Linser, Rasmus

[["dc.bibliographiccitation.firstpage","5230"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Chemical Science"],["dc.bibliographiccitation.lastpage","5234"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Chandra Mondal, Kartik"],["dc.contributor.author","Roy, Sudipta"],["dc.contributor.author","Dittrich, Birger"],["dc.contributor.author","Maity, Bholanath"],["dc.contributor.author","Dutta, Sayan"],["dc.contributor.author","Koley, Debasis"],["dc.contributor.author","Vasa, Suresh Kumar"],["dc.contributor.author","Linser, Rasmus"],["dc.contributor.author","Dechert, Sebastian"],["dc.contributor.author","Roesky, Herbert W."],["dc.date.accessioned","2015-07-17T07:46:46Z"],["dc.date.accessioned","2021-10-27T13:12:19Z"],["dc.date.available","2015-07-17T07:46:46Z"],["dc.date.available","2021-10-27T13:12:19Z"],["dc.date.issued","2015"],["dc.description.abstract","Silicondiselenide is a semiconductor and exists as an insoluble polymer (SiSe2)n which is prepared by reacting elemental silicon with selenium powder in the temperature range of 400–850 °C. Herein, we report on the synthesis, isolation, and characterization of carbene stabilized molecular silicondiselenide in the form of (cAAC)2Si2Se4 (3) [cAAC = cyclic alkyl(amino)carbene]. 3 is synthesized via reaction of diatomic silicon(0) compound (cAAC)2Si2 (2) with black selenium powder at −78 °C to room temperature. The intensely orange colored compound 3 is soluble in polar organic solvents and stable at room temperature for a month under an inert atmosphere. 3 decomposes above 245 °C. The molecular structure of 3 has been confirmed by X-ray single crystal diffraction. It is also characterized by UV-vis, IR, Raman spectroscopy and mass spectrometry. The stability, bonding, and electron density distributions of 3 have been studied by theoretical calculations."],["dc.identifier.doi","10.1039/C5SC01516B"],["dc.identifier.isi","000359214100017"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11973"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91681"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Royal Soc Chemistry"],["dc.relation.issn","2041-6539"],["dc.relation.issn","2041-6520"],["dc.relation.orgunit","Fakultät für Chemie"],["dc.rights","Goescholar"],["dc.rights.access","openAccess"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject","silicondiselenide; semiconducting; soluble molecular variant"],["dc.title","A soluble molecular variant of the semiconducting silicondiselenide"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","14893"],["dc.bibliographiccitation.journal","Nature Communications"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Jaipuria, Garima"],["dc.contributor.author","Leonov, Andrei"],["dc.contributor.author","Giller, Karin"],["dc.contributor.author","Vasa, Suresh Kumar"],["dc.contributor.author","Jaremko, Lukasz"],["dc.contributor.author","Jaremko, Mariusz"],["dc.contributor.author","Linser, Rasmus"],["dc.contributor.author","Becker, Stefan"],["dc.contributor.author","Zweckstetter, Markus"],["dc.date.accessioned","2018-11-07T10:26:01Z"],["dc.date.available","2018-11-07T10:26:01Z"],["dc.date.issued","2017"],["dc.description.abstract","Cholesterol is an important regulator of membrane protein function. However, the exact mechanisms involved in this process are still not fully understood. Here we study how the tertiary and quaternary structure of the mitochondrial translocator protein TSPO, which binds cholesterol with nanomolar affinity, is affected by this sterol. Residue-specific analysis of TSPO by solid-state NMR spectroscopy reveals a dynamic monomer-dimer equilibrium of TSPO in the membrane. Binding of cholesterol to TSPO's cholesterol-recognition motif leads to structural changes across the protein that shifts the dynamic equilibrium towards the translocator monomer. Consistent with an allosteric mechanism, a mutation within the oligomerization interface perturbs transmembrane regions located up to 35 angstrom away from the interface, reaching TSPO's cholesterol-binding motif. The lower structural stability of the intervening transmembrane regions provides a mechanistic basis for signal transmission. Our study thus reveals an allosteric signal pathway that connects membrane protein tertiary and quaternary structure with cholesterol binding."],["dc.identifier.doi","10.1038/ncomms14893"],["dc.identifier.isi","000397799000001"],["dc.identifier.pmid","28358007"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14416"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42959"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","2041-1723"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","12390"],["dc.bibliographiccitation.issue","40"],["dc.bibliographiccitation.journal","Proceedings of the National Academy of Sciences of the United States of America"],["dc.bibliographiccitation.lastpage","12395"],["dc.bibliographiccitation.volume","112"],["dc.contributor.author","Linser, Rasmus"],["dc.contributor.author","Salvi, Nicola"],["dc.contributor.author","Briones, Rodolfo"],["dc.contributor.author","Rovó, Petra"],["dc.contributor.author","de Groot, Bert