Bucher, Gregor

[["dc.bibliographiccitation.artnumber","25"],["dc.bibliographiccitation.journal","BMC Developmental Biology"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Peel, Andrew D."],["dc.contributor.author","Schanda, Julia"],["dc.contributor.author","Grossmann, Daniela"],["dc.contributor.author","Ruge, Frank"],["dc.contributor.author","Oberhofer, Georg"],["dc.contributor.author","Gilles, Anna F."],["dc.contributor.author","Schinko, Johannes B."],["dc.contributor.author","Klingler, Martin"],["dc.contributor.author","Bucher, Gregor"],["dc.date.accessioned","2018-11-07T09:23:38Z"],["dc.date.available","2018-11-07T09:23:38Z"],["dc.date.issued","2013"],["dc.description.abstract","Background: The Drosophila larval head is evolutionarily derived at the genetic and morphological level. In the beetle Tribolium castaneum, development of the larval head more closely resembles the ancestral arthropod condition. Unlike in Drosophila, a knirps homologue (Tc-kni) is required for development of the antennae and mandibles. However, published Tc-kni data are restricted to cuticle phenotypes and Tc-even-skipped and Tc-wingless stainings in knockdown embryos. Hence, it has remained unclear whether the entire antennal and mandibular segments depend on Tc-kni function, and whether the intervening intercalary segment is formed completely. We address these questions with a detailed examination of Tc-kni function. Results: By examining the expression of marker genes in RNAi embryos, we show that Tc-kni is required only for the formation of the posterior parts of the antennal and mandibular segments (i.e. the parasegmental boundaries). Moreover, we find that the role of Tc-kni is distinct in these segments: Tc-kni is required for the initiation of the antennal parasegment boundary, but only for the maintenance of the mandibular parasegmental boundary. Surprisingly, Tc-kni controls the timing of expression of the Hox gene Tc-labial in the intercalary segment, although this segment does form in the absence of Tc-kni function. Unexpectedly, we find that the pair-rule gene Tc-even-skipped helps set the posterior boundary of Tc-kni expression in the mandible. Using the mutant antennaless, a likely regulatory Null mutation at the Tc-kni locus, we provide evidence that our RNAi studies represent a Null situation. Conclusions: Tc-kni is required for the initiation of the antennal and the maintenance of the mandibular parasegmental boundaries. Tc-kni is not required for specification of the anterior regions of these segments, nor the intervening intercalary segment, confirming that Tc-kni is not a canonical 'gap-gene'. Our finding that a gap gene orthologue is regulated by a pair rule gene adds to the view that the segmentation gene hierarchies differ between Tribolium and Drosophila upstream of the pair rule gene level. In Tribolium, as in Drosophila, head and trunk segmentation gene networks cooperate to pattern the mandibular segment, albeit involving Tc-kni as novel component."],["dc.description.sponsorship","Deutsche Forschunggemeinschaft DFG [BU-1443/3-1]; DFG [Kl656/2]"],["dc.identifier.doi","10.1186/1471-213X-13-25"],["dc.identifier.isi","000321137000001"],["dc.identifier.pmid","23777260"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9126"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29627"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1471-213X"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Tc-knirps plays different roles in the specification of antennal and mandibular parasegment boundaries and is regulated by a pair-rule gene in the beetle Tribolium castaneum"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Nucleic acids research"],["dc.contributor.author","Dönitz, Jürgen"],["dc.contributor.author","Gerischer, Lizzy"],["dc.contributor.author","Hahnke, Stefan"],["dc.contributor.author","Pfeiffer, Stefan"],["dc.contributor.author","Bucher, Gregor"],["dc.date.accessioned","2019-07-09T11:44:35Z"],["dc.date.available","2019-07-09T11:44:35Z"],["dc.date.issued","2017-10-24"],["dc.description.abstract","The iBeetle-Base provides access to sequence and phenotype information for genes of the beetle Tribolium castaneum. It has been updated including more and updated data and new functions. RNAi phenotypes are now available for >50% of the genes, which represents an expansion of 60% compared to the previous version. Gene sequence information has been updated based on the new official gene set OGS3 and covers all genes. Interoperability with FlyBase has been enhanced: First, gene information pages of homologous genes are interlinked between both databases. Second, some steps of a new query pipeline allow transforming gene lists from either species into lists with related gene IDs, names or GO terms. This facilitates the comparative analysis of gene functions between fly and beetle. The backend of the pipeline is implemented as endpoints of a RESTful interface, such that it can be reused by other projects or tools. A novel online interface allows the community to propose GO terms for their gene of interest expanding the range of animals where GO terms are defined. iBeetle-Base is available at http://ibeetle-base.uni-goettingen.de/."],["dc.identifier.doi","10.1093/nar/gkx984"],["dc.identifier.pmid","29069517"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14825"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59041"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1362-4962"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Expanded and updated data and a query pipeline for iBeetle-Base."