Knabe, Wolfgang

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Cell and Tissue Research"],["dc.bibliographiccitation.lastpage","13"],["dc.bibliographiccitation.volume","316"],["dc.contributor.author","Knabe, Wolfgang"],["dc.contributor.author","Washausen, Stefan"],["dc.contributor.author","Brunnett, G."],["dc.contributor.author","Kuhn, H. J."],["dc.date.accessioned","2018-11-07T10:49:47Z"],["dc.date.available","2018-11-07T10:49:47Z"],["dc.date.issued","2004"],["dc.description.abstract","Whether rhombomere-specific patterns of apoptosis exist in the developing hindbrain of vertebrates is under debate. We have investigated the sequence of apoptotic events in three-dimensionally reconstructed hindbrains of Tupaia belangeri (8- to 19-somite embryos). Apoptotic cells were identified by structural criteria and by applying an in situ tailing technique to visualize DNA fragmentation. Seven rhombomeres originated from three pro-rhombomeres. Among pre-migratory neural crest cells in the dorsal thirds of the neural folds, the earliest apoptotic concentrations appeared in the developing third rhombomere (r3). Dorsal apoptotic maxima then persisted in r3, extended from r3 to r2, and also arose in r5. Transverse apoptotic bands increased the total amount of apoptotic cells in odd-numbered rhombomeres first in r3 and, with a delay, also in r5. This sequence of apoptotic events was paralleled by an approximate rostrocaudal sequence of neural crest cell delamination from the even-numbered rhombomeres. Thus, large-scale apoptosis in r3 and r5 helped to establish crest-free zones that segregated streams of migrating neural crest cells adjacent to r2, r4, and r6. The sequence of apoptotic events observed in the dorsal thirds of rhombomeres matches that reported for the chick embryo. Other shared features are apoptotic peaks in the position of a circumscribed ventricular protrusion of fusing parts of the neural folds in r1 and r2, and Y-shaped apoptotic patterns composed of apoptotic maxima in the dorsal and lateral thirds of r1, r2, and r3. These rhombomere-specific patterns of apoptosis may therefore represent a conserved character, at least in amniotes."],["dc.identifier.doi","10.1007/s00441-004-0855-0"],["dc.identifier.isi","000220298800001"],["dc.identifier.pmid","14986099"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48509"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0302-766X"],["dc.title","Rhombomere-specific patterns of apoptosis in the tree shrew Tupaia belangeri"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","428"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The Journal of Comparative Neurology"],["dc.bibliographiccitation.lastpage","436"],["dc.bibliographiccitation.volume","420"],["dc.contributor.author","Malz, Cordula R."],["dc.contributor.author","Knabe, Wolfgang"],["dc.contributor.author","Kuhn, H. J."],["dc.date.accessioned","2018-11-07T10:51:01Z"],["dc.date.available","2018-11-07T10:51:01Z"],["dc.date.issued","2000"],["dc.description.abstract","The distribution of the calcium-binding protein calretinin was studied in peripheral and central parts of the main olfactory system (MOS) and the vomeronasal system (VNS) of adult tree shrew Tupaia belangeri. The calretinin immunoreaction was carried out with a peroxidase-coupled polyclonal antibody. In the VNS, complete labeling of all receptor cells and vomeronasal nerve fibers was observed, whereas only a subset of the somata and dendrites of receptor cells and of the olfactory nerve fibers of the MOS was immunoreactive. From the immunoreactive dendritic clubs of vomeronasal receptor cells, calretinin-labeled structures, presumably clumps of microvilli, arose that terminated within immunopositive portions of the mucus. In the main olfactory bulb, the neuropil of some of the glomeruli was immunoreactive. All periglomerular and many mitral. cells were labeled. The external plexiform layer was subdivided into a faintly immunoreactive superficial half and a strongly immunoreactive deep half. Immunoreactive basal dendrites of mitral cells could be followed into either the deep half or the superficial half. In the laminated internal granular layer, a subset of immunopositive granule cells extended dendrites into the external plexiform layer. Mitral cells and granule cells with dendrites ascending to different levels of the external plexiform layer may represent functional subclasses. In the accessory olfactory bulb, all vomeronasal nerve fibers, glomeruli, and mitral/tufted cells were labeled, whereas immunoreactive periglomerular cells and internal granule cells were only scattered. In Tupaia, calretinin immunoreactivity is a more general property of the primary