Beham, Alexander Wilhelm

[["dc.bibliographiccitation.firstpage","418"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Immunobiology"],["dc.bibliographiccitation.lastpage","426"],["dc.bibliographiccitation.volume","218"],["dc.contributor.author","Kaminski, Wolfgang E."],["dc.contributor.author","Beham, Alexander W."],["dc.contributor.author","Kzhyshkowska, Julia"],["dc.contributor.author","Gratchev, Alexei"],["dc.contributor.author","Puellmann, Kerstin"],["dc.date.accessioned","2018-11-07T09:27:29Z"],["dc.date.available","2018-11-07T09:27:29Z"],["dc.date.issued","2013"],["dc.description.abstract","Since decades there is consensus among immunologists that in jawless and jawed vertebrates flexible immune recognition is strictly confined to the lymphoid lineage. In jawed vertebrates the adaptive immune system is represented by two lineages of lymphocytes. B cells and T cells that express recombinatorial antigen receptors of enormous diversity known as immunoglobulins and the T cell receptor (TCR). The recent identification of recombined immune receptors that are structurally based on the TCR in subpopulations of neutrophils and eosinophils (referred to here as TCR-like immunoreceptors, \"TCRL\") provides unexpected evidence for the existence of flexible host defense mechanisms beyond the realm of lymphocytes. Consistent with this, subpopulations of monocytes and macrophages from humans and mice now have also been shown to constitutively express recombined TCR-like immunoreceptors. Available in vitro evidence suggests that the TCRL in macrophages may exert functions as facilitators of phagocytosis and self-recruitment. More importantly, our recent findings that the macrophage-TCRL is implicated in granuloma formation in tuberculosis and the neutrophil-TCRL is associated with autoimmune hemolytic anemia establish for the first time a link between myeloid recombinatorial immune receptors and clinical disease. The discovery of recombined TCR-like immune receptors in granulocytes and macrophages extends the principle of combinatorial immune recognition to phagocytic cells. Conceptually, this unifies the two hitherto disparate cardinal features of innate and adaptive immunity, phagocytic capacity and recombinatorial immune recognition on a common cellular platform. Moreover, it strongly suggests that flexible host defense in vertebrates may operate on a broader cellular basis than currently thought. (C) 2012 Published by Elsevier GmbH."],["dc.identifier.doi","10.1016/j.imbio.2012.05.024"],["dc.identifier.isi","000316235700015"],["dc.identifier.pmid","22749215"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30547"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Gmbh, Urban & Fischer Verlag"],["dc.relation.issn","0171-2985"],["dc.title","On the horizon: Flexible immune recognition outside lymphocytes"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","The Journal of Immunology"],["dc.bibliographiccitation.volume","182"],["dc.contributor.author","Puellmann, Kerstin"],["dc.contributor.author","Beham, Alexander W."],["dc.contributor.author","Fuchs, Tina"],["dc.contributor.author","Kzhyshkowska, Julia"],["dc.contributor.author","Gratchev, Alexei"],["dc.contributor.author","Laird, Rebecca"],["dc.contributor.author","Wessels, Johannes Theodor"],["dc.contributor.author","Neumaier, Michael"],["dc.contributor.author","Ganser, Arnold"],["dc.contributor.author","Kaminski, Wolfgang E."],["dc.date.accessioned","2018-11-07T08:31:11Z"],["dc.date.available","2018-11-07T08:31:11Z"],["dc.date.issued","2009"],["dc.identifier.isi","000209763602309"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17065"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Assoc Immunologists"],["dc.publisher.place","Bethesda"],["dc.relation.issn","1550-6606"],["dc.relation.issn","0022-1767"],["dc.title","Macrophages express a TCR alpha beta-based variable immunoreceptor"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","39"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Immunobiology"],["dc.bibliographiccitation.lastpage","44"],["dc.bibliographiccitation.volume","222"],["dc.contributor.author","Fuchs, Tina"],["dc.contributor.author","Hahn, Martin"],["dc.contributor.author","Riabov, Vladimir"],["dc.contributor.author","Yin, Shuiping"],["dc.contributor.author","Kzhyshkowska, Julia"],["dc.contributor.author","Busch, Svenja"],["dc.contributor.author","Puellmann, Kerstin"],["dc.contributor.author","Beham, Alexander