Aspelmeier, Timo

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Biophysical Journal"],["dc.bibliographiccitation.volume","106"],["dc.contributor.author","Walla, Peter Jomo"],["dc.contributor.author","Hafi, Nour"],["dc.contributor.author","Grunwald, Matthias"],["dc.contributor.author","van den Heuvel, Laura"],["dc.contributor.author","Timo, Aspelmeier"],["dc.contributor.author","Zagrebelsky, Marta"],["dc.contributor.author","Korte, Martin"],["dc.contributor.author","Munk, Axel"],["dc.date.accessioned","2018-11-07T09:44:56Z"],["dc.date.available","2018-11-07T09:44:56Z"],["dc.date.issued","2014"],["dc.identifier.isi","000337000400120"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34507"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cell Press"],["dc.publisher.place","Cambridge"],["dc.relation.eventlocation","San Francisco, CA"],["dc.title","Nanoscopy by Fluorescence Demodulation and Polarization Angle Narrowing"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","14001"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","EPL"],["dc.bibliographiccitation.volume","120"],["dc.contributor.author","Mokhtari, Zahra"],["dc.contributor.author","Aspelmeier, Timo"],["dc.contributor.author","Zippelius, Annette"],["dc.date.accessioned","2020-12-10T18:41:38Z"],["dc.date.available","2020-12-10T18:41:38Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1209/0295-5075/120/14001"],["dc.identifier.eissn","1286-4854"],["dc.identifier.issn","0295-5075"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77635"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Collective rotations of active particles interacting with obstacles"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","163"],["dc.bibliographiccitation.journal","Annual Review of Statistics and Its Application"],["dc.bibliographiccitation.lastpage","202"],["dc.bibliographiccitation.volume","2"],["dc.contributor.author","Aspelmeier, Timo"],["dc.contributor.author","Egner, Alexander"],["dc.contributor.author","Munk, Axel"],["dc.date.accessioned","2017-09-07T11:44:43Z"],["dc.date.available","2017-09-07T11:44:43Z"],["dc.date.issued","2015"],["dc.description.abstract","Conventional light microscopes have been used for centuries for the study of small length scales down to approximately 250 nm. Images from such a microscope are typically blurred and noisy, and the measurement error in such images can often be well approximated by Gaussian or Poisson noise. In the past, this approximation has been the focus of a multitude of deconvolution techniques in imaging. However, conventional microscopes have an intrinsic physical limit of resolution. Although this limit remained unchallenged for a century, it was broken for the first time in the 1990s with the advent of modern superresolution fluorescence microscopy techniques. Since then, superresolution fluorescence microscopy has become an indispensable tool for studying the structure and dynamics of living organisms. Current experimental advances go to the physical limits of imaging, where discrete quantum effects are predominant. Consequently, this technique is inherently of a non-Gaussian statistical nature, and we argue that recent technological progress also challenges the long-standing Poisson assumption. Thus, analysis and exploitation of the discrete physical mechanisms of fluorescent molecules and light, as well as their distributions in time and space, have become necessary to achieve the highest resolution possible. This article presents an overview of some physical principles underlying modern fluorescence microscopy techniques from a statistical modeling and analysis perspective. To this end, we develop a prototypical model for fluorophore dynamics and use it to discuss statistical methods for image deconvolution and more complicated image reconstruction and enhancement techniques. Several examples are discussed in more detail, including variational multiscale methods for confocal and stimulated emission depletion (STED) microscopy, drift correction for single marker switching (SMS) microscopy, and sparse estimation and background removal for superresolution by polarization angle demodulation (SPoD). We illustrate that such methods benefit from advances in large-scale computing, for example, from recent tools from convex optimization. We argue that in the future, even higher resolutions will require more detailed models that delve into sub-Poissonian statistics."],["dc.identifier.doi","10.1146/annurev-statistics-010814-020343"],["dc.identifier.gro","3141981"],["dc.identifier.isi","000356627500009"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/3223"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","2326-8298"],["dc.title","Modern Statistical Challenges in High-Resolution Fluorescence Microscopy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","032123"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Physical Review E"],["dc.bibliographiccitation.volume","93"],["dc.contributor.author","Katzgraber, Helmut