence interval 2.2, 5.8). In our sample, there was no significant association between migraine and depression as defined by the BDI score (9.6% in migraine vs. 4.0% in control subjects, P = 0.190). Depression was, however, not significantly more frequent in migraine patients with RLS (13.6%) than in migraine patients without RLS (8.7%). In addition, migraine patients with RLS had a significantly higher BDI score. RLS features did not differ significantly between migraine patients with RLS and control subjects with RLS. There is an association between RLS and migraine and, in addition, a co-association with depression. The underlying mechanism, however, remains undetermined and might be related to a dysfunction of dopaminergic metabolism in migraine."],["dc.identifier.doi","10.1111/j.1468-2982.2007.01453.x"],["dc.identifier.isi","000250402900009"],["dc.identifier.pmid","17888079"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49836"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.relation.issn","0333-1024"],["dc.title","Comorbidity of migraine and restless legs syndrome - a case-control study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","SLEEP"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Trenkwalder, Claudia"],["dc.contributor.author","Canelo, M."],["dc.date.accessioned","2018-11-07T08:48:06Z"],["dc.date.available","2018-11-07T08:48:06Z"],["dc.date.issued","2005"],["dc.format.extent","A266"],["dc.identifier.isi","000228906101298"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21124"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Acad Sleep Medicine"],["dc.publisher.place","Westchester"],["dc.relation.conference","19th Annual Meeting of the Associated-Professional-Sleep-Societies"],["dc.relation.eventlocation","Denver, CO"],["dc.relation.issn","0161-8105"],["dc.title","Pramipexole reduces the impact of RLS symptoms on daily functioning"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]