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","D720"],["dc.bibliographiccitation.issue","D1"],["dc.bibliographiccitation.journal","Nucleic Acids Research"],["dc.bibliographiccitation.lastpage","D725"],["dc.bibliographiccitation.volume","43"],["dc.contributor.author","Doenitz, Juergen"],["dc.contributor.author","Schmitt-Engel, Christian"],["dc.contributor.author","Grossmann, Daniela"],["dc.contributor.author","Gerischer, Lizzy"],["dc.contributor.author","Tech, Maike"],["dc.contributor.author","Schoppmeier, Michael"],["dc.contributor.author","Klingler, Martin"],["dc.contributor.author","Bucher, Gregor"],["dc.date.accessioned","2018-11-07T10:01:53Z"],["dc.date.available","2018-11-07T10:01:53Z"],["dc.date.issued","2015"],["dc.description.abstract","The iBeetle-Base (http://ibeetle-base.uni-goettingen.de) makes available annotations of RNAi phenotypes, which were gathered in a large scale RNAi screen in the red flour beetle Tribolium castaneum (iBeetle screen). In addition, it provides access to sequence information and links for all Tribolium cas-taneum genes. The iBeetle-Base contains the annotations of phenotypes of several thousands of genes knocked down during embryonic and metamorphic epidermis and muscle development in addition to phenotypes linked to oogenesis and stink gland biology. The phenotypes are described according to the EQM (entity, quality, modifier) system using controlled vocabularies and the Tribolium morphological ontology (TrOn). Furthermore, images linked to the respective annotations are provided. The data are searchable either for specific phenotypes using a complex 'search for morphological defects' or a 'quick search' for gene names and IDs. The red flour beetle Tribolium castaneum has become an important model system for insect functional genetics and is a representative of the most species rich taxon, the Coleoptera, which comprise several devastating pests. It is used for studying insect typical development, the evolution of development and for research on metabolism and pest control. Besides Drosophila, Tribolium is the first insect model organism where large scale unbiased screens have been performed."],["dc.description.sponsorship","Open-Access-Publikationsfunds 2014"],["dc.identifier.doi","10.1093/nar/gku1054"],["dc.identifier.isi","000350210400105"],["dc.identifier.pmid","25378303"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11085"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38124"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","1362-4962"],["dc.relation.issn","0305-1048"],["dc.rights","CC BY-NC 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/4.0"],["dc.title","iBeetle-Base: a database for RNAi phenotypes in the red flour beetle Tribolium castaneum"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","445"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Development Genes and Evolution"],["dc.bibliographiccitation.lastpage","451"],["dc.bibliographiccitation.volume","218"],["dc.contributor.author","Boell, Louis A."],["dc.contributor.author","Bucher, Gregor"],["dc.date.accessioned","2018-11-07T11:12:20Z"],["dc.date.available","2018-11-07T11:12:20Z"],["dc.date.issued","2008"],["dc.description.abstract","In order to broaden the comparative scope of evolutionary developmental biology and to refine our picture of animal macroevolution, it is necessary to establish new model organisms, especially from previously underrepresented groups, like the Lophotrochozoa. We have established the culture and protocols for molecular developmental biology in the rotifer species Brachionus plicatilis Muller (Rotifera, Monogononta). Rotifers are nonsegmented animals with enigmatic basal position within the lophotrochozoans and marked by several evolutionary novelties like the wheel organ (corona), the median eye, and the nonpaired posterior foot. The expression of Bp-Pax-6 is shown using whole-mount in situ hybridization. The inexpensive easy culture and experimental tractability of Brachionus as well as the range of interesting questions to which it holds the key make it a promising addition to the \"zoo\" of evo-devo model organisms."],["dc.identifier.doi","10.1007/s00427-008-0234-z"],["dc.identifier.isi","258086100005"],["dc.identifier.pmid","18594859"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/3536"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53641"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0949-944X"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Whole-mount in situ hybridization in the Rotifer Brachionus plicatilis representing a basal branch of lophotrochozoans"],["dc.title.original","3536"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e1002416"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","PLoS