Hellriegel, Martin

[["dc.bibliographiccitation.firstpage","1334"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","The Journal of Obstetrics and Gynaecology Research"],["dc.bibliographiccitation.lastpage","1342"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Gründker, Carsten"],["dc.contributor.author","Wokoun, Ulrike"],["dc.contributor.author","Hellriegel, Martin"],["dc.contributor.author","Emons, Günter"],["dc.date.accessioned","2020-12-10T18:29:03Z"],["dc.date.available","2020-12-10T18:29:03Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1111/jog.13980"],["dc.identifier.eissn","1447-0756"],["dc.identifier.issn","1341-8076"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76505"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Inhibition of aerobic glycolysis enhances the anti‐tumor efficacy of Zoptarelin Doxorubicin in triple‐negative breast cancer cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1905"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","European Journal of Cancer"],["dc.bibliographiccitation.lastpage","1914"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","du Bois, Andreas"],["dc.contributor.author","Ewald-Riegler, Nina"],["dc.contributor.author","de Gregorio, Nikolaus"],["dc.contributor.author","Reuss, Alexander"],["dc.contributor.author","Mahner, Sven"],["dc.contributor.author","Fotopoulou, Christina"],["dc.contributor.author","Kommoss, Friedrich"],["dc.contributor.author","Schmalfeldt, Barbara"],["dc.contributor.author","Hilpert, Felix"],["dc.contributor.author","Fehm, Tanja"],["dc.contributor.author","Burges, Alexander"],["dc.contributor.author","Meier, Werner"],["dc.contributor.author","Hillemanns, Peter"],["dc.contributor.author","Hanker, Lars"],["dc.contributor.author","Hasenburg, Annette"],["dc.contributor.author","Strauss, Hans-Georg"],["dc.contributor.author","Hellriegel, Martin"],["dc.contributor.author","Wimberger, Pauline"],["dc.contributor.author","Keyver-Paik, Mignon-Denise"],["dc.contributor.author","Baumann, Klaus"],["dc.contributor.author","Canzler, Ulrich"],["dc.contributor.author","Wollschlaeger, Kerstin"],["dc.contributor.author","Forner, Dirk"],["dc.contributor.author","Pfisterer, Jacobus"],["dc.contributor.author","Schroeder, Willibald"],["dc.contributor.author","Muenstedt, Karsten"],["dc.contributor.author","Richter, Barbara"],["dc.contributor.author","Kommoss, Stefan"],["dc.contributor.author","Hauptmann, Steffen"],["dc.date.accessioned","2018-11-07T09:25:05Z"],["dc.date.available","2018-11-07T09:25:05Z"],["dc.date.issued","2013"],["dc.description.abstract","Background: Borderline ovarian tumours (BOTs) are recognised as a unique entity of ovarian tumours that do not exert infiltrative destructive growth or stromal invasion. Prognosis of BOT is much better compared to the more common invasive epithelial ovarian cancer. Information regarding prognostic factors is inconclusive and no prospective studies exist that evaluate therapeutic strategies. We therefore started a retrospective-prospective cohort study to better understand BOT and identify scenarios in which future studies could be developed. Methods: Consecutive patients with BOT treated between 1998 and 2008 in 24 German centres were analysed. The retrospective part of the study retrieved patients' data from hospital records and clinical tumour registries while active follow-up and an independent central pathology review were carried out prospectively. Findings: BOT was confirmed in 950 patients, two thirds had serous BOT and 30.5% mucinous BOT. Most were diagnosed in stage I (82.3%); 7.6% and 10.1% had stages II and III, respectively. Overall, 74 patients (7.8%) experienced relapse and 43 (4.5%) died within the observation period. Multivariate analysis revealed higher stage, incomplete staging, tumour residuals, and organ preservation as independent prognostic factors for disease recurrence. Neither microinvasion nor micropapillary growth pattern showed any significant impact. Of 74 relapsed patients, 30% had malignant transformation to invasive ovarian cancer with five-year progression-free survival and overall survival of 12% and 50%, respectively. Interpretation: Prognosis of BOT correlates with tumour-related as well as surgery-related factors. The balance between recurrence risk and organ preservation and fertility-sparing surgery is an important issue deserving further research. (C) 2013 