Dresing, Klaus

[["dc.bibliographiccitation.firstpage","521"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Der Unfallchirurg"],["dc.bibliographiccitation.lastpage","527"],["dc.bibliographiccitation.volume","110"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.contributor.author","Hingelbaum, S."],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Roessler, M."],["dc.contributor.author","Stuermer, Klaus-Michael"],["dc.date.accessioned","2018-11-07T11:02:18Z"],["dc.date.available","2018-11-07T11:02:18Z"],["dc.date.issued","2007"],["dc.description.abstract","Background. The anatomic region on the lateral cortex of the ileum, where a palpable \"groove\" is formed by angulations of the lateral cortex of the iliac wing, is recommended as the insertion point for the pelvic emergency clamp by many authors. In our opinion this technique often leads to an incomplete closure of the anterior pelvic ring as well as to bacterial contamination of the access for the sacroiliac joint screw fixation and is accompanied by a risk for nerve and vessel injuries. To reduce these risks the pelvic clamp was placed at a supra-acetabular location. The goal of our study was to report on our experiences with the supra-acetabular position of the pelvic emergency clamp and to compare our results with the current literature. Material and method. From September 1998 to February 2006 the pelvic emergency clamp was applied in 15 polytraumatized patients (9 male, 6 female), with a mean age of 46 years (19-93) and a mean injury severity score (ISS) of 40 points (25-66) with mechanically and hemodynamically unstable pelvic ring fractures. According to the AO classification the injury pattern was type B2 in four cases, type B3 in one case, type C1 in seven cases, type C2 in two cases and type C3 in one case. The pelvic clamp was percutaneously applied 2-3 cm cranial to the acetabular roof. The duration from hospital admission until the pelvic emergency clamp was applied amounted to an average of 54 min (15-150); the procedure itself was performed in all cases in less than 15 min. The mean Hb at arrival in the emergency department was 7.4 (2.4-13.8) mg/dl and the mean systolic blood pressure 69 (0-130) mmHg. Results. In 14 patients a complete closure of the anterior and posterior pelvic ring could be achieved; in 1 patient an overcompression of the anterior pelvic ring was observed. Four patients died due to massive bleeding. Three patients with isolated pelvic ring fractures became hemodynamically stable within 20 min after treatment with the supra-acetabular pelvic clamp. Nine patients needed additional emergency surgery because of intracerebral, intrathoracic or intra-abdominal injuries. On average in the first 6 h, 36.7 (9-175) units of erythrocyte concentrates and 34.5 (4-200) units of fresh frozen plasma were transfused. Conclusions. The supra-acetabular pelvic clamp leads to a homogeneous force distribution to the pelvic ring and enables complete closure of the anterior and posterior pelvic ring in unstable pelvic fractures. Reduction of the intrapelvic volume and compression of the posterior pelvic ring can thus be achieved. Risks for intrapelvic perforation or injuries of vessels and nerves are low. No bacterial contamination of the access for the sacroiliac screw fixation occurs. To avoid overcompression of the unstable pelvic ring, manual or radiological control of the closure of the ventral pelvic ring is necessary."],["dc.identifier.doi","10.1007/s00113-007-1228-4"],["dc.identifier.isi","000247257500005"],["dc.identifier.pmid","17318312"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51348"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0177-5537"],["dc.title","The supra-acetabular pelvic clamp. Emergency treatment for unstable pelvic ring fractures"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1026"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Der Chirurg"],["dc.bibliographiccitation.lastpage","1033"],["dc.bibliographiccitation.volume","74"],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Pouwels, Claudia"],["dc.contributor.author","Bonsack, S."],["dc.contributor.author","Oellerich, M."],["dc.contributor.author","Schworer, H."],["dc.contributor.author","Uy, Angela"],["dc.contributor.author","Sturmer, K. M."],["dc.date.accessioned","2018-11-07T10:34:55Z"],["dc.date.available","2018-11-07T10:34:55Z"],["dc.date.issued","2003"],["dc.description.abstract","Background. Trauma and emergency surgeons (S) are in contact with high-risk patients (P) infected with HBV, HCV, and HIV without knowing which P is and which is not infected. The aim of this