G."],["dc.contributor.author","Larson, Derek"],["dc.contributor.author","Moore, M. A."],["dc.contributor.author","Wittmann, Matthew"],["dc.contributor.author","Yeo, Joonhyun"],["dc.contributor.author","Aspelmeier, Timo"],["dc.date.accessioned","2020-12-10T18:25:34Z"],["dc.date.available","2020-12-10T18:25:34Z"],["dc.date.issued","2016"],["dc.description.abstract","We study in Ising spin glasses the finite-size effects near the spin-glass transition in zero field and at the de Almeida-Thouless transition in a field by Monte Carlo methods and by analytical approximations. In zero field, the finite-size scaling function associated with the spin-glass susceptibility of the Sherrington-Kirkpatrick mean-field spin-glass model is of the same form as that of one-dimensional spin-glass models with power-law long-range interactions in the regime where they can be a proxy for the Edwards-Anderson short-range spin-glass model above the upper critical dimension. We also calculate a simple analytical approximation for the spin-glass susceptibility crossover function. The behavior of the spin-glass susceptibility near the de Almeida-Thouless transition line has also been studied, but here we have only been able to obtain analytically its behavior in the asymptotic limit above and below the transition. We have also simulated the one-dimensional system in a field in the non-mean-field regime to illustrate that when the Imry-Ma droplet length scale exceeds the system size one can then be erroneously lead to conclude that there is a de Almeida-Thouless transition even though it is absent."],["dc.identifier.doi","10.1103/PhysRevE.93.032123"],["dc.identifier.eissn","2470-0053"],["dc.identifier.isi","000372423000004"],["dc.identifier.issn","2470-0045"],["dc.identifier.pmid","27078308"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75746"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Physical Soc"],["dc.relation.issn","2470-0053"],["dc.relation.issn","2470-0045"],["dc.title","Finite-size critical scaling in Ising spin glasses in the mean-field regime"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","154907"],["dc.bibliographiccitation.issue","15"],["dc.bibliographiccitation.journal","The Journal of Chemical Physics"],["dc.bibliographiccitation.volume","124"],["dc.contributor.author","Otto, Matthias"],["dc.contributor.author","Aspelmeier, Timo"],["dc.contributor.author","Zippelius, Annette"],["dc.date.accessioned","2021-06-01T10:51:02Z"],["dc.date.available","2021-06-01T10:51:02Z"],["dc.date.issued","2006"],["dc.identifier.doi","10.1063/1.2186325"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86866"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1089-7690"],["dc.relation.issn","0021-9606"],["dc.title","Microscopic dynamics of thin hard rods"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","144205"],["dc.bibliographiccitation.issue","14"],["dc.bibliographiccitation.journal","PHYSICAL REVIEW B"],["dc.bibliographiccitation.volume","74"],["dc.contributor.author","Braun, Alexander"],["dc.contributor.author","Aspelmeier, Timo"],["dc.date.accessioned","2018-11-07T09:13:19Z"],["dc.date.available","2018-11-07T09:13:19Z"],["dc.date.issued","2006"],["dc.description.abstract","We study the m-component vector spin glass in the limit m ->infinity on a Bethe lattice. The cavity method allows for a solution of the model in a self-consistent field approximation and for a perturbative solution of the full problem near the phase transition. The low-temperature phase of the model is analyzed numerically and a generalized Bose-Einstein condensation is found, as in the fully connected model. Scaling relations between four distinct zero-temperature exponents are found."],["dc.identifier.doi","10.1103/PhysRevB.74.144205"],["dc.identifier.isi","000241723400037"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27145"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Physical Soc"],["dc.relation.issn","1550-235X"],["dc.relation.issn","1098-0121"],["dc.title","The m-component spin glass on a Bethe lattice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","094439"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","PHYSICAL REVIEW B"],["dc.bibliographiccitation.volume","81"],["dc.contributor.author","Aspelmeier, Timo"],["dc.contributor.author","Braun, Alexander"],["dc.date.accessioned","2018-11-07T08:45:43Z"],["dc.date.available","2018-11-07T08:45:43Z"],["dc.date.issued","2010"],["dc.description.abstract","We calculate the finite-size scaling of the sample-to-sample fluctuations of the free energy Delta F of the m component vector spin glass in the large-m limit. This is accomplished using a variant of the interpolating Hamiltonian technique which is used to establish a connection between the free energy fluctuations and bond chaos. The calculation of bond chaos then shows that the scaling of the free-energy fluctuations with system size N is Delta F similar to N(mu) with 1/5 <= mu <= 3/10, and very likely mu = 1/5 exactly."],["dc.description.sponsorship","German Science Foundation (DFG) [AS 136/2-1]"],["dc.identifier.doi","10.1103/PhysRevB.81.094439"],["dc.identifier.isi","000276207300089"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20516"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Physical