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.ejca.2013.01.035"],["dc.identifier.isi","000318610500013"],["dc.identifier.pmid","23490647"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29985"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ltd"],["dc.relation.issn","0959-8049"],["dc.title","Borderline tumours of the ovary: A cohort study of the Arbeitsgmeinschaft Gynakologische Onkologie (AGO) Study Group"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Prieske, K"],["dc.contributor.author","Woelber, L"],["dc.contributor.author","Muallem, M.Z"],["dc.contributor.author","Eulenburg, C"],["dc.contributor.author","Jückstock, J"],["dc.contributor.author","Hilpert, F"],["dc.contributor.author","de Gregorio, N"],["dc.contributor.author","Iborra, S"],["dc.contributor.author","Ignatov, A"],["dc.contributor.author","Hillemanns, P"],["dc.contributor.author","Fuerst, S.T"],["dc.contributor.author","Strauss, H.G"],["dc.contributor.author","Baumann, K"],["dc.contributor.author","Thiel, F"],["dc.contributor.author","Mustea, A"],["dc.contributor.author","Meier, W"],["dc.contributor.author","Harter, P"],["dc.contributor.author","Wimberger, P"],["dc.contributor.author","Hanker, L"],["dc.contributor.author","Schmalfeldt, B"],["dc.contributor.author","Canzler, U"],["dc.contributor.author","Fehm, T"],["dc.contributor.author","Luyten, A"],["dc.contributor.author","Hellriegel, M"],["dc.contributor.author","Kosse, J"],["dc.contributor.author","Heiss, C"],["dc.contributor.author","Hantschmann, P"],["dc.contributor.author","Mallmann, P"],["dc.contributor.author","Tanner, B"],["dc.contributor.author","Pfisterer, J"],["dc.contributor.author","Sehouli, J"],["dc.contributor.author","Mahner, S"],["dc.date.accessioned","2021-04-22T06:16:02Z"],["dc.date.available","2021-04-22T06:16:02Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1055/s-0040-1718171"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/84282"],["dc.notes.intern","DOI-Import GROB-399"],["dc.relation.conference","Kongressabstracts zur Tagung 2020 der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe (DGGG)"],["dc.relation.eventend","2020-10-10"],["dc.relation.eventlocation","München"],["dc.relation.eventstart","2020-10-07"],["dc.relation.ispartof","Geburtshilfe und FrauenheilkundeKongressabstracts zur Tagung 2020 der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe (DGGG)"],["dc.relation.issn","1438-8804"],["dc.title","The influence of age on treatment and prognosis of patients with squamous cell vulvar cancer (VSCC)- a subset analysis of the AGO-CaRE-1 study"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0165705"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Eulenburg, Christine"],["dc.contributor.author","Suling, Anna"],["dc.contributor.author","Neuser, Petra"],["dc.contributor.author","Reuss, Alexander"],["dc.contributor.author","Canzler, Ulrich"],["dc.contributor.author","Fehm, Tanja"],["dc.contributor.author","Luyten, Alexander"],["dc.contributor.author","Hellriegel, Martin"],["dc.contributor.author","Woelber, Linn"],["dc.contributor.author","Mahner, Sven"],["dc.date.accessioned","2018-11-07T10:06:36Z"],["dc.date.available","2018-11-07T10:06:36Z"],["dc.date.issued","2016"],["dc.description.abstract","Propensity scoring (PS) is an established tool to account for measured confounding in non-randomized studies. These methods are sensitive to missing values, which are a common problem in observational data. The combination of multiple imputation of missing values and different propensity scoring techniques is addressed in this work. For a sample of lymph node-positive vulvar cancer patients, we re-analyze associations between the application of radiotherapy and disease-related and non-related survival. Inverse-probability-of-treatment-weighting (IPTW) and PS stratification are applied after multiple imputation by chained equation (MICE). Methodological issues are described in detail. Interpretation of the results and methodological limitations are discussed."],["dc.description.sponsorship","Medac oncology company"],["dc.identifier.doi","10.1371/journal.pone.0165705"],["dc.identifier.isi","000386714200041"],["dc.identifier.pmid","27802342"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13939"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39125"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Propensity Scoring after Multiple Imputation in a Retrospective Study on Adjuvant Radiation Therapy in Lymph-Node Positive Vulvar Cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1481"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Oncology Reports"],["dc.bibliographiccitation.lastpage","1487"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Foest, Crispin"],["dc.contributor.author","Duwe, Francesca"],["dc.contributor.author","Hellriegel, Martin"],["dc.contributor.author","Schweyer, Stefan"],["dc.contributor.author","Emons, Guenter"],["dc.contributor.author","Gruendker, Carsten"],["dc.date.accessioned","2018-11-07T08:56:40Z"],["dc.date.available","2018-11-07T08:56:40Z"],["dc.date.issued","2011"],["dc.description.abstract","Triple-negative breast cancer does not express estrogen and progesterone receptors and there is no over-expression/amplification of the HER2-neu gene. Therefore, this subtype of breast cancer lacks the benefits of specific therapies which target these receptors. About 60% of all human breast cancers express receptors for luteinizing hormone releasing hormone (LHRH, GnRH), which might be used as a target. The LHRH receptor can be used for targeted chemotherapy with eytotoxic luteinizing hormone releasing hormone, agonists such as AEZS-108 (AN-152), in which doxorubicin is linked to [D-Lys(6)]LHRH. In the present study we have analyzed by in vitro and in vivo experiments whether the cytotoxic LHRH agonist AEZS-108 (AN-152) induces apoptosis in triple-negative human breast cancer cells that express LHRH receptors. LHRH receptor expression in tumor biopsy specimens of triple-negative breast cancers was tested using immunohistochemistry. Cell proliferation was analyzed using alamar blue proliferation assay. Induction of apoptosis was quantified by measurement of loss of mitochondria] membrane potential. In vivo experiments were performed using nude mice bearing xenografted human breast tumors. Thirty-one of 42 triple-negative breast cancers (73.8%) expressed LHRH receptors. We could show that treatment of triple-negative but LHRH-positive MDA-MB-231, HCC1806 and HCC1937 human breast cancer cells with AEZS-108 (AN-152) resulted in apoptotic cell death in vitro via activation of caspase-3. The antitumor effects were confirmed in nude mice. AEZS-108 (AN-I 52) inhibited the growth of xenotransplants of triple-negative human breast cancers in nude mice completely, without any apparent side effects. The cytotoxic LHRH agonist AEZS-108 (AN-152) seems to be a suitable drug for an efficacious therapy for triple-negative breast cancers with little toxicity."],["dc.description.sponsorship","Deutsche Krebshilfe, Dr Mildred Scheel Stiftung"],["dc.identifier.doi","10.3892/or.2011.1188"],["dc.identifier.isi","000289817300035"],["dc.identifier.pmid","21331448"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23205"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Spandidos Publ Ltd"],["dc.relation.issn","1021-335X"],["dc.title","Targeted chemotherapy for triple-negative breast cancers via LHRH receptor"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","906"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Der Gynäkologe"],["dc.bibliographiccitation.lastpage","913"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Hellriegel, M."],["dc.contributor.author","Bauerschmitz, G."],["dc.contributor.author","Emons, G."],["dc.date.accessioned","2020-12-10T14:08:44Z"],["dc.date.available","2020-12-10T14:08:44Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s00129-017-4162-8"],["dc.identifier.eissn","1433-0393"],["dc.identifier.issn","0017-5994"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70535"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Palliativmedizinische Konzepte beim Mammakarzinom"],["dc.title.alternative","Palliative medical concepts in breast cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","191"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Archives of Gynecology and