paper was to analyze routine screening (SCR) in trauma care. Method. Microparticle enzyme immunoassays (MEIA) (Abbott Axym system) were analyzed from routine blood samples: HBsAg (Q), HCV version 3.0, HIV 1/2gO. All positive or uncertain samples were confirmed with ELISA/PCR. Results. From January 2002 to October 2002 a total of 1074 emergency P were examined. The results were available within 50 min after admittance to the emergency room. In 53 of 1074 (4.9%) the MEIA was positive or in threshold margins (LV): HBV 15 P plus 3 LV (9 secured by ELISA/PCR), prevalence (PV) 0.84%. HCV 34 P plus I LV (31 secured with ELISA/PCR), PV 2.9%. HIV 2 P, PV 1.86parts per thousand, 1 in co-infection with HCV, I with HBV. Of 42 infections, 21 were unknown before screening, and in 5 P the S suspected an infection. After screening, nine surgical procedures were changed to safer procedures. Conclusion. MEIA is a good tool for quick SCR of HCV, HBV, and HIV in emergency surgery (ES). When the infection is known the S is more aware to perform only safe procedures during surgery (no touch technique) or to use more protective devices (e.g., fluid shield, double gloves). Our results indicate that surgeons and nurses in ES are exposed four to six times more often to infection with HCV, HBV, and HIV than represented by officially published data. We recommend routine SCR of HBV, HCV, and HIV for all P in ES. Prevention procedures are discussed."],["dc.identifier.doi","10.1007/s00104-003-0741-4"],["dc.identifier.isi","000187002800008"],["dc.identifier.pmid","14605720"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/44981"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0009-4722"],["dc.title","HCV, HBV, and HIV infection: risk for surgeon and staff. Results and consequences of routine screening in emergency patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","GMS Medizinische Informatik, Biometrie und Epidemiologie"],["dc.bibliographiccitation.lastpage","7"],["dc.contributor.author","Stürmer, Klaus Michael"],["dc.contributor.author","Wagner, Markus"],["dc.contributor.author","Duwenkamp, Christopher"],["dc.contributor.author","Ahrens, Christoph Alexander"],["dc.contributor.author","Plischke, Maik"],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Bott, Oliver Johannes"],["dc.date.accessioned","2019-07-09T11:52:48Z"],["dc.date.available","2019-07-09T11:52:48Z"],["dc.date.issued","2009"],["dc.description.abstract","Hintergrund und Fragestellung: Die durch röntgentechnische Diagnoseverfahren in der Medizin entstehende Strahlenbelastung für Patient und Personal soll laut Strahlenschutzverordnung so gering wie möglich gehalten werden. Um dieses zu erreichen ist ein professioneller und bedachter Umgang mit den Röntgengeräten unabdingbar. Dieses Verhalten kann derzeit jedoch nur theoretisch vermittelt werden, da sich ein Üben mit realer Strahlung von selbst verbietet. Daher stellt sich die Frage wie man die Strahlenschutzausbildung durch eine verbesserte Vermittlung der komplexen Thematik unterstützen kann. Methoden: Das CBT-System (Computer Based Training) virtX, welches das Erlernen der korrekten Handhabung mobiler Röntgengeräte unterstützt, wurde um Aspekte aus dem Bereich des Strahlenschutzes erweitert. Es wurde eine prototypische Visualisierung der entstehenden Streustrahlung sowie die Darstellung des Nutzstrahlenganges integriert. Des Weiteren wurde die Berechnung und Anzeige der virtuellen Einfallsdosis für das durchstrahlte Volumen sowie für den Bereich des Bildverstärkers hinzugefügt. Für die Berechnung und Visualisierung all dieser Komponenten werden die in virtX parametrisierbaren C-Bogen-Einstellungen, z.B. Stellung der Blenden, Positionierung des Röntgengerätes zum durchstrahlten Volumen und Strahlenintensität, herangezogen. Das so erweiterte System wurde auf einem dreitägigen Kurs für OP-Personal mit über 120 Teilnehmern eingesetzt und auf der Basis von Fragebögen evaluiert. Ergebnisse: Von den Teilnehmern gaben 55 einen ausgefüllten Evaluations-Fragebogen ab (Responserate 82%). Das Durchschnittsalter der 39 weiblichen und 15 männlichen Teilnehmer (einer o.A.) lag bei 33±8 Jahren, die Berufserfahrung bei 9,37±7 Jahren. Die Erfahrung mit dem C-Bogen wurde von einem Teilnehmer (2%) mit „Keine oder bisher nur Einführung erhalten“, von acht Teilnehmern (14%) mit „bediene einen C-Bogen gelegentlich“ und von 46 (84%) mit „bediene einen C-Bogen regelmäßig“ angegeben. 