W."],["dc.contributor.author","Neumaier, Michael"],["dc.contributor.author","Kaminski, Wolfgang E."],["dc.date.accessioned","2018-11-07T10:29:34Z"],["dc.date.available","2018-11-07T10:29:34Z"],["dc.date.issued","2017"],["dc.description.abstract","Recent evidence indicates the presence of macrophage subpopulations that express the TCR alpha beta in two major inflammatory diseases, tuberculosis and atherosclerosis. Inflammation is also a well-established attribute of cancer progression and macrophages are one of the major immune cells that infiltrate tumors. Here, we demonstrate that the macrophage-TCR alpha beta is expressed in the tumor microenvironment of human and murine malignancies. We identify TCR alpha beta(+) macrophages in each case of four randomly selected distinct human tumor entities. In human tumor tissues, the TCR alpha beta expressed by macrophages in the tumor microenvironment is a combinatorial and individual-specific immune receptor. Furthermore, we routinely find TCR alpha beta(+) macrophage subpopulations in experimental tumors (TS/A, mammary adenocarcinoma) which we induced both in normal mice and mice deficient in the macrophage receptor stabilin-1. Expression of the combinatorial murine tumor macrophage TCRotS is individual-specific and independent of stabilin-1. These results demonstrate that TCR alpha beta expression is a characteristic feature of macrophages in the tumor microenvironment and identify an as yet unrecognized flexible element in the macrophage-based host response to tumors. (C) 2015 Elsevier GmbH. All rights reserved."],["dc.identifier.doi","10.1016/j.imbio.2015.09.022"],["dc.identifier.isi","000390613800005"],["dc.identifier.pmid","26494401"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43664"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Elsevier Gmbh, Urban & Fischer Verlag"],["dc.relation.issn","0171-2985"],["dc.title","A combinatorial alpha beta T cell receptor expressed by macrophages in the tumor microenvironment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","509"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Langenbeck s Archives of Surgery"],["dc.bibliographiccitation.lastpage","519"],["dc.bibliographiccitation.volume","402"],["dc.contributor.author","Dango, Sebastian"],["dc.contributor.author","Beißbarth, Tim"],["dc.contributor.author","Weiss, Elisabeth"],["dc.contributor.author","Hosseini, Ali Seif Amir"],["dc.contributor.author","Raddatz, Dirk"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Ghadimi, Michael B."],["dc.contributor.author","Beham, Alexander Wilhelm"],["dc.date.accessioned","2018-11-07T10:24:29Z"],["dc.date.available","2018-11-07T10:24:29Z"],["dc.date.issued","2017"],["dc.description.abstract","Upper GI bleeding remains one of the most common emergencies with a substantial overall mortality rate of up to 30%. In severe ill patients, death does not occur due to failure of hemostasis, either medical or surgical, but mainly from comorbidities, treatment complications, and decreased tolerated blood loss. Management strategies have changed dramatically over the last two decades and include primarily endoscopic intervention in combination with acid-suppressive therapy and decrease in surgical intervention. Herein, we present one of the largest patient-based analysis assessing clinical parameters and outcome in patients undergoing endoscopy with an upper GI bleeding. Data were further analyzed to identify potential new risk factors and to investigate the role of surgery. In this retrospective study, we aimed to analyze outcome of patients with an UGIB and data were analyzed to identify potential new risk factors and the role of surgery. Data collection included demographic data, laboratory results, endoscopy reports, and details of management including blood administration, and surgery was carried out. Patient events were grouped and defined as \"overall\" events and \"operated,\" \"non-operated,\" and \"operated and death\" as well as \"non-operated and death\" where appropriate. Blatchford, clinical