Stephani, Caspar

[["dc.bibliographiccitation.firstpage","103"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Journal of the Neurological Sciences"],["dc.bibliographiccitation.lastpage","109"],["dc.bibliographiccitation.volume","354"],["dc.contributor.author","Wickmann, Franziska"],["dc.contributor.author","Stephani, Caspar"],["dc.contributor.author","Czesnik, Dirk"],["dc.contributor.author","Klinker, Florian"],["dc.contributor.author","Timaeus, Charles"],["dc.contributor.author","Chaieb, Leila"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Antal, Andrea"],["dc.date.accessioned","2018-11-07T09:54:38Z"],["dc.date.available","2018-11-07T09:54:38Z"],["dc.date.issued","2015"],["dc.description.abstract","The present study aimed to investigate the efficacy of repetitive cathodal direct current stimulation (rctDCS) over the visual cortex as a prophylactic treatment in patients with menstrual migraine. 20 female patients were recruited in this double-blind, placebo-controlled study and were assigned to receive either cathodal or sham stimulation. Over 3 menstrual cycles, tDCS with 2 mA intensity and 20 min duration was applied to the visual cortex of the patients, in 5 consecutive sessions 1-5 days prior to the first day of their menstruation. The primary endpoint of the study was the frequency of the migraine attacks at the end of the treatment period, however, additional parameters, such as the number of migraine related days and the intensity of pain were also recorded 3 months before, during and 3 months post-treatment Visual cortex excitability was determined by measuring the phosphene thresholds (PTs) using single pulse transcranial magnetic stimulation (TMS) over the visual cortex. Sixteen patients completed the study. A significant decrease in the number of migraine attacks (p = 0.04) was found in the cathodal group compared to baseline but not compared to sham (p = 0.053). In parallel the PTs increased significantly in this group, compared to the sham group (p < 0.05). Our results indicate that prophylactic treatment with rctDCS over the visual cortex might be able to decrease the number of attacks in patients with menstrual migraine, probably by modifying cortical excitability. (C) 2015 Elsevier B.V. All rights reserved."],["dc.description.sponsorship","Migraine Foundation"],["dc.identifier.doi","10.1016/j.jns.2015.05.009"],["dc.identifier.isi","000356978600018"],["dc.identifier.pmid","26003225"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36574"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1878-5883"],["dc.relation.issn","0022-510X"],["dc.title","Prophylactic treatment in menstrual migraine: A proof-of-concept study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0284"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Critical Care Explorations"],["dc.bibliographiccitation.lastpage","5"],["dc.bibliographiccitation.volume","2"],["dc.contributor.author","Hofmann-Winkler, Heike"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Alt-Epping, Sabine"],["dc.contributor.author","Bräuer, Anselm"],["dc.contributor.author","Büttner, Benedikt"],["dc.contributor.author","Müller, Martin"],["dc.contributor.author","Fricke, Torben"],["dc.contributor.author","Grundmann, Julian"],["dc.contributor.author","Harnisch, Lars-Olav"],["dc.contributor.author","Heise, Daniel"],["dc.contributor.author","Kernchen, Andrea"],["dc.contributor.author","Pressler, Meike"],["dc.contributor.author","Stephani, Caspar"],["dc.contributor.author","Tampe, Björn"],["dc.contributor.author","Kaul, Artur"],["dc.contributor.author","Gärtner, Sabine"],["dc.contributor.author","Kramer, Stefanie"],["dc.contributor.author","Pöhlmann, Stefan"],["dc.contributor.author","Winkler, Martin Sebastian"],["dc.date.accessioned","2020-11-27T11:23:20Z"],["dc.date.accessioned","2021-10-27T13:22:21Z"],["dc.date.available","2020-11-27T11:23:20Z"],["dc.date.available","2021-10-27T13:22:21Z"],["dc.date.issued","2020"],["dc.description.abstract","Objectives: Severe acute respiratory syndrome coronavirus 2 cell entry depends on angiotensin-converting enzyme 2 and transmembrane serine protease 2 and is blocked in cell culture by camostat mesylate, a clinically proven protease inhibitor. Whether camostat mesylate is able to lower disease burden in coronavirus disease 2019 sepsis is currently unknown. Design: Retrospective observational case series. Setting: Patient treated in ICU of University hospital Göttingen, Germany. Patients: Eleven critical ill coronavirus disease 