45 (92%) der Teilnehmer gaben an, durch die Visualisierung der Streustrahlung etwas Neues zur Vermeidung unnötiger Strahlenbelastung dazugelernt zu haben. Schlussfolgerung: Trotz einer bislang nur prototypischen Visualisierung der Streustrahlung können mit virtX zentrale Aspekte und Verhaltensweisen zur Vermeidung unnötiger Strahlenbelastung erfolgreich vermittelt werden und so Lücken der traditionellen Strahlenschutzausbildung geschlossen werden."],["dc.identifier.doi","10.3205/mibe000081"],["dc.identifier.fs","568165"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5967"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60279"],["dc.language.iso","de"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1860-9171"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","virtX: ein Lehr- und Lernsystem für mobile Röntgengeräte zur Verbesserung der Ausbildung im Strahlenschutz"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Der Unfallchirurg"],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Kraus, Ralf"],["dc.contributor.author","Fernandez, Francisco"],["dc.contributor.author","Schmittenbecher, Peter"],["dc.contributor.author","Dresing, Kaya"],["dc.contributor.author","Strohm, Peter"],["dc.contributor.author","Spering, Christopher"],["dc.contributor.authorgroup","Sektion Kindertraumatologie der Deutschen Gesellschaft für Unfallchirurgie"],["dc.date.accessioned","2022-01-11T14:08:07Z"],["dc.date.available","2022-01-11T14:08:07Z"],["dc.date.issued","2021"],["dc.description.abstract","Zusammenfassung Hintergrund Die Indikation zum Röntgen sollte bei pädiatrischen und jugendlichen Traumapatienten streng dem ALARA-Prinzip (as low as reasonable achievable) folgen. Die Wirkung der Strahlung auf das wachsende sensible Gewebe dieser Patienten darf nicht außer acht gelassen werden. Fragestellung Die Sektion Kindertraumatologie der Deutschen Gesellschaft für Unfallchirurgie (SKT) wollte klären wie in der Traumaversorgung dem Prinzip gefolgt wird. Methoden Eine Online-Umfrage war 10 Wochen lang offen. Zielgruppen waren Unfall-, Kinder- und Allgemeinchirurgen sowie Orthopäden. Ergebnisse Von 15.11.2019 bis 29.02.2020 beteiligten sich 788 Ärzte: Niederlassung 20,56 %, MVZ 4,31 %, Krankenhaus 75,13 %; Assistenzarzt 16,62 %, Oberarzt 38,07 %, Chefarzt 22,59 %. Nach Facharztqualifikation ergab sich die Verteilung: 38,34 % Chirurgie, 33,16 % Unfallchirurgie, 36,66 % spezielle Unfallchirurgie, 70,34 % Orthopädie und Unfallchirurgie, 18,78 % Kinderchirurgie. Häufigkeit des Kontakts mit Frakturen in der o. g. Altersgruppe wurde angegeben mit 37 % < 10/Monat, 27 % < 20/M, 36 %> 20/M. Etwa 52 % fordern immer Röntgenaufnahmen in 2 Ebenen nach akutem Trauma. Das Röntgen der Gegenseite bei unklaren Befunden lehnen 70 % ab. 23 % wenden die Sonographie regelmäßig in der Frakturdiagnostik an. Bei polytraumatisierten Kindern und Jugendlichen wird das Ganzkörper-CT bei 18 % nie, bei 50 % selten und bei 14 % standardmäßig eingesetzt. Diskussion Die Analyse zeigt, dass es kein einheitliches radiologisches Management von Kindern und Jugendlichen mit Frakturen unter den Befragten gibt. Schlussfolgerung Vergleicht man die Ergebnisse der Umfrage mit den kürzlich in dieser Zeitschrift veröffentlichten Konsensergebnissen des SKT, so bedarf es noch Überzeugungsarbeit, um den Einsatz von Röntgenstrahlen bei der Primärdiagnostik zu ändern."],["dc.description.abstract","Abstract Background The indication for radiography should strictly follow the ALARA (as low as reasonably achievable) principle in pediatric and adolescent trauma patients. The effect of radiation on the growing sensitive tissue of these patients should not be disregarded. Question The Pediatric Traumatology Section (SKT) of the German Trauma Society (DGU) wanted to clarify how the principle is followed in trauma care. Methods An online survey was open for 10 weeks. Target groups were trauma surgeons, pediatric surgeons, general surgeons, and orthopedic surgeons. Results From Nov. 15, 2019, to Feb. 29, 2020, 788 physicians participated: branch office 20.56%, MVZ 4.31%, hospital 75.13%; resident 16.62%, senior 38.07%, chief 22.59%. By specialist qualification, the distribution was: 38.34% surgery, 33.16% trauma surgery, 36.66% special trauma surgery, 70.34% orthopedics and trauma surgery, 18.78% pediatric surgery. Frequency of contact with fractures in the above age group was reported as 37% < 10/month, 27% < 20/M, 36% > 20/M. About 52% always request radiographs in 2 planes after acute trauma. X-ray of the opposite side for unclear findings was rejected by 70%. 