Genetics"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Posnien, Nico"],["dc.contributor.author","Koniszewski, Nikolaus Dieter Bernhard"],["dc.contributor.author","Hein, Hendrikje Jeannette"],["dc.contributor.author","Bucher, Gregor"],["dc.date.accessioned","2018-11-07T08:49:04Z"],["dc.date.available","2018-11-07T08:49:04Z"],["dc.date.issued","2011"],["dc.description.abstract","Several highly conserved genes play a role in anterior neural plate patterning of vertebrates and in head and brain patterning of insects. However, head involution in Drosophila has impeded a systematic identification of genes required for insect head formation. Therefore, we use the red flour beetle Tribolium castaneum in order to comprehensively test the function of orthologs of vertebrate neural plate patterning genes for a function in insect head development. RNAi analysis reveals that most of these genes are indeed required for insect head capsule patterning, and we also identified several genes that had not been implicated in this process before. Furthermore, we show that Tc-six3/optix acts upstream of Tc-wingless, Tc-orthodenticle1, and Tc-eyeless to control anterior median development. Finally, we demonstrate that Tc-six3/optix is the first gene known to be required for the embryonic formation of the central complex, a midline-spanning brain part connected to the neuroendocrine pars intercerebralis. These functions are very likely conserved among bilaterians since vertebrate six3 is required for neuroendocrine and median brain development with certain mutations leading to holoprosencephaly."],["dc.identifier.doi","10.1371/journal.pgen.1002416"],["dc.identifier.isi","000299167900033"],["dc.identifier.pmid","22216011"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8437"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21366"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1553-7390"],["dc.rights","CC BY 2.5"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.5"],["dc.title","Candidate Gene Screen in the Red Flour Beetle Tribolium Reveals Six3 as Ancient Regulator of Anterior Median Head and Central Complex Development"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1819"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Proceedings of the National Academy of Sciences"],["dc.bibliographiccitation.lastpage","1824"],["dc.bibliographiccitation.volume","115"],["dc.contributor.author","Ansari, Salim"],["dc.contributor.author","Troelenberg, Nicole"],["dc.contributor.author","Dao, Van Anh"],["dc.contributor.author","Richter, Tobias"],["dc.contributor.author","Bucher, Gregor"],["dc.contributor.author","Klingler, Martin"],["dc.date.accessioned","2020-12-10T18:12:48Z"],["dc.date.available","2020-12-10T18:12:48Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1073/pnas.1716512115"],["dc.identifier.eissn","1091-6490"],["dc.identifier.issn","0027-8424"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74503"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Double abdomen in a short-germ insect: Zygotic control of axis formation revealed in the beetle Tribolium castaneum"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","62"],["dc.bibliographiccitation.journal","BMC Biology"],["dc.bibliographiccitation.lastpage","27"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Schwager, Evelyn E."],["dc.contributor.author","Sharma, Prashant P."],["dc.contributor.author","Clark, Thomas"],["dc.contributor.author","Leite, Daniel J."],["dc.contributor.author","Wierschin, Torsten"],["dc.contributor.author","Pechmann, Matthias"],["dc.contributor.author","Akiyama-Oda, Yasuko"],["dc.contributor.author","Esposito, Lauren"],["dc.contributor.author","Bechsgaard, Jesper"],["dc.contributor.author","Bilde, Trine"],["dc.contributor.author","Buffry, Alexandra D."],["dc.contributor.author","Chao, Hsu"],["dc.contributor.author","Huyen, Dinh"],["dc.contributor.author","Doddapaneni, Harshavardhan"],["dc.contributor.author","Dugan, Shannon"],["dc.contributor.author","Eibner, Cornelius"],["dc.contributor.author","Extavour, Cassandra G."],["dc.contributor.author","Funch, Peter"],["dc.contributor.author","Garb, Jessica"],["dc.contributor.author","Gonzalez, Luis B."],["dc.contributor.author","Gonzalez, Vanessa L."],["dc.contributor.author","Griffiths-Jones, Sam"],["dc.contributor.author","Han, Yi"],["dc.contributor.author","Hayashi, Cheryl"],["dc.contributor.author","Hilbrant, Maarten"],["dc.contributor.author","Hughes, Daniel S. T."],["dc.contributor.author","Janssen, Ralf"],["dc.contributor.author","Lee, Sandra L."],["dc.contributor.author","Maeso, Ignacio"],["dc.contributor.author","Murali, Shwetha C."],["dc.contributor.author","Muzny, Donna M."],["dc.contributor.author","Nunes da Fonseca, Rodrigo"],["dc.contributor.author","Paese, Christian L. B."],["dc.contributor.author","Qu, Jiaxin"],["dc.contributor.author","Ronshaugen, Matthew"],["dc.contributor.author","Schomburg, Christoph"],["dc.contributor.author","Schönauer, Anna"],["dc.contributor.author","Stollewerk, Angelika"],["dc.contributor.author","Torres-Oliva, Montserrat"],["dc.contributor.author","Turetzek, Natascha"],["dc.contributor.author","Vanthournout, Bram"],["dc.contributor.author","Werren, John