as well as complete Rockall-score analysis, risk stratification, and disease-related mortality rate were calculated for each group for comparison. Overall, 253 patients were eligible for analysis: endoscopy was carried out in 96% of all patients, 17% needed surgical intervention after endoscopic failure of bleeding control due to persistent bleeding, and the remaining 4% of patients were subjected directly to surgery. The median length of stay to discharge was 26 days. Overall mortality was 22%; out of them, almost 5% were operated and died. Anticoagulation was associated with a high in-hospital mortality risk (23%) and was increased once patients were taken to surgery (43%). Patients taking steroids presented with a risk of death of 26%, once taken to surgery the risk increased to 80%. Patients with liver cirrhosis had a risk of death of 42%; we observed a better outcome for these patients once taken to theater. Clinically, once scored with Blatchford score, statistical correlation was found for initial need for blood transfusion and surgical intervention. Clinical as well as complete Rockall score revealed a correlation between need for blood transfusion as well as surgical intervention in addition with a decreased outcome with increasing Rockall scores. Risk factor analysis including comorbidity, drug administration, and anticoagulation therapy introduced the combination of tumor and non-steroidal antirheumatic medication as independent risk factors for increased disease-related mortality. UGIB remains challenging and endoscopy is the first choice of intervention. Care must be taken once a patient is taking antirheumatic non-steroidal pain medication and suffers from cancer. In patients with presence of liver cirrhosis, an earlier surgical intervention may be considered, in particular for patients with recurrent bleeding. Embolization is not widely available and carries the risk of necrosis of the affected organ and should be restricted to a subgroup of patients not primarily eligible for surgery once endoscopy has failed. Taken together, an interdisciplinary approach including gastroenterologists as well as surgeons should be used once the patient is admitted to the hospital to define the best treatment option."],["dc.identifier.doi","10.1007/s00423-017-1552-2"],["dc.identifier.isi","000400365500012"],["dc.identifier.pmid","28091770"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42673"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Springer"],["dc.relation.issn","1435-2451"],["dc.relation.issn","1435-2443"],["dc.title","Relevance of surgery in patients with non-variceal upper gastrointestinal bleeding"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Neurology"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Fuchs, Tina"],["dc.contributor.author","Puellmann, Kerstin"],["dc.contributor.author","Dreyfus, David H."],["dc.contributor.author","Piehler, Armin P."],["dc.contributor.author","Reuter, Björn"],["dc.contributor.author","Schwarzbach, Christopher"],["dc.contributor.author","Willmann, Olaf"],["dc.contributor.author","Yepes, Diego"],["dc.contributor.author","Costina, Victor"],["dc.contributor.author","Findeisen, Peter"],["dc.contributor.author","Mahrt, Jens"],["dc.contributor.author","Wang, Chunlin"],["dc.contributor.author","Han, Jian"],["dc.contributor.author","Beham, Alexander W."],["dc.contributor.author","Neumaier, Michael"],["dc.contributor.author","Kaminski, Wolfgang E."],["dc.date.accessioned","2020-12-10T18:44:32Z"],["dc.date.available","2020-12-10T18:44:32Z"],["dc.date.issued","2019"],["dc.description.abstract","Bacterial meningitis is a life-threatening disease that evokes an intense neutrophil-dominated host response to microbes invading the subarachnoid space. Recent evidence indicates the existence of combinatorial V(D)J immune receptors in neutrophils that are based on the T cell receptor (TCR). Here, we investigated expression of the novel neutrophil TCRαβ-based V(D)J receptors in cerebrospinal fluid (CSF) from human patients with acute-phase bacterial meningitis using immunocytochemical, genetic immunoprofiling, cell biological, and mass spectrometric techniques. We find that the human neutrophil combinatorial V(D)J receptors are rapidly