2019 patients with organ failure were treated in ICU. Interventions: Compassionate use of camostat mesylate (six patients, camostat group) or hydroxychloroquine (five patients, hydroxychloroquine group). Measurements and Main Results: Clinical courses were assessed by Sepsis-related Organ Failure Assessment score at days 1, 3, and 8. Further, viral load, oxygenation, and inflammatory markers were determined. Sepsis-related Organ Failure Assessment score was comparable between camostat and hydroxychloroquine groups upon ICU admission. During observation, the Sepsis-related Organ Failure Assessment score decreased in the camostat group but remained elevated in the hydroxychloroquine group. The decline in disease severity in camostat mesylate treated patients was paralleled by a decline in inflammatory markers and improvement of oxygenation. Conclusions: The severity of coronavirus disease 2019 decreased upon camostat mesylate treatment within a period of 8 days and a similar effect was not observed in patients receiving hydroxychloroquine. Camostat mesylate thus warrants further evaluation within randomized clinical trials."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2020"],["dc.identifier.doi","10.1097/CCE.0000000000000284"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17663"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/92088"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.eissn","2639-8028"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","Camostat Mesylate May Reduce Severity of Coronavirus Disease 2019 Sepsis: A First Observation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","208"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Clinical Neurophysiology"],["dc.bibliographiccitation.lastpage","209"],["dc.bibliographiccitation.volume","129"],["dc.contributor.author","Khan, A."],["dc.contributor.author","Paulus, W."],["dc.contributor.author","Stephani, C."],["dc.date.accessioned","2020-12-10T14:23:08Z"],["dc.date.available","2020-12-10T14:23:08Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.clinph.2017.11.002"],["dc.identifier.issn","1388-2457"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71848"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Short-term intraindividual variability of the posterior dominant alpha frequency in the electroencephalogram"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","85"],["dc.bibliographiccitation.journal","Clinical Neurophysiology Practice"],["dc.bibliographiccitation.lastpage","89"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Stephani, C."],["dc.contributor.author","Khan, A."],["dc.contributor.author","Koubeissi, M."],["dc.contributor.author","Paulus, W."],["dc.date.accessioned","2020-12-10T14:23:10Z"],["dc.date.available","2020-12-10T14:23:10Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.cnp.2019.04.002"],["dc.identifier.issn","2467-981X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71860"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Sex influences the frequency of the posterior basic alpha rhythm in patients with epilepsy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","790"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Movement Disorders"],["dc.bibliographiccitation.lastpage","791"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Stephani, Caspar"],["dc.contributor.author","Trenkwalder, Claudia"],["dc.date.accessioned","2018-11-07T08:43:56Z"],["dc.date.available","2018-11-07T08:43:56Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1002/mds.23015"],["dc.identifier.isi","000277311500024"],["dc.identifier.pmid","20198646"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20093"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.relation.issn","0885-3185"],["dc.title","Rhabdomyolysis After Low-Dose Quetiapine in a Patient with Parkinson's Disease with Drug-Induced Psychosis: A Case Report"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","724"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Brain Stimulation"],["dc.bibliographiccitation.lastpage","729"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Stephani, Caspar"],["dc.contributor.author","Koubeissi, Mohamad Z."],["dc.date.accessioned","2018-11-07T09:55:14Z"],["dc.date.available","2018-11-07T09:55:14Z"],["dc.date.issued","2015"],["dc.description.abstract","Background: The thresholds of current intensities required to evoke a clinical response during intracranial electrical stimulation mapping vary. Objective: We