projecting neurons of the VNS than of the MOS and possibly indicates the involvement of calretinin in the perception of certain of the olfactory qualities. (C) 2000 Wiley-Liss,Inc."],["dc.identifier.doi","10.1002/(SICI)1096-9861(20000515)420:4<428::AID-CNE2>3.0.CO;2-2"],["dc.identifier.isi","000086745000002"],["dc.identifier.pmid","10805918"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48788"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.relation.issn","0021-9967"],["dc.title","Pattern of calretinin immunoreactivity in the main olfactory system and the vomeronasal system of the tree shrew, Tupaia belangeri"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","REPRODUCTION"],["dc.bibliographiccitation.volume","149"],["dc.contributor.author","Rath, Detlef"],["dc.contributor.author","Barcikowski, S."],["dc.contributor.author","de Graaf, S."],["dc.contributor.author","Garrels, W."],["dc.contributor.author","Grossfeld, R."],["dc.contributor.author","Klein, Sabine"],["dc.contributor.author","Knabe, Wolfgang"],["dc.contributor.author","Knorr, C."],["dc.contributor.author","Kues, W."],["dc.contributor.author","Meyer, H."],["dc.contributor.author","Michl, J."],["dc.contributor.author","Moench-Tegeder, G."],["dc.contributor.author","Rehbock, C."],["dc.contributor.author","Taylor, U."],["dc.contributor.author","Washausen, Stefan"],["dc.date.accessioned","2018-11-07T10:00:13Z"],["dc.date.available","2018-11-07T10:00:13Z"],["dc.date.issued","2015"],["dc.identifier.doi","10.1530/REP-12-0151e"],["dc.identifier.isi","000351918000001"],["dc.identifier.pmid","25680787"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37751"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Bioscientifica Ltd"],["dc.relation.issn","1470-1626"],["dc.title","Sex selection of sperm in farm animals: status report and developmental prospects (vol 145, pg R15, 2013)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","83"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","ANATOMY AND EMBRYOLOGY"],["dc.bibliographiccitation.lastpage","97"],["dc.bibliographiccitation.volume","205"],["dc.contributor.author","Malz, Cordula R."],["dc.contributor.author","Knabe, Wolfgang"],["dc.contributor.author","Kuhn, H. J."],["dc.date.accessioned","2018-11-07T10:29:56Z"],["dc.date.available","2018-11-07T10:29:56Z"],["dc.date.issued","2002"],["dc.description.abstract","The prenatal patterns of calretinin immunoreactivity were studied in the olfactory systems of Tupaia belangeri. We investigated the peripheral and primary central parts of the vomeronasal system and of the main olfactory system from the 19th to the 43rd (last) day of gestation and compared the findings with the known calretinin immunoreactivity patterns in adult T belangeri and the published data on other mammals. The onset of calretinin immunoreactivity was noted in the main olfactory system on the 23rd day of gestation and, in the vomeronasal system, on the 25th day of gestation: single precursors of receptor cells with calretinin immunoreactive perikarya and processes were observed in both epithelia. Their neuronal identity was proven by olfactory marker protein immunoreactivity. On the 42nd day of gestation, almost all receptor cells and nerve fibers, many interneurons and projecting cells were calretinin immunoreactive in the main olfactory and in the vomeronasal systems. In contrast to the intensive calretinin labeling previously observed in virtually all vomeronasal epithelial cells of adult T belangeri, among developing receptor cells a population of intensively labeled, basally located perikarya was distinguishable from a population of less intensively stained, more apically located ones. In the main olfactory epithelium of fetal T belangeri, calretinin immunoreactive receptor cells occurred in the middle layers. Whereas in the vomeronasal sensory epithelium differently reacting layers of receptor cells might represent the two known subfamilies of receptor cells, in the main olfactory epithelium the differing calretinin expression in the layers of the epithelium, most probably, did not reflect known subfamilies of odour receptor cells. Transiently, ectopic calretinin immunoreactive receptor cells were observed in the future non-sensory epithelium of the vomeronasal organ."],["dc.identifier.doi","10.1007/s00429-002-0244-y"],["dc.identifier.isi","000176029800002"],["dc.identifier.pmid","12021911"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43754"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0340-2061"],["dc.title","Calretinin immunoreactivity in the prenatally developing olfactory systems of the tree shrew Tupaia belangeri"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","PII