induced in CSF neutrophils during the first hours of bacterial meningitis. Immune receptor repertoire diversity is consistently increased in CSF neutrophils relative to circulating neutrophils and phagocytosis of baits directed to the variable immunoreceptor is enhanced in CSF neutrophils during acute-phase meningitis. Our results reveal that a flexible immune response involving neutrophil V(D)J receptors which enhance phagocytosis is immediately initiated at the site of acute bacterial infection."],["dc.identifier.doi","10.3389/fneur.2019.00307"],["dc.identifier.eissn","1664-2295"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78494"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1664-2295"],["dc.rights","http://creativecommons.org/licenses/by/4.0/"],["dc.title","Immediate Neutrophil-Variable-T Cell Receptor Host Response in Bacterial Meningitis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","404"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Aging and Disease"],["dc.bibliographiccitation.lastpage","413"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Kaminski, Wolfgang E."],["dc.contributor.author","Beham, Alexander W."],["dc.contributor.author","Puellmann, Kerstin"],["dc.date.accessioned","2018-11-07T09:05:34Z"],["dc.date.available","2018-11-07T09:05:34Z"],["dc.date.issued","2012"],["dc.description.abstract","Longstanding immunological dogma holds that flexible immune recognition, which forms the mechanistic basis of adaptive immunity, is strictly confined to the lymphocyte lineage. In higher vertebrates, flexible immune recognition is represented by recombinatorial antigen receptors of enormous diversity known as immunoglobulins, expressed by B lymphocytes, and the T cell receptor (TCR), expressed by T lymphocytes. The recent discovery of recombinatorial immune receptors that are structurally based on the TCR (referred to as TCR-like immunoreceptors, \"TCRL\") in myeloid phagocytes such as neutrophils and monocytes/macrophages now challenges the lymphocentric paradigm of flexible immunity. Here, we introduce the emerging concept of \"extralymphocytic flexible immune recognition\" and discuss its implications for inflammation and aging."],["dc.description.sponsorship","Deutsche Vereinte Gesellschaft fur Klinische Chemie und Labormedizin"],["dc.identifier.isi","000208951500005"],["dc.identifier.pmid","23185720"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Int Soc Aging & Disease"],["dc.relation.issn","2152-5250"],["dc.title","Extralymphocytic Flexible Immune Recognition: a New Angle on Inflammation and Aging"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Liver Transplantation"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Goralczyk, Armin Dietmar"],["dc.contributor.author","Beham, Alexander W."],["dc.contributor.author","Obed, Aiman"],["dc.contributor.author","Lorf, Thomas"],["dc.date.accessioned","2018-11-07T08:42:53Z"],["dc.date.available","2018-11-07T08:42:53Z"],["dc.date.issued","2010"],["dc.format.extent","S233"],["dc.identifier.isi","000278428000570"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19812"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","John Wiley & Sons Inc"],["dc.publisher.place","Hoboken"],["dc.relation.conference","16th Annual Congress of the International-Liver-Transplantation-Society"],["dc.relation.eventlocation","Hong Kong, PEOPLES R CHINA"],["dc.relation.issn","1527-6465"],["dc.title","Enlargement of the Venous Outflow Tract Reduces Portal Hypertension in Living Donor Liver Transplantation"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","9823"],["dc.bibliographiccitation.journal","The Lancet"],["dc.bibliographiccitation.volume","379"],["dc.contributor.author","Fuchs, Tina"],["dc.contributor.author","Puellmann, Kerstin"],["dc.contributor.author","Schneider, Sven"],["dc.contributor.author","Kruth, Jens"],["dc.contributor.author","Schulze, Torsten J."],["dc.contributor.author","Neumaier, Michael"],["dc.contributor.author","Beham, Alexander W."],["dc.contributor.author","Kaminski, Wolfgang E."],["dc.date.accessioned","2018-11-07T09:11:14Z"],["dc.date.available","2018-11-07T09:11:14Z"],["dc.date.issued","2012"],["dc.format.extent","1364"],["dc.identifier.isi","000302531100035"],["dc.identifier.pmid","22483032"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26671"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","0140-6736"],["dc.title","An autoimmune double attack"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","143"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Zentralblatt für Chirurgie - Zeitschrift für Allgemeine Viszeral- Thorax- und Gefäßchirurgie"],["dc.bibliographiccitation.lastpage","144"],["dc.bibliographiccitation.volume","141"],["dc.contributor.author","Egberts, J.