23% use sonography regularly in fracture diagnosis. In polytrauma children and adolescents, whole-body CT is never used in 18%, rarely in 50%, and standard in 14%. Discussion The analysis shows that there is no uniform radiological management of children and adolescents with fractures among the respondents. Conclusion Comparing the results of the survey with the consensus findings of the SKT recently published in this journal, persuasion is still needed to change the use of radiography in primary diagnosis."],["dc.description.abstract","Zusammenfassung Hintergrund Die Indikation zum Röntgen sollte bei pädiatrischen und jugendlichen Traumapatienten streng dem ALARA-Prinzip (as low as reasonable achievable) folgen. Die Wirkung der Strahlung auf das wachsende sensible Gewebe dieser Patienten darf nicht außer acht gelassen werden. Fragestellung Die Sektion Kindertraumatologie der Deutschen Gesellschaft für Unfallchirurgie (SKT) wollte klären wie in der Traumaversorgung dem Prinzip gefolgt wird. Methoden Eine Online-Umfrage war 10 Wochen lang offen. Zielgruppen waren Unfall-, Kinder- und Allgemeinchirurgen sowie Orthopäden. Ergebnisse Von 15.11.2019 bis 29.02.2020 beteiligten sich 788 Ärzte: Niederlassung 20,56 %, MVZ 4,31 %, Krankenhaus 75,13 %; Assistenzarzt 16,62 %, Oberarzt 38,07 %, Chefarzt 22,59 %. Nach Facharztqualifikation ergab sich die Verteilung: 38,34 % Chirurgie, 33,16 % Unfallchirurgie, 36,66 % spezielle Unfallchirurgie, 70,34 % Orthopädie und Unfallchirurgie, 18,78 % Kinderchirurgie. Häufigkeit des Kontakts mit Frakturen in der o. g. Altersgruppe wurde angegeben mit 37 % < 10/Monat, 27 % < 20/M, 36 %> 20/M. Etwa 52 % fordern immer Röntgenaufnahmen in 2 Ebenen nach akutem Trauma. Das Röntgen der Gegenseite bei unklaren Befunden lehnen 70 % ab. 23 % wenden die Sonographie regelmäßig in der Frakturdiagnostik an. Bei polytraumatisierten Kindern und Jugendlichen wird das Ganzkörper-CT bei 18 % nie, bei 50 % selten und bei 14 % standardmäßig eingesetzt. Diskussion Die Analyse zeigt, dass es kein einheitliches radiologisches Management von Kindern und Jugendlichen mit Frakturen unter den Befragten gibt. Schlussfolgerung Vergleicht man die Ergebnisse der Umfrage mit den kürzlich in dieser Zeitschrift veröffentlichten Konsensergebnissen des SKT, so bedarf es noch Überzeugungsarbeit, um den Einsatz von Röntgenstrahlen bei der Primärdiagnostik zu ändern."],["dc.description.abstract","Abstract Background The indication for radiography should strictly follow the ALARA (as low as reasonably achievable) principle in pediatric and adolescent trauma patients. The effect of radiation on the growing sensitive tissue of these patients should not be disregarded. Question The Pediatric Traumatology Section (SKT) of the German Trauma Society (DGU) wanted to clarify how the principle is followed in trauma care. Methods An online survey was open for 10 weeks. Target groups were trauma surgeons, pediatric surgeons, general surgeons, and orthopedic surgeons. Results From Nov. 15, 2019, to Feb. 29, 2020, 788 physicians participated: branch office 20.56%, MVZ 4.31%, hospital 75.13%; resident 16.62%, senior 38.07%, chief 22.59%. By specialist qualification, the distribution was: 38.34% surgery, 33.16% trauma surgery, 36.66% special trauma surgery, 70.34% orthopedics and trauma surgery, 18.78% pediatric surgery. Frequency of contact with fractures in the above age group was reported as 37% < 10/month, 27% < 20/M, 36% > 20/M. About 52% always request radiographs in 2 planes after acute trauma. X-ray of the opposite side for unclear findings was rejected by 70%. 23% use sonography regularly in fracture diagnosis. In polytrauma children and adolescents, whole-body CT is never used in 18%, rarely in 50%, and standard in 14%. Discussion The analysis shows that there is no uniform radiological management of children and adolescents with fractures among the respondents. Conclusion Comparing the results of the survey with the consensus findings of the SKT recently published in this journal, persuasion is still needed to change the use of radiography in primary diagnosis."],["dc.identifier.doi","10.1007/s00113-021-01115-2"],["dc.identifier.pii","1115"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/97940"],["dc.language.iso","de"],["dc.notes.intern","DOI-Import GROB-507"],["dc.relation.eissn","1433-044X"],["dc.relation.issn","0177-5537"],["dc.title","Bildgebung nach Unfall in Klinik und Praxis bei Kindern und Jugendlichen"],["dc.title.alternative","Teil 1 der Ergebnisse einer bundesweiten Online-Umfrage der Sektion Kindertraumatologie der Deutschen Gesellschaft für Unfallchirurgie"],["dc.title.translated","Imaging after trauma in clinics and practice for children and adolescents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","220"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Operative Orthopädie und