Soc"],["dc.relation.issn","1098-0121"],["dc.title","Sample-to-sample fluctuations and bond chaos in the m-component spin glass"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","7a"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Biophysical Journal"],["dc.bibliographiccitation.lastpage","8a"],["dc.bibliographiccitation.volume","108"],["dc.contributor.author","Walla, Peter J."],["dc.contributor.author","Hafi, Nour"],["dc.contributor.author","Matthias, Grunwald"],["dc.contributor.author","Jess, Laura S."],["dc.contributor.author","Aspelmeier, Timo"],["dc.contributor.author","Martha, Zagrebelski"],["dc.contributor.author","Pfennig, Dominik"],["dc.contributor.author","Korte, Martin"],["dc.contributor.author","Munk, Axel"],["dc.date.accessioned","2022-06-08T07:57:47Z"],["dc.date.available","2022-06-08T07:57:47Z"],["dc.date.issued","2015"],["dc.identifier.doi","10.1016/j.bpj.2014.11.063"],["dc.identifier.pii","S0006349514012727"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/110212"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-575"],["dc.relation.issn","0006-3495"],["dc.title","Fluorescence Nanoscopy by Polarization Modulation (SPoD) and Polarization Angle Narrowing (ExPAN)"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","579"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Nature Methods"],["dc.bibliographiccitation.lastpage","584"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Hafi, Nour"],["dc.contributor.author","Grunwald, Matthias"],["dc.contributor.author","van den Heuvel, Laura S."],["dc.contributor.author","Aspelmeier, Timo"],["dc.contributor.author","Chen, Jian-Hua"],["dc.contributor.author","Zagrebelsky, Marta"],["dc.contributor.author","Schütte, Ole M."],["dc.contributor.author","Steinem, Claudia"],["dc.contributor.author","Korte, Martin"],["dc.contributor.author","Munk, Axel"],["dc.contributor.author","Walla, Peter J."],["dc.date.accessioned","2017-09-07T11:46:16Z"],["dc.date.available","2017-09-07T11:46:16Z"],["dc.date.issued","2014"],["dc.description.abstract","When excited with rotating linear polarized light, differently oriented fluorescent dyes emit periodic signals peaking at different times. We show that measurement of the average orientation of fluorescent dyes attached to rigid sample structures mapped to regularly defined (50 nm)(2) image nanoareas can provide subdiffraction resolution (super resolution by polarization demodulation, SPoD). Because the polarization angle range for effective excitation of an oriented molecule is rather broad and unspecific, we narrowed this range by simultaneous irradiation with a second, de-excitation, beam possessing a polarization perpendicular to the excitation beam (excitation polarization angle narrowing, ExPAN). This shortened the periodic emission flashes, allowing better discrimination between molecules or nanoareas. Our method requires neither the generation of nanometric interference structures nor the use of switchable or blinking fluorescent probes. We applied the method to standard wide-field microscopy with camera detection and to two-photon scanning microscopy, imaging the fine structural details of neuronal spines."],["dc.identifier.doi","10.1038/NMETH.2919"],["dc.identifier.gro","3142133"],["dc.identifier.isi","000335873400027"],["dc.identifier.pmid","24705472"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/4911"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1548-7105"],["dc.relation.haserratum","/handle/2/768"],["dc.relation.issn","1548-7091"],["dc.title","Fluorescence nanoscopy by polarization modulation and polarization angle narrowing"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","098001"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Physical Review Letters"],["dc.bibliographiccitation.volume","102"],["dc.contributor.author","Fiege, Andrea"],["dc.contributor.author","Aspelmeier, Timo"],["dc.contributor.author","Zippelius, Annette"],["dc.date.accessioned","2018-11-07T08:31:44Z"],["dc.date.available","2018-11-07T08:31:44Z"],["dc.date.issued","2009"],["dc.description.abstract","We study the velocity autocorrelation function of a driven granular fluid in the stationary state in three dimensions. As the critical volume fraction of the glass transition in the corresponding elastic system is approached, we observe pronounced cage effects in the velocity autocorrelation function as well as a strong decrease of the diffusion constant, depending on the inelasticity. At moderate densities the velocity autocorrelation function is shown to decay algebraically in time, like t(-3/2), if momentum is conserved locally, and like t(-1), if momentum is not conserved by the driving. A simple scaling argument supports the observed long-time tails."],["dc.identifier.doi","10.1103/PhysRevLett.102.098001"],["dc.identifier.isi","000263911900068"],["dc.identifier.pmid","19392566"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17187"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Physical Soc"],["dc.relation.issn","0031-9007"],["dc.title","Long-Time Tails and Cage Effect in Driven Granular Fluids"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]