Obstetrics"],["dc.bibliographiccitation.lastpage","199"],["dc.bibliographiccitation.volume","300"],["dc.contributor.author","Vercellino, G. F."],["dc.contributor.author","Erdemoglu, E."],["dc.contributor.author","Lichtenberg, P."],["dc.contributor.author","Muallem, M. Z."],["dc.contributor.author","Richter, R."],["dc.contributor.author","Abu-Rustum, N. R."],["dc.contributor.author","Plante, M."],["dc.contributor.author","Lécuru, F."],["dc.contributor.author","Greggi, S."],["dc.contributor.author","Monk, B. J."],["dc.contributor.author","Sagae, S."],["dc.contributor.author","Denkert, C."],["dc.contributor.author","Keller, M."],["dc.contributor.author","Alhakeem, M."],["dc.contributor.author","Hellriegel, M."],["dc.contributor.author","Dückelmann, A. M."],["dc.contributor.author","Chiantera, V."],["dc.contributor.author","Sehouli, Jalid"],["dc.date.accessioned","2020-12-10T14:10:29Z"],["dc.date.available","2020-12-10T14:10:29Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00404-019-05164-2"],["dc.identifier.eissn","1432-0711"],["dc.identifier.issn","0932-0067"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70773"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","A GCIG international survey: clinical practice patterns of sentinel lymph node biopsies in cervical cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Geburtshilfe und Frauenheilkunde"],["dc.bibliographiccitation.volume","73"],["dc.contributor.author","Hellriegel, Martin"],["dc.contributor.author","Bauerschmitz, Gerd"],["dc.contributor.author","Emons, Guenter"],["dc.date.accessioned","2018-11-07T09:20:27Z"],["dc.date.available","2018-11-07T09:20:27Z"],["dc.date.issued","2013"],["dc.format.extent","871"],["dc.identifier.doi","10.1055/s-0033-1350813"],["dc.identifier.isi","000325552500009"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28879"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","1438-8804"],["dc.relation.issn","0016-5751"],["dc.title","Breast Cancer Local Recurrence following ductal-invasive Breast Cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Woelber, L"],["dc.contributor.author","Bommert, M"],["dc.contributor.author","Harter, P"],["dc.contributor.author","Prieske, K"],["dc.contributor.author","zu Eulenburg, C"],["dc.contributor.author","Jueckstock, J"],["dc.contributor.author","Hilpert, F"],["dc.contributor.author","de Gregorio, N"],["dc.contributor.author","Iborra, S"],["dc.contributor.author","Sehouli, J"],["dc.contributor.author","Ignatov, A"],["dc.contributor.author","Hillemanns, P"],["dc.contributor.author","Fuerst, S"],["dc.contributor.author","Strauss, HG"],["dc.contributor.author","Baumann, K"],["dc.contributor.author","Thiel, F"],["dc.contributor.author","Mustea, A"],["dc.contributor.author","Meier, W"],["dc.contributor.author","Wimberger, P"],["dc.contributor.author","Hanker, L"],["dc.contributor.author","Schmalfeldt, B"],["dc.contributor.author","Canzler, U"],["dc.contributor.author","Fehm, T"],["dc.contributor.author","Luyten, A"],["dc.contributor.author","Hellriegel, M"],["dc.contributor.author","Kosse, J"],["dc.contributor.author","Heiss, C"],["dc.contributor.author","Hantschmann, P"],["dc.contributor.author","Mallmann, P"],["dc.contributor.author","Tanner, B"],["dc.contributor.author","Pfisterer, J"],["dc.contributor.author","Mahner, S"],["dc.contributor.author","Jaeger, A"],["dc.date.accessioned","2021-04-22T06:16:03Z"],["dc.date.available","2021-04-22T06:16:03Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1055/s-0040-1717203"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/84284"],["dc.notes.intern","DOI-Import GROB-399"],["dc.relation.conference","Kongressabstracts zur Tagung 2020 der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe (DGGG)"],["dc.relation.eventend","2020-10-10"],["dc.relation.eventlocation","München"],["dc.relation.eventstart","2020-10-07"],["dc.relation.ispartof","Geburtshilfe und FrauenheilkundeKongressabstracts zur Tagung 2020 der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe (DGGG)"],["dc.relation.issn","1438-8804"],["dc.title","Role of pelvic lymph node resection in vulvar cancer – a subset analysis of the AGO-CaRE-1 study"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","914"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Der Gynäkologe"],["dc.bibliographiccitation.lastpage","919"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Bauerschmitz, G. J."],["dc.contributor.author","Hellriegel, M."],["dc.contributor.author","Emons, G."],["dc.date.accessioned","2020-12-10T14:08:43Z"],["dc.date.available","2020-12-10T14:08:43Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s00129-017-4156-6"],["dc.identifier.eissn","1433-0393"],["dc.identifier.issn","0017-5994"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70534"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Palliative Konzepte beim Endometrium‑, Zervix- und Vulvakarzinom"],["dc.title.alternative","Palliative concepts for endometrial, cervical and vulvar cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]