Traumatologie"],["dc.bibliographiccitation.lastpage","224"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Dresing, K."],["dc.date.accessioned","2021-06-01T10:49:02Z"],["dc.date.available","2021-06-01T10:49:02Z"],["dc.date.issued","2013"],["dc.identifier.doi","10.1007/s00064-013-0254-3"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86144"],["dc.language.iso","de"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1439-0981"],["dc.relation.issn","0934-6694"],["dc.title","Infektionen in Unfallchirurgie und Orthopädie"],["dc.title.translated","Infections in trauma and orthopedic surgery"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","E31"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Radiographics"],["dc.bibliographiccitation.lastpage","E41"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Bott, Oliver Johannes"],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Wagner, Markus"],["dc.contributor.author","Raab, Bjoern-Werner"],["dc.contributor.author","Teistler, Michael"],["dc.date.accessioned","2018-11-07T08:56:23Z"],["dc.date.available","2018-11-07T08:56:23Z"],["dc.date.issued","2011"],["dc.description.abstract","Mobile image intensifier systems (C-arms) are used frequently in orthopedic and reconstructive surgery, especially in trauma and emergency settings, but image quality and radiation exposure levels may vary widely, depending on the extent of the C-arm operator's knowledge and experience. Current training programs consist mainly of theoretical instruction in C-arm operation, the physical foundations of radiography, and radiation avoidance, and are largely lacking in hands-on application. A computer-based simulation program such as that tested by the authors may be one way to improve the effectiveness of C-arm training. In computer simulations of various scenarios commonly encountered in the operating room, trainees using the virtX program interact with three-dimensional models to test their knowledge base and improve their skill levels. Radiographs showing the simulated patient anatomy and surgical implants are \"reconstructed\" from data computed on the basis of the trainee's positioning of models of a C-arm, patient, and table, and are displayed in real time on the desktop monitor. Trainee performance is signaled in real time by color graphics in several control panels and, on completion of the exercise, is compared in detail with the performance of an expert operator. Testing of this computer-based training program in continuing medical education courses for operating room personnel showed an improvement in the overall understanding of underlying principles of intraoperative radiography performed with a C-arm, with resultant higher image quality, lower overall radiation exposure, and greater time efficiency. Supplemental material available at http://radiographics.rsna.org/lookup/suppl/doi:10.1148/rg.313105125/-/DC1. (C) RSNA, 2011 . radiographics.rsna.org"],["dc.identifier.doi","10.1148/rg.313105125"],["dc.identifier.isi","000290590500003"],["dc.identifier.pmid","21357414"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23137"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0271-5333"],["dc.title","Use of a C-Arm Fluoroscopy Simulator to Support Training in Intraoperative Radiography"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","214"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Cells Tissues Organs"],["dc.bibliographiccitation.lastpage","227"],["dc.bibliographiccitation.volume","170"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.contributor.author","Barvencik, F."],["dc.contributor.author","Lohmann, Christoph H."],["dc.contributor.author","Viereck, Volker"],["dc.contributor.author","Siggelkow, Heide"],["dc.contributor.author","Breme, J."],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Sturmer, K. M."],["dc.date.accessioned","2018-11-07T10:32:53Z"],["dc.date.available","2018-11-07T10:32:53Z"],["dc.date.issued","2002"],["dc.description.abstract","The goal of this study was to characterize growth, mineralization and bone formation of osteoblast-like cells in titanium pore channels of defined diameter. Titanium implants with continuous drill channels of diameters of 300, 400, 500, 600 and 1,000 mum were inserted into human osteoblast-like cell cultures. The ingrowth of the cells into the drill channels was investigated by transmitted-light microscopy and scanning electron microscopy. Immunofluorescence and histological analysis of 15-channel sections of each diameter were used to investigate the growth behavior and the matrix protein patterns. Mineralization was evidenced by Alizarin red staining