S0165-0270(02)00247-9"],["dc.bibliographiccitation.firstpage","169"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Neuroscience Methods"],["dc.bibliographiccitation.lastpage","180"],["dc.bibliographiccitation.volume","121"],["dc.contributor.author","Knabe, Wolfgang"],["dc.contributor.author","Washausen, Stefan"],["dc.contributor.author","Brunnett, G."],["dc.contributor.author","Kuhn, H. R."],["dc.date.accessioned","2018-11-07T09:42:12Z"],["dc.date.available","2018-11-07T09:42:12Z"],["dc.date.issued","2002"],["dc.description.abstract","The present study demonstrates how, predominantly by external fiducials, histological serial sections used to reconstruct patterns of individually marked cellular events in large organs or whole embryos can be realigned with the help of 'reference series'. Resin-embedded embryos were cut at 1 mum and consecutive sections were alternately placed on two sets of slides. For cytological diagnosis and acquisition of embryonic contours, stained sections of the first series, termed 'working series', were scanned with the x 100 objective using 'Huge Image', a recently established image acquisition system. For acquisition of the contours of the resin block, adjacent unstained sections of the second series, termed 'reference series', were scanned with the x 5 objective. Thereafter, 'hybrid sections' were created which combined vectorized embryonic contours and cellular events taken from the working series with vectorized block contours taken from the reference series. For realignment, consecutive 'hybrid sections' were matched by best-fit of the block contours. Stacks of realigned 'hybrid sections' were shaped like truncated pyramids and, thus, reflected repeated 'trimming' of the resin block during the sectioning procedure. Among 266 'hybrid sections' at intervals of 8 gm, needed to reconstruct the brain of a 15-day-old embryo of Tupaia belangeri (Scandentia), internal fiducials were required five times for realigning a total of six adjacent truncated pyramids. Application of this method provided realistic reconstructions of the positions of apoptotic cells in the entire developing brain without the need of secondary introduction of external fiducials. (C) 2002 Elsevier Science B.V. All rights reserved."],["dc.identifier.doi","10.1016/S0165-0270(02)00247-9"],["dc.identifier.isi","000179968900006"],["dc.identifier.pmid","12468007"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33903"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0165-0270"],["dc.title","Use of 'reference series' to realign histological serial sections for three-dimensional reconstructions of the positions of cellular events in the developing brain"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","719"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Neuroscience"],["dc.bibliographiccitation.lastpage","723"],["dc.contributor.author","Riechers, Claas-Christian"],["dc.contributor.author","Knabe, Wolfgang"],["dc.contributor.author","Sirén, Anna-Leena"],["dc.contributor.author","Gariepy, C. E."],["dc.contributor.author","Yanagisawa, M."],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.date.accessioned","2017-09-07T11:45:48Z"],["dc.date.available","2017-09-07T11:45:48Z"],["dc.date.issued","2004"],["dc.identifier.gro","3150462"],["dc.identifier.pmid","15026112"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7228"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.issn","0306-4522"],["dc.title","Endothelin B receptor deficient transgenic rescue rats: A rescue phenomenon in the brain"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","49"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Brain Structure and Function"],["dc.bibliographiccitation.lastpage","65"],["dc.bibliographiccitation.volume","214"],["dc.contributor.author","Knabe, Wolfgang"],["dc.contributor.author","Obermayer, Bastian"],["dc.contributor.author","Kuhn, Hans-Juerg"],["dc.contributor.author","Brunnett, Guido"],["dc.contributor.author","Washausen, Stefan"],["dc.date.accessioned","2018-11-07T11:21:18Z"],["dc.date.available","2018-11-07T11:21:18Z"],["dc.date.issued","2009"],["dc.description.abstract","The neurogenic trigeminal placode develops from the crescent-shaped panplacodal primordium which delineates the neural plate anteriorly. We show that, in Tupaia belangeri, the trigeminal placode is represented by a field of focal ectodermal thickenings which over time changes positions from as far rostral as the level of the forebrain to as far caudal as opposite rhombomere 3. Delamination proceeds rostrocaudally from the ectoderm adjacent to the rostral midbrain, and contributes neurons to the trigeminal ganglion as well as to the ciliary ganglion/oculomotor