H."],["dc.contributor.author","Wolff, Carsten"],["dc.contributor.author","Worley, Kim C."],["dc.contributor.author","Bucher, Gregor"],["dc.contributor.author","Gibbs, Richard A."],["dc.contributor.author","Coddington, Jonathan"],["dc.contributor.author","Oda, Hiroki"],["dc.contributor.author","Stanke, Mario"],["dc.contributor.author","Ayoub, Nadia A."],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.contributor.author","Flot, Jean-Francois"],["dc.contributor.author","Posnien, Nico"],["dc.contributor.author","Richards, Stephen"],["dc.contributor.author","McGregor, Alistair P."],["dc.date.accessioned","2019-07-09T11:44:25Z"],["dc.date.available","2019-07-09T11:44:25Z"],["dc.date.issued","2017"],["dc.description.abstract","The duplication of genes can occur through various mechanisms and is thought to make a major contribution to the evolutionary diversification of organisms. There is increasing evidence for a large-scale duplication of genes in some chelicerate lineages including two rounds of whole genome duplication (WGD) in horseshoe crabs. To investigate this further, we sequenced and analyzed the genome of the common house spider Parasteatoda tepidariorum. We found pervasive duplication of both coding and non-coding genes in this spider, including two clusters of Hox genes. Analysis of synteny conservation across the P. tepidariorum genome suggests that there has been an ancient WGD in spiders. Comparison with the genomes of other chelicerates, including that of the newly sequenced bark scorpion Centruroides sculpturatus, suggests that this event occurred in the common ancestor of spiders and scorpions, and is probably independent of the WGDs in horseshoe crabs. Furthermore, characterization of the sequence and expression of the Hox paralogs in P. tepidariorum suggests that many have been subject to neo-functionalization and/or sub-functionalization since their duplication. Our results reveal that spiders and scorpions are likely the descendants of a polyploid ancestor that lived more than 450 MYA. Given the extensive morphological diversity and ecological adaptations found among these animals, rivaling those of vertebrates, our study of the ancient WGD event in Arachnopulmonata provides a new comparative platform to explore common and divergent evolutionary outcomes of polyploidization events across eukaryotes."],["dc.identifier.doi","10.1186/s12915-017-0399-x"],["dc.identifier.pmid","28756775"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15127"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59010"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","In goescholar not merged with http://resolver.sub.uni-goettingen.de/purl?gs-1/14757 but duplicate"],["dc.rights","CC BY 4.0"],["dc.rights.access","openAccess"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","The house spider genome reveals an ancient whole-genome duplication during arachnid evolution"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Development"],["dc.contributor.author","Garcia-Perez, Natalia Carolina"],["dc.contributor.author","Bucher, Gregor"],["dc.contributor.author","Buescher, Marita"],["dc.date.accessioned","2021-09-01T06:42:54Z"],["dc.date.available","2021-09-01T06:42:54Z"],["dc.date.issued","2021"],["dc.description.abstract","Gene regulatory mechanisms which specify subtype identity of central complex (CX) neurons are the subject of intense investigation. The CX is a compartment within the brain common to all insect species and functions as a “command center” which directs motor actions. It is made up of several thousand neurons with more than 60 morphologically distinct identities. Accordingly, transcriptional programs must effect the specification of at least as many neuronal subtypes. We demonstrate a role for the transcription factor Shaking hands (Skh) in the specification of embryonic CX neurons in Tribolium. The developmental dynamics of Tc-skh expression are characteristic for terminal selectors of subtype identity. In the embryonic brain, Tc-skh expression is restricted to a subset of neurons, many of which survive to adulthood and contribute to the mature CX. Tc-skh expression is maintained throughout the lifetime in at least some CX neurons. Tc-skh knock-down results in axon outgrowth defects thus preventing the formation of an embryonic CX primordium. The as yet unstudied Drosophila skh shows a similar embryonic expression pattern suggesting that subtype specification of CX neurons may be conserved."],["dc.description.abstract","Gene regulatory mechanisms which specify subtype identity of central complex (CX) neurons are the subject of intense investigation. The CX is a compartment within the brain common to all insect species and functions as a “command center” which directs motor actions. It is made up of several thousand neurons with more than 60 morphologically distinct identities. Accordingly, transcriptional programs must effect the specification of at least as many neuronal subtypes. We demonstrate a role for the transcription factor Shaking hands (Skh) in the specification of embryonic CX neurons in Tribolium. The developmental dynamics of Tc-skh expression are characteristic