-H."],["dc.contributor.author","Beham, Alexander W."],["dc.contributor.author","Ghadimi, Michael B."],["dc.date.accessioned","2018-11-07T10:16:05Z"],["dc.date.available","2018-11-07T10:16:05Z"],["dc.date.issued","2016"],["dc.description.abstract","The implementation of robot-assisted surgery requires a multi disciplinary approach with appropriate training and cooperation of surgical, anesthetic and technical staff. Besides acquiring the technical skills and getting used to complex technique, patient selection and an appropriate frequency of procedures are required to avoid complications."],["dc.identifier.doi","10.1055/s-0042-104068"],["dc.identifier.isi","000374495000010"],["dc.identifier.pmid","27074210"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40963"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","1438-9592"],["dc.relation.issn","0044-409X"],["dc.title","Implementation of Robot-Assisted Surgery"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4691"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","European Radiology"],["dc.bibliographiccitation.lastpage","4698"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Hosseini, Ali Seif Amir"],["dc.contributor.author","Uhlig, Johannes"],["dc.contributor.author","Streit, Ulrike"],["dc.contributor.author","Voit, Dirk"],["dc.contributor.author","Uhlig, Annemarie"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Ghadimi, Michael B."],["dc.contributor.author","Sprenger, Thilo"],["dc.contributor.author","Beham, Alexander Wilhelm"],["dc.contributor.author","Uecker, Martin"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Biggemann, Lorenz"],["dc.date.accessioned","2020-05-13T13:45:02Z"],["dc.date.available","2020-05-13T13:45:02Z"],["dc.date.issued","2019"],["dc.description.abstract","Purpose To assess the diagnostic potential of dynamic real-time MRI for fundoplication failure in patients with persistent or recurrent GERD-like (gastroesophageal reflux disease) complaints. Material and methods Twenty-two consecutive patients (male n = 11; female n = 11; median age 59 years) with recurrent or persistent GERD-like symptom after fundoplication were enrolled between 2015 and 2017. Median duration of GERD-like symptoms was 21 months. Real-time MRI (3 Tesla) was performed at 40 ms temporal resolution using undersampled radial fast low-angle shot acquisitions with nonlinear inverse image reconstruction. MRI movies dynamically visualized bolus transit of pineapple juice through the gastroesophageal junction, position of the fundoplication wrap and recurring hernia or reflux during Valsalva maneuver. MRI results were compared to endoscopic findings. Results Real-time MRI was successfully completed in all patients without adverse events (average examination time 15 min). Morphological correlates for GERD-like symptoms were evident in 20 patients (90.1%) with gastric reflux in 19 cases. Nine patients (40.1%) had wrap disruption and recurrent gastric hernia. Wrap migration or telescoping hernia was detected in nine patients (40.1%). One patient presented with continued reflux despite intact fundoplication wrap. Esophageal dysmotility with delayed bolus passage was observed in one case. On endoscopy, gastric hernia or wrap disruption was diagnosed in seven cases, and esophagitis or Barret’s metaplasia in nine cases."],["dc.identifier.doi","10.1007/s00330-019-06025-x"],["dc.identifier.pmid","30805702"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/65369"],["dc.language.iso","en"],["dc.relation.eissn","1432-1084"],["dc.relation.issn","0938-7994"],["dc.title","Real-time MRI for the dynamic assessment of fundoplication failure in patients with gastroesophageal reflux disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]