Koch, Philipp

[["dc.bibliographiccitation.firstpage","A665"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Gastroenterology"],["dc.bibliographiccitation.volume","118"],["dc.contributor.author","Roth, Judith C."],["dc.contributor.author","Koch, Philipp"],["dc.contributor.author","Contente, Ana"],["dc.contributor.author","Dobbelstein, Matthias"],["dc.date.accessioned","2022-03-01T11:45:28Z"],["dc.date.available","2022-03-01T11:45:28Z"],["dc.date.issued","2000"],["dc.identifier.doi","10.1016/S0016-5085(00)84796-4"],["dc.identifier.pii","S0016508500847964"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103338"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.issn","0016-5085"],["dc.title","Tumor-derived mutations within the DNA-binding domain of p53 that phenotypically resemble the deletion of the proline-rich domain"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","384"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","International Archives of Occupational and Environmental Health"],["dc.bibliographiccitation.lastpage","388"],["dc.bibliographiccitation.volume","73"],["dc.contributor.author","Westphal, Goetz Alexander"],["dc.contributor.author","Schnuch, Axel"],["dc.contributor.author","Schulz, Thomas G."],["dc.contributor.author","Reich, Kristian"],["dc.contributor.author","Aberer, Werner"],["dc.contributor.author","Brasch, Jochen"],["dc.contributor.author","Koch, P."],["dc.contributor.author","Wessbecher, R."],["dc.contributor.author","Szliska, Christiane"],["dc.contributor.author","Bauer, A."],["dc.contributor.author","Hallier, Ernst"],["dc.date.accessioned","2018-11-07T10:37:14Z"],["dc.date.available","2018-11-07T10:37:14Z"],["dc.date.issued","2000"],["dc.description.abstract","Objective: Thimerosal is an important preservative in vaccines and ophthalmologic preparations. The substance is known to be a type IV sensitizing agent. High sensitization rates were observed in contact-allergic patients and in health care workers who had been exposed to thimerosal-preserved vaccines. There is evidence for the involvement of the glutathione system in the metabolism of thimerosal or its decomposition products (organomercury alkyl compounds). Thus detoxification by polymorphically expressed glutathione S-transferases such as GSTT1 and GSTM1 might have a protective effect against sensitization by these substances. Methods: To address this question, a case control study was conducted, including 91 Central European individuals with a positive patch-test reaction to thimerosal. This population was compared with 169 healthy controls and additionally with 114 individuals affected by an allergy against para-substituted aryl compounds. The latter population was included in order to test whether possible associations were due to substance-specific effects, or were a general feature connected with type IV immunological diseases. Homozygous deletions of GSTT1 and GSTM1 were determined by polymerase chain reaction. Results: Glutathione S-transferase M1 deficiency was significantly more frequent among patients sensitized to thimerosal (65.9%, P = 0.013) compared with the healthy control group (49.1%) and the \"para-compound\" group (48%, P = 0.034). Glutathione S-transferase T1 deficiency in the thimerosal/mercury group (19.8%) was barely elevated versus healthy controls (16.0%) and the \"para-compound\" group (14.0%). The combined deletion (GSTT1-/GSTM1-) was markedly more frequent among thimerosal-sensitized patients than in healthy controls (17.6% vs. 6.5%, P = 0.0093) and in the \"para-compound\" group (17.6% vs. 6.1%; P = 0.014), revealing a synergistic effect of these enzyme deficiencies (healthy controls vs. thimerosal GSTM1 negative individuals, OR = 2.0 [CI = 1.2-3.4], GSTT1-, OR = 1.2 [CI = 0.70-2.1], GSTM1/T1-, OR = 3.1 [CI = 1.4-6.5]). Conclusions: Since the glutathione-dependent system was repeatedly shown to be involved in the metabolism of thimerosal decomposition products, the observed association may be of functional relevance."],["dc.identifier.doi","10.1007/s004200000159"],["dc.identifier.isi","000089088300005"],["dc.identifier.pmid","11007341"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45516"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0340-0131"],["dc.title","Homozygous gene deletions of the glutathione S-transferases M1, and T1 are associated with thimerosal sensitization"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","118"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Contact Dermatitis"],["dc.bibliographiccitation.lastpage","130"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Lessmann, Holger"],["dc.contributor.author","Dickel, Heinrich"],["dc.contributor.author","Frosch, Peter