and high-resolution microradiography. The ingrowth of human osteoblast-like cells in the drill channels occurred in a sequence of four characteristic stages. In stage 1, osteoblast precursor cells adhered to the wall of the channel and migrated three-dimensionally into the channel by forming foot-like protoplasmic processes. For all 15 sample drill channels that were investigated, the cell ingrowth over 20 days amounted on average to 793 mum (+/- 179) into 600-mum-diameter channels, where they migrated significantly faster than in all the other channels. In stage 2, approximately on day 5-7, the osteoblast-like cells began to anchor on the substrate wall by matrix proteins and to build up a dense network of matrix proteins in the drill channel. The mineralization of the extracellular matrix, while depending on cell stimulation, was initiated in stage 3, on average after 4 weeks. In drill channels of a diameter of 1,000 mum the cell growth was incomplete and no mineralization was found by radiological assessment. Starting in week 6, in the drill channels of diameters ranging from 300 to 600 mum, the network of extracellular matrix proteins and osteoblast-like cells began to form an osteon-like structure. Neither the highly developed migration behavior of osteoblastic cells nor the reorganization from a fiber-like matrix to a lamellar structure have so far been described for cell cultures."],["dc.identifier.doi","10.1159/000047925"],["dc.identifier.isi","000174840400002"],["dc.identifier.pmid","11919409"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/44464"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","1422-6405"],["dc.title","Migration, matrix production and lamellar bone formation of human osteoblast-like cells in porous titanium implants"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","101"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Sportverletzung · Sportschaden"],["dc.bibliographiccitation.lastpage","107"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Losch, Andreas"],["dc.contributor.author","Meybohm, Patrick"],["dc.contributor.author","Schmalz, T."],["dc.contributor.author","Fuchs, M."],["dc.contributor.author","Vamvukakis, F."],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Blumentritt, S."],["dc.contributor.author","Sturmer, K. M."],["dc.date.accessioned","2018-11-07T10:08:45Z"],["dc.date.available","2018-11-07T10:08:45Z"],["dc.date.issued","2002"],["dc.description.abstract","Retrospectively 20 patients with a surgically treated ankle fracture caused by hobby-accidents were examined clinically and radiologically by a score modified to Phillips after 12 months postoperatively. Further they have taken part in a dynamical gait analysis at the same time. A group of 20 healthy adults was used as a control group comparable to age, sex, height and weight. Although 19 patients out of 20 have achieved a good result at the score evaluation and none of them was clinically noticed with any pathological gait, gait analysis has shown a significant slowed gait speed and a decreased stride lenght. The reduction of the plantarflexor moment at the injured ankle joint immediately following heel contact was yet the most remarkable result of the gait analysis. The changes of gait pattern are interpreted as an adapted and internalized motion pattern caused by pain and behaviour of rest at any time while the mobilisation-phase was going on. It could not document any significant correlation between subjective and clinical parameters and parameters registered by gait analysis. However, a significant correlation of gait-analysed parameters was found between the injured and uninjured side. By dynamical gait analysis it is possible to quantify remarkable gait changes, to obtain objektive data, but also to demonstrate asymmetrical loading and motion that were not clinically detectable previously. It follows that it can be relevant to patients with complaints by leading them to specific physiotherapeutical treatment and gait training so that they would be able to carry on their sports-activities again."],["dc.identifier.doi","10.1055/s-2002-34750"],["dc.identifier.isi","000178978300001"],["dc.identifier.pmid","12382182"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39530"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0932-0555"],["dc.title","Functional results of dynamical gait analysis after 1 year of hobby-athletes with a surgically treated ankle fracture"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","602"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Der