complex. Proliferative events are centered on the field prior to the peak of delamination. They are preceded, paralleled and, finally, outnumbered by apoptotic events which proceed rostrocaudally from non-delaminating to delaminating parts of the field. Apoptosis persists upon regression of the placode, thereby exhibiting a massive \"wedge\" of apoptotic cells which includes the postulated position of the \"ventrolateral postoptic placode\" (Lee et al. in Dev Biol 263:176-190, 2003), merges with groups of lens-associated apoptotic cells, and disappears upon lens detachment. In conjunction with earlier work (Washausen et al. in Dev Biol 278:86-102, 2005) our findings suggest that apoptosis contributes repeatedly to the disintegration of the panplacodal primordium, to the elimination of subsets of premigratory placodal neuroblasts, and to the regression of placodes."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [KN 525/1-1, KN 525/1-2, BR 1185/4-1]"],["dc.identifier.doi","10.1007/s00429-009-0228-2"],["dc.identifier.isi","000272158400005"],["dc.identifier.pmid","19915864"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/4151"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55743"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1863-2653"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Apoptosis and proliferation in the trigeminal placode"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","86"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Developmental Biology"],["dc.bibliographiccitation.lastpage","102"],["dc.bibliographiccitation.volume","278"],["dc.contributor.author","Washausen, Stefan"],["dc.contributor.author","Obermayer, Bastian"],["dc.contributor.author","Brunnett, Guido"],["dc.contributor.author","Kuhn, Hans-Jürg"],["dc.contributor.author","Knabe, Wolfgang"],["dc.date.accessioned","2018-11-07T11:25:44Z"],["dc.date.available","2018-11-07T11:25:44Z"],["dc.date.issued","2005"],["dc.description.abstract","Epibranchial placodes and rhombencephalic neural crest provide precursor cells for the geniculate, petrosal, and nodose ganglia., In chick embryos and in Tupaia belangeri, apoptosis, in rhombomeres 3 and 5 helps to select premigratory precursor cells and to segregate crest cell streams derived from the even-numbered rhombomeres. Much less is known about the patterns and functions of apoptosis in epibranchial placodes. We found that, in Tupaia belangeri, combined anlagen of the otic placode and epibranchial placode 1 transiently share a primordial low grade thickening with post-otic epibranchial placodes. Three-dimensional reconstructions reveal complementary, spatially, and temporally regulated apoptotic and proliferative events that demarcate the otic placode and epibranchial placode 1, and help to individualize three pairs of epibranchial placodes in a rostrocaudal sequence. Later, rostrocaudal waves of proliferation and apoptosis extend from dorsal to ventral parts of the placodes, paralleled by the dorsoventral progression of precursor cell delamination. These findings suggest a role for apoptosis during the process of neuroblast generation in the epibranchial placodes. Finally, apoptosis eliminates remnants of the placodes in the presence of late invading macrophages. (C) 2004 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.ydbio.2004.10.016"],["dc.identifier.isi","000226680400008"],["dc.identifier.pmid","15649463"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56692"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","Najko"],["dc.relation.issn","0012-1606"],["dc.title","Apoptosis and proliferation in developing, mature, and regressing epibranchial placodes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","503"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","ANATOMY AND EMBRYOLOGY"],["dc.bibliographiccitation.lastpage","512"],["dc.bibliographiccitation.volume","207"],["dc.contributor.author","Knabe, Wolfgang"],["dc.contributor.author","Knerlich, F."],["dc.contributor.author","Washausen, Stefan"],["dc.contributor.author","Kietzmann, Thomas"],["dc.contributor.author","Siren, A. L."],["dc.contributor.author","Brunnett, G."],["dc.contributor.author","Kuhn, H. J."],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.date.accessioned","2018-11-07T10:50:26Z"],["dc.date.available","2018-11-07T10:50:26Z"],["dc.date.issued","2004"],["dc.description.abstract","The expression patterns of erythropoietin (EPO) and its receptor (EPOR) were investigated in the midbrain and in adjacent parts of the synencephalon and hindbrain of embryonic C57Bl mice. On embryonic (E) day 8 (E8), virtually all neuroepithelial cells expressed EPOR. After neural tube closure, subsets of these