J."],["dc.contributor.author","Koch, P."],["dc.contributor.author","Becker, D."],["dc.contributor.author","Jappe, Uta"],["dc.contributor.author","Aberer, Werner"],["dc.contributor.author","Schnuch, Axel"],["dc.contributor.author","Uter, Wolfgang"],["dc.date.accessioned","2018-11-07T10:45:53Z"],["dc.date.available","2018-11-07T10:45:53Z"],["dc.date.issued","2004"],["dc.description.abstract","Based on the information of the interdisciplinary task force on allergy diagnostics in the metal branch, in 2001, the German Contact Dermatitis Research Group (DKG) compiled two metalworking fluid (MWF) test series with currently and previously used components, respectively. After 2 years of patch testing, we present results obtained with these series, based on data of the Information Network of Departments of Dermatology (IVDK). 251 metalworkers who were patch tested because of suspected MWF dermatitis in 2002 and 2003 were included in this retrospective data analysis. Of these, 206 were tested with the current MWF series and 155 with the historical MWF series. Among the current MWF allergens, monoethanolamine ranked 1st with 11.6% positive reactions. Diethanolamine (3.0%), triethanolamine (1.1%), and diglycolamine (1.9%) elicited positive reactions far less frequently. Allergic reactions to p-aminoazobenzene were frequently observed (6.0%), but the relevance of these reactions is still obscure. Positive reactions to biocides ranged from 4.5% for Bioban((R)) CS 1135 to 0.5% for iodopropynyl butylcarbamate and 2-phenoxyethanol. Concomitant reactions to formaldehyde, which caused positive reactions in 3.3%, and formaldehyde releasers occurred to varying extents without conclusive pattern. No positive reactions were seen to dibutyl phthalate, di-2-ethylhexyl phthalate, tricresyl phosphate, isopropyl myristate or benzotriazole. With the historical MWF test series, positive reactions to methyldibromo glutaronitrile (MDBGN) were observed most frequently. However, sensitization via allergen sources other than MWF seems likely, as MDBGN, during the study period, has been one of the most frequent preservative allergens in cosmetics and body care products. Other historical MWF allergens comprised morpholinyl mercaptobenzothiazole (3.3%), benzisothiazolinone (BIT; 2.0%) and Bioban((R)) P 1487(1.3%). BIT is currently used in MWF again, so it was shifted to the current MWF test series. As decreasing reaction frequencies to former MWF allergens that are no longer used can be expected, the historical series should be re-evaluated after some years. The test series with current MWF allergens has to be kept up-to-date based on information from industry and to be kept concise by eliminating test substances which never cause positive reactions."],["dc.identifier.doi","10.1111/j.0105-1873.2004.00416.x"],["dc.identifier.isi","000224434600003"],["dc.identifier.pmid","15479200"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47608"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley"],["dc.relation.issn","1600-0536"],["dc.relation.issn","0105-1873"],["dc.title","Patch test results with the metalworking fluid series of the German Contact Dermatitis Research Group (DKG)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","242"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Contact Dermatitis"],["dc.bibliographiccitation.lastpage","243"],["dc.bibliographiccitation.volume","46"],["dc.contributor.author","Uter, Wolfgang"],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Pirker, C."],["dc.contributor.author","Aberer, Werner"],["dc.contributor.author","Kranke, B."],["dc.contributor.author","Richter, G."],["dc.contributor.author","John, S. M."],["dc.contributor.author","Becker, D."],["dc.contributor.author","Koch, P."],["dc.contributor.author","Szliska, Christiane"],["dc.contributor.author","Fartasch, Manige"],["dc.contributor.author","Frosch, Peter J."],["dc.date.accessioned","2018-11-07T10:30:48Z"],["dc.date.available","2018-11-07T10:30:48Z"],["dc.date.issued","2002"],["dc.identifier.doi","10.1034/j.1600-0536.2002.460413.x"],["dc.identifier.isi","000176797000013"],["dc.identifier.pmid","12081707"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43950"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Munksgaard"],["dc.relation.issn","0105-1873"],["dc.title","Ammonium thiolactate and thiolactic acid: important hairdressers' allergens?