Unfallchirurg"],["dc.bibliographiccitation.lastpage","606"],["dc.bibliographiccitation.volume","103"],["dc.contributor.author","Fuchs, M."],["dc.contributor.author","Burchhardt, H."],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Radebold, T."],["dc.contributor.author","Sturmer, K. M."],["dc.date.accessioned","2018-11-07T10:43:14Z"],["dc.date.available","2018-11-07T10:43:14Z"],["dc.date.issued","2000"],["dc.description.abstract","Surgical treatment of calcaneal fractures is demanding due to the poor musculocutaneous coverage. Infection with osteitis is a severe complication with open fractures. The appearance of osteitis requires aggressive surgical treatment including amputation in case of persistence, leading to considerable invalidism. We report the case of an 37-year-old mason with an grade III open calcaneal fracture caused by a fall. Osteitis appeared after primary osteosynthesis with open reduction and eventually - after several revisions required a calcanectomy. By preservation of the forefoot and midfoot and thanks to sufficient orthesis treatment the patient was able to return to his profession after eigth months."],["dc.identifier.doi","10.1007/s001130050589"],["dc.identifier.isi","000088319800013"],["dc.identifier.pmid","10969549"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46997"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0177-5537"],["dc.title","Resection of the calcaneus as a treatment option in osteitis at following an open calcaneal fracture"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","331"],["dc.bibliographiccitation.issue","5-6"],["dc.bibliographiccitation.journal","Journal of Molecular Histology"],["dc.bibliographiccitation.lastpage","341"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Tezval, Mohammad"],["dc.contributor.author","Tezval, Hossein"],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.contributor.author","Blaschke, Martina"],["dc.contributor.author","Stuermer, Klaus Michael"],["dc.contributor.author","Siggelkow, Heide"],["dc.date.accessioned","2018-11-07T11:23:52Z"],["dc.date.available","2018-11-07T11:23:52Z"],["dc.date.issued","2009"],["dc.description.abstract","Urocortin-1 (UCN) a corticotropin releasing-factor (CRF) related peptide, has been found to be expressed in many different tissues like the central nervous system, the cardiovascular system, adipose tissue, and skeletal muscle. The effects of UCN are mediated via stimulation of CRF-receptors 1 and 2 (CRFR1 and 2, CRFR's) with a high affinity for CRFR2. It has been shown that the CRF-related peptides and CRFR's are involved in the regulation of stress-related endocrine, autonomic and behavioural responses. Using immunocytochemistry, immunohistochemistry and RT-PCR, we now can show the differentiation dependent expression of UCN mRNA and peptide in human mesenchymal progenitor cells (MSCs) directed to the osteoblastic phenotype for the first time. UCN expression was down regulated by TGF-beta and BMP-2 in the early proliferation phase of osteoblast development, whereas dexamethasone (dex) minimally induced UCN gene expression during matrix maturation after 24 h stimulation. Stimulation of MSCs for 28 days with ascorbate/beta-glycerophosphate (asc/bGp) induced UCN gene expression at day 14. This effect was prevented when using 1,25-vitamin D3 or dex in addition. There was no obvious correlation to osteocalcin (OCN) gene expression in these experiments. In MSCs from patients with metabolic bone disease (n = 9) UCN gene expression was significantly higher compared to MSCs from normal controls (n = 6). Human MSCs did not express any of the CRFR's during differentiation to osteoblasts. Our results indicate that UCN is produced during the development of MSCs to osteoblasts and differentially regulated during culture as well as by differentiation factors. The expression is maximal between proliferation and matrix maturation phase. However, UCN does not seem to act on the osteoblast itself as shown by the missing CRFR's. Our results suggest new perspectives on the role of urocortin in human skeletal tissue in health and disease."],["dc.identifier.doi","10.1007/s10735-009-9244-z"],["dc.identifier.isi","000275443300002"],["dc.identifier.pmid","19949969"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/4160"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56279"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1567-2379"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Differentiation dependent expression of urocortin's mRNA and peptide in human osteoprogenitor cells: influence of BMP-2, TGF-beta-1 and dexamethasone"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]