Hellen, Peter

[["dc.bibliographiccitation.firstpage","e167"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Neurology Genetics"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Smogavec, Mateja"],["dc.contributor.author","Zschüntzsch, Jana"],["dc.contributor.author","Kress, Wolfram"],["dc.contributor.author","Mohr, Julia"],["dc.contributor.author","Hellen, Peter"],["dc.contributor.author","Zoll, Barbara"],["dc.contributor.author","Pauli, Silke"],["dc.contributor.author","Schmidt, Jens"],["dc.date.accessioned","2020-12-10T18:41:39Z"],["dc.date.available","2020-12-10T18:41:39Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1212/NXG.0000000000000167"],["dc.identifier.eissn","2376-7839"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77641"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Novel fukutin mutations in limb-girdle muscular dystrophy type 2M with childhood onset"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","19"],["dc.bibliographiccitation.journal","The Journal of Headache and Pain"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Neeb, Lars"],["dc.contributor.author","Hellen, Peter"],["dc.contributor.author","Hoffmann, Jan"],["dc.contributor.author","Dirnagl, Ulrich"],["dc.contributor.author","Reuter, Uwe"],["dc.date.accessioned","2018-11-07T10:17:50Z"],["dc.date.available","2018-11-07T10:17:50Z"],["dc.date.issued","2016"],["dc.description.abstract","Background: Methylprednisolone (MPD) is a rapid acting highly effective cluster headache preventive and also suppresses the recurrence of migraine attacks. Previously, we could demonstrate that elevated CGRP plasma levels in a cluster headache bout are normalized after a course of high dose corticosteroids. Here we assess whether MPD suppresses interleukin-1 beta (IL-1 beta)- and prostaglandin E-2 (PGE(2))-induced CGRP release in a cell culture model of trigeminal ganglia cells, which could account for the preventive effect in migraine and cluster headache. Metoprololi >>(MTP), a migraine preventive with a slow onset of action, was used for comparison. Methods: Primary cultures of rat trigeminal ganglia were stimulated for 24 h with 10 ng/ml IL-1 beta or for 4 h with 10 mu M PGE(2) following the exposure to 10 or 100 mu M MPD or 100 nM or 10 A mu M MTP for 45 min or 24 h. CGRP was determined by using a commercial enzyme immunoassay. Results: MPD but not MTP blocked IL-1 beta-induced CGRP release from cultured trigeminal cells. PGE(2)-stimulated CGRP release from trigeminal ganglia cell culture was not affected by pre-stimulation whether with MPD or MTP. Conclusion: MPD but not MTP suppresses cytokine (IL-1 beta)-induced CGRP release from trigeminal ganglia cells. We propose that blockade of cytokine mediated trigeminal activation may represent a potential mechanism of action that mediates the preventive effect of MTP on cluster headache and recurrent migraine attacks."],["dc.description.sponsorship","Bundesministerium fur Bildung und Forschung (BMBF) [01EM 0515]"],["dc.identifier.doi","10.1186/s10194-016-0609-x"],["dc.identifier.isi","000371424500001"],["dc.identifier.pmid","26931452"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13180"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41306"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1129-2377"],["dc.relation.issn","1129-2369"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Methylprednisolone blocks interleukin 1 beta induced calcitonin gene related peptide release in trigeminal ganglia cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","667"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Der Radiologe"],["dc.bibliographiccitation.lastpage","672"],["dc.bibliographiccitation.volume","56"],["dc.contributor.author","Yilmaz, U."],["dc.contributor.author","Hellen, Peter"],["dc.date.accessioned","2018-11-07T10:10:57Z"],["dc.date.available","2018-11-07T10:10:57Z"],["dc.date.issued","2016"],["dc.description.abstract","In the emergency department 65 % of spinal injuries and 2-5 % of blunt force injuries involve the cervical spine. Of these injuries approximately 50 % involve C5 and/or C6 and 30 % involve C2. Older patients tend to have higher spinal injuries and younger patients tend to have lower injuries. The anatomical and development-related characteristics of the pediatric spine as well as degenerative and comorbid pathological changes of the spine in the elderly can make the radiological evaluation of spinal injuries difficult with respect to possible trauma sequelae in young and old patients. Two different North American studies have investigated clinical criteria to rule out cervical spine injuries with sufficient certainty and without using imaging. Imaging of cervical trauma should be performed when injuries cannot be clinically excluded according to evidence-based criteria. Degenerative changes and anatomical differences have to be taken into account in the evaluation of imaging of elderly and pediatric patients."],["dc.identifier.doi","10.1007/s00117-016-0135-5"],["dc.identifier.isi","000381398400003"],["dc.identifier.pmid","27435614"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39954"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-2102"],["dc.relation.issn","0033-832X"],["dc.title","Cervical Spine Trauma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","E386"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Critical Care Medicine"],["dc.bibliographiccitation.lastpage","E389"],["dc.bibliographiccitation.volume","43"],["dc.contributor.author","Riech, Sebastian"],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Hellen, Peter"],["dc.contributor.author","Bartsch, Peter"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Knauth, Michael"],["dc.date.accessioned","2018-11-07T09:51:53Z"],["dc.date.available","2018-11-07T09:51:53Z"],["dc.date.issued","2015"],["dc.description.abstract","Objectives: After suffering from severe acute respiratory distress syndrome, several patients show generalized brain alterations and atrophy. A distinctive morphologic pattern of cerebral injury, however, has not been found so far. Data Sources: We present the history of three patients who survived severe acute respiratory distress syndrome. In these patients, MRI of the brain showed multiple microhemorrhages predominantly in the splenium of the corpus callosum. An identical pattern of microhemorrhages has previously been described in mountaineers who suffered from high-altitude cerebral edema. Conclusions: This report demonstrates that patients after treatment for acute respiratory distress syndrome and high-altitude cerebral edema show congruent cerebral injuries. Further investigation into the similarities of the causative conditions and neurologic consequences might reveal underlying pathophysiologic mechanisms and clinical implications of this observation."],["dc.description.sponsorship","Pulsion Medical; CareFusion; Maquet Critical Care"],["dc.identifier.doi","10.1097/CCM.0000000000001150"],["dc.identifier.isi","000369256800007"],["dc.identifier.pmid","26110491"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36002"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1530-0293"],["dc.relation.issn","0090-3493"],["dc.title","The Pattern of Brain Microhemorrhages After Severe Lung Failure Resembles the One Seen in High-Altitude Cerebral Edema"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]