L."],["dc.contributor.author","Wagner, Gerhard"],["dc.date.accessioned","2021-03-05T08:58:46Z"],["dc.date.available","2021-03-05T08:58:46Z"],["dc.date.issued","2015"],["dc.identifier.doi","10.1073/pnas.1513782112"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/80239"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-393"],["dc.relation.eissn","1091-6490"],["dc.relation.issn","0027-8424"],["dc.title","The membrane anchor of the transcriptional activator SREBP is characterized by intrinsic conformational flexibility"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1782"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Angewandte Chemie International Edition"],["dc.bibliographiccitation.lastpage","1786"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","Schweizer, Julia I."],["dc.contributor.author","Scheibel, Markus G."],["dc.contributor.author","Diefenbach, Martin"],["dc.contributor.author","Neumeyer, Felix"],["dc.contributor.author","Wuertele, Christian"],["dc.contributor.author","Kulminskaya, Natalia"],["dc.contributor.author","Linser, Rasmus"],["dc.contributor.author","Auner, Norbert"],["dc.contributor.author","Schneider, Sven"],["dc.contributor.author","Holthausen, Max C."],["dc.date.accessioned","2018-11-07T10:19:10Z"],["dc.date.available","2018-11-07T10:19:10Z"],["dc.date.issued","2016"],["dc.description.abstract","An experimental and theoretical study of the base-stabilized disilene 1 is reported, which forms at low temperatures in the disproportionation reaction of Si2Cl6 or neo-Si5Cl12 with equimolar amounts of NMe2Et. Single-crystal X-ray diffraction and quantum-chemical bonding analysis disclose an unprecedented structure in silicon chemistry featuring a dative Si -> Si single bond between two silylene moieties, Me2EtN -> SiCl2 -> Si(SiCl3)(2). The central ambiphilic SiCl2 group is linked by dative bonds to the amine donor and the bis(trichlorosilyl) silylene acceptor, which leads to push-pull stabilization. Based on experimental and theoretical examinations a formation mechanism is presented that involves an autocatalytic reaction of the intermediately formed anion Si(SiCl3)(3)(-) with neo-Si5Cl12 to yield 1."],["dc.identifier.doi","10.1002/anie.201510477"],["dc.identifier.isi","000369854000033"],["dc.identifier.pmid","26696311"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41609"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","1521-3773"],["dc.relation.issn","1433-7851"],["dc.title","A Disilene Base Adduct with a Dative Si-Si Single Bond"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","16776"],["dc.bibliographiccitation.issue","48"],["dc.bibliographiccitation.journal","Journal of the American Chemical Society"],["dc.bibliographiccitation.lastpage","16779"],["dc.bibliographiccitation.volume","136"],["dc.contributor.author","Roy, Sudipta"],["dc.contributor.author","Mondal, Kartik Chandra"],["dc.contributor.author","Krause, Lennard"],["dc.contributor.author","Stollberg, Peter"],["dc.contributor.author","Herbst-Irmer, Regine"],["dc.contributor.author","Stalke, Dietmar"],["dc.contributor.author","Meyer, Jann"],["dc.contributor.author","Stueckl, A. Claudia"],["dc.contributor.author","Maity, Bholanath"],["dc.contributor.author","Koley, Debasis"],["dc.contributor.author","Vasa, Suresh Kumar"],["dc.contributor.author","Xiang, Sheng Qi"],["dc.contributor.author","Linser, Rasmus"],["dc.contributor.author","Roesky, Herbert W."],["dc.date.accessioned","2018-11-07T09:31:31Z"],["dc.date.available","2018-11-07T09:31:31Z"],["dc.date.issued","2014"],["dc.description.abstract","A silicon atom in the zero oxidation state stabilized by two carbene ligands is known as siladicarbene (silylone). There are two pairs of electrons on the silicon atom in silylone. This was recently confirmed by both experimental and theoretical charge density investigations. The silylone is stable up to 195 degrees C in an inert atmosphere. However, a substoichiometric amount (33 mol%) of potassium metal triggers the activation of the unsaturated C:Si:C backbone, leading to a selective reaction with a tertiary C-H bond in an atom-economical approach to form a six-membered cyclic silylene with three-coordinate silicon atom. Cyclic voltammetry shows that this reaction proceeds via the formation of a silylone radical anion intermediate, which is further confirmed by EPR spectroscopy."],["dc.identifier.doi","10.1021/ja510427r"],["dc.identifier.isi","000345883900020"],["dc.identifier.pmid","25383936"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31550"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Chemical Soc"],["dc.relation.issn","0002-7863"],["dc.title","Electron-Induced Conversion of Silylones to Six-Membered Cyclic Silylenes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2639"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Journal of the American Chemical Society"],["dc.bibliographiccitation.lastpage","2646"],["dc.bibliographiccitation.volume","139"],["dc.contributor.author","Xiang, Shengqi"],["dc.contributor.author","Kulminskaya, Natalia"],["dc.contributor.author","Habenstein, Birgit"],["dc.contributor.author","Biernat, Jacek"],["dc.contributor.author","Tepper, Katharina"],["dc.contributor.author","Paulat, Maria"],["dc.contributor.author","Griesinger, Christian"],["dc.contributor.author","Becker, Stefan"],["dc.contributor.author","Lange, Adam"],["dc.contributor.author","Mandelkow, Eckhard"],["dc.contributor.author","Linser, Rasmus"],["dc.date.accessioned","2018-01-17T11:35:58Z"],["dc.date.available","2018-01-17T11:35:58Z"],["dc.date.issued","2017"],["dc.description.abstract","Fibrillar