wanted to test if there is systematic variation of threshold currents between different brain areas. Methods: Electrode contacts of depth electrodes in a series of patients undergoing presurgical evaluation for epilepsy surgery were stimulated. The brain regions we studied included the insular cortex, the pericentral cortex, and the intervening white matter. Results: Current intensities that elicited clinical responses in central subcortical white matter tracts were significantly lower than those needed to evoke a clinical response in the cortex. Conclusion: We found systematic differences of threshold stimulation intensities between cortical and subcortical structures in the human brain. In addition to known neurophysiologic differences between white and grey matter, the systematic difference in stimulation thresholds may be due to the direction of the white matter tracts with respect to the electrode orientation and to inherent properties of specific brain regions. (C) 2015 Elsevier Inc. All rights reserved."],["dc.description.sponsorship","Stiftungsrat fur die deutsche Wissenschaft [S 134-10.044]"],["dc.identifier.doi","10.1016/j.brs.2015.02.011"],["dc.identifier.isi","000357542100006"],["dc.identifier.pmid","25842075"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36700"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1876-4754"],["dc.relation.issn","1935-861X"],["dc.title","Differences of Intracranial Electrical Stimulation Thresholds in the Human Brain"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","18"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Intensive Care Medicine Experimental"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Stephani, C."],["dc.contributor.author","Choi, A. H. K."],["dc.contributor.author","Moerer, O."],["dc.date.accessioned","2021-06-01T10:48:07Z"],["dc.date.accessioned","2022-08-18T12:41:23Z"],["dc.date.available","2021-06-01T10:48:07Z"],["dc.date.available","2022-08-18T12:41:23Z"],["dc.date.issued","2021-04-06"],["dc.date.updated","2022-07-29T12:18:43Z"],["dc.description.abstract","Abstract\r\n \r\n Purpose\r\n Measurements of cerebrospinal fluid (CSF) lactate can aid in detecting infections of the central nervous system and surrounding structures. Neurosurgical patients with temporary lumbar or ventricular CSF drainage harbor an increased risk for developing infections of the central nervous system, which require immediate therapeutic responses. Since blood gas analyzers enable rapid blood-lactate measurements, we were interested in finding out if we can reliably measure CSF-lactate by this point-of-care technique.\r\n \r\n \r\n Methods\r\n Neurosurgical patients on our intensive care unit (ICU) with either lumbar or external ventricular drainage due to a variety of reasons were included in this prospective observational study. Standard of care included measurements of leucocyte counts, total protein and lactate measurements in CSF by the neurochemical laboratory of our University Medical Center twice a week. With respect to this study, we additionally performed nearly daily measurements of cerebrospinal fluid by blood gas analyzers to determine the reliability of CSF-lactate measured by blood gas analyzers as compared to the standard measurements with a certified device.\r\n \r\n \r\n Results\r\n 62 patients were included in this study. We performed 514 CSF-lactate measurements with blood gas analyzers and compared 180 of these to the in-house standard CSF-lactate measurements. Both techniques correlated highly significantly (Pearson correlation index 0.94) even though lacking full concordance in a Bland–Altman plotting. Of particular importance, regular measurements enabled immediate detection of central infection in three patients who had developed meningitis during the course of their treatment.\r\n \r\n \r\n Conclusion\r\n Blood gas analyzers measure CSF-lactate with sufficient reliability and can help in the timely detection of a developing meningitis. In addition to and triggering established CSF diagnostics, CSF-lactate measurements by blood gas analyzers may improve surveillance of patients with CSF drainage.\r\n This study was retrospectively registered on April 20th 2020 in the German trial register. The trial registration number is DRKS00021466."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.citation","Intensive Care Medicine Experimental. 