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1834"],["dc.bibliographiccitation.issue","14"],["dc.bibliographiccitation.journal","Oncogene"],["dc.bibliographiccitation.lastpage","1842"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Roth, Judith"],["dc.contributor.author","Koch, Philipp"],["dc.contributor.author","Contente, Ana"],["dc.contributor.author","Dobbelstein, Matthias"],["dc.date.accessioned","2022-03-01T11:46:06Z"],["dc.date.available","2022-03-01T11:46:06Z"],["dc.date.issued","2000"],["dc.identifier.doi","10.1038/sj.onc.1203500"],["dc.identifier.pii","BF1203500"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103559"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1476-5594"],["dc.relation.issn","0950-9232"],["dc.title","Tumor-derived mutations within the DNA-binding domain of p53 that phenotypically resemble the deletion of the proline-rich domain"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","576A"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Blood"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","96"],["dc.contributor.author","Diehl, Volker"],["dc.contributor.author","Franklin, J."],["dc.contributor.author","Sieber, M."],["dc.contributor.author","Hasenclever, Dirk"],["dc.contributor.author","Wolf, J."],["dc.contributor.author","Engert, Andreas"],["dc.contributor.author","Hermann, R."],["dc.contributor.author","Longin, C."],["dc.contributor.author","Koch, P."],["dc.contributor.author","Wulf, Gerald"],["dc.contributor.author","Hanel, M."],["dc.contributor.author","Muller-Hermelink, H. K."],["dc.contributor.author","Duhmke, E."],["dc.contributor.author","Loeffler, Markus"],["dc.date.accessioned","2018-11-07T10:04:19Z"],["dc.date.available","2018-11-07T10:04:19Z"],["dc.date.issued","2000"],["dc.identifier.isi","000165256102474"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38669"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Hematology"],["dc.publisher.place","Washington"],["dc.relation.issn","0006-4971"],["dc.title","Dose escalated BEACOPP chemotherapy improves failure free survival in advanced Hodgkin's disease: Updated results of the German Hodgkin's Lymphoma Study Group."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3370"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","The Journal of the Acoustical Society of America"],["dc.bibliographiccitation.lastpage","3378"],["dc.bibliographiccitation.volume","130"],["dc.contributor.author","Koch, P."],["dc.contributor.author","Kurz, Thomas"],["dc.contributor.author","Parlitz, Ulrich"],["dc.contributor.author","Lauterborn, Werner"],["dc.date.accessioned","2018-11-07T08:50:06Z"],["dc.date.available","2018-11-07T08:50:06Z"],["dc.date.issued","2011"],["dc.description.abstract","Bubble dynamics is investigated numerically with special emphasis on the static pressure and the positional stability of the bubble in a standing sound field. The bubble habitat, made up of not dissolving, positionally and spherically stable bubbles, is calculated in the parameter space of the bubble radius at rest and sound pressure amplitude for different sound field frequencies, static pressures, and gas concentrations of the liquid. The bubble habitat grows with static pressure and shrinks with sound field frequency. The range of diffusionally stable bubble oscillations, found at positive slopes of the habitat-diffusion border, can be increased substantially with static pressure. (C) 2011 Acoustical Society of America. [DOI: 10.1121/1.3626159]"],["dc.identifier.doi","10.1121/1.3626159"],["dc.identifier.isi","000297486600020"],["dc.identifier.pmid","22088010"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21618"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Acoustical Soc Amer Amer Inst Physics"],["dc.relation.issn","0001-4966"],["dc.title","Bubble dynamics in a standing sound field: The bubble habitat"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","159"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Ultrasonics Sonochemistry"],["dc.bibliographiccitation.lastpage","162"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Luther, S."],["dc.contributor.author","Mettin, Robert"],["dc.contributor.author","Koch, P."],["dc.contributor.author","Lauterborn, Werner"],["dc.date.accessioned","2018-11-07T08:57:50Z"],["dc.date.available","2018-11-07T08:57:50Z"],["dc.date.issued","2001"],["dc.description.abstract","Acoustically induced cavitation at 20 kHz is observed by means of high speed CCD recording at a framerate of 2250 per second. Using digital image processing the bubbles' trajectories are reconstructed. The experimental data reveal that collision and coalescence of bubbles is a predominant phenomenon that limits their individual lifetime. Measurements of bubble sizes and velocities are in agreement with previous results. (C) 2001 Published by Elsevier Science B.V."],["dc.identifier.doi","10.1016/S1350-4177(01)00073-6"],["dc.identifier.isi","000169537500002"],["dc.identifier.pmid","11441593"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23497"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.publisher.place","Amsterdam"],["dc.relation.conference","7th