aggregates of Aβ and Tau in the brain are the major hallmarks of Alzheimer's disease. Most Tau fibers have a twisted appearance, but the twist can be variable and even absent. This ambiguity, which has also been associated with different phenotypes of tauopathies, has led to controversial assumptions about fibril constitution, and it is unclear to-date what the molecular causes of this polymorphism are. To tackle this question, we used solid-state NMR strategies providing assignments of non-seeded three-repeat-domain Tau3RD with an inherent heterogeneity. This is in contrast to the general approach to characterize the most homogeneous preparations by construct truncation or intricate seeding protocols. Here, carbon and nitrogen chemical-shift conservation between fibrils revealed invariable secondary-structure properties, however, with inter-monomer interactions variable among samples. Residues with variable amide shifts are localized mostly to N- and C-terminal regions within the rigid beta structure in the repeat region of Tau3RD. By contrast, the hexapeptide motif in repeat R3, a crucial motif for fibril formation, shows strikingly low variability of all NMR parameters: Starting as a nucleation site for monomer-monomer contacts, this six-residue sequence element also turns into a well-defined structural element upon fibril formation. Given the absence of external causes in vitro, the interplay of structurally differently conserved elements in this protein likely reflects an intrinsic property of Tau fibrils."],["dc.identifier.doi","10.1021/jacs.6b09619"],["dc.identifier.pmid","28124562"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/11683"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1520-5126"],["dc.title","A Two-Component Adhesive: Tau Fibrils Arise from a Combination of a Well-Defined Motif and Conformationally Flexible Interactions"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","6180"],["dc.bibliographiccitation.issue","19"],["dc.bibliographiccitation.journal","Journal of the American Chemical Society"],["dc.bibliographiccitation.lastpage","6183"],["dc.bibliographiccitation.volume","137"],["dc.contributor.author","Roy, Sudipta"],["dc.contributor.author","Dittrich, Birger"],["dc.contributor.author","Mondal, Totan"],["dc.contributor.author","Koley, Debasis"],["dc.contributor.author","Stueckl, A. Claudia"],["dc.contributor.author","Schwederski, Brigitte"],["dc.contributor.author","Kaim, Wolfgang"],["dc.contributor.author","John, Michael"],["dc.contributor.author","Vasa, Suresh Kumar"],["dc.contributor.author","Linser, Rasmus"],["dc.contributor.author","Roesky, Herbert W."],["dc.date.accessioned","2018-11-07T09:57:09Z"],["dc.date.available","2018-11-07T09:57:09Z"],["dc.date.issued","2015"],["dc.description.abstract","A cyclic alltyl(ainino) carbene (cAAC) stabilized dimer [(cAAC)Si(P-Tip)](2) (2) (Tip = 2,4,6-triisopropylphenyl) is reported. 2 can be considered as a dimer of the heavier ketenimine (R2C=C=N-R) analogue. The dark-red rod-shaped crystals of 2 were synthesized by reduction of the precursor, cAAC-dichlorosilylene-stabilized phosphinidene (cAAC)SiCl2 -> P-Tip with sodium napthalenide. The crystals of 2 are storable at room temperature for several months and stable up to 215 degrees C under an inert atmosphere. X-ray single-crystal diffraction revealed that 2 contains a cyclic nonplanar four-membered SiPSiP ring: Magnetic susceptibility measurements confirmed the singlet spin ground state of 2. Cyclic voltammetry of 2 Showed a quasi-reversible one-electron reduction indicating the formation of the corresponding radical anion 2(center dot-), which was further characterized by EPR measurements in solution. The electronic structure and bonding of 2 and 2(center dot-) were studied by theoretical calculations. The experimentally obtained data are in good agreement with the calculated values."],["dc.identifier.doi","10.1021/jacs.5b03407"],["dc.identifier.isi","000355053100018"],["dc.identifier.pmid","25919008"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37099"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Chemical Soc"],["dc.relation.issn","0002-7863"],["dc.title","Carbene Supported Dimer of Heavier Ketenimine Analogue with P and Si Atoms"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","858"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of the American Chemical Society"],["dc.bibliographiccitation.lastpage","869"],["dc.bibliographiccitation.volume","141"],["dc.contributor.author","Rovó, Petra"],["dc.contributor.author","Smith, Colin A."],["dc.contributor.author","Gauto, Diego"],["dc.contributor.author","de Groot, Bert L."],["dc.contributor.author","Schanda, Paul"],["dc.contributor.author","Linser, Rasmus"],["dc.date.accessioned","2021-03-05T08:58:24Z"],["dc.date.available","2021-03-05T08:58:24Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1021/jacs.8b09258"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/80124"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-393"],["dc.relation.eissn","1520-5126"],["dc.relation.issn","0002-7863"],["dc.title","Mechanistic Insights into Microsecond Time-Scale Motion of Solid Proteins Using Complementary 15N and 1H Relaxation Dispersion Techniques"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]