2021 Apr 06;9(1):18"],["dc.identifier.doi","10.1186/s40635-021-00385-9"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17752"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85834"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112992"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","Springer International Publishing"],["dc.relation.eissn","2197-425X"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject","Cerebrospinal fluid"],["dc.subject","Lactate"],["dc.subject","Meningitis"],["dc.subject","Blood gas analyzer"],["dc.subject","Point-of-care"],["dc.title","Point-of-care detection of lactate in cerebrospinal fluid"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Pulmonology"],["dc.contributor.author","Stephani, C."],["dc.contributor.author","Herrmann, P."],["dc.contributor.author","Ritter, C.O."],["dc.contributor.author","Lotz, J."],["dc.contributor.author","Saager, L."],["dc.contributor.author","Meissner, K."],["dc.contributor.author","Moerer, O."],["dc.date.accessioned","2021-06-01T10:49:53Z"],["dc.date.available","2021-06-01T10:49:53Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1016/j.pulmoe.2020.12.011"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86451"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","2531-0437"],["dc.title","Anatomic lung recruitment in the early phase of severe COVID-19-pneumonia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","177"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Neurology"],["dc.bibliographiccitation.lastpage","179"],["dc.bibliographiccitation.volume","86"],["dc.contributor.author","Koubeissi, Mohamad Z."],["dc.contributor.author","Vaca, Guadalupe Fernandez-Baca"],["dc.contributor.author","Maciunas, Robert"],["dc.contributor.author","Stephani, Caspar"],["dc.date.accessioned","2018-11-07T10:19:27Z"],["dc.date.available","2018-11-07T10:19:27Z"],["dc.date.issued","2016"],["dc.description.abstract","Objective:To investigate the effects of extraoperative electrical stimulation of fiber tracts connecting the language territories.Methods:We describe results of extraoperative electrical stimulation of stereotactic electrodes in 3 patients with epilepsy who underwent presurgical evaluation for epilepsy surgery. Contacts of these electrodes sampled, among other structures, the suprainsular white matter of the left hemisphere.Results:Aside from speech disturbance and speech arrest, subcortical electrical stimulation of white matter tracts directly superior to the insula representing the anterior part of the arcuate fascicle, reproducibly induced complex verbal auditory phenomena including (1) hearing one's own voice in the absence of overt speech, and (2) lack of perception of arrest or alteration in ongoing repetition of words.Conclusion:These results represent direct evidence that the anterior part of the arcuate fascicle is part of a network that is important in the mediation of speech planning and awareness likely by linking the language areas of the inferior parietal and posterior inferior frontal cortices. More specifically, our observations suggest that this structure may be relevant to the pathophysiology of thought disorders and auditory verbal hallucinations."],["dc.description.sponsorship","Stifterverband fur die Deutsche Wissenschaft [S134-10.044]"],["dc.identifier.doi","10.1212/WNL.0000000000002246"],["dc.identifier.isi","000368454800012"],["dc.identifier.pmid","26643545"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41658"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1526-632X"],["dc.relation.issn","0028-3878"],["dc.title","A white matter tract mediating awareness of speech"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","186"],["dc.bibliographiccitation.journal","Epilepsia"],["dc.bibliographiccitation.lastpage","187"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Stephani, Caspar"],["dc.contributor.author","Fernandez-Baca-Vaca, G."],["dc.contributor.author","Maciunas, Robert"],["dc.contributor.author","Koubeissi, Mohamad Z."],["dc.contributor.author","Lueders, Heike"],["dc.date.accessioned","2018-11-07T11:22:31Z"],["dc.date.available","2018-11-07T11:22:31Z"],["dc.date.issued","2009"],["dc.identifier.isi","000270550500390"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56011"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.publisher.place","Malden"],["dc.relation.conference","63rd Annual Meeting of the American-Epilepsy-Society"],["dc.relation.eventlocation","Boston, MA"],["dc.relation.issn","0013-9580"],["dc.title","FUNCTIONAL NEUROANATOMY OF THE INSULAR CORTEX"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]