Meeting of the European-Society-of-Sonochemistry"],["dc.relation.eventlocation","BIARRITZ GUETHARY, FRANCE"],["dc.relation.issn","1350-4177"],["dc.title","Observation of acoustic cavitation bubbles at 2250 frames per second"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","39"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Ultrasonics Sonochemistry"],["dc.bibliographiccitation.lastpage","42"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Appel, J."],["dc.contributor.author","Koch, P."],["dc.contributor.author","Mettin, Robert"],["dc.contributor.author","Krefting, D."],["dc.contributor.author","Lauterborn, Werner"],["dc.date.accessioned","2018-11-07T10:53:17Z"],["dc.date.available","2018-11-07T10:53:17Z"],["dc.date.issued","2004"],["dc.description.abstract","Filamentary formations of acoustic cavitation bubbles in an ultrasonic resonator are recorded by high-speed stereoscopic means. The bubble locations and motions are reconstructed in three dimensions, and a velocity distribution of bubbles is obtained. Experimental bubble trajectories are compared to a one-to-one simulation by a particle modeling approach which shows reasonable agreement. Such investigations are important for a better understanding of the mechanisms taking place in applications of intense ultrasound in liquids, and for verification and improvement of particle modeling of cavitation bubbles. (C) 2003 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/S1350-4177(03)00111-1"],["dc.identifier.isi","000186903400009"],["dc.identifier.pmid","14624986"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49325"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.publisher.place","Amsterdam"],["dc.relation.conference","Meeting on the Applications of Power Ultrasound in Physical and Chemical Processing (USound3)"],["dc.relation.eventlocation","PARIS, FRANCE"],["dc.relation.issn","1350-4177"],["dc.title","Stereoscopic high-speed recording of bubble filaments"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","85"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Contact Dermatitis"],["dc.bibliographiccitation.lastpage","90"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Lessmann, Holger"],["dc.contributor.author","Frosch, Peter J."],["dc.contributor.author","Pirker, C."],["dc.contributor.author","Koch, P."],["dc.contributor.author","Aschoff, R."],["dc.contributor.author","Richter, G."],["dc.contributor.author","Becker, D."],["dc.contributor.author","Eckert, C."],["dc.contributor.author","Uter, Wolfgang"],["dc.contributor.author","Schnuch, Axel"],["dc.contributor.author","Fuchs, Tina"],["dc.date.accessioned","2018-11-07T10:37:10Z"],["dc.date.available","2018-11-07T10:37:10Z"],["dc.date.issued","2003"],["dc.description.abstract","Water-based metalworking fluids (MWFs) may cause both irritant and allergic contact dermatitis. Several well-known MWF allergens are available for patch testing, but considering the wide variety of possible components used in MWF, our diagnostic arsenal covers only a small part of potential allergens. We therefore selected 13 frequently used MWF components that might be sensitizers and had not yet been tested routinely. In 5 centres, 233 dermatitis patients with present or past occupational exposure to MWF were patch tested with this and other panels. Only 7 patients showed positive reactions to the study panel. Allergic reactions to the emulsifier diglycolamine [syn. 2-(2-aminoethoxy) ethanol] were seen in 5 patients, and 1 patient each reacted positively to 2-amino-2-ethyl-1,3-propanediol (AEPD) and methyldiethanolamine (MDEA). Clinical relevance of the reactions to diglycolamine was unequivocally proven by its presence in the MWF from the patients' workplace in 3 cases. Diglycolamine seems to be an important MWF allergen, independently from monoethanolamine and diethanolamine. A test concentration of 1% petrolatum (pet.) appears to be appropriate. The importance of AEPD and MDEA as MWF allergens still remains to be established. The lack of positive test reactions to the other MWF components tested may be due to their low-sensitizing potential or too low a patch test concentration being used."],["dc.identifier.doi","10.1111/j.0105-1873.2003.00187.x"],["dc.identifier.isi","000186892100005"],["dc.identifier.pmid","14641356"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45500"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Munksgaard"],["dc.relation.issn","0105-1873"],["dc.title","Patch testing with components of water-based metalworking fluids"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]