for terminal selectors of subtype identity. In the embryonic brain, Tc-skh expression is restricted to a subset of neurons, many of which survive to adulthood and contribute to the mature CX. Tc-skh expression is maintained throughout the lifetime in at least some CX neurons. Tc-skh knock-down results in axon outgrowth defects thus preventing the formation of an embryonic CX primordium. The as yet unstudied Drosophila skh shows a similar embryonic expression pattern suggesting that subtype specification of CX neurons may be conserved."],["dc.identifier.doi","10.1242/dev.199368"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89171"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-455"],["dc.relation.eissn","1477-9129"],["dc.relation.issn","0950-1991"],["dc.title","Shaking hands is a homeodomain transcription factor that controls axon outgrowth of central complex neurons in the insect model Tribolium"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","399"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Arthropod Structure & Development"],["dc.bibliographiccitation.lastpage","410"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Posnien, Nico"],["dc.contributor.author","Schinko, Johannes B."],["dc.contributor.author","Kittelmann, Sebastian"],["dc.contributor.author","Bucher, Gregor"],["dc.date.accessioned","2018-11-07T08:37:17Z"],["dc.date.available","2018-11-07T08:37:17Z"],["dc.date.issued","2010"],["dc.description.abstract","Many questions regarding evolution and ontogeny of the insect head remain open. Likewise, the genetic basis of insect head development is poorly understood. Recently, the investigation of gene expression data and the analysis of patterning gene function have revived interest in insect head development. Here, we argue that the red flour beetle Tribolium castaneum is a well suited model organism to spearhead research with respect to the genetic control of insect head development. We review recent molecular data and discuss its bearing on early development and morphogenesis of the head. We present a novel hypothesis on the ontogenetic origin of insect head sutures and review recent insights into the question on the origin of the labrum. Further, we argue that the study of developmental genes may identify the elusive anterior non-segmental region and present some evidence in favor of its existence. With respect to the question of evolution of patterning we show that the head Anlagen of the fruit fly Drosophila melanogaster and Tribolium differ considerably and we review profound differences of their genetic regulation. Finally, we discuss which insect model species might help us to answer the open questions concerning the genetic regulation of head development and its evolution. (C) 2010 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.asd.2010.08.002"],["dc.identifier.isi","000285819100002"],["dc.identifier.pmid","20800703"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18495"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ltd"],["dc.relation.issn","1467-8039"],["dc.title","Genetics, development and composition of the insect head - A beetle's view"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","107"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Developmental Biology"],["dc.bibliographiccitation.lastpage","116"],["dc.bibliographiccitation.volume","338"],["dc.contributor.author","Posnien, Nico"],["dc.contributor.author","Bucher, Gregor"],["dc.date.accessioned","2018-11-07T08:46:09Z"],["dc.date.available","2018-11-07T08:46:09Z"],["dc.date.issued","2010"],["dc.description.abstract","The insect head is composed of several segments. During embryonic development, the segments fuse to form a rigid head capsule where obvious segmental boundaries are lacking. Hence, the assignment of regions of the insect head to specific segments is hampered, especially with respect to dorsal (vertex) and lateral (gena) parts. We show that upon Tribolium labial (Tc-lab) knock down, the intercalary segment is deleted but not transformed. Furthermore, we find that the intercalary segment contributes to lateral parts of the head cuticle in Tribolium. Based on several additional mutant and RNAi phenotypes that interfere with gnathal segment development, we show that these segments do not contribute to the dorsal head capsule apart from the dorsal ridge. Opposing the classical view but in line with findings in the vinegar fly Drosophila melanogaster and the milkweed bug Oncopeltus fasciatus, we propose a \"bend and zipper\" model for insect head capsule formation. (C) 2009 Elsevier Inc, All rights reserved."],["dc.description.sponsorship","DFG [BU-1443/2]; Marie-Curie Research Training Network \"Zoonet\""],["dc.identifier.doi","10.1016/j.ydbio.2009.11.010"],["dc.identifier.isi","000274173400010"],["dc.identifier.pmid","19913530"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20618"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","1095-564X"],["dc.relation.issn","0012-1606"],["dc.title","Formation of the insect head involves lateral contribution of the intercalary segment, which depends on Tc-labial function"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]