cells downregulated EPOR. In contrast, radial glial cells were EPOR-immunolabeled from E11 onwards. Simultaneously, subpopulations of early developing neurons upregulated EPO and expressed HIF-1, known to transcriptionally activate EPO. Three-dimensional reconstructions revealed subpopulations of EPO-expressing neurons: (1) in the trigeminal mesencephalic nucleus (TMN), (2) at the rostral transition of the midbrain and synencephalon, (3) in the basal plate of the midbrain, (4) in the trigeminal motor nucleus, and (5) in the trigeminal principal sensory nucleus. In the rostral midbrain and synencephalon, EPO-immunoreactive neurons were attached to EPOR-expressing radial glial cells. The identity of radial glial cells was proven by their immunoreactivity for antibodies against astrocyte-specific glutamate transporter, brain lipid-binding protein, and nestin. From E12.5 onwards EPOR was downregulated in radial glial cells. Viable neurons of the TMN continued to express EPO and upregulated EPOR. Our findings provide new evidence that components of the EPO system are present in distinct locations of the embryonic brain and, by interactions between neurons and radial glial cells as well as among clustered TMN neurons, may contribute to its morphogenesis. Whether the observed expression patterns of EPO and EPOR may reflect EPO-mediated trophic and/or antiapoptotic effects on neurons is discussed."],["dc.identifier.doi","10.1007/s00429-003-0365-y"],["dc.identifier.isi","000220086500009"],["dc.identifier.pmid","14770308"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48650"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0340-2061"],["dc.title","Expression patterns of erythropoietin and its receptor in the developing midbrain"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","453"],["dc.bibliographiccitation.journal","Journal of Anatomy"],["dc.bibliographiccitation.lastpage","461"],["dc.bibliographiccitation.volume","196"],["dc.contributor.author","Ochs, Matthias"],["dc.contributor.author","Mayhew, T. M."],["dc.contributor.author","Knabe, Wolfgang"],["dc.date.accessioned","2018-11-07T11:13:09Z"],["dc.date.available","2018-11-07T11:13:09Z"],["dc.date.issued","2000"],["dc.description.abstract","The cellular ensheathment of capillaries in the 3 outer capillary layers of the central retina of the adult tree shrew Tupaia belangeri was studied quantitatively by transmission electron microscopy. Using a stereological approach, the relative surface of capillary basal lamina ensheathed by Muller cells and by nonmacroglial cells (collectively termed non-Muller cells) was estimated in 5 animals. The participation of Muller cells was distinctly different in the 3 capillary layers studied. In the outermost capillary layer 1, the mean (standard deviation) percentage surface coverage by non-Muller cell processes was 46.8 (15.3)%. Much less of the capillary basal lamina was ensheathed by non-Muller cells in capillary layers 2 and 3 (3.0 (2.1)% and 0.3 (0.3)% respectively). The observed total variation of the stereological estimates for the surface fraction of Muller cells (expressed as the between-subject coefficient of variation) was significantly higher in capillary layer 1 (28.8%) compared with capillary layers 2 (2.2%) and 3 (0.3%). In capillary layer 1, the high observed total variation was due to a high biological variation among animals for the fractions of both Muller cell and non-Muller cell ensheathment. The rare occurrence of direct contacts between the capillary basal lamina and the perikarya of either microglial cells (capillary layer 3) or amacrine cells (capillary layer 2) corresponded well to the low stereological values obtained for the relative capillary surface ensheathed by non-Muller cells in these capillary layers. Previously, extensive and frequent contacts between the basal lamina of capillaries belonging to capillary layer 1 and horizontal cells had been observed in single sections. The present study quantitatively demonstrates a marked paucity of macroglial investment of capillaries located in capillary layer 1 of Tupaia. It can be concluded that horizontal cells ensheath most of the capillary surface not invested by Muller cells."],["dc.identifier.doi","10.1046/j.1469-7580.2000.19630453.x"],["dc.identifier.isi","000087533000015"],["dc.identifier.pmid","10853967"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53826"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cambridge Univ Press"],["dc.relation.issn","0021-8782"],["dc.title","To what extent are the retinal capillaries ensheathed by Muller cells? A stereological study in the tree shrew Tupaia belangeri"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]